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Updated November 2019
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Protein Info
Short Name:
FGD5
Full Name:
FYVE, RhoGEF and PH domain-containing protein 5
Alias:
FLJ00274; FLJ39957; FYVE, RhoGEF and PH domain containing 5; ZFYVE23; Zinc finger FYVE domain-containing 23; Zinc finger FYVE domain-containing protein 23
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
159907
Number AA:
1462
UniProt ID:
Q6ZNL6
International Prot ID:
IPI00397955
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005856
GO:0030027
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0031267
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0046847
GO:0043088
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
I
A
P
K
P
R
L
T
A
P
N
E
W
R
A
Site 2
S24
A
P
N
E
W
R
A
S
V
Y
L
N
D
S
L
Site 3
Y26
N
E
W
R
A
S
V
Y
L
N
D
S
L
N
K
Site 4
S30
A
S
V
Y
L
N
D
S
L
N
K
C
S
N
G
Site 5
S52
G
L
D
E
G
P
R
S
I
P
K
C
S
E
S
Site 6
S57
P
R
S
I
P
K
C
S
E
S
E
T
D
E
D
Site 7
S59
S
I
P
K
C
S
E
S
E
T
D
E
D
Y
I
Site 8
T61
P
K
C
S
E
S
E
T
D
E
D
Y
I
V
V
Site 9
Y65
E
S
E
T
D
E
D
Y
I
V
V
P
R
V
P
Site 10
S83
D
E
P
K
D
E
G
S
V
G
N
K
A
L
V
Site 11
S91
V
G
N
K
A
L
V
S
P
E
S
S
A
E
E
Site 12
S94
K
A
L
V
S
P
E
S
S
A
E
E
E
E
E
Site 13
S95
A
L
V
S
P
E
S
S
A
E
E
E
E
E
R
Site 14
S120
G
T
G
A
G
E
D
S
V
A
P
T
A
P
G
Site 15
S132
A
P
G
A
G
A
L
S
R
E
G
E
E
G
T
Site 16
T156
G
C
A
D
E
P
G
T
L
E
Q
V
S
R
S
Site 17
S161
P
G
T
L
E
Q
V
S
R
S
E
E
E
E
K
Site 18
S177
V
Q
P
H
R
E
C
S
L
E
D
S
G
P
W
Site 19
S181
R
E
C
S
L
E
D
S
G
P
W
A
G
E
G
Site 20
T209
E
D
Q
E
P
P
D
T
P
G
E
G
E
E
D
Site 21
S223
D
D
E
E
G
C
A
S
T
D
P
A
G
A
D
Site 22
S233
P
A
G
A
D
E
G
S
G
P
D
R
P
T
E
Site 23
T239
G
S
G
P
D
R
P
T
E
D
M
G
Q
D
A
Site 24
T249
M
G
Q
D
A
E
D
T
S
E
E
P
P
E
K
Site 25
S250
G
Q
D
A
E
D
T
S
E
E
P
P
E
K
E
Site 26
S294
G
G
E
Q
V
D
L
S
E
P
P
D
H
E
K
Site 27
S320
E
D
H
A
Q
D
E
S
A
E
E
S
C
Q
I
Site 28
S324
Q
D
E
S
A
E
E
S
C
Q
I
V
P
F
E
Site 29
T340
D
C
M
E
D
F
V
T
S
L
T
G
S
P
Y
Site 30
S341
C
M
E
D
F
V
T
S
L
T
G
S
P
Y
E
Site 31
T343
E
D
F
V
T
S
L
T
G
S
P
Y
E
F
F
Site 32
T352
S
P
Y
E
F
F
P
T
E
S
T
S
F
C
S
Site 33
T355
E
F
F
P
T
E
S
T
S
F
C
S
E
S
C
Site 34
S356
F
F
P
T
E
S
T
S
F
C
S
E
S
C
S
Site 35
S359
T
E
S
T
S
F
C
S
E
S
C
S
P
L
S
Site 36
S361
S
T
S
F
C
S
E
S
C
S
P
L
S
E
S
Site 37
S363
S
F
C
S
E
S
C
S
P
L
S
E
S
A
K
Site 38
S366
S
E
S
C
S
P
L
S
E
S
A
K
G
L
E
Site 39
S368
S
C
S
P
L
S
E
S
A
K
G
L
E
S
E
Site 40
S450
G
E
G
G
Q
A
A
S
D
A
L
G
G
Y
G
Site 41
S458
D
A
L
G
G
Y
G
S
K
E
E
L
N
C
E
Site 42
T478
V
P
A
D
R
K
N
T
S
T
R
V
R
P
H
Site 43
S479
P
A
D
R
K
N
T
S
T
R
V
R
P
H
S
Site 44
T480
A
D
R
K
N
T
S
T
R
V
R
P
H
S
G
Site 45
S486
S
T
R
V
R
P
H
S
G
K
V
A
G
Y
V
Site 46
Y492
H
S
G
K
V
A
G
Y
V
P
E
T
V
P
E
Site 47
T496
V
A
G
Y
V
P
E
T
V
P
E
E
T
G
P
Site 48
S507
E
T
G
P
E
A
G
S
S
A
P
G
I
G
G
Site 49
S508
T
G
P
E
A
G
S
S
A
P
G
I
G
G
A
Site 50
T522
A
A
E
E
V
G
K
T
L
L
S
L
E
G
K
Site 51
S525
E
V
G
K
T
L
L
S
L
E
G
K
P
L
E
Site 52
T545
P
A
K
P
R
A
F
T
L
Y
P
R
S
F
S
Site 53
Y547
K
P
R
A
F
T
L
Y
P
R
S
F
S
V
E
Site 54
S550
A
F
T
L
Y
P
R
S
F
S
V
E
G
R
E
Site 55
S552
T
L
Y
P
R
S
F
S
V
E
G
R
E
I
P
Site 56
S561
E
G
R
E
I
P
V
S
V
Y
Q
E
P
E
G
Site 57
Y563
R
E
I
P
V
S
V
Y
Q
E
P
E
G
S
G
Site 58
S584
K
R
K
E
D
N
L
S
L
S
C
V
I
G
S
Site 59
S586
K
E
D
N
L
S
L
S
C
V
I
G
S
S
G
Site 60
S591
S
L
S
C
V
I
G
S
S
G
S
F
S
Q
R
Site 61
S592
L
S
C
V
I
G
S
S
G
S
F
S
Q
R
N
Site 62
S594
C
V
I
G
S
S
G
S
F
S
Q
R
N
H
L
Site 63
S596
I
G
S
S
G
S
F
S
Q
R
N
H
L
P
S
Site 64
S603
S
Q
R
N
H
L
P
S
S
G
T
S
T
P
S
Site 65
S604
Q
R
N
H
L
P
S
S
G
T
S
T
P
S
S
Site 66
T606
N
H
L
P
S
S
G
T
S
T
P
S
S
M
V
Site 67
S607
H
L
P
S
S
G
T
S
T
P
S
S
M
V
D
Site 68
T608
L
P
S
S
G
T
S
T
P
S
S
M
V
D
I
Site 69
S610
S
S
G
T
S
T
P
S
S
M
V
D
I
P
P
Site 70
S611
S
G
T
S
T
P
S
S
M
V
D
I
P
P
P
Site 71
T625
P
F
D
L
A
C
I
T
K
K
P
I
T
K
S
Site 72
T630
C
I
T
K
K
P
I
T
K
S
S
P
S
L
L
Site 73
S632
T
K
K
P
I
T
K
S
S
P
S
L
L
I
E
Site 74
S633
K
K
P
I
T
K
S
S
P
S
L
L
I
E
S
Site 75
S635
P
I
T
K
S
S
P
S
L
L
I
E
S
D
S
Site 76
S640
S
P
S
L
L
I
E
S
D
S
P
D
K
Y
K
Site 77
S642
S
L
L
I
E
S
D
S
P
D
K
Y
K
K
K
Site 78
Y646
E
S
D
S
P
D
K
Y
K
K
K
K
S
S
F
Site 79
S651
D
K
Y
K
K
K
K
S
S
F
K
R
F
L
A
Site 80
S652
K
Y
K
K
K
K
S
S
F
K
R
F
L
A
L
Site 81
T660
F
K
R
F
L
A
L
T
F
K
K
K
T
E
N
Site 82
S676
L
H
V
D
V
N
V
S
S
S
R
S
S
S
E
Site 83
S677
H
V
D
V
N
V
S
S
S
R
S
S
S
E
S
Site 84
S678
V
D
V
N
V
S
S
S
R
S
S
S
E
S
S
Site 85
S680
V
N
V
S
S
S
R
S
S
S
E
S
S
Y
H
Site 86
S681
N
V
S
S
S
R
S
S
S
E
S
S
Y
H
G
Site 87
S682
V
S
S
S
R
S
S
S
E
S
S
Y
H
G
P
Site 88
S684
S
S
R
S
S
S
E
S
S
Y
H
G
P
S
R
Site 89
S685
S
R
S
S
S
E
S
S
Y
H
G
P
S
R
I
Site 90
Y686
R
S
S
S
E
S
S
Y
H
G
P
S
R
I
L
Site 91
S699
I
L
E
V
D
R
R
S
L
S
N
S
P
Q
L
Site 92
S701
E
V
D
R
R
S
L
S
N
S
P
Q
L
K
S
Site 93
S703
D
R
R
S
L
S
N
S
P
Q
L
K
S
R
T
Site 94
S708
S
N
S
P
Q
L
K
S
R
T
G
K
L
R
A
Site 95
S716
R
T
G
K
L
R
A
S
E
S
P
S
S
L
I
Site 96
S718
G
K
L
R
A
S
E
S
P
S
S
L
I
F
Y
Site 97
S720
L
R
A
S
E
S
P
S
S
L
I
F
Y
R
D
Site 98
S721
R
A
S
E
S
P
S
S
L
I
F
Y
R
D
G
Site 99
Y725
S
P
S
S
L
I
F
Y
R
D
G
K
R
K
G
Site 100
S736
K
R
K
G
V
P
F
S
R
T
V
S
R
V
E
Site 101
T738
K
G
V
P
F
S
R
T
V
S
R
V
E
S
F
Site 102
S740
V
P
F
S
R
T
V
S
R
V
E
S
F
E
D
Site 103
S744
R
T
V
S
R
V
E
S
F
E
D
R
S
R
P
Site 104
S749
V
E
S
F
E
D
R
S
R
P
P
F
L
P
L
Site 105
T759
P
F
L
P
L
P
L
T
K
P
R
S
I
S
F
Site 106
S763
L
P
L
T
K
P
R
S
I
S
F
P
S
A
D
Site 107
S765
L
T
K
P
R
S
I
S
F
P
S
A
D
T
S
Site 108
S768
P
R
S
I
S
F
P
S
A
D
T
S
D
Y
E
Site 109
T771
I
S
F
P
S
A
D
T
S
D
Y
E
N
I
P
Site 110
S772
S
F
P
S
A
D
T
S
D
Y
E
N
I
P
A
Site 111
Y774
P
S
A
D
T
S
D
Y
E
N
I
P
A
M
N
Site 112
Y784
I
P
A
M
N
S
D
Y
E
N
I
Q
I
P
P
Site 113
T801
P
A
R
A
G
A
F
T
K
L
F
E
D
Q
S
Site 114
S808
T
K
L
F
E
D
Q
S
R
A
L
S
T
A
N
Site 115
S812
E
D
Q
S
R
A
L
S
T
A
N
E
N
D
G
Site 116
Y820
T
A
N
E
N
D
G
Y
V
D
M
S
S
F
N
Site 117
S825
D
G
Y
V
D
M
S
S
F
N
A
F
E
S
K
Site 118
S831
S
S
F
N
A
F
E
S
K
Q
Q
S
A
D
Q
Site 119
S835
A
F
E
S
K
Q
Q
S
A
D
Q
D
A
E
S
Site 120
S842
S
A
D
Q
D
A
E
S
A
Y
T
E
P
Y
K
Site 121
Y844
D
Q
D
A
E
S
A
Y
T
E
P
Y
K
V
C
Site 122
T845
Q
D
A
E
S
A
Y
T
E
P
Y
K
V
C
P
Site 123
S854
P
Y
K
V
C
P
I
S
S
A
A
P
K
E
D
Site 124
T863
A
A
P
K
E
D
L
T
S
D
E
E
Q
R
S
Site 125
S864
A
P
K
E
D
L
T
S
D
E
E
Q
R
S
S
Site 126
S870
T
S
D
E
E
Q
R
S
S
E
E
E
D
S
A
Site 127
S871
S
D
E
E
Q
R
S
S
E
E
E
D
S
A
S
Site 128
S876
R
S
S
E
E
E
D
S
A
S
R
D
P
S
V
Site 129
S878
S
E
E
E
D
S
A
S
R
D
P
S
V
T
H
Site 130
S882
D
S
A
S
R
D
P
S
V
T
H
K
V
E
G
Site 131
T884
A
S
R
D
P
S
V
T
H
K
V
E
G
Q
S
Site 132
S903
I
A
Q
E
L
L
S
S
E
K
A
Y
V
E
M
Site 133
T936
M
D
H
E
G
R
D
T
L
A
R
E
E
L
R
Site 134
S947
E
E
L
R
Q
G
L
S
E
L
P
A
I
H
D
Site 135
S968
E
E
L
E
E
R
L
S
N
W
E
S
Q
Q
K
Site 136
S972
E
R
L
S
N
W
E
S
Q
Q
K
V
A
D
V
Site 137
Y1000
H
I
L
Q
F
D
R
Y
L
G
L
L
S
E
N
Site 138
S1005
D
R
Y
L
G
L
L
S
E
N
C
L
H
S
P
Site 139
S1024
A
V
R
E
F
E
Q
S
V
Q
G
G
S
Q
T
Site 140
Y1053
Y
Q
V
L
L
T
D
Y
L
N
N
L
C
P
D
Site 141
S1061
L
N
N
L
C
P
D
S
A
E
Y
D
N
T
Q
Site 142
Y1064
L
C
P
D
S
A
E
Y
D
N
T
Q
G
A
L
Site 143
T1067
D
S
A
E
Y
D
N
T
Q
G
A
L
S
L
I
Site 144
S1072
D
N
T
Q
G
A
L
S
L
I
S
K
V
T
D
Site 145
S1084
V
T
D
R
A
N
D
S
M
E
Q
G
E
N
L
Site 146
S1100
K
L
V
H
I
E
H
S
V
R
G
Q
G
D
L
Site 147
Y1142
L
M
N
D
V
L
L
Y
T
Y
P
Q
K
D
G
Site 148
Y1144
N
D
V
L
L
Y
T
Y
P
Q
K
D
G
K
Y
Site 149
Y1151
Y
P
Q
K
D
G
K
Y
R
L
K
N
T
L
A
Site 150
T1156
G
K
Y
R
L
K
N
T
L
A
V
A
N
M
K
Site 151
S1165
A
V
A
N
M
K
V
S
R
P
V
M
E
K
V
Site 152
Y1174
P
V
M
E
K
V
P
Y
A
L
K
I
E
T
S
Site 153
S1188
S
E
S
C
L
M
L
S
A
S
S
C
A
E
R
Site 154
S1190
S
C
L
M
L
S
A
S
S
C
A
E
R
D
E
Site 155
Y1199
C
A
E
R
D
E
W
Y
G
C
L
S
R
A
L
Site 156
Y1210
S
R
A
L
P
E
D
Y
K
A
Q
A
L
A
A
Site 157
Y1280
R
N
C
S
R
N
K
Y
P
L
K
Y
L
K
D
Site 158
Y1284
R
N
K
Y
P
L
K
Y
L
K
D
R
M
A
K
Site 159
S1317
L
M
R
E
R
P
V
S
M
S
F
P
L
S
S
Site 160
S1319
R
E
R
P
V
S
M
S
F
P
L
S
S
P
R
Site 161
S1323
V
S
M
S
F
P
L
S
S
P
R
F
S
G
S
Site 162
S1324
S
M
S
F
P
L
S
S
P
R
F
S
G
S
A
Site 163
S1328
P
L
S
S
P
R
F
S
G
S
A
F
S
S
V
Site 164
S1330
S
S
P
R
F
S
G
S
A
F
S
S
V
F
Q
Site 165
S1333
R
F
S
G
S
A
F
S
S
V
F
Q
S
I
N
Site 166
S1338
A
F
S
S
V
F
Q
S
I
N
P
S
T
F
K
Site 167
S1342
V
F
Q
S
I
N
P
S
T
F
K
K
Q
K
K
Site 168
T1343
F
Q
S
I
N
P
S
T
F
K
K
Q
K
K
V
Site 169
S1367
S
G
E
G
S
A
I
S
G
Y
L
S
R
C
K
Site 170
Y1369
E
G
S
A
I
S
G
Y
L
S
R
C
K
R
G
Site 171
S1371
S
A
I
S
G
Y
L
S
R
C
K
R
G
K
R
Site 172
Y1393
V
I
K
G
K
V
L
Y
T
Y
M
A
S
E
D
Site 173
T1394
I
K
G
K
V
L
Y
T
Y
M
A
S
E
D
K
Site 174
Y1395
K
G
K
V
L
Y
T
Y
M
A
S
E
D
K
V
Site 175
T1413
S
M
P
L
L
G
F
T
I
A
P
E
K
E
E
Site 176
S1423
P
E
K
E
E
G
S
S
E
V
G
P
I
F
H
Site 177
S1440
H
K
K
T
L
F
Y
S
F
K
A
E
D
T
N
Site 178
S1448
F
K
A
E
D
T
N
S
A
Q
R
W
I
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation