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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NBEAL2
Full Name:
Neurobeachin-like protein 2
Alias:
KIAA0540; neurobeachin-like 2
Type:
Adaptor/scaffold
Mass (Da):
302517
Number AA:
2754
UniProt ID:
Q6ZNJ1
International Prot ID:
IPI00894235
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
Y
E
L
W
L
L
Y
Y
A
Q
K
D
L
G
Y
Site 2
Y22
Y
A
Q
K
D
L
G
Y
L
Q
Q
W
L
K
A
Site 3
S39
G
A
F
K
K
S
I
S
L
S
S
L
E
P
R
Site 4
S41
F
K
K
S
I
S
L
S
S
L
E
P
R
R
P
Site 5
S42
K
K
S
I
S
L
S
S
L
E
P
R
R
P
E
Site 6
T129
P
P
P
Q
G
R
G
T
Q
L
E
N
V
A
L
Site 7
Y149
C
E
G
L
F
D
P
Y
Q
T
W
R
R
Q
R
Site 8
T151
G
L
F
D
P
Y
Q
T
W
R
R
Q
R
S
G
Site 9
S157
Q
T
W
R
R
Q
R
S
G
E
V
I
S
S
K
Site 10
S162
Q
R
S
G
E
V
I
S
S
K
E
K
S
K
Y
Site 11
S163
R
S
G
E
V
I
S
S
K
E
K
S
K
Y
K
Site 12
S167
V
I
S
S
K
E
K
S
K
Y
K
F
P
P
A
Site 13
Y169
S
S
K
E
K
S
K
Y
K
F
P
P
A
A
L
Site 14
S187
F
S
A
F
F
Q
E
S
L
Q
N
A
D
H
L
Site 15
S231
G
S
V
K
G
L
L
S
V
V
R
G
W
S
R
Site 16
S237
L
S
V
V
R
G
W
S
R
G
P
A
P
D
P
Site 17
S264
A
V
H
V
L
H
A
S
R
A
P
P
R
G
P
Site 18
S294
D
W
P
A
G
L
S
S
G
P
E
E
A
L
V
Site 19
T326
D
R
P
V
L
Q
A
T
F
L
S
N
N
C
F
Site 20
S343
L
T
R
L
I
Q
N
S
K
L
Y
L
Q
S
R
Site 21
Y346
L
I
Q
N
S
K
L
Y
L
Q
S
R
A
P
P
Site 22
S357
R
A
P
P
E
G
D
S
D
L
A
T
R
L
L
Site 23
T361
E
G
D
S
D
L
A
T
R
L
L
T
E
P
D
Site 24
T365
D
L
A
T
R
L
L
T
E
P
D
V
Q
K
V
Site 25
T377
Q
K
V
L
D
Q
D
T
D
A
I
A
V
H
V
Site 26
S393
R
V
L
T
C
I
M
S
D
S
P
S
A
K
E
Site 27
S397
C
I
M
S
D
S
P
S
A
K
E
V
F
K
E
Site 28
Y408
V
F
K
E
R
I
G
Y
P
H
L
Q
E
V
L
Site 29
S417
H
L
Q
E
V
L
Q
S
H
G
P
P
T
H
R
Site 30
T422
L
Q
S
H
G
P
P
T
H
R
L
L
Q
E
L
Site 31
S439
M
A
V
E
G
D
H
S
M
C
P
P
P
P
I
Site 32
S481
R
L
R
W
L
C
D
S
C
P
A
S
R
A
T
Site 33
S527
L
Q
A
L
G
R
V
S
I
R
P
M
E
L
R
Site 34
S545
R
P
R
P
G
L
D
S
E
P
G
G
A
E
A
Site 35
S566
G
A
V
I
R
T
L
S
G
M
A
R
H
Q
G
Site 36
Y580
G
P
A
R
A
L
R
Y
F
D
L
T
P
S
M
Site 37
T619
H
P
M
D
T
A
P
T
P
A
P
T
R
P
L
Site 38
Y632
P
L
Q
R
K
Q
L
Y
S
F
F
T
S
S
G
Site 39
S633
L
Q
R
K
Q
L
Y
S
F
F
T
S
S
G
S
Site 40
T636
K
Q
L
Y
S
F
F
T
S
S
G
S
G
F
E
Site 41
S637
Q
L
Y
S
F
F
T
S
S
G
S
G
F
E
A
Site 42
Y662
A
V
C
T
R
K
E
Y
L
T
M
S
L
P
E
Site 43
T664
C
T
R
K
E
Y
L
T
M
S
L
P
E
V
S
Site 44
S666
R
K
E
Y
L
T
M
S
L
P
E
V
S
F
A
Site 45
S671
T
M
S
L
P
E
V
S
F
A
D
S
A
W
H
Site 46
S692
V
P
G
R
R
P
F
S
Q
N
L
V
H
V
Y
Site 47
Y699
S
Q
N
L
V
H
V
Y
K
D
G
H
L
V
K
Site 48
T707
K
D
G
H
L
V
K
T
A
P
L
R
C
P
S
Site 49
S714
T
A
P
L
R
C
P
S
L
S
E
P
F
S
S
Site 50
S716
P
L
R
C
P
S
L
S
E
P
F
S
S
C
C
Site 51
S720
P
S
L
S
E
P
F
S
S
C
C
I
G
S
A
Site 52
T732
G
S
A
G
Y
R
T
T
T
T
T
T
G
L
P
Site 53
T733
S
A
G
Y
R
T
T
T
T
T
T
G
L
P
T
Site 54
T734
A
G
Y
R
T
T
T
T
T
T
G
L
P
T
P
Site 55
T735
G
Y
R
T
T
T
T
T
T
G
L
P
T
P
P
Site 56
T746
P
T
P
P
V
P
A
T
L
A
Y
T
H
P
A
Site 57
T755
A
Y
T
H
P
A
L
T
R
S
Q
S
V
P
A
Site 58
S757
T
H
P
A
L
T
R
S
Q
S
V
P
A
S
T
Site 59
S759
P
A
L
T
R
S
Q
S
V
P
A
S
T
G
L
Site 60
S763
T
H
P
A
L
T
R
S
Q
S
V
P
A
S
T
Site 61
S783
L
Q
E
G
S
I
D
S
T
L
A
G
T
Q
D
Site 62
T784
Q
E
G
S
I
D
S
T
L
A
G
T
Q
D
T
Site 63
T791
T
L
A
G
T
Q
D
T
R
W
G
S
P
T
S
Site 64
S795
T
Q
D
T
R
W
G
S
P
T
S
L
E
G
E
Site 65
T797
D
T
R
W
G
S
P
T
S
L
E
G
E
L
G
Site 66
S798
T
R
W
G
S
P
T
S
L
E
G
E
L
G
A
Site 67
S842
E
G
E
L
H
E
L
S
T
R
L
L
L
H
Y
Site 68
Y849
S
T
R
L
L
L
H
Y
S
P
Q
A
C
K
N
Site 69
S850
T
R
L
L
L
H
Y
S
P
Q
A
C
K
N
N
Site 70
S863
N
N
I
C
L
D
L
S
P
S
H
G
L
D
G
Site 71
T873
H
G
L
D
G
R
L
T
G
H
R
V
E
T
W
Site 72
T879
L
T
G
H
R
V
E
T
W
D
V
K
D
V
V
Site 73
T930
E
L
T
S
G
H
N
T
Q
G
L
V
L
P
L
Site 74
S940
L
V
L
P
L
G
K
S
S
E
E
R
M
E
R
Site 75
S941
V
L
P
L
G
K
S
S
E
E
R
M
E
R
N
Site 76
Y1044
V
R
L
G
H
I
Q
Y
M
S
S
I
V
R
E
Site 77
S1046
L
G
H
I
Q
Y
M
S
S
I
V
R
E
H
R
Site 78
Y1060
R
Q
K
L
R
K
K
Y
G
V
Q
F
I
L
D
Site 79
Y1073
L
D
A
L
R
T
H
Y
S
P
Q
R
E
R
P
Site 80
S1074
D
A
L
R
T
H
Y
S
P
Q
R
E
R
P
L
Site 81
S1092
D
L
R
T
V
Q
T
S
L
L
G
L
A
R
E
Site 82
S1104
A
R
E
F
L
V
R
S
L
S
A
D
D
V
Q
Site 83
S1196
N
E
R
L
P
E
R
S
R
Q
R
L
R
L
R
Site 84
Y1269
R
Q
L
F
H
L
I
Y
G
Q
P
D
V
V
R
Site 85
T1298
L
Y
V
L
E
A
A
T
A
G
S
P
P
P
S
Site 86
S1301
L
E
A
A
T
A
G
S
P
P
P
S
S
P
E
Site 87
S1305
T
A
G
S
P
P
P
S
S
P
E
S
P
T
S
Site 88
S1306
A
G
S
P
P
P
S
S
P
E
S
P
T
S
P
Site 89
S1309
P
P
P
S
S
P
E
S
P
T
S
P
K
P
A
Site 90
S1312
S
S
P
E
S
P
T
S
P
K
P
A
P
P
K
Site 91
T1322
P
A
P
P
K
P
P
T
E
S
P
A
E
P
S
Site 92
S1324
P
P
K
P
P
T
E
S
P
A
E
P
S
D
V
Site 93
S1329
T
E
S
P
A
E
P
S
D
V
F
L
P
S
E
Site 94
S1335
P
S
D
V
F
L
P
S
E
A
P
C
P
D
P
Site 95
Y1346
C
P
D
P
D
G
F
Y
H
A
L
S
P
F
C
Site 96
S1350
D
G
F
Y
H
A
L
S
P
F
C
T
P
F
D
Site 97
S1363
F
D
L
G
L
E
R
S
S
V
G
S
G
N
T
Site 98
S1364
D
L
G
L
E
R
S
S
V
G
S
G
N
T
A
Site 99
S1367
L
E
R
S
S
V
G
S
G
N
T
A
G
G
G
Site 100
S1377
T
A
G
G
G
G
S
S
G
T
L
T
P
A
S
Site 101
T1379
G
G
G
G
S
S
G
T
L
T
P
A
S
Q
P
Site 102
T1381
G
G
S
S
G
T
L
T
P
A
S
Q
P
G
T
Site 103
S1384
S
G
T
L
T
P
A
S
Q
P
G
T
P
S
P
Site 104
T1388
T
P
A
S
Q
P
G
T
P
S
P
L
D
G
P
Site 105
S1390
A
S
Q
P
G
T
P
S
P
L
D
G
P
R
P
Site 106
S1406
P
A
A
P
G
R
H
S
S
S
L
S
N
V
L
Site 107
S1407
A
A
P
G
R
H
S
S
S
L
S
N
V
L
E
Site 108
S1408
A
P
G
R
H
S
S
S
L
S
N
V
L
E
D
Site 109
S1410
G
R
H
S
S
S
L
S
N
V
L
E
D
G
S
Site 110
S1417
S
N
V
L
E
D
G
S
L
P
E
P
T
I
S
Site 111
S1424
S
L
P
E
P
T
I
S
G
D
D
T
S
N
T
Site 112
T1428
P
T
I
S
G
D
D
T
S
N
T
S
N
P
Q
Site 113
S1429
T
I
S
G
D
D
T
S
N
T
S
N
P
Q
Q
Site 114
T1431
S
G
D
D
T
S
N
T
S
N
P
Q
Q
T
S
Site 115
S1432
G
D
D
T
S
N
T
S
N
P
Q
Q
T
S
E
Site 116
S1461
T
W
R
G
V
E
G
S
D
E
A
A
W
R
E
Site 117
S1474
R
E
R
G
Q
V
F
S
V
L
T
Q
L
G
A
Site 118
T1484
T
Q
L
G
A
S
A
T
L
V
R
P
P
D
C
Site 119
S1495
P
P
D
C
I
K
R
S
L
L
E
M
M
L
E
Site 120
S1503
L
L
E
M
M
L
E
S
A
L
T
D
I
K
E
Site 121
T1609
R
L
H
M
L
L
Q
T
A
V
P
A
R
R
E
Site 122
Y1620
A
R
R
E
E
A
C
Y
V
L
S
K
L
E
A
Site 123
S1636
L
G
R
V
L
N
T
S
S
L
E
S
A
T
D
Site 124
S1637
G
R
V
L
N
T
S
S
L
E
S
A
T
D
E
Site 125
S1640
L
N
T
S
S
L
E
S
A
T
D
E
A
G
S
Site 126
S1647
S
A
T
D
E
A
G
S
P
L
A
A
A
A
A
Site 127
Y1676
R
T
L
L
D
R
A
Y
E
P
L
G
L
Q
W
Site 128
S1687
G
L
Q
W
G
L
P
S
L
P
P
T
N
G
S
Site 129
T1691
G
L
P
S
L
P
P
T
N
G
S
P
T
F
F
Site 130
S1694
S
L
P
P
T
N
G
S
P
T
F
F
E
D
F
Site 131
T1696
P
P
T
N
G
S
P
T
F
F
E
D
F
Q
A
Site 132
T1729
M
S
Q
F
E
M
D
T
Y
A
K
S
H
D
L
Site 133
Y1730
S
Q
F
E
M
D
T
Y
A
K
S
H
D
L
M
Site 134
Y1745
S
G
F
W
N
A
C
Y
D
M
L
M
S
S
G
Site 135
S1762
R
Q
W
E
R
A
Q
S
R
R
A
F
Q
E
L
Site 136
Y1785
A
R
L
E
G
L
R
Y
T
A
V
L
K
Q
Q
Site 137
T1786
R
L
E
G
L
R
Y
T
A
V
L
K
Q
Q
A
Site 138
T1822
G
A
W
A
L
R
D
T
P
I
P
R
W
K
L
Site 139
S1830
P
I
P
R
W
K
L
S
S
A
E
T
Y
S
R
Site 140
S1831
I
P
R
W
K
L
S
S
A
E
T
Y
S
R
M
Site 141
T1834
W
K
L
S
S
A
E
T
Y
S
R
M
R
L
K
Site 142
Y1835
K
L
S
S
A
E
T
Y
S
R
M
R
L
K
L
Site 143
S1836
L
S
S
A
E
T
Y
S
R
M
R
L
K
L
V
Site 144
T1867
N
L
G
E
V
P
L
T
P
T
E
E
A
S
L
Site 145
T1869
G
E
V
P
L
T
P
T
E
E
A
S
L
P
L
Site 146
S1885
V
T
K
E
A
K
V
S
T
P
P
E
L
L
Q
Site 147
T1886
T
K
E
A
K
V
S
T
P
P
E
L
L
Q
E
Site 148
T1906
D
E
L
A
E
L
E
T
P
M
E
A
A
E
L
Site 149
S1923
Q
R
E
K
L
V
L
S
A
E
C
Q
L
V
T
Site 150
T1943
P
G
L
L
E
V
T
T
Q
N
V
Y
F
Y
D
Site 151
Y1947
E
V
T
T
Q
N
V
Y
F
Y
D
G
S
T
E
Site 152
S1952
N
V
Y
F
Y
D
G
S
T
E
R
V
E
T
E
Site 153
T1953
V
Y
F
Y
D
G
S
T
E
R
V
E
T
E
E
Site 154
T1958
G
S
T
E
R
V
E
T
E
E
G
I
G
Y
D
Site 155
Y1964
E
T
E
E
G
I
G
Y
D
F
R
R
P
L
A
Site 156
S1986
R
R
F
N
L
R
R
S
A
L
E
L
F
F
I
Site 157
T2008
N
F
P
C
K
V
G
T
T
P
V
S
S
P
S
Site 158
T2009
F
P
C
K
V
G
T
T
P
V
S
S
P
S
Q
Site 159
S2012
K
V
G
T
T
P
V
S
S
P
S
Q
T
P
R
Site 160
S2013
V
G
T
T
P
V
S
S
P
S
Q
T
P
R
P
Site 161
S2015
T
T
P
V
S
S
P
S
Q
T
P
R
P
Q
P
Site 162
T2017
P
V
S
S
P
S
Q
T
P
R
P
Q
P
G
P
Site 163
T2029
P
G
P
I
P
P
H
T
Q
V
R
N
Q
V
Y
Site 164
S2037
Q
V
R
N
Q
V
Y
S
W
L
L
R
L
R
P
Site 165
S2046
L
L
R
L
R
P
P
S
Q
G
Y
L
S
S
R
Site 166
Y2049
L
R
P
P
S
Q
G
Y
L
S
S
R
S
P
Q
Site 167
S2051
P
P
S
Q
G
Y
L
S
S
R
S
P
Q
E
M
Site 168
S2052
P
S
Q
G
Y
L
S
S
R
S
P
Q
E
M
L
Site 169
S2054
Q
G
Y
L
S
S
R
S
P
Q
E
M
L
R
A
Site 170
S2062
P
Q
E
M
L
R
A
S
G
L
T
Q
K
W
V
Site 171
Y2078
R
E
I
S
N
F
E
Y
L
M
Q
L
N
T
I
Site 172
T2084
E
Y
L
M
Q
L
N
T
I
A
G
R
T
Y
N
Site 173
Y2090
N
T
I
A
G
R
T
Y
N
D
L
S
Q
Y
P
Site 174
Y2096
T
Y
N
D
L
S
Q
Y
P
V
F
P
W
V
L
Site 175
S2108
W
V
L
Q
D
Y
V
S
P
T
L
D
L
S
N
Site 176
T2110
L
Q
D
Y
V
S
P
T
L
D
L
S
N
P
A
Site 177
S2114
V
S
P
T
L
D
L
S
N
P
A
V
F
R
D
Site 178
Y2141
A
Q
L
V
R
E
K
Y
E
S
F
E
D
P
A
Site 179
S2143
L
V
R
E
K
Y
E
S
F
E
D
P
A
G
T
Site 180
T2150
S
F
E
D
P
A
G
T
I
D
K
F
H
Y
G
Site 181
Y2156
G
T
I
D
K
F
H
Y
G
T
H
Y
S
N
A
Site 182
Y2160
K
F
H
Y
G
T
H
Y
S
N
A
A
G
V
M
Site 183
S2178
I
R
V
E
P
F
T
S
L
H
V
Q
L
Q
S
Site 184
S2185
S
L
H
V
Q
L
Q
S
G
R
F
D
C
S
D
Site 185
S2191
Q
S
G
R
F
D
C
S
D
R
Q
F
H
S
V
Site 186
S2208
A
W
Q
A
R
L
E
S
P
A
D
V
K
E
L
Site 187
T2240
D
L
G
C
L
Q
L
T
N
E
K
V
G
D
V
Site 188
S2255
V
L
P
P
W
A
S
S
P
E
D
F
I
Q
Q
Site 189
S2269
Q
H
R
Q
A
L
E
S
E
Y
V
S
A
H
L
Site 190
Y2271
R
Q
A
L
E
S
E
Y
V
S
A
H
L
H
E
Site 191
S2273
A
L
E
S
E
Y
V
S
A
H
L
H
E
W
I
Site 192
Y2286
W
I
D
L
I
F
G
Y
K
Q
R
G
P
A
A
Site 193
Y2301
E
E
A
L
N
V
F
Y
Y
C
T
Y
E
G
A
Site 194
T2315
A
V
D
L
D
H
V
T
D
E
R
E
R
K
A
Site 195
T2333
I
I
S
N
F
G
Q
T
P
C
Q
L
L
K
E
Site 196
S2347
E
P
H
P
T
R
L
S
A
E
E
A
A
H
R
Site 197
T2360
H
R
L
A
R
L
D
T
N
S
P
S
I
F
Q
Site 198
S2362
L
A
R
L
D
T
N
S
P
S
I
F
Q
H
L
Site 199
S2398
V
P
H
R
Q
P
H
S
F
I
T
Q
G
S
P
Site 200
T2419
S
A
S
G
L
L
G
T
H
S
W
L
P
Y
D
Site 201
S2421
S
G
L
L
G
T
H
S
W
L
P
Y
D
R
N
Site 202
Y2425
G
T
H
S
W
L
P
Y
D
R
N
I
S
N
Y
Site 203
S2430
L
P
Y
D
R
N
I
S
N
Y
F
S
F
S
K
Site 204
Y2432
Y
D
R
N
I
S
N
Y
F
S
F
S
K
D
P
Site 205
S2434
R
N
I
S
N
Y
F
S
F
S
K
D
P
T
M
Site 206
S2436
I
S
N
Y
F
S
F
S
K
D
P
T
M
G
S
Site 207
T2440
F
S
F
S
K
D
P
T
M
G
S
H
K
T
Q
Site 208
T2446
P
T
M
G
S
H
K
T
Q
R
L
L
S
G
P
Site 209
S2451
H
K
T
Q
R
L
L
S
G
P
W
V
P
G
S
Site 210
S2458
S
G
P
W
V
P
G
S
G
V
S
G
Q
A
L
Site 211
S2476
P
D
G
K
L
L
F
S
G
G
H
W
D
G
S
Site 212
S2483
S
G
G
H
W
D
G
S
L
R
V
T
A
L
P
Site 213
T2487
W
D
G
S
L
R
V
T
A
L
P
R
G
K
L
Site 214
S2496
L
P
R
G
K
L
L
S
Q
L
S
C
H
L
D
Site 215
S2617
E
G
Q
I
V
V
Q
S
S
A
W
E
R
P
G
Site 216
T2628
E
R
P
G
A
Q
V
T
Y
S
L
H
L
Y
S
Site 217
S2630
P
G
A
Q
V
T
Y
S
L
H
L
Y
S
V
N
Site 218
Y2634
V
T
Y
S
L
H
L
Y
S
V
N
G
K
L
R
Site 219
S2635
T
Y
S
L
H
L
Y
S
V
N
G
K
L
R
A
Site 220
S2643
V
N
G
K
L
R
A
S
L
P
L
A
E
Q
P
Site 221
S2692
P
M
K
V
A
I
R
S
V
A
V
T
K
E
R
Site 222
S2720
V
V
V
A
G
Q
P
S
E
V
R
S
S
Q
F
Site 223
S2724
G
Q
P
S
E
V
R
S
S
Q
F
A
R
K
L
Site 224
S2725
Q
P
S
E
V
R
S
S
Q
F
A
R
K
L
W
Site 225
S2734
F
A
R
K
L
W
R
S
S
R
R
I
S
Q
V
Site 226
S2735
A
R
K
L
W
R
S
S
R
R
I
S
Q
V
S
Site 227
S2739
W
R
S
S
R
R
I
S
Q
V
S
S
G
E
T
Site 228
S2742
S
R
R
I
S
Q
V
S
S
G
E
T
E
Y
N
Site 229
S2743
R
R
I
S
Q
V
S
S
G
E
T
E
Y
N
P
Site 230
T2746
S
Q
V
S
S
G
E
T
E
Y
N
P
T
E
A
Site 231
Y2748
V
S
S
G
E
T
E
Y
N
P
T
E
A
R
_
Site 232
T2751
G
E
T
E
Y
N
P
T
E
A
R
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation