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Updated November 2019
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Protein Info
Short Name:
ARHGEF18
Full Name:
Rho guanine nucleotide exchange factor 18
Alias:
114 kDa Rho-specific guanine nucleotide exchange factor; KIAA0521; MGC15913; P114-RhoGEF; P114-Rho-GEF; P114-RHO-GEF; Rho/rac guanine nucleotide exchange factor (GEF) 18; Rho-specific guanine nucleotide exchange factor p114; Septin-associated RhoGEF
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
130814
Number AA:
1173
UniProt ID:
Q6ZSZ5
International Prot ID:
IPI00179437
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005083
GO:0005085
GO:0005088
PhosphoSite+
KinaseNET
Biological Process:
GO:0009966
GO:0035023
GO:0046578
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
R
E
D
A
A
L
F
S
R
R
I
P
P
R
H
Site 2
S60
A
N
M
G
N
A
H
S
K
S
G
D
R
H
S
Site 3
S62
M
G
N
A
H
S
K
S
G
D
R
H
S
A
L
Site 4
S67
S
K
S
G
D
R
H
S
A
L
P
G
R
P
E
Site 5
S76
L
P
G
R
P
E
L
S
F
Y
G
S
F
P
R
Site 6
Y78
G
R
P
E
L
S
F
Y
G
S
F
P
R
K
W
Site 7
S80
P
E
L
S
F
Y
G
S
F
P
R
K
W
S
E
Site 8
S86
G
S
F
P
R
K
W
S
E
N
V
F
L
D
N
Site 9
S102
L
L
T
S
K
I
L
S
M
L
R
P
Q
S
E
Site 10
S108
L
S
M
L
R
P
Q
S
E
R
G
F
R
A
G
Site 11
Y119
F
R
A
G
D
L
R
Y
P
T
H
F
L
S
T
Site 12
T121
A
G
D
L
R
Y
P
T
H
F
L
S
T
N
S
Site 13
S125
R
Y
P
T
H
F
L
S
T
N
S
V
L
A
S
Site 14
S136
V
L
A
S
V
T
A
S
L
K
E
H
P
R
G
Site 15
T144
L
K
E
H
P
R
G
T
L
L
S
D
G
S
P
Site 16
S147
H
P
R
G
T
L
L
S
D
G
S
P
A
L
S
Site 17
S150
G
T
L
L
S
D
G
S
P
A
L
S
R
N
V
Site 18
S154
S
D
G
S
P
A
L
S
R
N
V
G
M
T
V
Site 19
T160
L
S
R
N
V
G
M
T
V
S
Q
K
G
G
P
Site 20
S162
R
N
V
G
M
T
V
S
Q
K
G
G
P
Q
P
Site 21
T170
Q
K
G
G
P
Q
P
T
P
S
P
A
G
P
G
Site 22
S172
G
G
P
Q
P
T
P
S
P
A
G
P
G
T
Q
Site 23
T178
P
S
P
A
G
P
G
T
Q
L
G
P
I
T
G
Site 24
T200
A
F
L
K
F
K
Q
T
A
D
D
S
L
S
L
Site 25
S204
F
K
Q
T
A
D
D
S
L
S
L
T
S
P
N
Site 26
S206
Q
T
A
D
D
S
L
S
L
T
S
P
N
T
E
Site 27
T208
A
D
D
S
L
S
L
T
S
P
N
T
E
S
I
Site 28
S209
D
D
S
L
S
L
T
S
P
N
T
E
S
I
F
Site 29
T212
L
S
L
T
S
P
N
T
E
S
I
F
V
E
D
Site 30
S214
L
T
S
P
N
T
E
S
I
F
V
E
D
P
Y
Site 31
Y221
S
I
F
V
E
D
P
Y
T
A
S
L
R
S
E
Site 32
T222
I
F
V
E
D
P
Y
T
A
S
L
R
S
E
I
Site 33
S224
V
E
D
P
Y
T
A
S
L
R
S
E
I
E
S
Site 34
S231
S
L
R
S
E
I
E
S
D
G
H
E
F
E
A
Site 35
S242
E
F
E
A
E
S
W
S
L
A
V
D
A
A
Y
Site 36
Y249
S
L
A
V
D
A
A
Y
A
K
K
Q
K
R
E
Site 37
Y265
V
K
R
Q
D
V
L
Y
E
L
M
Q
T
E
V
Site 38
T270
V
L
Y
E
L
M
Q
T
E
V
H
H
V
R
T
Site 39
Y285
L
K
I
M
L
K
V
Y
S
R
A
L
Q
E
E
Site 40
S296
L
Q
E
E
L
Q
F
S
S
K
A
I
G
R
L
Site 41
T313
C
A
D
D
L
L
E
T
H
S
H
F
L
A
R
Site 42
S315
D
D
L
L
E
T
H
S
H
F
L
A
R
L
K
Site 43
S328
L
K
E
R
R
Q
E
S
L
E
E
G
S
D
R
Site 44
S333
Q
E
S
L
E
E
G
S
D
R
N
Y
V
I
Q
Site 45
Y337
E
E
G
S
D
R
N
Y
V
I
Q
K
I
G
D
Site 46
S351
D
L
L
V
Q
Q
F
S
G
E
N
G
E
R
M
Site 47
Y362
G
E
R
M
K
E
K
Y
G
V
F
C
S
G
H
Site 48
S367
E
K
Y
G
V
F
C
S
G
H
N
E
A
V
S
Site 49
S374
S
G
H
N
E
A
V
S
H
Y
K
L
L
L
Q
Site 50
T412
Q
E
C
I
L
L
V
T
Q
R
I
T
K
Y
P
Site 51
T429
V
E
R
I
I
Q
N
T
E
A
G
T
E
D
Y
Site 52
Y436
T
E
A
G
T
E
D
Y
E
D
L
T
Q
A
L
Site 53
T440
T
E
D
Y
E
D
L
T
Q
A
L
N
L
I
K
Site 54
S477
A
G
K
M
D
L
K
S
S
S
K
L
K
N
G
Site 55
S478
G
K
M
D
L
K
S
S
S
K
L
K
N
G
L
Site 56
S479
K
M
D
L
K
S
S
S
K
L
K
N
G
L
T
Site 57
T486
S
K
L
K
N
G
L
T
F
R
K
E
D
M
L
Site 58
T507
E
G
M
L
C
W
K
T
T
S
G
R
L
K
D
Site 59
Y534
L
Q
E
K
D
Q
K
Y
V
F
A
S
V
D
S
Site 60
S538
D
Q
K
Y
V
F
A
S
V
D
S
K
P
P
V
Site 61
S541
Y
V
F
A
S
V
D
S
K
P
P
V
I
S
L
Site 62
S547
D
S
K
P
P
V
I
S
L
Q
K
L
I
V
R
Site 63
Y576
S
L
Q
G
P
E
M
Y
E
I
Y
T
S
S
K
Site 64
Y579
G
P
E
M
Y
E
I
Y
T
S
S
K
E
D
R
Site 65
S581
E
M
Y
E
I
Y
T
S
S
K
E
D
R
N
A
Site 66
S599
H
I
Q
R
A
V
E
S
C
P
D
E
E
E
G
Site 67
S609
D
E
E
E
G
P
F
S
L
P
E
E
E
R
K
Site 68
T623
K
V
V
E
A
R
A
T
R
L
R
D
F
Q
E
Site 69
S633
R
D
F
Q
E
R
L
S
M
K
D
Q
L
I
A
Site 70
Y650
L
L
E
K
Q
Q
I
Y
L
E
M
A
E
M
G
Site 71
S675
L
F
R
G
G
D
P
S
E
T
L
Q
G
E
L
Site 72
T677
R
G
G
D
P
S
E
T
L
Q
G
E
L
I
L
Site 73
S686
Q
G
E
L
I
L
K
S
A
M
S
E
I
E
G
Site 74
S696
S
E
I
E
G
I
Q
S
L
I
C
R
R
L
G
Site 75
S704
L
I
C
R
R
L
G
S
A
N
G
Q
A
E
D
Site 76
S714
G
Q
A
E
D
G
G
S
S
T
G
P
P
R
R
Site 77
T724
G
P
P
R
R
A
E
T
F
A
G
Y
D
C
T
Site 78
Y728
R
A
E
T
F
A
G
Y
D
C
T
N
S
P
T
Site 79
T731
T
F
A
G
Y
D
C
T
N
S
P
T
K
N
G
Site 80
S733
A
G
Y
D
C
T
N
S
P
T
K
N
G
S
F
Site 81
S739
N
S
P
T
K
N
G
S
F
K
K
K
V
S
S
Site 82
S745
G
S
F
K
K
K
V
S
S
T
D
P
R
P
R
Site 83
S746
S
F
K
K
K
V
S
S
T
D
P
R
P
R
D
Site 84
S760
D
W
R
G
P
P
N
S
P
D
L
K
L
S
D
Site 85
S766
N
S
P
D
L
K
L
S
D
S
D
I
P
G
S
Site 86
S768
P
D
L
K
L
S
D
S
D
I
P
G
S
S
E
Site 87
S773
S
D
S
D
I
P
G
S
S
E
E
S
P
Q
V
Site 88
S774
D
S
D
I
P
G
S
S
E
E
S
P
Q
V
V
Site 89
S777
I
P
G
S
S
E
E
S
P
Q
V
V
E
A
P
Site 90
T786
Q
V
V
E
A
P
G
T
E
S
D
P
R
L
P
Site 91
S788
V
E
A
P
G
T
E
S
D
P
R
L
P
T
V
Site 92
T794
E
S
D
P
R
L
P
T
V
L
E
S
E
L
V
Site 93
Y824
V
I
A
H
Q
D
S
Y
V
E
T
Q
R
A
A
Site 94
T827
H
Q
D
S
Y
V
E
T
Q
R
A
A
I
Q
E
Site 95
S843
E
K
Q
F
R
L
Q
S
T
R
G
N
L
L
L
Site 96
S873
A
A
L
E
K
L
Q
S
Q
L
R
H
E
Q
Q
Site 97
Y928
L
E
R
Q
R
Q
A
Y
Q
H
D
L
E
R
L
Site 98
T960
R
R
L
K
K
Q
N
T
A
P
G
A
L
P
P
Site 99
T969
P
G
A
L
P
P
D
T
L
A
E
A
Q
P
P
Site 100
S977
L
A
E
A
Q
P
P
S
H
P
P
S
F
N
G
Site 101
S981
Q
P
P
S
H
P
P
S
F
N
G
E
G
L
E
Site 102
S997
P
R
V
S
M
L
P
S
G
V
G
P
E
Y
A
Site 103
Y1003
P
S
G
V
G
P
E
Y
A
E
R
P
E
V
A
Site 104
S1014
P
E
V
A
R
R
D
S
A
P
T
E
S
R
L
Site 105
T1017
A
R
R
D
S
A
P
T
E
S
R
L
A
K
S
Site 106
S1019
R
D
S
A
P
T
E
S
R
L
A
K
S
D
V
Site 107
S1024
T
E
S
R
L
A
K
S
D
V
P
I
Q
L
L
Site 108
S1032
D
V
P
I
Q
L
L
S
A
T
N
Q
F
Q
R
Site 109
S1065
G
K
D
K
G
G
K
S
R
G
S
Q
R
W
E
Site 110
S1068
K
G
G
K
S
R
G
S
Q
R
W
E
S
S
A
Site 111
S1073
R
G
S
Q
R
W
E
S
S
A
S
F
D
L
K
Site 112
S1074
G
S
Q
R
W
E
S
S
A
S
F
D
L
K
Q
Site 113
S1076
Q
R
W
E
S
S
A
S
F
D
L
K
Q
Q
L
Site 114
S1094
K
L
M
G
K
D
E
S
T
S
R
N
R
R
S
Site 115
T1095
L
M
G
K
D
E
S
T
S
R
N
R
R
S
L
Site 116
S1096
M
G
K
D
E
S
T
S
R
N
R
R
S
L
S
Site 117
S1101
S
T
S
R
N
R
R
S
L
S
P
I
L
P
G
Site 118
S1103
S
R
N
R
R
S
L
S
P
I
L
P
G
R
H
Site 119
S1111
P
I
L
P
G
R
H
S
P
A
P
P
P
D
P
Site 120
S1124
D
P
G
F
P
A
P
S
P
P
P
A
D
S
P
Site 121
S1130
P
S
P
P
P
A
D
S
P
S
E
G
F
S
L
Site 122
S1132
P
P
P
A
D
S
P
S
E
G
F
S
L
K
A
Site 123
S1136
D
S
P
S
E
G
F
S
L
K
A
G
G
T
A
Site 124
S1152
L
P
G
P
P
A
P
S
P
L
P
A
T
P
L
Site 125
T1157
A
P
S
P
L
P
A
T
P
L
S
A
K
E
D
Site 126
S1160
P
L
P
A
T
P
L
S
A
K
E
D
A
S
K
Site 127
S1166
L
S
A
K
E
D
A
S
K
E
D
V
I
F
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation