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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GBP6
Full Name:
Guanylate-binding protein 6
Alias:
GTP-binding protein 6;Guanine nucleotide-binding protein 6
Type:
Mass (Da):
72427
Number AA:
633
UniProt ID:
Q6ZN66
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S52
G
L
Y
R
T
G
K
S
Y
L
M
N
H
L
A
Site 2
Y53
L
Y
R
T
G
K
S
Y
L
M
N
H
L
A
G
Site 3
S69
N
H
G
F
P
L
G
S
T
V
Q
S
E
T
K
Site 4
T70
H
G
F
P
L
G
S
T
V
Q
S
E
T
K
G
Site 5
S73
P
L
G
S
T
V
Q
S
E
T
K
G
I
W
M
Site 6
T75
G
S
T
V
Q
S
E
T
K
G
I
W
M
W
C
Site 7
S113
K
G
D
P
K
N
D
S
W
I
F
A
L
A
V
Site 8
Y144
Q
A
L
E
Q
L
H
Y
V
T
E
L
T
E
L
Site 9
S156
T
E
L
I
K
A
K
S
S
P
R
P
D
G
V
Site 10
S157
E
L
I
K
A
K
S
S
P
R
P
D
G
V
E
Site 11
S166
R
P
D
G
V
E
D
S
T
E
F
V
S
F
F
Site 12
T167
P
D
G
V
E
D
S
T
E
F
V
S
F
F
P
Site 13
S171
E
D
S
T
E
F
V
S
F
F
P
D
F
L
W
Site 14
Y199
H
P
I
T
E
D
E
Y
L
E
N
A
L
K
L
Site 15
T216
G
N
N
P
R
V
Q
T
S
N
F
P
R
E
C
Site 16
T240
C
F
V
F
D
R
P
T
N
D
K
D
L
L
A
Site 17
T280
F
T
H
A
R
T
K
T
L
R
E
G
I
T
V
Site 18
T286
K
T
L
R
E
G
I
T
V
T
G
N
R
L
G
Site 19
S324
T
L
A
Q
R
E
N
S
A
A
V
Q
R
A
A
Site 20
Y333
A
V
Q
R
A
A
D
Y
Y
S
Q
Q
M
A
Q
Site 21
Y334
V
Q
R
A
A
D
Y
Y
S
Q
Q
M
A
Q
R
Site 22
S335
Q
R
A
A
D
Y
Y
S
Q
Q
M
A
Q
R
V
Site 23
T346
A
Q
R
V
K
L
P
T
D
T
L
Q
E
L
L
Site 24
T348
R
V
K
L
P
T
D
T
L
Q
E
L
L
D
M
Site 25
S371
I
A
I
F
M
E
H
S
F
K
D
E
N
Q
E
Site 26
S401
F
L
L
Q
N
E
E
S
S
V
Q
Y
C
Q
A
Site 27
Y405
N
E
E
S
S
V
Q
Y
C
Q
A
K
L
N
E
Site 28
S425
M
E
S
I
S
A
G
S
F
S
V
P
G
G
H
Site 29
Y435
V
P
G
G
H
K
L
Y
M
E
T
K
E
R
I
Site 30
Y446
K
E
R
I
E
Q
D
Y
W
Q
V
P
R
K
G
Site 31
S466
V
F
Q
R
F
L
E
S
Q
M
V
I
E
E
S
Site 32
S477
I
E
E
S
I
L
Q
S
D
K
A
L
T
D
R
Site 33
T482
L
Q
S
D
K
A
L
T
D
R
E
K
A
V
A
Site 34
S522
Q
M
E
A
Q
D
K
S
R
K
E
N
I
A
Q
Site 35
Y568
H
E
G
F
K
K
K
Y
E
E
M
N
A
E
I
Site 36
T590
D
T
T
K
N
D
D
T
P
W
I
A
R
T
L
Site 37
S624
H
G
V
K
G
V
S
S
L
F
K
K
H
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation