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Updated November 2019
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Protein Info
Short Name:
Protein FAM75D1
Full Name:
Protein FAM75D1
Alias:
Type:
Mass (Da):
175618
Number AA:
1576
UniProt ID:
Q6ZQQ2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
L
C
F
L
N
S
Y
T
E
T
G
L
S
P
D
Site 2
T14
F
L
N
S
Y
T
E
T
G
L
S
P
D
S
H
Site 3
S17
S
Y
T
E
T
G
L
S
P
D
S
H
W
L
D
Site 4
S20
E
T
G
L
S
P
D
S
H
W
L
D
I
D
P
Site 5
Y50
F
Y
V
V
L
T
L
Y
S
S
P
T
E
K
N
Site 6
S52
V
V
L
T
L
Y
S
S
P
T
E
K
N
N
D
Site 7
T75
K
R
R
R
K
G
G
T
F
K
G
F
P
D
W
Site 8
S84
K
G
F
P
D
W
K
S
F
Q
R
E
E
E
E
Site 9
S97
E
E
E
R
K
L
L
S
L
L
K
S
F
G
P
Site 10
S107
K
S
F
G
P
P
V
S
C
S
P
R
G
Q
H
Site 11
S109
F
G
P
P
V
S
C
S
P
R
G
Q
H
H
D
Site 12
T117
P
R
G
Q
H
H
D
T
N
H
F
R
R
L
L
Site 13
S145
A
D
I
Q
Q
L
L
S
W
E
S
L
K
D
A
Site 14
S148
Q
Q
L
L
S
W
E
S
L
K
D
A
A
P
S
Site 15
S155
S
L
K
D
A
A
P
S
V
S
P
L
A
S
S
Site 16
S157
K
D
A
A
P
S
V
S
P
L
A
S
S
A
S
Site 17
S161
P
S
V
S
P
L
A
S
S
A
S
A
T
E
S
Site 18
S162
S
V
S
P
L
A
S
S
A
S
A
T
E
S
S
Site 19
S164
S
P
L
A
S
S
A
S
A
T
E
S
S
F
T
Site 20
S168
S
S
A
S
A
T
E
S
S
F
T
L
A
S
T
Site 21
S169
S
A
S
A
T
E
S
S
F
T
L
A
S
T
P
Site 22
T171
S
A
T
E
S
S
F
T
L
A
S
T
P
S
A
Site 23
S174
E
S
S
F
T
L
A
S
T
P
S
A
T
P
P
Site 24
T175
S
S
F
T
L
A
S
T
P
S
A
T
P
P
E
Site 25
S177
F
T
L
A
S
T
P
S
A
T
P
P
E
D
L
Site 26
S187
P
P
E
D
L
I
L
S
P
R
P
K
A
S
P
Site 27
S193
L
S
P
R
P
K
A
S
P
P
P
P
L
I
L
Site 28
S213
T
T
L
A
D
L
F
S
P
S
P
L
R
D
P
Site 29
S215
L
A
D
L
F
S
P
S
P
L
R
D
P
L
P
Site 30
S227
P
L
P
P
Q
P
V
S
P
L
D
S
K
F
P
Site 31
S231
Q
P
V
S
P
L
D
S
K
F
P
I
D
H
S
Site 32
S238
S
K
F
P
I
D
H
S
P
P
Q
Q
L
P
F
Site 33
S258
H
H
I
E
R
V
E
S
S
L
Q
P
E
A
S
Site 34
S259
H
I
E
R
V
E
S
S
L
Q
P
E
A
S
L
Site 35
S283
S
T
L
C
Q
D
I
S
Q
A
M
N
P
I
D
Site 36
S302
H
H
G
P
P
I
P
S
A
L
P
P
E
D
C
Site 37
T310
A
L
P
P
E
D
C
T
V
T
Q
S
K
S
S
Site 38
T312
P
P
E
D
C
T
V
T
Q
S
K
S
S
L
T
Site 39
S314
E
D
C
T
V
T
Q
S
K
S
S
L
T
I
L
Site 40
S316
C
T
V
T
Q
S
K
S
S
L
T
I
L
K
T
Site 41
S329
K
T
F
P
E
M
L
S
L
G
G
S
G
G
S
Site 42
S333
E
M
L
S
L
G
G
S
G
G
S
S
T
S
A
Site 43
S336
S
L
G
G
S
G
G
S
S
T
S
A
P
T
I
Site 44
S337
L
G
G
S
G
G
S
S
T
S
A
P
T
I
K
Site 45
T338
G
G
S
G
G
S
S
T
S
A
P
T
I
K
G
Site 46
S339
G
S
G
G
S
S
T
S
A
P
T
I
K
G
I
Site 47
S349
T
I
K
G
I
D
H
S
H
L
A
S
S
E
F
Site 48
S366
W
Q
P
H
A
K
D
S
F
S
S
N
F
V
P
Site 49
S368
P
H
A
K
D
S
F
S
S
N
F
V
P
S
D
Site 50
T382
D
F
M
E
E
L
L
T
L
H
S
S
E
A
F
Site 51
S437
E
N
G
K
K
P
G
S
F
P
K
Q
L
R
P
Site 52
Y446
P
K
Q
L
R
P
N
Y
Q
L
N
S
S
R
N
Site 53
S450
R
P
N
Y
Q
L
N
S
S
R
N
M
L
T
S
Site 54
S451
P
N
Y
Q
L
N
S
S
R
N
M
L
T
S
I
Site 55
S457
S
S
R
N
M
L
T
S
I
A
V
K
H
D
L
Site 56
S467
V
K
H
D
L
A
E
S
F
P
F
W
A
S
K
Site 57
Y500
E
D
H
L
E
Q
K
Y
V
Q
L
F
W
G
L
Site 58
S509
Q
L
F
W
G
L
P
S
L
H
S
E
S
L
H
Site 59
S512
W
G
L
P
S
L
H
S
E
S
L
H
P
T
V
Site 60
T518
H
S
E
S
L
H
P
T
V
L
V
Q
R
G
H
Site 61
S539
F
N
G
I
T
N
T
S
I
S
H
E
S
P
V
Site 62
S541
G
I
T
N
T
S
I
S
H
E
S
P
V
L
P
Site 63
S544
N
T
S
I
S
H
E
S
P
V
L
P
P
P
Q
Site 64
S554
L
P
P
P
Q
P
L
S
L
P
S
T
Q
P
L
Site 65
S557
P
Q
P
L
S
L
P
S
T
Q
P
L
P
L
P
Site 66
T558
Q
P
L
S
L
P
S
T
Q
P
L
P
L
P
Q
Site 67
T566
Q
P
L
P
L
P
Q
T
L
P
Q
G
Q
S
P
Site 68
S572
Q
T
L
P
Q
G
Q
S
P
H
L
T
Q
V
K
Site 69
T576
Q
G
Q
S
P
H
L
T
Q
V
K
S
L
A
Q
Site 70
S580
P
H
L
T
Q
V
K
S
L
A
Q
P
Q
S
P
Site 71
S586
K
S
L
A
Q
P
Q
S
P
F
R
A
L
L
P
Site 72
S615
R
P
Q
N
E
A
R
S
L
L
P
S
E
I
N
Site 73
S619
E
A
R
S
L
L
P
S
E
I
N
H
L
E
W
Site 74
S641
E
S
L
W
G
L
P
S
V
V
Q
K
S
Q
E
Site 75
S646
L
P
S
V
V
Q
K
S
Q
E
D
F
C
P
P
Site 76
S663
N
P
E
L
V
R
K
S
F
K
V
H
V
P
I
Site 77
S680
I
P
G
D
F
P
L
S
S
E
V
R
K
K
L
Site 78
S681
P
G
D
F
P
L
S
S
E
V
R
K
K
L
E
Site 79
S709
L
P
R
R
I
H
E
S
L
S
L
L
R
P
Q
Site 80
S711
R
R
I
H
E
S
L
S
L
L
R
P
Q
S
K
Site 81
S717
L
S
L
L
R
P
Q
S
K
I
S
E
L
S
V
Site 82
S720
L
R
P
Q
S
K
I
S
E
L
S
V
S
E
R
Site 83
S723
Q
S
K
I
S
E
L
S
V
S
E
R
I
H
G
Site 84
S725
K
I
S
E
L
S
V
S
E
R
I
H
G
P
L
Site 85
S748
R
C
N
V
L
K
K
S
A
S
S
F
P
R
S
Site 86
S750
N
V
L
K
K
S
A
S
S
F
P
R
S
F
H
Site 87
S751
V
L
K
K
S
A
S
S
F
P
R
S
F
H
E
Site 88
S755
S
A
S
S
F
P
R
S
F
H
E
R
S
S
N
Site 89
S760
P
R
S
F
H
E
R
S
S
N
M
L
S
M
E
Site 90
S761
R
S
F
H
E
R
S
S
N
M
L
S
M
E
N
Site 91
S765
E
R
S
S
N
M
L
S
M
E
N
V
G
N
Y
Site 92
Y772
S
M
E
N
V
G
N
Y
Q
G
Y
S
Q
E
T
Site 93
S776
V
G
N
Y
Q
G
Y
S
Q
E
T
V
P
K
D
Site 94
T791
H
L
L
H
G
P
E
T
S
S
D
K
D
L
R
Site 95
S793
L
H
G
P
E
T
S
S
D
K
D
L
R
S
N
Site 96
S799
S
S
D
K
D
L
R
S
N
S
E
R
D
L
E
Site 97
S801
D
K
D
L
R
S
N
S
E
R
D
L
E
T
H
Site 98
T807
N
S
E
R
D
L
E
T
H
M
M
H
L
S
G
Site 99
S813
E
T
H
M
M
H
L
S
G
N
D
S
G
V
R
Site 100
S817
M
H
L
S
G
N
D
S
G
V
R
L
G
Q
K
Site 101
T831
K
Q
L
E
N
A
L
T
V
R
L
S
K
K
F
Site 102
S835
N
A
L
T
V
R
L
S
K
K
F
E
E
I
N
Site 103
T849
N
E
G
R
M
P
G
T
V
H
S
S
W
H
S
Site 104
S852
R
M
P
G
T
V
H
S
S
W
H
S
V
K
Q
Site 105
S856
T
V
H
S
S
W
H
S
V
K
Q
T
M
S
L
Site 106
T860
S
W
H
S
V
K
Q
T
M
S
L
P
E
K
S
Site 107
S862
H
S
V
K
Q
T
M
S
L
P
E
K
S
H
S
Site 108
S867
T
M
S
L
P
E
K
S
H
S
Q
I
K
H
R
Site 109
S869
S
L
P
E
K
S
H
S
Q
I
K
H
R
N
L
Site 110
T878
I
K
H
R
N
L
V
T
L
V
S
E
D
H
C
Site 111
S881
R
N
L
V
T
L
V
S
E
D
H
C
V
D
T
Site 112
T888
S
E
D
H
C
V
D
T
S
Q
E
I
S
F
L
Site 113
S889
E
D
H
C
V
D
T
S
Q
E
I
S
F
L
S
Site 114
S893
V
D
T
S
Q
E
I
S
F
L
S
S
N
K
Q
Site 115
S896
S
Q
E
I
S
F
L
S
S
N
K
Q
K
M
L
Site 116
S897
Q
E
I
S
F
L
S
S
N
K
Q
K
M
L
E
Site 117
S931
E
S
I
E
I
F
K
S
K
A
D
L
S
T
S
Site 118
S936
F
K
S
K
A
D
L
S
T
S
F
S
H
F
D
Site 119
S938
S
K
A
D
L
S
T
S
F
S
H
F
D
L
P
Site 120
S940
A
D
L
S
T
S
F
S
H
F
D
L
P
S
S
Site 121
S946
F
S
H
F
D
L
P
S
S
A
T
F
I
S
Q
Site 122
S947
S
H
F
D
L
P
S
S
A
T
F
I
S
Q
G
Site 123
T949
F
D
L
P
S
S
A
T
F
I
S
Q
G
D
S
Site 124
S952
P
S
S
A
T
F
I
S
Q
G
D
S
K
D
G
Site 125
S956
T
F
I
S
Q
G
D
S
K
D
G
V
S
K
S
Site 126
S961
G
D
S
K
D
G
V
S
K
S
R
S
R
S
T
Site 127
S963
S
K
D
G
V
S
K
S
R
S
R
S
T
F
Q
Site 128
S965
D
G
V
S
K
S
R
S
R
S
T
F
Q
G
E
Site 129
S967
V
S
K
S
R
S
R
S
T
F
Q
G
E
K
L
Site 130
T968
S
K
S
R
S
R
S
T
F
Q
G
E
K
L
G
Site 131
S979
E
K
L
G
T
T
S
S
V
P
I
L
D
R
P
Site 132
S990
L
D
R
P
H
P
V
S
S
P
V
V
Q
E
G
Site 133
S991
D
R
P
H
P
V
S
S
P
V
V
Q
E
G
Q
Site 134
T1000
V
V
Q
E
G
Q
G
T
L
R
R
Q
F
S
D
Site 135
S1006
G
T
L
R
R
Q
F
S
D
T
D
H
D
L
I
Site 136
T1008
L
R
R
Q
F
S
D
T
D
H
D
L
I
E
T
Site 137
S1017
H
D
L
I
E
T
D
S
K
D
G
A
S
T
S
Site 138
S1024
S
K
D
G
A
S
T
S
L
R
R
G
T
T
D
Site 139
T1029
S
T
S
L
R
R
G
T
T
D
F
Q
S
E
K
Site 140
T1030
T
S
L
R
R
G
T
T
D
F
Q
S
E
K
L
Site 141
S1034
R
G
T
T
D
F
Q
S
E
K
L
D
S
T
S
Site 142
S1039
F
Q
S
E
K
L
D
S
T
S
S
F
P
I
L
Site 143
T1040
Q
S
E
K
L
D
S
T
S
S
F
P
I
L
G
Site 144
S1041
S
E
K
L
D
S
T
S
S
F
P
I
L
G
H
Site 145
S1042
E
K
L
D
S
T
S
S
F
P
I
L
G
H
S
Site 146
T1053
L
G
H
S
Y
L
V
T
S
P
V
N
Q
E
K
Site 147
S1054
G
H
S
Y
L
V
T
S
P
V
N
Q
E
K
Q
Site 148
T1063
V
N
Q
E
K
Q
G
T
L
R
R
E
F
S
D
Site 149
S1069
G
T
L
R
R
E
F
S
D
T
D
N
D
L
T
Site 150
T1071
L
R
R
E
F
S
D
T
D
N
D
L
T
E
S
Site 151
T1076
S
D
T
D
N
D
L
T
E
S
V
R
T
T
E
Site 152
S1078
T
D
N
D
L
T
E
S
V
R
T
T
E
D
G
Site 153
T1082
L
T
E
S
V
R
T
T
E
D
G
R
Q
T
F
Site 154
T1088
T
T
E
D
G
R
Q
T
F
L
P
P
P
H
S
Site 155
S1095
T
F
L
P
P
P
H
S
I
V
D
E
V
S
Q
Site 156
S1101
H
S
I
V
D
E
V
S
Q
K
Q
T
V
L
A
Site 157
T1105
D
E
V
S
Q
K
Q
T
V
L
A
S
R
C
S
Site 158
S1132
E
S
W
D
K
R
K
S
S
F
H
N
V
D
R
Site 159
S1133
S
W
D
K
R
K
S
S
F
H
N
V
D
R
L
Site 160
T1146
R
L
Q
G
S
R
K
T
F
P
V
T
N
A
L
Site 161
T1150
S
R
K
T
F
P
V
T
N
A
L
Q
S
Q
T
Site 162
S1155
P
V
T
N
A
L
Q
S
Q
T
R
N
N
L
T
Site 163
T1162
S
Q
T
R
N
N
L
T
T
S
K
S
G
S
C
Site 164
T1163
Q
T
R
N
N
L
T
T
S
K
S
G
S
C
S
Site 165
S1164
T
R
N
N
L
T
T
S
K
S
G
S
C
S
L
Site 166
S1166
N
N
L
T
T
S
K
S
G
S
C
S
L
T
N
Site 167
S1168
L
T
T
S
K
S
G
S
C
S
L
T
N
V
K
Site 168
S1170
T
S
K
S
G
S
C
S
L
T
N
V
K
A
S
Site 169
T1172
K
S
G
S
C
S
L
T
N
V
K
A
S
T
S
Site 170
S1190
E
I
F
P
P
R
I
S
V
P
Q
D
P
K
S
Site 171
S1197
S
V
P
Q
D
P
K
S
S
Y
L
K
N
Q
M
Site 172
Y1199
P
Q
D
P
K
S
S
Y
L
K
N
Q
M
L
S
Site 173
S1206
Y
L
K
N
Q
M
L
S
Q
L
K
L
V
Q
R
Site 174
S1216
K
L
V
Q
R
K
H
S
Q
P
Q
S
H
F
T
Site 175
S1220
R
K
H
S
Q
P
Q
S
H
F
T
D
M
S
F
Site 176
T1223
S
Q
P
Q
S
H
F
T
D
M
S
F
A
L
D
Site 177
S1226
Q
S
H
F
T
D
M
S
F
A
L
D
N
L
S
Site 178
S1233
S
F
A
L
D
N
L
S
S
K
D
L
L
T
N
Site 179
S1234
F
A
L
D
N
L
S
S
K
D
L
L
T
N
S
Site 180
T1239
L
S
S
K
D
L
L
T
N
S
Q
G
I
S
S
Site 181
S1241
S
K
D
L
L
T
N
S
Q
G
I
S
S
G
D
Site 182
S1245
L
T
N
S
Q
G
I
S
S
G
D
M
G
T
S
Site 183
S1246
T
N
S
Q
G
I
S
S
G
D
M
G
T
S
Q
Site 184
S1252
S
S
G
D
M
G
T
S
Q
V
V
H
V
H
L
Site 185
S1262
V
H
V
H
L
E
D
S
G
I
R
V
A
Q
K
Site 186
T1276
K
Q
E
P
R
V
P
T
C
V
L
Q
K
C
Q
Site 187
S1295
P
P
A
V
N
R
V
S
P
V
R
P
K
G
G
Site 188
S1314
G
D
A
G
L
G
T
S
Q
R
R
R
K
S
L
Site 189
S1320
T
S
Q
R
R
R
K
S
L
P
V
H
N
K
T
Site 190
T1327
S
L
P
V
H
N
K
T
S
G
E
V
L
G
S
Site 191
S1334
T
S
G
E
V
L
G
S
K
S
S
P
T
L
K
Site 192
S1336
G
E
V
L
G
S
K
S
S
P
T
L
K
T
Q
Site 193
S1337
E
V
L
G
S
K
S
S
P
T
L
K
T
Q
P
Site 194
T1339
L
G
S
K
S
S
P
T
L
K
T
Q
P
P
P
Site 195
T1342
K
S
S
P
T
L
K
T
Q
P
P
P
E
N
L
Site 196
S1367
W
F
N
K
P
S
I
S
Y
E
E
Q
E
S
S
Site 197
Y1368
F
N
K
P
S
I
S
Y
E
E
Q
E
S
S
W
Site 198
S1373
I
S
Y
E
E
Q
E
S
S
W
E
K
G
S
S
Site 199
S1374
S
Y
E
E
Q
E
S
S
W
E
K
G
S
S
L
Site 200
S1379
E
S
S
W
E
K
G
S
S
L
S
S
C
V
Q
Site 201
S1380
S
S
W
E
K
G
S
S
L
S
S
C
V
Q
N
Site 202
S1382
W
E
K
G
S
S
L
S
S
C
V
Q
N
I
G
Site 203
S1383
E
K
G
S
S
L
S
S
C
V
Q
N
I
G
R
Site 204
T1409
A
Q
K
I
R
K
D
T
R
E
F
L
E
E
K
Site 205
T1426
H
R
H
G
I
D
I
T
C
P
Q
E
P
L
S
Site 206
S1433
T
C
P
Q
E
P
L
S
F
P
V
G
L
G
K
Site 207
Y1461
V
Q
G
C
P
C
N
Y
R
A
P
S
C
K
V
Site 208
S1465
P
C
N
Y
R
A
P
S
C
K
V
T
R
T
K
Site 209
T1469
R
A
P
S
C
K
V
T
R
T
K
S
C
S
Q
Site 210
T1471
P
S
C
K
V
T
R
T
K
S
C
S
Q
Q
A
Site 211
S1473
C
K
V
T
R
T
K
S
C
S
Q
Q
A
I
F
Site 212
S1475
V
T
R
T
K
S
C
S
Q
Q
A
I
F
V
G
Site 213
Y1485
A
I
F
V
G
Q
N
Y
P
T
R
I
R
Q
I
Site 214
S1513
K
G
K
I
L
C
Q
S
H
P
Q
S
M
P
H
Site 215
S1517
L
C
Q
S
H
P
Q
S
M
P
H
R
K
P
V
Site 216
T1530
P
V
P
H
P
N
P
T
C
R
R
Q
V
S
L
Site 217
S1545
V
C
P
A
V
P
T
S
A
K
S
P
V
F
S
Site 218
T1558
F
S
D
V
P
F
L
T
G
Q
K
M
L
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation