KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MAP3K15
Full Name:
Mitogen-activated protein kinase kinase kinase 15
Alias:
BA723P2.3; EC 2.7.11.25; FLJ16518; M3K15; MAP3K7; MAPK,ERK kinase kinase 15; MAPK/ERK kinase kinase 15; MEK kinase 15; MEKK 15
Type:
EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor);
STE
group; STE11 family
Mass (Da):
147437
Number AA:
1313
UniProt ID:
Q6ZN16
International Prot ID:
IPI00412740
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004709
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
A
G
A
L
G
A
A
S
E
S
P
Q
C
P
P
Site 2
S19
A
L
G
A
A
S
E
S
P
Q
C
P
P
P
P
Site 3
S48
A
E
G
A
A
G
G
S
G
E
G
E
S
G
G
Site 4
Y65
R
R
A
L
R
A
V
Y
V
R
S
E
S
S
Q
Site 5
S68
L
R
A
V
Y
V
R
S
E
S
S
Q
G
G
A
Site 6
S70
A
V
Y
V
R
S
E
S
S
Q
G
G
A
A
G
Site 7
T99
E
A
E
G
A
H
L
T
S
V
P
F
G
E
L
Site 8
S100
A
E
G
A
H
L
T
S
V
P
F
G
E
L
D
Site 9
S131
V
V
D
M
S
D
V
S
R
Q
P
S
L
F
Y
Site 10
S135
S
D
V
S
R
Q
P
S
L
F
Y
H
L
G
V
Site 11
T162
Y
H
D
T
D
A
D
T
A
L
S
L
K
D
M
Site 12
S165
T
D
A
D
T
A
L
S
L
K
D
M
V
T
Q
Site 13
T171
L
S
L
K
D
M
V
T
Q
K
N
T
A
S
S
Site 14
S206
S
D
A
Q
R
R
A
S
E
Y
M
Q
P
N
W
Site 15
Y208
A
Q
R
R
A
S
E
Y
M
Q
P
N
W
D
N
Site 16
Y243
H
V
T
S
C
V
Y
Y
K
E
T
L
L
N
D
Site 17
Y258
I
R
K
A
R
E
K
Y
Q
G
E
E
L
A
K
Site 18
T277
I
K
L
R
M
D
N
T
E
V
L
T
S
D
I
Site 19
Y298
S
Y
R
D
I
Q
D
Y
D
A
M
V
K
L
V
Site 20
T313
E
T
L
E
M
L
P
T
C
D
L
A
D
Q
H
Site 21
S335
F
A
L
N
R
R
N
S
T
G
D
R
E
K
A
Site 22
T336
A
L
N
R
R
N
S
T
G
D
R
E
K
A
L
Site 23
S352
I
M
L
Q
V
L
Q
S
C
D
H
P
G
P
D
Site 24
S375
Y
K
D
I
F
L
D
S
D
C
K
D
D
T
S
Site 25
T381
D
S
D
C
K
D
D
T
S
R
D
S
A
I
E
Site 26
S382
S
D
C
K
D
D
T
S
R
D
S
A
I
E
W
Site 27
S385
K
D
D
T
S
R
D
S
A
I
E
W
Y
R
K
Site 28
S398
R
K
G
F
E
L
Q
S
S
L
Y
S
G
I
N
Site 29
S399
K
G
F
E
L
Q
S
S
L
Y
S
G
I
N
L
Site 30
S420
A
G
Q
Q
F
E
T
S
L
E
L
R
K
I
G
Site 31
S432
K
I
G
V
R
L
N
S
L
L
G
R
K
G
S
Site 32
S439
S
L
L
G
R
K
G
S
L
E
K
M
N
N
Y
Site 33
Y446
S
L
E
K
M
N
N
Y
W
D
V
G
Q
F
F
Site 34
Y481
K
L
K
P
P
V
W
Y
L
R
S
L
V
Q
N
Site 35
S484
P
P
V
W
Y
L
R
S
L
V
Q
N
L
L
L
Site 36
T498
L
I
R
R
F
K
K
T
I
I
E
H
S
P
R
Site 37
S503
K
K
T
I
I
E
H
S
P
R
Q
E
R
L
N
Site 38
T537
P
V
L
V
I
E
P
T
K
V
Y
Q
P
S
Y
Site 39
Y544
T
K
V
Y
Q
P
S
Y
V
S
I
N
N
E
A
Site 40
S557
E
A
E
E
R
T
V
S
L
W
H
V
S
P
T
Site 41
S562
T
V
S
L
W
H
V
S
P
T
E
M
K
Q
M
Site 42
T575
Q
M
H
E
W
N
F
T
A
S
S
I
K
G
I
Site 43
S578
E
W
N
F
T
A
S
S
I
K
G
I
S
L
S
Site 44
S583
A
S
S
I
K
G
I
S
L
S
K
F
D
E
R
Site 45
S585
S
I
K
G
I
S
L
S
K
F
D
E
R
C
C
Site 46
Y595
D
E
R
C
C
F
L
Y
V
H
D
N
S
D
D
Site 47
Y606
N
S
D
D
F
Q
I
Y
F
S
T
E
E
Q
C
Site 48
S608
D
D
F
Q
I
Y
F
S
T
E
E
Q
C
S
R
Site 49
S614
F
S
T
E
E
Q
C
S
R
F
F
S
L
V
K
Site 50
S618
E
Q
C
S
R
F
F
S
L
V
K
E
M
I
T
Site 51
T642
E
G
E
T
D
G
D
T
L
E
Y
E
Y
D
H
Site 52
Y645
T
D
G
D
T
L
E
Y
E
Y
D
H
D
A
N
Site 53
Y667
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Site 54
S688
K
E
I
P
E
R
D
S
R
Y
S
Q
P
L
H
Site 55
Y690
I
P
E
R
D
S
R
Y
S
Q
P
L
H
E
E
Site 56
S691
P
E
R
D
S
R
Y
S
Q
P
L
H
E
E
I
Site 57
Y703
E
E
I
A
L
H
K
Y
L
K
H
R
N
I
V
Site 58
Y712
K
H
R
N
I
V
Q
Y
L
G
S
V
S
E
N
Site 59
Y721
G
S
V
S
E
N
G
Y
I
K
I
F
M
E
Q
Site 60
S735
Q
V
P
G
G
S
L
S
A
L
L
R
S
K
W
Site 61
Y763
Q
I
L
E
G
L
K
Y
L
H
E
N
Q
I
V
Site 62
T783
G
D
N
V
L
V
N
T
Y
S
G
V
V
K
I
Site 63
Y784
D
N
V
L
V
N
T
Y
S
G
V
V
K
I
S
Site 64
S791
Y
S
G
V
V
K
I
S
D
F
G
T
S
K
R
Site 65
S796
K
I
S
D
F
G
T
S
K
R
L
A
G
V
N
Site 66
T808
G
V
N
P
C
T
E
T
F
T
G
T
L
Q
Y
Site 67
T812
C
T
E
T
F
T
G
T
L
Q
Y
M
A
P
E
Site 68
Y828
I
D
Q
G
P
R
G
Y
G
A
P
A
D
I
W
Site 69
S847
T
I
I
E
M
A
T
S
K
P
P
F
H
E
L
Site 70
S887
E
A
R
A
F
I
L
S
C
F
E
P
D
P
H
Site 71
T898
P
D
P
H
K
R
A
T
T
A
E
L
L
R
E
Site 72
T899
D
P
H
K
R
A
T
T
A
E
L
L
R
E
G
Site 73
S924
N
R
I
A
F
K
P
S
E
G
P
R
G
V
V
Site 74
T936
G
V
V
L
A
L
P
T
Q
G
E
P
M
A
T
Site 75
T943
T
Q
G
E
P
M
A
T
S
S
S
E
H
G
S
Site 76
S944
Q
G
E
P
M
A
T
S
S
S
E
H
G
S
V
Site 77
S945
G
E
P
M
A
T
S
S
S
E
H
G
S
V
S
Site 78
S946
E
P
M
A
T
S
S
S
E
H
G
S
V
S
P
Site 79
S950
T
S
S
S
E
H
G
S
V
S
P
D
S
D
A
Site 80
S952
S
S
E
H
G
S
V
S
P
D
S
D
A
Q
P
Site 81
S955
H
G
S
V
S
P
D
S
D
A
Q
P
D
A
L
Site 82
T966
P
D
A
L
F
E
R
T
R
A
P
R
H
H
L
Site 83
S978
H
H
L
G
H
L
L
S
V
P
D
E
S
S
A
Site 84
S984
L
S
V
P
D
E
S
S
A
L
E
D
R
G
L
Site 85
S993
L
E
D
R
G
L
A
S
S
P
E
D
R
D
Q
Site 86
S994
E
D
R
G
L
A
S
S
P
E
D
R
D
Q
G
Site 87
S1009
L
F
L
L
R
K
D
S
E
R
R
A
I
L
Y
Site 88
Y1016
S
E
R
R
A
I
L
Y
K
I
L
W
E
E
Q
Site 89
S1044
S
S
E
E
L
H
L
S
V
G
H
I
K
Q
I
Site 90
S1061
I
L
R
D
F
I
R
S
P
E
H
R
V
M
A
Site 91
T1070
E
H
R
V
M
A
T
T
I
S
K
L
K
V
D
Site 92
S1082
K
V
D
L
D
F
D
S
S
S
I
S
Q
I
H
Site 93
S1083
V
D
L
D
F
D
S
S
S
I
S
Q
I
H
L
Site 94
S1084
D
L
D
F
D
S
S
S
I
S
Q
I
H
L
V
Site 95
Y1159
M
D
E
A
E
E
G
Y
P
P
A
T
G
P
G
Site 96
T1187
L
G
E
L
R
Q
E
T
N
R
L
L
E
H
L
Site 97
Y1201
L
V
E
K
E
R
E
Y
Q
N
L
L
R
Q
T
Site 98
T1208
Y
Q
N
L
L
R
Q
T
L
E
Q
K
T
Q
E
Site 99
S1225
H
L
Q
L
K
L
K
S
N
C
I
T
E
N
P
Site 100
T1229
K
L
K
S
N
C
I
T
E
N
P
A
G
P
Y
Site 101
T1257
L
Q
G
A
D
A
K
T
I
E
K
I
V
E
E
Site 102
T1267
K
I
V
E
E
G
Y
T
L
S
D
I
L
N
E
Site 103
S1269
V
E
E
G
Y
T
L
S
D
I
L
N
E
I
T
Site 104
Y1282
I
T
K
E
D
L
R
Y
L
R
L
R
G
G
L
Site 105
S1295
G
L
L
C
R
L
W
S
A
V
S
Q
Y
R
R
Site 106
S1298
C
R
L
W
S
A
V
S
Q
Y
R
R
A
Q
E
Site 107
S1307
Y
R
R
A
Q
E
A
S
E
T
K
D
K
A
_
Site 108
T1309
R
A
Q
E
A
S
E
T
K
D
K
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation