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Updated November 2019
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Protein Info
Short Name:
RNF111
Full Name:
E3 ubiquitin-protein ligase Arkadia
Alias:
RING finger protein 111
Type:
Mass (Da):
108876
Number AA:
994
UniProt ID:
Q6ZNA4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
S
Q
W
T
P
E
Y
K
E
L
Y
T
L
K
Site 2
Y12
T
P
E
Y
K
E
L
Y
T
L
K
V
D
M
K
Site 3
S20
T
L
K
V
D
M
K
S
E
I
P
S
D
A
P
Site 4
S24
D
M
K
S
E
I
P
S
D
A
P
K
T
Q
E
Site 5
T29
I
P
S
D
A
P
K
T
Q
E
S
L
K
G
I
Site 6
S32
D
A
P
K
T
Q
E
S
L
K
G
I
L
L
H
Site 7
S58
A
G
V
E
M
I
N
S
K
V
G
N
E
F
S
Site 8
S65
S
K
V
G
N
E
F
S
H
L
C
D
D
S
Q
Site 9
S71
F
S
H
L
C
D
D
S
Q
K
Q
E
K
E
M
Site 10
S88
N
Q
Q
E
Q
E
K
S
L
V
V
R
K
K
R
Site 11
S97
V
V
R
K
K
R
K
S
Q
Q
A
G
P
S
Y
Site 12
Y104
S
Q
Q
A
G
P
S
Y
V
Q
N
C
V
K
E
Site 13
T124
G
L
R
Q
H
L
G
T
P
S
D
E
D
N
D
Site 14
S126
R
Q
H
L
G
T
P
S
D
E
D
N
D
S
S
Site 15
S132
P
S
D
E
D
N
D
S
S
F
S
D
C
L
S
Site 16
S133
S
D
E
D
N
D
S
S
F
S
D
C
L
S
S
Site 17
S135
E
D
N
D
S
S
F
S
D
C
L
S
S
P
S
Site 18
S139
S
S
F
S
D
C
L
S
S
P
S
S
S
L
H
Site 19
S140
S
F
S
D
C
L
S
S
P
S
S
S
L
H
F
Site 20
S142
S
D
C
L
S
S
P
S
S
S
L
H
F
G
D
Site 21
S143
D
C
L
S
S
P
S
S
S
L
H
F
G
D
S
Site 22
S144
C
L
S
S
P
S
S
S
L
H
F
G
D
S
D
Site 23
S150
S
S
L
H
F
G
D
S
D
T
V
T
S
D
E
Site 24
T152
L
H
F
G
D
S
D
T
V
T
S
D
E
D
K
Site 25
T154
F
G
D
S
D
T
V
T
S
D
E
D
K
E
V
Site 26
S155
G
D
S
D
T
V
T
S
D
E
D
K
E
V
S
Site 27
S162
S
D
E
D
K
E
V
S
V
R
H
S
Q
T
I
Site 28
S166
K
E
V
S
V
R
H
S
Q
T
I
L
N
A
K
Site 29
S174
Q
T
I
L
N
A
K
S
R
S
H
S
A
R
S
Site 30
S176
I
L
N
A
K
S
R
S
H
S
A
R
S
H
K
Site 31
S178
N
A
K
S
R
S
H
S
A
R
S
H
K
W
P
Site 32
T187
R
S
H
K
W
P
R
T
E
T
E
S
V
S
G
Site 33
T189
H
K
W
P
R
T
E
T
E
S
V
S
G
L
L
Site 34
S191
W
P
R
T
E
T
E
S
V
S
G
L
L
M
K
Site 35
S205
K
R
P
C
L
H
G
S
S
L
R
R
L
P
C
Site 36
S206
R
P
C
L
H
G
S
S
L
R
R
L
P
C
R
Site 37
S221
K
R
F
V
K
N
N
S
S
Q
R
T
Q
K
Q
Site 38
S222
R
F
V
K
N
N
S
S
Q
R
T
Q
K
Q
K
Site 39
T225
K
N
N
S
S
Q
R
T
Q
K
Q
K
E
R
I
Site 40
Y247
E
V
L
A
R
R
K
Y
A
L
L
P
S
S
S
Site 41
S252
R
K
Y
A
L
L
P
S
S
S
S
S
S
E
N
Site 42
S253
K
Y
A
L
L
P
S
S
S
S
S
S
E
N
D
Site 43
S254
Y
A
L
L
P
S
S
S
S
S
S
E
N
D
L
Site 44
S255
A
L
L
P
S
S
S
S
S
S
E
N
D
L
S
Site 45
S256
L
L
P
S
S
S
S
S
S
E
N
D
L
S
S
Site 46
S257
L
P
S
S
S
S
S
S
E
N
D
L
S
S
E
Site 47
S262
S
S
S
E
N
D
L
S
S
E
S
S
S
S
S
Site 48
S263
S
S
E
N
D
L
S
S
E
S
S
S
S
S
S
Site 49
S265
E
N
D
L
S
S
E
S
S
S
S
S
S
T
E
Site 50
S266
N
D
L
S
S
E
S
S
S
S
S
S
T
E
G
Site 51
S267
D
L
S
S
E
S
S
S
S
S
S
T
E
G
E
Site 52
S268
L
S
S
E
S
S
S
S
S
S
T
E
G
E
E
Site 53
S269
S
S
E
S
S
S
S
S
S
T
E
G
E
E
D
Site 54
S270
S
E
S
S
S
S
S
S
T
E
G
E
E
D
L
Site 55
T271
E
S
S
S
S
S
S
T
E
G
E
E
D
L
F
Site 56
S282
E
D
L
F
V
S
A
S
E
N
H
Q
N
N
P
Site 57
T308
V
V
I
E
A
S
S
T
P
Q
V
T
A
N
E
Site 58
T320
A
N
E
E
I
N
V
T
S
T
D
S
E
V
E
Site 59
T330
D
S
E
V
E
I
V
T
V
G
E
S
Y
R
S
Site 60
S334
E
I
V
T
V
G
E
S
Y
R
S
R
S
T
L
Site 61
Y335
I
V
T
V
G
E
S
Y
R
S
R
S
T
L
G
Site 62
S337
T
V
G
E
S
Y
R
S
R
S
T
L
G
H
S
Site 63
S339
G
E
S
Y
R
S
R
S
T
L
G
H
S
R
S
Site 64
T340
E
S
Y
R
S
R
S
T
L
G
H
S
R
S
H
Site 65
S344
S
R
S
T
L
G
H
S
R
S
H
W
S
Q
G
Site 66
S346
S
T
L
G
H
S
R
S
H
W
S
Q
G
S
S
Site 67
S349
G
H
S
R
S
H
W
S
Q
G
S
S
S
H
A
Site 68
S352
R
S
H
W
S
Q
G
S
S
S
H
A
S
R
P
Site 69
S353
S
H
W
S
Q
G
S
S
S
H
A
S
R
P
Q
Site 70
S354
H
W
S
Q
G
S
S
S
H
A
S
R
P
Q
E
Site 71
S357
Q
G
S
S
S
H
A
S
R
P
Q
E
P
R
N
Site 72
S366
P
Q
E
P
R
N
R
S
R
I
S
T
V
I
Q
Site 73
S369
P
R
N
R
S
R
I
S
T
V
I
Q
P
L
R
Site 74
T370
R
N
R
S
R
I
S
T
V
I
Q
P
L
R
Q
Site 75
T386
A
A
E
V
V
D
L
T
V
D
E
D
E
P
T
Site 76
T393
T
V
D
E
D
E
P
T
V
V
P
T
T
S
A
Site 77
S399
P
T
V
V
P
T
T
S
A
R
M
E
S
Q
A
Site 78
S404
T
T
S
A
R
M
E
S
Q
A
T
S
A
S
I
Site 79
T407
A
R
M
E
S
Q
A
T
S
A
S
I
N
N
S
Site 80
S408
R
M
E
S
Q
A
T
S
A
S
I
N
N
S
N
Site 81
S410
E
S
Q
A
T
S
A
S
I
N
N
S
N
P
S
Site 82
S414
T
S
A
S
I
N
N
S
N
P
S
T
S
E
Q
Site 83
S417
S
I
N
N
S
N
P
S
T
S
E
Q
A
S
D
Site 84
T418
I
N
N
S
N
P
S
T
S
E
Q
A
S
D
T
Site 85
S419
N
N
S
N
P
S
T
S
E
Q
A
S
D
T
A
Site 86
S423
P
S
T
S
E
Q
A
S
D
T
A
S
A
V
T
Site 87
T425
T
S
E
Q
A
S
D
T
A
S
A
V
T
S
S
Site 88
S427
E
Q
A
S
D
T
A
S
A
V
T
S
S
Q
P
Site 89
S431
D
T
A
S
A
V
T
S
S
Q
P
S
T
V
S
Site 90
S432
T
A
S
A
V
T
S
S
Q
P
S
T
V
S
E
Site 91
S435
A
V
T
S
S
Q
P
S
T
V
S
E
T
S
A
Site 92
T436
V
T
S
S
Q
P
S
T
V
S
E
T
S
A
T
Site 93
S438
S
S
Q
P
S
T
V
S
E
T
S
A
T
L
T
Site 94
S441
P
S
T
V
S
E
T
S
A
T
L
T
S
N
S
Site 95
T443
T
V
S
E
T
S
A
T
L
T
S
N
S
T
T
Site 96
T445
S
E
T
S
A
T
L
T
S
N
S
T
T
G
T
Site 97
S446
E
T
S
A
T
L
T
S
N
S
T
T
G
T
S
Site 98
S448
S
A
T
L
T
S
N
S
T
T
G
T
S
I
G
Site 99
T450
T
L
T
S
N
S
T
T
G
T
S
I
G
D
D
Site 100
T452
T
S
N
S
T
T
G
T
S
I
G
D
D
S
R
Site 101
S458
G
T
S
I
G
D
D
S
R
R
T
T
S
S
A
Site 102
T461
I
G
D
D
S
R
R
T
T
S
S
A
V
T
E
Site 103
T462
G
D
D
S
R
R
T
T
S
S
A
V
T
E
T
Site 104
S463
D
D
S
R
R
T
T
S
S
A
V
T
E
T
G
Site 105
S464
D
S
R
R
T
T
S
S
A
V
T
E
T
G
P
Site 106
T467
R
T
T
S
S
A
V
T
E
T
G
P
P
A
M
Site 107
S479
P
A
M
P
R
L
P
S
C
C
P
Q
H
S
P
Site 108
S485
P
S
C
C
P
Q
H
S
P
C
G
G
S
S
Q
Site 109
S491
H
S
P
C
G
G
S
S
Q
N
H
H
A
L
G
Site 110
T502
H
A
L
G
H
P
H
T
S
C
F
Q
Q
H
G
Site 111
T521
H
H
H
H
H
H
H
T
P
H
P
A
V
P
V
Site 112
S529
P
H
P
A
V
P
V
S
P
S
F
S
D
P
A
Site 113
S553
Q
A
P
C
G
A
N
S
S
S
G
T
S
Y
H
Site 114
S554
A
P
C
G
A
N
S
S
S
G
T
S
Y
H
E
Site 115
S555
P
C
G
A
N
S
S
S
G
T
S
Y
H
E
Q
Site 116
S558
A
N
S
S
S
G
T
S
Y
H
E
Q
Q
A
L
Site 117
Y559
N
S
S
S
G
T
S
Y
H
E
Q
Q
A
L
P
Site 118
S570
Q
A
L
P
V
D
L
S
N
S
G
I
R
S
H
Site 119
S572
L
P
V
D
L
S
N
S
G
I
R
S
H
G
S
Site 120
S576
L
S
N
S
G
I
R
S
H
G
S
G
S
F
H
Site 121
S579
S
G
I
R
S
H
G
S
G
S
F
H
G
A
S
Site 122
S581
I
R
S
H
G
S
G
S
F
H
G
A
S
A
F
Site 123
S586
S
G
S
F
H
G
A
S
A
F
D
P
C
C
P
Site 124
S612
Q
A
A
A
A
A
P
S
Q
P
L
S
S
I
D
Site 125
S616
A
A
P
S
Q
P
L
S
S
I
D
G
Y
G
S
Site 126
S617
A
P
S
Q
P
L
S
S
I
D
G
Y
G
S
S
Site 127
Y621
P
L
S
S
I
D
G
Y
G
S
S
M
V
A
Q
Site 128
S624
S
I
D
G
Y
G
S
S
M
V
A
Q
P
Q
P
Site 129
S638
P
Q
P
P
P
Q
P
S
L
S
S
C
R
H
Y
Site 130
S640
P
P
P
Q
P
S
L
S
S
C
R
H
Y
M
P
Site 131
S641
P
P
Q
P
S
L
S
S
C
R
H
Y
M
P
P
Site 132
Y645
S
L
S
S
C
R
H
Y
M
P
P
P
Y
A
S
Site 133
Y650
R
H
Y
M
P
P
P
Y
A
S
L
T
R
P
L
Site 134
S652
Y
M
P
P
P
Y
A
S
L
T
R
P
L
H
H
Site 135
T654
P
P
P
Y
A
S
L
T
R
P
L
H
H
Q
A
Site 136
S662
R
P
L
H
H
Q
A
S
A
C
P
H
S
H
G
Site 137
S667
Q
A
S
A
C
P
H
S
H
G
N
P
P
P
Q
Site 138
T675
H
G
N
P
P
P
Q
T
Q
P
P
P
Q
V
D
Site 139
Y683
Q
P
P
P
Q
V
D
Y
V
I
P
H
P
V
H
Site 140
S694
H
P
V
H
A
F
H
S
Q
I
S
S
H
A
T
Site 141
S698
A
F
H
S
Q
I
S
S
H
A
T
S
H
P
V
Site 142
T701
S
Q
I
S
S
H
A
T
S
H
P
V
A
P
P
Site 143
S702
Q
I
S
S
H
A
T
S
H
P
V
A
P
P
P
Site 144
S715
P
P
P
T
H
L
A
S
T
A
A
P
I
P
Q
Site 145
T716
P
P
T
H
L
A
S
T
A
A
P
I
P
Q
H
Site 146
T727
I
P
Q
H
L
P
P
T
H
Q
P
I
S
H
H
Site 147
S732
P
P
T
H
Q
P
I
S
H
H
I
P
A
T
A
Site 148
T738
I
S
H
H
I
P
A
T
A
P
P
A
Q
R
L
Site 149
Y783
P
H
R
M
H
P
N
Y
G
H
G
H
H
I
H
Site 150
T822
G
V
T
A
A
T
Y
T
P
G
A
L
H
P
H
Site 151
Y833
L
H
P
H
L
A
H
Y
H
A
P
P
R
L
H
Site 152
Y857
M
V
P
D
M
A
G
Y
P
H
I
R
Y
I
S
Site 153
Y862
A
G
Y
P
H
I
R
Y
I
S
S
G
L
D
G
Site 154
S864
Y
P
H
I
R
Y
I
S
S
G
L
D
G
T
S
Site 155
S865
P
H
I
R
Y
I
S
S
G
L
D
G
T
S
F
Site 156
T870
I
S
S
G
L
D
G
T
S
F
R
G
P
F
R
Site 157
S871
S
S
G
L
D
G
T
S
F
R
G
P
F
R
G
Site 158
S898
G
N
V
N
R
G
A
S
Q
G
T
I
E
R
C
Site 159
T906
Q
G
T
I
E
R
C
T
Y
P
H
K
Y
K
K
Site 160
Y907
G
T
I
E
R
C
T
Y
P
H
K
Y
K
K
V
Site 161
Y911
R
C
T
Y
P
H
K
Y
K
K
V
T
T
D
W
Site 162
T938
E
E
G
T
E
E
D
T
E
E
K
C
T
I
C
Site 163
T943
E
D
T
E
E
K
C
T
I
C
L
S
I
L
E
Site 164
S947
E
K
C
T
I
C
L
S
I
L
E
E
G
E
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation