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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RUFY4
Full Name:
RUN and FYVE domain-containing protein 4
Alias:
Type:
Mass (Da):
64350
Number AA:
571
UniProt ID:
Q6ZNE9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
G
D
G
Q
G
P
V
T
D
T
S
A
E
L
H
Site 2
S36
Q
G
P
V
T
D
T
S
A
E
L
H
R
L
C
Site 3
S59
F
D
Q
K
E
Q
K
S
F
L
G
P
R
K
D
Site 4
Y67
F
L
G
P
R
K
D
Y
W
D
F
L
C
T
A
Site 5
S90
E
P
I
H
F
V
R
S
Q
D
K
L
K
T
P
Site 6
T96
R
S
Q
D
K
L
K
T
P
L
G
K
G
R
A
Site 7
S125
L
Q
L
C
L
L
N
S
E
L
T
R
E
W
Y
Site 8
Y132
S
E
L
T
R
E
W
Y
G
P
R
S
P
L
L
Site 9
S136
R
E
W
Y
G
P
R
S
P
L
L
C
P
E
R
Site 10
S150
R
Q
E
D
I
L
D
S
L
Y
A
L
N
G
V
Site 11
S176
D
G
A
W
P
M
F
S
E
S
R
C
S
S
S
Site 12
S178
A
W
P
M
F
S
E
S
R
C
S
S
S
T
Q
Site 13
S181
M
F
S
E
S
R
C
S
S
S
T
Q
T
Q
G
Site 14
S182
F
S
E
S
R
C
S
S
S
T
Q
T
Q
G
R
Site 15
S183
S
E
S
R
C
S
S
S
T
Q
T
Q
G
R
R
Site 16
T184
E
S
R
C
S
S
S
T
Q
T
Q
G
R
R
P
Site 17
T186
R
C
S
S
S
T
Q
T
Q
G
R
R
P
R
K
Site 18
Y205
P
K
K
I
P
A
A
Y
G
G
P
E
N
V
Q
Site 19
S216
E
N
V
Q
I
E
D
S
H
T
S
Q
A
I
C
Site 20
T218
V
Q
I
E
D
S
H
T
S
Q
A
I
C
L
Q
Site 21
S219
Q
I
E
D
S
H
T
S
Q
A
I
C
L
Q
D
Site 22
S239
Q
L
A
G
L
P
R
S
Q
Q
Q
R
H
L
P
Site 23
S255
F
L
E
K
K
G
E
S
S
R
K
H
R
Y
P
Site 24
Y261
E
S
S
R
K
H
R
Y
P
Q
S
M
W
E
P
Site 25
S264
R
K
H
R
Y
P
Q
S
M
W
E
P
E
G
K
Site 26
T292
E
I
F
L
G
N
S
T
P
S
T
Q
G
Q
G
Site 27
T295
L
G
N
S
T
P
S
T
Q
G
Q
G
K
G
A
Site 28
T328
L
V
A
E
G
Q
R
T
T
E
G
T
H
K
K
Site 29
T329
V
A
E
G
Q
R
T
T
E
G
T
H
K
K
E
Site 30
T332
G
Q
R
T
T
E
G
T
H
K
K
E
A
E
W
Site 31
S349
V
Q
R
L
L
M
P
S
P
R
G
A
V
E
G
Site 32
S359
G
A
V
E
G
A
V
S
G
S
R
Q
G
S
G
Site 33
S361
V
E
G
A
V
S
G
S
R
Q
G
S
G
G
S
Site 34
S365
V
S
G
S
R
Q
G
S
G
G
S
S
I
L
G
Site 35
S369
R
Q
G
S
G
G
S
S
I
L
G
E
P
W
V
Site 36
T382
W
V
L
Q
G
H
A
T
K
E
D
S
T
V
E
Site 37
S386
G
H
A
T
K
E
D
S
T
V
E
N
P
Q
V
Site 38
T387
H
A
T
K
E
D
S
T
V
E
N
P
Q
V
Q
Site 39
S410
R
E
E
Q
A
E
V
S
L
Q
D
E
I
K
S
Site 40
S417
S
L
Q
D
E
I
K
S
L
R
L
G
L
R
K
Site 41
S451
Q
A
L
R
E
Q
L
S
R
C
Q
E
E
R
A
Site 42
Y478
A
E
R
R
D
A
M
Y
Q
E
E
L
G
G
Q
Site 43
S515
Q
R
L
Q
H
L
S
S
M
A
P
E
C
C
V
Site 44
S532
S
K
I
F
G
R
F
S
R
R
Y
P
C
R
L
Site 45
Y535
F
G
R
F
S
R
R
Y
P
C
R
L
C
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation