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Updated November 2019
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Protein Info
Short Name:
FLJ44290
Full Name:
Dynein heavy chain 12, axonemal
Alias:
Axonemal beta dynein heavy chain 12;Axonemal dynein heavy chain 12-like protein;Axonemal dynein heavy chain 7-like protein;Ciliary dynein heavy chain 12;Dynein heavy chain 7-like, axonemal;Dynein heavy chain domain-containing protein 2
Type:
DY12L
Mass (Da):
91694
Number AA:
784
UniProt ID:
Q6ZR08
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T34
P
E
N
I
G
V
D
T
P
T
Q
S
K
L
L
Site 2
Y43
T
Q
S
K
L
L
K
Y
R
R
S
K
E
Q
Q
Site 3
S46
K
L
L
K
Y
R
R
S
K
E
Q
Q
Q
K
I
Site 4
T73
D
R
T
L
G
K
R
T
P
L
L
P
P
P
D
Site 5
Y81
P
L
L
P
P
P
D
Y
P
Q
T
M
T
S
E
Site 6
T84
P
P
P
D
Y
P
Q
T
M
T
S
E
M
K
K
Site 7
Y96
M
K
K
K
G
F
N
Y
I
Y
M
K
Q
C
V
Site 8
S106
M
K
Q
C
V
E
S
S
P
L
V
P
I
Q
Q
Site 9
S126
M
L
R
L
I
P
E
S
L
K
E
G
K
E
R
Site 10
S139
E
R
E
E
L
L
E
S
L
I
N
E
V
S
S
Site 11
S145
E
S
L
I
N
E
V
S
S
D
F
E
N
S
M
Site 12
S151
V
S
S
D
F
E
N
S
M
K
R
Y
L
V
Q
Site 13
S168
L
V
K
P
P
V
K
S
L
E
D
E
G
G
P
Site 14
S179
E
G
G
P
L
P
E
S
P
V
G
L
D
Y
S
Site 15
Y185
E
S
P
V
G
L
D
Y
S
N
P
W
H
S
S
Site 16
Y193
S
N
P
W
H
S
S
Y
V
Q
A
R
N
Q
I
Site 17
T220
M
L
L
D
L
G
Y
T
T
F
A
D
T
V
L
Site 18
T221
L
L
D
L
G
Y
T
T
F
A
D
T
V
L
L
Site 19
S243
K
G
P
I
D
C
E
S
L
K
T
D
L
S
I
Site 20
S249
E
S
L
K
T
D
L
S
I
Q
T
R
N
A
E
Site 21
Y264
E
K
I
M
N
T
W
Y
P
K
V
I
N
L
F
Site 22
T272
P
K
V
I
N
L
F
T
K
K
E
A
L
E
G
Site 23
T331
P
I
F
K
I
E
L
T
F
D
D
D
K
M
E
Site 24
Y340
D
D
D
K
M
E
F
Y
P
T
F
Q
D
L
E
Site 25
T342
D
K
M
E
F
Y
P
T
F
Q
D
L
E
D
N
Site 26
T366
E
A
L
Q
N
V
Q
T
I
P
S
W
L
S
G
Site 27
S375
P
S
W
L
S
G
T
S
T
P
V
N
L
D
T
Site 28
T376
S
W
L
S
G
T
S
T
P
V
N
L
D
T
E
Site 29
T382
S
T
P
V
N
L
D
T
E
L
P
E
H
V
L
Site 30
Y411
L
E
G
A
R
K
H
Y
E
T
Y
V
E
K
Y
Site 31
Y414
A
R
K
H
Y
E
T
Y
V
E
K
Y
N
W
L
Site 32
T432
T
A
V
E
N
I
E
T
F
Q
T
E
D
H
T
Site 33
T439
T
F
Q
T
E
D
H
T
F
D
E
Y
T
E
F
Site 34
Y443
E
D
H
T
F
D
E
Y
T
E
F
I
E
K
F
Site 35
T478
L
D
C
E
D
L
K
T
G
L
T
N
K
A
K
Site 36
S532
E
E
M
M
D
L
I
S
Y
V
E
K
A
R
T
Site 37
S552
L
I
L
R
I
Q
E
S
K
R
Q
M
S
Y
F
Site 38
S557
Q
E
S
K
R
Q
M
S
Y
F
L
D
V
F
L
Site 39
T575
E
D
L
A
L
N
A
T
V
L
M
W
P
R
K
Site 40
Y638
E
L
E
R
M
Q
Q
Y
V
T
D
V
R
Q
L
Site 41
Y673
F
K
W
E
L
T
K
Y
P
E
L
D
K
L
K
Site 42
Y686
L
K
V
N
I
E
P
Y
Q
K
F
F
N
F
V
Site 43
S724
E
A
D
V
E
E
F
S
R
E
I
F
K
T
L
Site 44
T730
F
S
R
E
I
F
K
T
L
K
F
F
Q
T
K
Site 45
T768
E
E
P
K
D
N
A
T
I
T
M
C
R
M
R
Site 46
T770
P
K
D
N
A
T
I
T
M
C
R
M
R
A
R
Site 47
Y788
Q
I
S
E
I
V
G
Y
D
L
T
P
D
S
G
Site 48
T791
E
I
V
G
Y
D
L
T
P
D
S
G
T
T
L
Site 49
S794
G
Y
D
L
T
P
D
S
G
T
T
L
R
K
V
Site 50
T797
L
T
P
D
S
G
T
T
L
R
K
V
L
K
L
Site 51
T807
K
V
L
K
L
N
L
T
P
Y
L
E
Q
F
E
Site 52
S821
E
V
I
S
A
G
A
S
K
E
F
S
L
E
K
Site 53
S825
A
G
A
S
K
E
F
S
L
E
K
A
M
N
T
Site 54
S845
E
D
I
A
F
H
I
S
L
Y
R
D
T
G
V
Site 55
T872
L
D
D
Q
I
I
K
T
Q
T
M
R
G
S
P
Site 56
T874
D
Q
I
I
K
T
Q
T
M
R
G
S
P
F
I
Site 57
S878
K
T
Q
T
M
R
G
S
P
F
I
K
P
F
E
Site 58
Y985
I
M
K
G
L
N
A
Y
L
E
K
K
R
L
F
Site 59
S1009
D
E
M
L
E
I
L
S
E
T
K
D
P
L
R
Site 60
Y1091
I
A
A
A
R
L
A
Y
P
E
S
A
R
R
D
Site 61
S1094
A
R
L
A
Y
P
E
S
A
R
R
D
W
V
R
Site 62
T1120
Q
M
F
W
T
S
E
T
Q
E
V
I
S
G
G
Site 63
Y1134
G
T
E
G
L
K
K
Y
Y
K
E
L
Q
N
Q
Site 64
Y1198
W
L
A
Q
L
R
Y
Y
W
E
N
E
N
A
R
Site 65
Y1215
I
I
N
C
N
V
K
Y
A
Y
E
Y
L
G
N
Site 66
Y1217
N
C
N
V
K
Y
A
Y
E
Y
L
G
N
S
P
Site 67
Y1219
N
V
K
Y
A
Y
E
Y
L
G
N
S
P
R
L
Site 68
S1223
A
Y
E
Y
L
G
N
S
P
R
L
V
I
T
P
Site 69
T1229
N
S
P
R
L
V
I
T
P
L
T
D
R
C
Y
Site 70
Y1359
A
I
T
M
N
P
G
Y
A
G
R
S
E
L
P
Site 71
Y1394
A
E
I
S
L
Y
S
Y
G
F
L
N
A
R
P
Site 72
S1414
V
M
T
Y
R
L
C
S
E
Q
L
S
S
Q
F
Site 73
S1418
R
L
C
S
E
Q
L
S
S
Q
F
H
Y
D
Y
Site 74
S1419
L
C
S
E
Q
L
S
S
Q
F
H
Y
D
Y
G
Site 75
Y1423
Q
L
S
S
Q
F
H
Y
D
Y
G
M
R
A
V
Site 76
Y1425
S
S
Q
F
H
Y
D
Y
G
M
R
A
V
K
A
Site 77
Y1444
A
G
N
L
K
L
K
Y
P
N
E
N
E
D
I
Site 78
S1456
E
D
I
L
L
L
R
S
I
K
D
V
N
E
P
Site 79
S1467
V
N
E
P
K
F
L
S
H
D
I
P
L
F
N
Site 80
Y1491
I
K
L
P
E
A
D
Y
H
E
F
L
E
C
A
Site 81
T1552
H
V
L
A
D
T
L
T
L
M
N
E
H
G
Y
Site 82
Y1567
G
E
E
E
K
V
I
Y
R
T
V
N
P
K
S
Site 83
T1569
E
E
K
V
I
Y
R
T
V
N
P
K
S
I
T
Site 84
S1574
Y
R
T
V
N
P
K
S
I
T
M
G
Q
L
F
Site 85
T1592
D
P
V
S
H
E
W
T
D
G
I
V
A
N
T
Site 86
S1606
T
F
R
E
F
A
L
S
E
T
P
D
R
K
W
Site 87
T1608
R
E
F
A
L
S
E
T
P
D
R
K
W
V
V
Site 88
T1630
L
W
I
E
S
M
N
T
V
L
D
D
N
K
K
Site 89
S1665
T
M
D
L
S
Q
A
S
P
A
T
V
S
R
C
Site 90
S1680
G
M
I
Y
L
E
P
S
Q
L
G
W
E
P
L
Site 91
S1689
L
G
W
E
P
L
V
S
S
W
L
N
S
L
K
Site 92
S1690
G
W
E
P
L
V
S
S
W
L
N
S
L
K
G
Site 93
Y1704
G
P
L
C
E
P
E
Y
Q
A
L
L
R
G
L
Site 94
Y1752
I
T
F
R
I
S
N
Y
F
K
Y
V
P
L
K
Site 95
Y1755
R
I
S
N
Y
F
K
Y
V
P
L
K
T
Q
C
Site 96
S1786
L
I
W
S
I
G
G
S
C
D
T
D
G
R
R
Site 97
T1789
S
I
G
G
S
C
D
T
D
G
R
R
V
F
D
Site 98
S1815
D
E
N
P
V
P
D
S
V
G
K
W
E
C
P
Site 99
Y1830
F
D
E
K
G
L
V
Y
D
Y
M
Y
E
L
K
Site 100
Y1832
E
K
G
L
V
Y
D
Y
M
Y
E
L
K
N
K
Site 101
Y1834
G
L
V
Y
D
Y
M
Y
E
L
K
N
K
G
R
Site 102
S1899
G
P
T
G
T
G
K
S
V
Y
V
K
D
K
L
Site 103
Y1901
T
G
T
G
K
S
V
Y
V
K
D
K
L
M
N
Site 104
Y1915
N
H
L
E
K
D
Q
Y
F
P
F
Y
I
N
L
Site 105
Y1919
K
D
Q
Y
F
P
F
Y
I
N
L
S
A
R
T
Site 106
S1923
F
P
F
Y
I
N
L
S
A
R
T
S
A
N
Q
Site 107
S1927
I
N
L
S
A
R
T
S
A
N
Q
V
Q
N
I
Site 108
Y1970
N
M
P
A
L
E
K
Y
G
A
Q
P
P
I
E
Site 109
T2019
G
G
G
R
N
P
V
T
P
R
C
I
R
H
F
Site 110
T2038
I
N
S
F
S
D
E
T
M
V
R
I
F
S
S
Site 111
Y2060
T
H
E
F
P
P
E
Y
F
V
I
G
N
Q
I
Site 112
T2085
S
V
E
N
L
L
P
T
P
T
K
S
H
Y
T
Site 113
S2089
L
L
P
T
P
T
K
S
H
Y
T
F
N
L
R
Site 114
T2092
T
P
T
K
S
H
Y
T
F
N
L
R
D
F
S
Site 115
Y2132
H
E
V
L
R
V
F
Y
D
R
L
I
N
D
D
Site 116
T2150
W
L
F
Q
L
T
K
T
V
I
K
D
H
F
K
Site 117
S2162
H
F
K
E
S
F
H
S
I
F
S
H
L
R
K
Site 118
T2175
R
K
Q
N
A
P
V
T
E
E
D
L
R
N
L
Site 119
Y2187
R
N
L
M
F
G
D
Y
M
N
P
D
L
E
G
Site 120
Y2199
L
E
G
D
D
R
V
Y
I
E
I
P
N
I
H
Site 121
Y2219
V
D
Q
C
L
D
E
Y
N
Q
T
H
K
T
R
Site 122
S2249
I
C
R
V
L
K
Q
S
G
G
N
A
L
L
V
Site 123
S2265
L
G
G
S
G
R
Q
S
L
T
R
L
A
T
S
Site 124
T2267
G
S
G
R
Q
S
L
T
R
L
A
T
S
M
A
Site 125
T2271
Q
S
L
T
R
L
A
T
S
M
A
K
M
H
I
Site 126
S2298
E
W
R
E
D
M
K
S
F
I
A
V
P
V
T
Site 127
S2313
N
R
I
V
D
N
K
S
K
I
L
E
K
R
L
Site 128
Y2322
I
L
E
K
R
L
R
Y
L
N
D
H
F
T
Y
Site 129
Y2332
D
H
F
T
Y
N
L
Y
C
N
I
C
R
S
L
Site 130
Y2364
L
A
R
K
E
I
E
Y
Q
E
L
M
F
L
L
Site 131
S2379
T
G
G
V
S
L
K
S
A
E
K
N
P
D
P
Site 132
Y2424
I
Y
E
W
R
E
I
Y
D
S
K
E
P
H
N
Site 133
S2426
E
W
R
E
I
Y
D
S
K
E
P
H
N
A
K
Site 134
T2460
C
L
R
P
D
K
I
T
P
A
I
T
N
Y
V
Site 135
Y2466
I
T
P
A
I
T
N
Y
V
T
D
K
L
G
K
Site 136
T2468
P
A
I
T
N
Y
V
T
D
K
L
G
K
K
F
Site 137
T2484
E
P
P
P
F
D
L
T
K
S
Y
L
D
S
N
Site 138
S2486
P
P
F
D
L
T
K
S
Y
L
D
S
N
C
T
Site 139
Y2487
P
F
D
L
T
K
S
Y
L
D
S
N
C
T
I
Site 140
S2509
P
G
A
D
P
M
A
S
L
L
K
F
A
N
D
Site 141
S2518
L
K
F
A
N
D
K
S
M
S
G
N
K
F
Q
Site 142
S2528
G
N
K
F
Q
A
I
S
L
G
Q
G
Q
G
P
Site 143
T2574
E
K
I
C
E
D
F
T
S
E
T
C
N
S
S
Site 144
T2577
C
E
D
F
T
S
E
T
C
N
S
S
F
R
L
Site 145
S2580
F
T
S
E
T
C
N
S
S
F
R
L
W
L
T
Site 146
S2581
T
S
E
T
C
N
S
S
F
R
L
W
L
T
S
Site 147
T2587
S
S
F
R
L
W
L
T
S
Y
P
S
S
K
F
Site 148
S2588
S
F
R
L
W
L
T
S
Y
P
S
S
K
F
P
Site 149
Y2589
F
R
L
W
L
T
S
Y
P
S
S
K
F
P
V
Site 150
T2597
P
S
S
K
F
P
V
T
I
L
Q
N
G
V
K
Site 151
T2606
L
Q
N
G
V
K
M
T
N
E
P
P
T
G
L
Site 152
Y2621
R
L
N
L
L
Q
S
Y
L
T
D
P
V
S
D
Site 153
T2623
N
L
L
Q
S
Y
L
T
D
P
V
S
D
P
E
Site 154
S2627
S
Y
L
T
D
P
V
S
D
P
E
F
F
K
G
Site 155
Y2671
P
L
G
W
N
I
P
Y
G
F
N
E
S
D
L
Site 156
S2676
I
P
Y
G
F
N
E
S
D
L
R
I
S
I
R
Site 157
S2681
N
E
S
D
L
R
I
S
I
R
Q
L
Q
L
F
Site 158
Y2733
L
A
D
F
Y
N
L
Y
I
V
E
N
P
H
Y
Site 159
Y2740
Y
I
V
E
N
P
H
Y
K
F
S
P
S
G
N
Site 160
S2743
E
N
P
H
Y
K
F
S
P
S
G
N
Y
F
A
Site 161
S2745
P
H
Y
K
F
S
P
S
G
N
Y
F
A
P
P
Site 162
Y2748
K
F
S
P
S
G
N
Y
F
A
P
P
K
G
T
Site 163
Y2759
P
K
G
T
Y
E
D
Y
I
E
F
I
K
K
L
Site 164
T2769
F
I
K
K
L
P
F
T
Q
H
P
E
I
F
G
Site 165
T2792
K
D
L
Q
Q
T
K
T
L
F
E
S
L
L
L
Site 166
S2796
Q
T
K
T
L
F
E
S
L
L
L
T
Q
G
G
Site 167
T2800
L
F
E
S
L
L
L
T
Q
G
G
S
K
Q
T
Site 168
S2804
L
L
L
T
Q
G
G
S
K
Q
T
G
A
S
G
Site 169
S2810
G
S
K
Q
T
G
A
S
G
S
T
D
Q
I
L
Site 170
S2830
D
I
L
N
K
L
P
S
D
F
D
I
E
M
A
Site 171
Y2841
I
E
M
A
L
R
K
Y
P
V
R
Y
E
E
S
Site 172
Y2845
L
R
K
Y
P
V
R
Y
E
E
S
M
N
T
V
Site 173
T2851
R
Y
E
E
S
M
N
T
V
L
V
Q
E
M
E
Site 174
T2866
R
F
N
N
L
I
I
T
I
R
N
T
L
R
D
Site 175
Y2909
E
I
W
A
K
R
S
Y
P
S
L
K
P
L
G
Site 176
S2911
W
A
K
R
S
Y
P
S
L
K
P
L
G
S
Y
Site 177
Y2933
L
N
F
L
Q
D
W
Y
N
S
G
K
P
C
V
Site 178
Y2960
L
T
G
A
M
Q
N
Y
A
R
K
Y
T
T
P
Site 179
Y2964
M
Q
N
Y
A
R
K
Y
T
T
P
I
D
L
L
Site 180
T2965
Q
N
Y
A
R
K
Y
T
T
P
I
D
L
L
G
Site 181
T2966
N
Y
A
R
K
Y
T
T
P
I
D
L
L
G
Y
Site 182
S2980
Y
E
F
E
V
I
P
S
D
T
S
D
T
S
P
Site 183
T2982
F
E
V
I
P
S
D
T
S
D
T
S
P
E
D
Site 184
S2983
E
V
I
P
S
D
T
S
D
T
S
P
E
D
G
Site 185
S2986
P
S
D
T
S
D
T
S
P
E
D
G
V
Y
I
Site 186
Y2992
T
S
P
E
D
G
V
Y
I
H
G
L
Y
L
D
Site 187
Y2997
G
V
Y
I
H
G
L
Y
L
D
G
A
R
W
D
Site 188
S3007
G
A
R
W
D
R
E
S
G
L
L
A
E
Q
Y
Site 189
S3033
W
I
K
P
T
Q
K
S
R
I
I
K
S
D
A
Site 190
S3038
Q
K
S
R
I
I
K
S
D
A
Y
V
C
P
L
Site 191
Y3041
R
I
I
K
S
D
A
Y
V
C
P
L
Y
K
T
Site 192
Y3046
D
A
Y
V
C
P
L
Y
K
T
S
E
R
K
G
Site 193
T3048
Y
V
C
P
L
Y
K
T
S
E
R
K
G
T
L
Site 194
S3049
V
C
P
L
Y
K
T
S
E
R
K
G
T
L
S
Site 195
T3054
K
T
S
E
R
K
G
T
L
S
T
T
G
H
S
Site 196
S3056
S
E
R
K
G
T
L
S
T
T
G
H
S
T
N
Site 197
T3057
E
R
K
G
T
L
S
T
T
G
H
S
T
N
F
Site 198
T3072
V
I
A
M
L
L
K
T
D
Q
P
T
R
H
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation