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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MACC1
Full Name:
Metastasis-associated in colon cancer protein 1
Alias:
7A5; Metastasis associated in colon cancer 1; SH3 domain-containing protein 7a5; SH3BP4L
Type:
Uncharacterized protein
Mass (Da):
96639
Number AA:
852
UniProt ID:
Q6ZN28
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008083
PhosphoSite+
KinaseNET
Biological Process:
GO:0051781
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
T
E
R
K
H
F
R
S
G
R
I
A
Q
S
M
Site 2
S17
R
S
G
R
I
A
Q
S
M
S
E
A
N
L
I
Site 3
S19
G
R
I
A
Q
S
M
S
E
A
N
L
I
D
M
Site 4
S32
D
M
E
A
G
K
L
S
K
S
C
N
I
T
E
Site 5
S34
E
A
G
K
L
S
K
S
C
N
I
T
E
C
Q
Site 6
T38
L
S
K
S
C
N
I
T
E
C
Q
D
P
D
L
Site 7
S61
T
L
R
G
N
N
A
S
K
V
A
N
P
F
W
Site 8
S72
N
P
F
W
N
Q
L
S
A
S
N
P
F
L
D
Site 9
S74
F
W
N
Q
L
S
A
S
N
P
F
L
D
D
I
Site 10
T82
N
P
F
L
D
D
I
T
Q
L
R
N
N
R
K
Site 11
S112
R
E
I
E
N
G
N
S
F
D
S
S
G
D
E
Site 12
S115
E
N
G
N
S
F
D
S
S
G
D
E
L
D
V
Site 13
S116
N
G
N
S
F
D
S
S
G
D
E
L
D
V
H
Site 14
T129
V
H
Q
L
L
R
Q
T
S
S
R
N
S
G
R
Site 15
S130
H
Q
L
L
R
Q
T
S
S
R
N
S
G
R
S
Site 16
S131
Q
L
L
R
Q
T
S
S
R
N
S
G
R
S
K
Site 17
S134
R
Q
T
S
S
R
N
S
G
R
S
K
S
V
S
Site 18
S137
S
S
R
N
S
G
R
S
K
S
V
S
E
L
L
Site 19
S139
R
N
S
G
R
S
K
S
V
S
E
L
L
D
I
Site 20
S141
S
G
R
S
K
S
V
S
E
L
L
D
I
L
D
Site 21
S160
A
H
Q
S
I
H
N
S
D
Q
I
L
L
H
D
Site 22
Y178
L
K
N
D
R
E
A
Y
K
M
A
W
L
S
Q
Site 23
S184
A
Y
K
M
A
W
L
S
Q
R
Q
L
A
R
S
Site 24
S191
S
Q
R
Q
L
A
R
S
C
L
D
L
N
T
I
Site 25
T197
R
S
C
L
D
L
N
T
I
S
Q
S
P
G
W
Site 26
S199
C
L
D
L
N
T
I
S
Q
S
P
G
W
A
Q
Site 27
S201
D
L
N
T
I
S
Q
S
P
G
W
A
Q
T
Q
Site 28
S230
G
S
V
Q
L
P
E
S
D
I
T
V
H
V
P
Site 29
T233
Q
L
P
E
S
D
I
T
V
H
V
P
Q
G
H
Site 30
S302
E
V
R
K
D
P
F
S
Q
V
M
T
E
M
V
Site 31
T306
D
P
F
S
Q
V
M
T
E
M
V
C
L
H
S
Site 32
S313
T
E
M
V
C
L
H
S
L
G
K
E
G
P
F
Site 33
S357
A
Q
A
K
A
L
P
S
P
A
A
T
I
W
D
Site 34
T361
A
L
P
S
P
A
A
T
I
W
D
Y
I
H
K
Site 35
Y365
P
A
A
T
I
W
D
Y
I
H
K
T
T
S
I
Site 36
Y375
K
T
T
S
I
G
I
Y
G
P
K
Y
I
H
P
Site 37
T401
N
Y
M
P
G
Q
L
T
I
S
D
I
K
K
G
Site 38
S403
M
P
G
Q
L
T
I
S
D
I
K
K
G
G
K
Site 39
S413
K
K
G
G
K
N
I
S
P
V
V
F
Q
L
W
Site 40
S424
F
Q
L
W
G
K
Q
S
F
L
L
D
K
P
Q
Site 41
S434
L
D
K
P
Q
D
L
S
I
S
I
F
S
C
D
Site 42
S473
V
H
Q
Q
F
L
F
S
L
V
E
H
R
E
M
Site 43
T504
V
A
Q
F
S
I
T
T
P
D
P
T
P
N
L
Site 44
T508
S
I
T
T
P
D
P
T
P
N
L
K
R
L
S
Site 45
S515
T
P
N
L
K
R
L
S
N
L
P
G
Y
L
Q
Site 46
Y520
R
L
S
N
L
P
G
Y
L
Q
K
K
E
E
I
Site 47
S529
Q
K
K
E
E
I
K
S
A
P
L
S
P
K
I
Site 48
S533
E
I
K
S
A
P
L
S
P
K
I
L
V
K
Y
Site 49
Y540
S
P
K
I
L
V
K
Y
P
T
F
Q
D
K
T
Site 50
T542
K
I
L
V
K
Y
P
T
F
Q
D
K
T
L
N
Site 51
S551
Q
D
K
T
L
N
F
S
N
Y
G
V
T
L
K
Site 52
S564
L
K
A
V
L
R
Q
S
K
I
D
Y
F
L
E
Site 53
Y568
L
R
Q
S
K
I
D
Y
F
L
E
Y
F
K
G
Site 54
Y572
K
I
D
Y
F
L
E
Y
F
K
G
D
T
I
A
Site 55
Y598
Q
S
K
V
K
E
W
Y
V
G
V
L
R
G
K
Site 56
S626
K
E
Q
V
M
F
M
S
D
S
V
F
T
T
R
Site 57
T632
M
S
D
S
V
F
T
T
R
N
L
L
E
Q
I
Site 58
Y648
L
P
L
K
K
L
T
Y
I
Y
S
V
V
L
T
Site 59
Y650
L
K
K
L
T
Y
I
Y
S
V
V
L
T
L
V
Site 60
S651
K
K
L
T
Y
I
Y
S
V
V
L
T
L
V
S
Site 61
T655
Y
I
Y
S
V
V
L
T
L
V
S
E
K
V
Y
Site 62
S658
S
V
V
L
T
L
V
S
E
K
V
Y
D
W
K
Site 63
Y662
T
L
V
S
E
K
V
Y
D
W
K
V
L
A
D
Site 64
S690
Q
I
Q
A
D
K
E
S
E
K
V
S
Y
V
I
Site 65
S694
D
K
E
S
E
K
V
S
Y
V
I
K
K
L
K
Site 66
Y695
K
E
S
E
K
V
S
Y
V
I
K
K
L
K
E
Site 67
T706
K
L
K
E
D
C
H
T
E
R
N
T
R
K
F
Site 68
T710
D
C
H
T
E
R
N
T
R
K
F
L
Y
E
L
Site 69
T741
I
Q
E
A
A
V
L
T
S
A
V
K
L
G
K
Site 70
T761
A
E
K
L
V
R
L
T
K
Q
Q
M
E
A
Y
Site 71
Y768
T
K
Q
Q
M
E
A
Y
E
I
P
H
R
G
N
Site 72
T776
E
I
P
H
R
G
N
T
G
D
V
A
V
E
M
Site 73
Y793
K
P
A
Y
D
F
L
Y
T
W
S
A
H
Y
G
Site 74
Y803
S
A
H
Y
G
N
N
Y
R
D
V
L
Q
D
L
Site 75
S812
D
V
L
Q
D
L
Q
S
A
L
D
R
M
K
N
Site 76
T844
S
L
E
V
L
R
V
T
A
F
S
T
S
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation