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Updated November 2019
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Protein Info
Short Name:
SRCAP
Full Name:
Helicase SRCAP
Alias:
Domino 1; Domino 2; DOMO1; EAF1; EC 3.6.1; KIAA0309; Snf2-related CBP activator; Snf2-related CREBBP activator protein; Swi2/Snf2-related ATPase; SWR1
Type:
EC 3.6.1.-; Transcription, coactivator/corepressor; Helicase; Acetyltransferase
Mass (Da):
343525
Number AA:
3230
UniProt ID:
Q6ZRS2
International Prot ID:
IPI00009101
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043234
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0004386
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0044419
GO:0006357
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
Q
S
S
P
S
P
A
H
P
Q
L
P
Site 2
T17
P
Q
L
P
V
L
Q
T
Q
M
V
S
D
G
M
Site 3
T25
Q
M
V
S
D
G
M
T
G
S
N
P
V
S
P
Site 4
S27
V
S
D
G
M
T
G
S
N
P
V
S
P
A
S
Site 5
S31
M
T
G
S
N
P
V
S
P
A
S
S
S
S
P
Site 6
S34
S
N
P
V
S
P
A
S
S
S
S
P
A
S
S
Site 7
S35
N
P
V
S
P
A
S
S
S
S
P
A
S
S
G
Site 8
S36
P
V
S
P
A
S
S
S
S
P
A
S
S
G
A
Site 9
S37
V
S
P
A
S
S
S
S
P
A
S
S
G
A
G
Site 10
S40
A
S
S
S
S
P
A
S
S
G
A
G
G
I
S
Site 11
S41
S
S
S
S
P
A
S
S
G
A
G
G
I
S
P
Site 12
S47
S
S
G
A
G
G
I
S
P
Q
H
I
A
Q
D
Site 13
S55
P
Q
H
I
A
Q
D
S
S
L
D
G
P
P
G
Site 14
S56
Q
H
I
A
Q
D
S
S
L
D
G
P
P
G
P
Site 15
T68
P
G
P
P
D
G
A
T
V
P
L
E
G
F
S
Site 16
S77
P
L
E
G
F
S
L
S
Q
A
A
D
L
A
N
Site 17
S92
K
G
P
K
W
E
K
S
H
A
E
I
A
E
Q
Site 18
S120
L
R
K
E
G
F
W
S
L
K
R
L
P
K
V
Site 19
S196
A
K
L
R
R
I
A
S
T
M
A
K
D
V
R
Site 20
T197
K
L
R
R
I
A
S
T
M
A
K
D
V
R
Q
Site 21
Y243
I
V
G
Q
T
E
K
Y
S
D
L
L
S
Q
S
Site 22
S244
V
G
Q
T
E
K
Y
S
D
L
L
S
Q
S
L
Site 23
S248
E
K
Y
S
D
L
L
S
Q
S
L
N
Q
P
L
Site 24
S250
Y
S
D
L
L
S
Q
S
L
N
Q
P
L
T
S
Site 25
T256
Q
S
L
N
Q
P
L
T
S
S
K
A
G
S
S
Site 26
S257
S
L
N
Q
P
L
T
S
S
K
A
G
S
S
P
Site 27
S258
L
N
Q
P
L
T
S
S
K
A
G
S
S
P
C
Site 28
S262
L
T
S
S
K
A
G
S
S
P
C
L
G
S
S
Site 29
S263
T
S
S
K
A
G
S
S
P
C
L
G
S
S
S
Site 30
S268
G
S
S
P
C
L
G
S
S
S
A
A
S
S
P
Site 31
S269
S
S
P
C
L
G
S
S
S
A
A
S
S
P
P
Site 32
S270
S
P
C
L
G
S
S
S
A
A
S
S
P
P
P
Site 33
S273
L
G
S
S
S
A
A
S
S
P
P
P
P
A
S
Site 34
S274
G
S
S
S
A
A
S
S
P
P
P
P
A
S
R
Site 35
S280
S
S
P
P
P
P
A
S
R
L
D
D
E
D
G
Site 36
T302
E
E
E
D
D
E
E
T
I
E
V
E
E
Q
Q
Site 37
S338
P
L
E
E
L
L
R
S
L
P
P
Q
L
L
E
Site 38
S348
P
Q
L
L
E
G
P
S
S
P
S
Q
T
P
S
Site 39
S349
Q
L
L
E
G
P
S
S
P
S
Q
T
P
S
S
Site 40
S351
L
E
G
P
S
S
P
S
Q
T
P
S
S
H
D
Site 41
T353
G
P
S
S
P
S
Q
T
P
S
S
H
D
S
D
Site 42
S355
S
S
P
S
Q
T
P
S
S
H
D
S
D
T
R
Site 43
S356
S
P
S
Q
T
P
S
S
H
D
S
D
T
R
D
Site 44
S359
Q
T
P
S
S
H
D
S
D
T
R
D
G
P
E
Site 45
T361
P
S
S
H
D
S
D
T
R
D
G
P
E
E
G
Site 46
S384
L
E
I
K
P
P
P
S
A
V
T
Q
R
N
K
Site 47
T387
K
P
P
P
S
A
V
T
Q
R
N
K
Q
P
W
Site 48
T404
D
E
D
D
E
E
F
T
A
N
E
E
E
A
E
Site 49
S434
V
D
H
A
M
E
L
S
E
L
A
R
E
G
E
Site 50
S443
L
A
R
E
G
E
L
S
M
E
E
L
L
Q
Q
Site 51
Y455
L
Q
Q
Y
A
G
A
Y
A
P
G
S
G
S
S
Site 52
S459
A
G
A
Y
A
P
G
S
G
S
S
E
D
E
D
Site 53
S474
E
D
E
V
D
A
N
S
S
D
C
E
P
E
G
Site 54
S475
D
E
V
D
A
N
S
S
D
C
E
P
E
G
P
Site 55
S493
E
E
P
P
Q
E
D
S
S
S
Q
S
D
S
V
Site 56
S494
E
P
P
Q
E
D
S
S
S
Q
S
D
S
V
E
Site 57
S495
P
P
Q
E
D
S
S
S
Q
S
D
S
V
E
D
Site 58
S497
Q
E
D
S
S
S
Q
S
D
S
V
E
D
R
S
Site 59
S499
D
S
S
S
Q
S
D
S
V
E
D
R
S
E
D
Site 60
S504
S
D
S
V
E
D
R
S
E
D
E
E
D
E
H
Site 61
S512
E
D
E
E
D
E
H
S
E
E
E
E
T
S
G
Site 62
T517
E
H
S
E
E
E
E
T
S
G
S
S
A
S
E
Site 63
S518
H
S
E
E
E
E
T
S
G
S
S
A
S
E
E
Site 64
S520
E
E
E
E
T
S
G
S
S
A
S
E
E
S
E
Site 65
S523
E
T
S
G
S
S
A
S
E
E
S
E
S
E
E
Site 66
S526
G
S
S
A
S
E
E
S
E
S
E
E
S
E
D
Site 67
S528
S
A
S
E
E
S
E
S
E
E
S
E
D
A
Q
Site 68
S531
E
E
S
E
S
E
E
S
E
D
A
Q
S
Q
S
Site 69
S536
E
E
S
E
D
A
Q
S
Q
S
Q
A
D
E
E
Site 70
S538
S
E
D
A
Q
S
Q
S
Q
A
D
E
E
E
E
Site 71
Y553
D
D
D
F
G
V
E
Y
L
L
A
R
D
E
E
Site 72
S562
L
A
R
D
E
E
Q
S
E
A
D
A
G
S
G
Site 73
S568
Q
S
E
A
D
A
G
S
G
P
P
T
P
G
P
Site 74
T572
D
A
G
S
G
P
P
T
P
G
P
T
T
L
G
Site 75
T577
P
P
T
P
G
P
T
T
L
G
P
K
K
E
I
Site 76
S593
D
I
A
A
A
A
E
S
L
Q
P
K
G
Y
T
Site 77
T604
K
G
Y
T
L
A
T
T
Q
V
K
T
P
I
P
Site 78
Y621
L
R
G
Q
L
R
E
Y
Q
H
I
G
L
D
W
Site 79
T631
I
G
L
D
W
L
V
T
M
Y
E
K
K
L
N
Site 80
Y633
L
D
W
L
V
T
M
Y
E
K
K
L
N
G
I
Site 81
Y699
S
F
K
I
L
T
Y
Y
G
A
Q
K
E
R
K
Site 82
Y742
F
R
R
K
N
W
R
Y
L
I
L
D
E
A
Q
Site 83
S761
F
K
S
Q
R
W
Q
S
L
L
N
F
N
S
Q
Site 84
S767
Q
S
L
L
N
F
N
S
Q
R
R
L
L
L
T
Site 85
T774
S
Q
R
R
L
L
L
T
G
T
P
L
Q
N
S
Site 86
T776
R
R
L
L
L
T
G
T
P
L
Q
N
S
L
M
Site 87
S781
T
G
T
P
L
Q
N
S
L
M
E
L
W
S
L
Site 88
T812
E
W
F
S
N
P
L
T
G
M
I
E
G
S
Q
Site 89
S818
L
T
G
M
I
E
G
S
Q
E
Y
N
E
G
L
Site 90
Y853
E
K
Q
M
P
K
K
Y
E
H
V
I
R
C
R
Site 91
Y869
S
K
R
Q
R
C
L
Y
D
D
F
M
A
Q
T
Site 92
T913
L
F
D
P
R
P
V
T
S
P
F
I
T
P
G
Site 93
T933
A
S
L
V
L
R
A
T
D
V
H
P
L
Q
R
Site 94
S956
I
G
L
E
G
R
V
S
R
Y
E
A
D
T
F
Site 95
Y958
L
E
G
R
V
S
R
Y
E
A
D
T
F
L
P
Site 96
T962
V
S
R
Y
E
A
D
T
F
L
P
R
H
R
L
Site 97
S970
F
L
P
R
H
R
L
S
R
R
V
L
L
E
V
Site 98
S1033
P
P
P
G
P
E
L
S
A
Q
P
T
P
G
P
Site 99
T1037
P
E
L
S
A
Q
P
T
P
G
P
V
P
Q
V
Site 100
S1079
L
P
P
L
Q
P
N
S
G
S
L
P
Q
V
L
Site 101
S1081
P
L
Q
P
N
S
G
S
L
P
Q
V
L
P
S
Site 102
S1094
P
S
P
L
G
V
L
S
G
T
S
R
P
P
T
Site 103
T1096
P
L
G
V
L
S
G
T
S
R
P
P
T
P
T
Site 104
S1097
L
G
V
L
S
G
T
S
R
P
P
T
P
T
L
Site 105
T1101
S
G
T
S
R
P
P
T
P
T
L
S
L
K
P
Site 106
T1103
T
S
R
P
P
T
P
T
L
S
L
K
P
T
P
Site 107
S1105
R
P
P
T
P
T
L
S
L
K
P
T
P
P
A
Site 108
T1109
P
T
L
S
L
K
P
T
P
P
A
P
V
R
L
Site 109
S1117
P
P
A
P
V
R
L
S
P
A
P
P
P
G
S
Site 110
S1124
S
P
A
P
P
P
G
S
S
S
L
L
K
P
L
Site 111
S1125
P
A
P
P
P
G
S
S
S
L
L
K
P
L
T
Site 112
S1172
A
P
Q
R
L
I
L
S
P
D
M
Q
A
R
L
Site 113
S1181
D
M
Q
A
R
L
P
S
G
E
V
V
S
I
G
Site 114
S1186
L
P
S
G
E
V
V
S
I
G
Q
L
A
S
L
Site 115
S1192
V
S
I
G
Q
L
A
S
L
A
Q
R
P
V
A
Site 116
T1208
A
G
G
S
K
P
L
T
F
Q
I
Q
G
N
K
Site 117
T1219
Q
G
N
K
L
T
L
T
G
A
Q
V
R
Q
L
Site 118
S1252
G
G
Q
H
H
L
I
S
Q
P
A
H
V
A
L
Site 119
S1273
T
P
G
P
T
P
V
S
V
L
P
S
S
T
P
Site 120
S1277
T
P
V
S
V
L
P
S
S
T
P
S
T
T
P
Site 121
S1278
P
V
S
V
L
P
S
S
T
P
S
T
T
P
A
Site 122
T1279
V
S
V
L
P
S
S
T
P
S
T
T
P
A
P
Site 123
S1281
V
L
P
S
S
T
P
S
T
T
P
A
P
T
G
Site 124
T1282
L
P
S
S
T
P
S
T
T
P
A
P
T
G
L
Site 125
T1283
P
S
S
T
P
S
T
T
P
A
P
T
G
L
S
Site 126
T1301
A
A
N
Q
V
P
P
T
M
V
N
N
T
G
V
Site 127
T1322
Q
A
P
R
D
G
L
T
P
V
P
P
L
A
P
Site 128
S1336
P
A
P
R
P
P
S
S
G
L
P
A
V
L
N
Site 129
T1347
A
V
L
N
P
R
P
T
L
T
P
G
R
L
P
Site 130
T1349
L
N
P
R
P
T
L
T
P
G
R
L
P
T
P
Site 131
T1355
L
T
P
G
R
L
P
T
P
T
L
G
T
A
R
Site 132
T1357
P
G
R
L
P
T
P
T
L
G
T
A
R
A
P
Site 133
T1367
T
A
R
A
P
M
P
T
P
T
L
V
R
P
L
Site 134
T1369
R
A
P
M
P
T
P
T
L
V
R
P
L
L
K
Site 135
S1382
L
K
L
V
H
S
P
S
P
E
V
S
A
S
A
Site 136
S1386
H
S
P
S
P
E
V
S
A
S
A
P
G
A
A
Site 137
S1388
P
S
P
E
V
S
A
S
A
P
G
A
A
P
L
Site 138
S1405
S
S
P
L
H
V
P
S
S
L
P
G
P
A
S
Site 139
S1406
S
P
L
H
V
P
S
S
L
P
G
P
A
S
S
Site 140
S1412
S
S
L
P
G
P
A
S
S
P
M
P
I
P
N
Site 141
S1413
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S
A
G
D
G
Site 293
S2956
P
I
P
G
T
I
S
S
A
G
D
G
N
S
E
Site 294
S2962
S
S
A
G
D
G
N
S
E
S
R
T
Q
P
P
Site 295
S2964
A
G
D
G
N
S
E
S
R
T
Q
P
P
P
H
Site 296
T2966
D
G
N
S
E
S
R
T
Q
P
P
P
H
P
S
Site 297
S2973
T
Q
P
P
P
H
P
S
P
L
T
P
L
P
P
Site 298
T2997
A
N
T
V
T
T
V
T
I
S
T
S
P
P
K
Site 299
S3001
T
T
V
T
I
S
T
S
P
P
K
R
K
R
G
Site 300
S3016
R
P
P
K
N
P
P
S
P
R
P
S
Q
L
P
Site 301
S3020
N
P
P
S
P
R
P
S
Q
L
P
V
L
D
R
Site 302
S3029
L
P
V
L
D
R
D
S
T
S
V
L
E
S
C
Site 303
T3030
P
V
L
D
R
D
S
T
S
V
L
E
S
C
G
Site 304
S3035
D
S
T
S
V
L
E
S
C
G
L
G
R
R
R
Site 305
S3050
Q
P
Q
G
Q
G
E
S
E
G
S
S
S
D
E
Site 306
S3053
G
Q
G
E
S
E
G
S
S
S
D
E
D
G
S
Site 307
S3054
Q
G
E
S
E
G
S
S
S
D
E
D
G
S
R
Site 308
S3055
G
E
S
E
G
S
S
S
D
E
D
G
S
R
P
Site 309
S3060
S
S
S
D
E
D
G
S
R
P
L
T
R
L
A
Site 310
T3064
E
D
G
S
R
P
L
T
R
L
A
R
L
R
L
Site 311
S3081
E
G
M
R
G
R
K
S
G
G
S
M
V
V
A
Site 312
S3084
R
G
R
K
S
G
G
S
M
V
V
A
V
I
Q
Site 313
S3099
D
D
L
D
L
A
D
S
G
P
G
G
L
E
L
Site 314
T3107
G
P
G
G
L
E
L
T
P
P
V
V
S
L
T
Site 315
S3112
E
L
T
P
P
V
V
S
L
T
P
K
L
R
S
Site 316
T3114
T
P
P
V
V
S
L
T
P
K
L
R
S
T
R
Site 317
S3119
S
L
T
P
K
L
R
S
T
R
L
R
P
G
S
Site 318
T3120
L
T
P
K
L
R
S
T
R
L
R
P
G
S
L
Site 319
S3126
S
T
R
L
R
P
G
S
L
V
P
P
L
E
T
Site 320
S3148
A
G
A
P
V
G
G
S
P
G
L
A
K
R
G
Site 321
S3161
R
G
R
L
Q
P
P
S
P
L
G
P
E
G
S
Site 322
S3168
S
P
L
G
P
E
G
S
V
E
E
S
E
A
E
Site 323
S3172
P
E
G
S
V
E
E
S
E
A
E
A
S
G
E
Site 324
S3177
E
E
S
E
A
E
A
S
G
E
E
E
E
G
D
Site 325
T3186
E
E
E
E
G
D
G
T
P
R
R
R
P
G
P
Site 326
T3199
G
P
R
R
L
V
G
T
T
N
Q
G
D
Q
R
Site 327
T3200
P
R
R
L
V
G
T
T
N
Q
G
D
Q
R
I
Site 328
S3210
G
D
Q
R
I
L
R
S
S
A
P
P
S
L
A
Site 329
S3211
D
Q
R
I
L
R
S
S
A
P
P
S
L
A
G
Site 330
S3222
S
L
A
G
P
A
V
S
H
R
G
R
K
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation