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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NBEAL1
Full Name:
Neurobeachin-like protein 1
Alias:
ALS2CR16; ALS2CR17; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein; beach; MGC164581; NBEAL; neurobeachin-like 1
Type:
Unknown function
Mass (Da):
150705
Number AA:
1314
UniProt ID:
Q6ZS30
International Prot ID:
IPI00784206
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
K
N
M
S
T
E
D
T
K
K
N
S
D
E
K
Site 2
T21
K
K
N
S
D
E
K
T
D
E
E
K
I
T
S
Site 3
T27
K
T
D
E
E
K
I
T
S
F
A
S
A
N
V
Site 4
S28
T
D
E
E
K
I
T
S
F
A
S
A
N
V
S
Site 5
S31
E
K
I
T
S
F
A
S
A
N
V
S
S
D
Q
Site 6
S35
S
F
A
S
A
N
V
S
S
D
Q
W
S
L
E
Site 7
S36
F
A
S
A
N
V
S
S
D
Q
W
S
L
E
D
Site 8
S40
N
V
S
S
D
Q
W
S
L
E
D
R
H
S
L
Site 9
S46
W
S
L
E
D
R
H
S
L
D
S
N
T
P
L
Site 10
S49
E
D
R
H
S
L
D
S
N
T
P
L
F
P
E
Site 11
T51
R
H
S
L
D
S
N
T
P
L
F
P
E
D
S
Site 12
S58
T
P
L
F
P
E
D
S
S
V
G
E
L
S
F
Site 13
S59
P
L
F
P
E
D
S
S
V
G
E
L
S
F
K
Site 14
S64
D
S
S
V
G
E
L
S
F
K
S
E
N
Q
E
Site 15
S67
V
G
E
L
S
F
K
S
E
N
Q
E
E
F
W
Site 16
S76
N
Q
E
E
F
W
H
S
N
P
S
H
L
S
L
Site 17
S79
E
F
W
H
S
N
P
S
H
L
S
L
D
L
S
Site 18
S82
H
S
N
P
S
H
L
S
L
D
L
S
G
I
D
Site 19
S86
S
H
L
S
L
D
L
S
G
I
D
S
C
E
M
Site 20
S90
L
D
L
S
G
I
D
S
C
E
M
S
D
S
G
Site 21
S94
G
I
D
S
C
E
M
S
D
S
G
S
Q
V
P
Site 22
S96
D
S
C
E
M
S
D
S
G
S
Q
V
P
D
S
Site 23
S98
C
E
M
S
D
S
G
S
Q
V
P
D
S
L
P
Site 24
S103
S
G
S
Q
V
P
D
S
L
P
S
T
P
S
P
Site 25
T107
V
P
D
S
L
P
S
T
P
S
P
V
E
S
T
Site 26
S109
D
S
L
P
S
T
P
S
P
V
E
S
T
K
S
Site 27
S113
S
T
P
S
P
V
E
S
T
K
S
F
S
V
H
Site 28
T114
T
P
S
P
V
E
S
T
K
S
F
S
V
H
S
Site 29
S116
S
P
V
E
S
T
K
S
F
S
V
H
S
D
R
Site 30
S118
V
E
S
T
K
S
F
S
V
H
S
D
R
E
S
Site 31
S121
T
K
S
F
S
V
H
S
D
R
E
S
S
I
T
Site 32
S125
S
V
H
S
D
R
E
S
S
I
T
N
D
M
G
Site 33
S126
V
H
S
D
R
E
S
S
I
T
N
D
M
G
F
Site 34
T128
S
D
R
E
S
S
I
T
N
D
M
G
F
S
D
Site 35
S134
I
T
N
D
M
G
F
S
D
D
F
S
L
L
E
Site 36
S138
M
G
F
S
D
D
F
S
L
L
E
S
Q
E
R
Site 37
S142
D
D
F
S
L
L
E
S
Q
E
R
C
E
E
E
Site 38
T173
L
E
K
S
D
D
D
T
W
I
E
R
G
Q
V
Site 39
S185
G
Q
V
F
S
A
L
S
K
P
G
I
S
S
E
Site 40
S191
L
S
K
P
G
I
S
S
E
L
L
R
P
S
D
Site 41
S197
S
S
E
L
L
R
P
S
D
E
I
K
L
T
L
Site 42
T203
P
S
D
E
I
K
L
T
L
L
Q
K
M
L
E
Site 43
S214
K
M
L
E
W
A
I
S
E
N
R
E
A
K
T
Site 44
T252
L
V
N
S
N
M
W
T
E
K
L
L
E
D
M
Site 45
S333
G
K
L
E
H
V
L
S
Q
S
I
K
E
Q
T
Site 46
S335
L
E
H
V
L
S
Q
S
I
K
E
Q
T
E
I
Site 47
T340
S
Q
S
I
K
E
Q
T
E
I
Y
S
F
L
I
Site 48
S344
K
E
Q
T
E
I
Y
S
F
L
I
P
L
V
R
Site 49
T373
H
L
P
S
L
P
F
T
N
G
S
S
S
F
F
Site 50
S376
S
L
P
F
T
N
G
S
S
S
F
F
E
D
F
Site 51
S378
P
F
T
N
G
S
S
S
F
F
E
D
F
Q
E
Site 52
Y395
N
S
N
E
W
Q
V
Y
I
E
K
Y
I
V
P
Site 53
Y399
W
Q
V
Y
I
E
K
Y
I
V
P
Y
M
K
Q
Site 54
Y407
I
V
P
Y
M
K
Q
Y
E
A
H
T
F
Y
D
Site 55
Y413
Q
Y
E
A
H
T
F
Y
D
G
H
E
N
M
A
Site 56
Y422
G
H
E
N
M
A
L
Y
W
K
D
C
Y
E
A
Site 57
S444
R
D
R
E
G
G
E
S
K
L
K
F
Q
E
L
Site 58
Y467
A
R
Q
E
N
L
R
Y
N
N
M
L
K
Q
L
Site 59
S476
N
M
L
K
Q
L
S
S
Q
Q
L
A
T
L
R
Site 60
T481
L
S
S
Q
Q
L
A
T
L
R
R
W
K
A
I
Site 61
Y491
R
W
K
A
I
Q
L
Y
L
T
C
E
R
G
P
Site 62
T493
K
A
I
Q
L
Y
L
T
C
E
R
G
P
W
A
Site 63
Y517
K
L
A
N
V
E
N
Y
S
R
M
R
L
K
L
Site 64
Y528
R
L
K
L
V
P
N
Y
N
F
K
T
H
E
E
Site 65
T532
V
P
N
Y
N
F
K
T
H
E
E
A
S
A
L
Site 66
S548
D
N
L
G
I
Q
H
S
Q
P
S
S
D
T
L
Site 67
S552
I
Q
H
S
Q
P
S
S
D
T
L
L
L
E
V
Site 68
T581
D
L
P
E
E
D
I
T
A
R
V
N
V
D
E
Site 69
Y625
E
I
T
T
Q
H
I
Y
F
Y
D
G
S
I
E
Site 70
Y656
R
E
I
H
L
R
R
Y
N
L
R
R
S
A
L
Site 71
S661
R
R
Y
N
L
R
R
S
A
L
E
I
F
H
V
Site 72
Y673
F
H
V
D
Q
S
N
Y
F
L
N
F
K
K
E
Site 73
Y686
K
E
V
R
N
K
I
Y
S
R
L
L
S
L
H
Site 74
S687
E
V
R
N
K
I
Y
S
R
L
L
S
L
H
S
Site 75
S691
K
I
Y
S
R
L
L
S
L
H
S
P
N
S
Y
Site 76
S694
S
R
L
L
S
L
H
S
P
N
S
Y
Y
G
S
Site 77
S697
L
S
L
H
S
P
N
S
Y
Y
G
S
R
S
P
Site 78
Y698
S
L
H
S
P
N
S
Y
Y
G
S
R
S
P
Q
Site 79
Y699
L
H
S
P
N
S
Y
Y
G
S
R
S
P
Q
E
Site 80
S701
S
P
N
S
Y
Y
G
S
R
S
P
Q
E
L
F
Site 81
S703
N
S
Y
Y
G
S
R
S
P
Q
E
L
F
K
A
Site 82
Y727
R
E
I
S
N
F
D
Y
L
I
Q
I
N
T
M
Site 83
Y739
N
T
M
A
G
R
T
Y
N
D
L
A
Q
Y
P
Site 84
Y755
F
P
W
I
L
Q
D
Y
T
S
E
E
L
D
L
Site 85
T756
P
W
I
L
Q
D
Y
T
S
E
E
L
D
L
N
Site 86
S757
W
I
L
Q
D
Y
T
S
E
E
L
D
L
N
N
Site 87
Y790
A
K
A
M
R
E
K
Y
E
N
F
E
D
P
M
Site 88
Y805
G
T
I
D
K
F
H
Y
G
T
H
Y
S
N
S
Site 89
Y809
K
F
H
Y
G
T
H
Y
S
N
S
A
G
V
M
Site 90
Y859
Q
A
L
M
D
N
P
Y
D
V
K
E
L
I
P
Site 91
Y910
K
S
A
E
D
F
I
Y
K
H
R
K
A
L
E
Site 92
S918
K
H
R
K
A
L
E
S
E
Y
V
S
A
H
L
Site 93
Y920
R
K
A
L
E
S
E
Y
V
S
A
H
L
H
E
Site 94
S922
A
L
E
S
E
Y
V
S
A
H
L
H
E
W
I
Site 95
Y935
W
I
D
L
I
F
G
Y
K
Q
R
G
P
A
A
Site 96
T964
A
V
D
L
D
A
L
T
D
E
K
E
R
K
A
Site 97
Y1005
G
T
H
G
W
L
P
Y
D
R
N
I
S
N
Y
Site 98
Y1012
Y
D
R
N
I
S
N
Y
F
T
F
I
K
D
Q
Site 99
T1014
R
N
I
S
N
Y
F
T
F
I
K
D
Q
T
V
Site 100
T1020
F
T
F
I
K
D
Q
T
V
T
N
P
K
T
Q
Site 101
T1026
Q
T
V
T
N
P
K
T
Q
R
S
I
N
G
S
Site 102
S1029
T
N
P
K
T
Q
R
S
I
N
G
S
F
A
P
Site 103
S1033
T
Q
R
S
I
N
G
S
F
A
P
G
L
E
I
Site 104
Y1130
S
K
P
F
Q
I
L
Y
G
H
T
N
E
V
L
Site 105
S1150
T
E
L
D
M
A
V
S
G
S
R
D
G
T
V
Site 106
S1177
E
G
H
I
V
V
Y
S
S
T
E
E
K
T
T
Site 107
S1178
G
H
I
V
V
Y
S
S
T
E
E
K
T
T
L
Site 108
T1184
S
S
T
E
E
K
T
T
L
K
D
K
N
A
L
Site 109
S1203
I
N
G
K
Y
L
G
S
Q
I
L
K
E
Q
V
Site 110
S1236
L
S
I
R
D
L
H
S
L
N
L
S
I
N
P
Site 111
S1240
D
L
H
S
L
N
L
S
I
N
P
L
A
M
R
Site 112
S1284
G
K
P
A
E
M
R
S
G
Q
L
S
R
K
F
Site 113
S1288
E
M
R
S
G
Q
L
S
R
K
F
W
G
S
S
Site 114
S1294
L
S
R
K
F
W
G
S
S
K
R
L
S
Q
I
Site 115
S1295
S
R
K
F
W
G
S
S
K
R
L
S
Q
I
S
Site 116
S1299
W
G
S
S
K
R
L
S
Q
I
S
A
G
E
T
Site 117
S1302
S
K
R
L
S
Q
I
S
A
G
E
T
E
Y
N
Site 118
T1306
S
Q
I
S
A
G
E
T
E
Y
N
T
Q
D
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation