KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TSHZ1
Full Name:
Teashirt homolog 1
Alias:
Antigen NY-CO-33;Serologically defined colon cancer antigen 33
Type:
Mass (Da):
117916
Number AA:
1077
UniProt ID:
Q6ZSZ6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
K
Q
Q
A
P
R
R
S
A
A
Y
V
P
E
E
Site 2
Y15
A
P
R
R
S
A
A
Y
V
P
E
E
E
L
K
Site 3
S37
H
V
E
D
D
G
L
S
L
D
I
Q
E
S
E
Site 4
Y45
L
D
I
Q
E
S
E
Y
M
C
N
E
E
T
E
Site 5
S58
T
E
I
K
E
A
Q
S
Y
Q
N
S
P
V
S
Site 6
Y59
E
I
K
E
A
Q
S
Y
Q
N
S
P
V
S
S
Site 7
S62
E
A
Q
S
Y
Q
N
S
P
V
S
S
A
T
N
Site 8
S65
S
Y
Q
N
S
P
V
S
S
A
T
N
Q
D
A
Site 9
S66
Y
Q
N
S
P
V
S
S
A
T
N
Q
D
A
G
Site 10
Y74
A
T
N
Q
D
A
G
Y
G
S
P
F
S
E
S
Site 11
S76
N
Q
D
A
G
Y
G
S
P
F
S
E
S
S
D
Site 12
S79
A
G
Y
G
S
P
F
S
E
S
S
D
Q
L
A
Site 13
S81
Y
G
S
P
F
S
E
S
S
D
Q
L
A
H
F
Site 14
S82
G
S
P
F
S
E
S
S
D
Q
L
A
H
F
K
Site 15
S92
L
A
H
F
K
G
S
S
S
R
E
E
K
E
D
Site 16
S93
A
H
F
K
G
S
S
S
R
E
E
K
E
D
P
Site 17
S105
E
D
P
Q
C
P
D
S
V
S
Y
P
Q
D
S
Site 18
S107
P
Q
C
P
D
S
V
S
Y
P
Q
D
S
L
A
Site 19
Y108
Q
C
P
D
S
V
S
Y
P
Q
D
S
L
A
Q
Site 20
S112
S
V
S
Y
P
Q
D
S
L
A
Q
I
K
A
V
Site 21
S131
F
S
E
S
C
W
S
S
L
A
L
D
L
K
K
Site 22
S139
L
A
L
D
L
K
K
S
G
S
T
T
S
T
N
Site 23
S141
L
D
L
K
K
S
G
S
T
T
S
T
N
D
A
Site 24
T143
L
K
K
S
G
S
T
T
S
T
N
D
A
S
Q
Site 25
S144
K
K
S
G
S
T
T
S
T
N
D
A
S
Q
K
Site 26
T145
K
S
G
S
T
T
S
T
N
D
A
S
Q
K
E
Site 27
S149
T
T
S
T
N
D
A
S
Q
K
E
S
S
A
P
Site 28
S153
N
D
A
S
Q
K
E
S
S
A
P
T
P
T
P
Site 29
T157
Q
K
E
S
S
A
P
T
P
T
P
P
T
C
P
Site 30
T159
E
S
S
A
P
T
P
T
P
P
T
C
P
V
S
Site 31
T162
A
P
T
P
T
P
P
T
C
P
V
S
T
T
G
Site 32
S166
T
P
P
T
C
P
V
S
T
T
G
P
T
T
S
Site 33
T167
P
P
T
C
P
V
S
T
T
G
P
T
T
S
T
Site 34
T172
V
S
T
T
G
P
T
T
S
T
P
S
T
S
C
Site 35
S173
S
T
T
G
P
T
T
S
T
P
S
T
S
C
S
Site 36
T174
T
T
G
P
T
T
S
T
P
S
T
S
C
S
S
Site 37
S176
G
P
T
T
S
T
P
S
T
S
C
S
S
S
T
Site 38
T177
P
T
T
S
T
P
S
T
S
C
S
S
S
T
S
Site 39
S178
T
T
S
T
P
S
T
S
C
S
S
S
T
S
H
Site 40
S180
S
T
P
S
T
S
C
S
S
S
T
S
H
S
S
Site 41
S181
T
P
S
T
S
C
S
S
S
T
S
H
S
S
T
Site 42
S182
P
S
T
S
C
S
S
S
T
S
H
S
S
T
T
Site 43
T183
S
T
S
C
S
S
S
T
S
H
S
S
T
T
S
Site 44
S184
T
S
C
S
S
S
T
S
H
S
S
T
T
S
T
Site 45
S186
C
S
S
S
T
S
H
S
S
T
T
S
T
S
S
Site 46
S187
S
S
S
T
S
H
S
S
T
T
S
T
S
S
S
Site 47
T188
S
S
T
S
H
S
S
T
T
S
T
S
S
S
S
Site 48
T189
S
T
S
H
S
S
T
T
S
T
S
S
S
S
G
Site 49
S190
T
S
H
S
S
T
T
S
T
S
S
S
S
G
Y
Site 50
T191
S
H
S
S
T
T
S
T
S
S
S
S
G
Y
D
Site 51
S192
H
S
S
T
T
S
T
S
S
S
S
G
Y
D
W
Site 52
S193
S
S
T
T
S
T
S
S
S
S
G
Y
D
W
H
Site 53
S194
S
T
T
S
T
S
S
S
S
G
Y
D
W
H
Q
Site 54
Y197
S
T
S
S
S
S
G
Y
D
W
H
Q
A
A
L
Site 55
T207
H
Q
A
A
L
A
K
T
L
Q
Q
T
S
S
Y
Site 56
S213
K
T
L
Q
Q
T
S
S
Y
G
L
L
P
E
P
Site 57
T225
P
E
P
S
L
F
S
T
V
Q
L
Y
R
Q
N
Site 58
Y236
Y
R
Q
N
N
K
L
Y
G
S
V
F
T
G
A
Site 59
T262
Y
D
T
L
V
E
L
T
V
H
M
N
E
T
G
Site 60
Y271
H
M
N
E
T
G
H
Y
R
D
D
N
R
D
K
Site 61
S280
D
D
N
R
D
K
D
S
E
K
T
K
R
W
S
Site 62
T283
R
D
K
D
S
E
K
T
K
R
W
S
K
P
R
Site 63
S287
S
E
K
T
K
R
W
S
K
P
R
K
R
S
L
Site 64
S293
W
S
K
P
R
K
R
S
L
M
E
M
E
G
K
Site 65
Y311
Q
K
V
L
K
C
M
Y
C
G
H
S
F
E
S
Site 66
S318
Y
C
G
H
S
F
E
S
L
Q
D
L
S
V
H
Site 67
S323
F
E
S
L
Q
D
L
S
V
H
M
I
K
T
K
Site 68
Y332
H
M
I
K
T
K
H
Y
Q
K
V
P
L
K
E
Site 69
S364
Q
D
L
A
P
P
C
S
P
E
P
A
G
M
A
Site 70
S377
M
A
A
E
V
A
L
S
E
S
A
K
D
Q
K
Site 71
Y389
D
Q
K
A
A
N
P
Y
V
T
P
N
N
R
Y
Site 72
T391
K
A
A
N
P
Y
V
T
P
N
N
R
Y
G
Y
Site 73
Y398
T
P
N
N
R
Y
G
Y
Q
N
G
A
S
Y
T
Site 74
Y404
G
Y
Q
N
G
A
S
Y
T
W
Q
F
E
A
R
Site 75
S423
L
K
C
M
E
C
G
S
S
H
D
T
L
Q
Q
Site 76
T427
E
C
G
S
S
H
D
T
L
Q
Q
L
T
A
H
Site 77
T445
T
G
H
F
L
K
V
T
T
S
A
S
K
K
G
Site 78
S447
H
F
L
K
V
T
T
S
A
S
K
K
G
K
Q
Site 79
S467
V
V
E
E
K
I
Q
S
I
P
L
P
P
T
T
Site 80
T473
Q
S
I
P
L
P
P
T
T
H
T
R
L
P
A
Site 81
T474
S
I
P
L
P
P
T
T
H
T
R
L
P
A
S
Site 82
T476
P
L
P
P
T
T
H
T
R
L
P
A
S
S
I
Site 83
S481
T
H
T
R
L
P
A
S
S
I
K
K
Q
P
D
Site 84
S482
H
T
R
L
P
A
S
S
I
K
K
Q
P
D
S
Site 85
S489
S
I
K
K
Q
P
D
S
P
A
G
S
T
T
S
Site 86
S493
Q
P
D
S
P
A
G
S
T
T
S
E
E
K
K
Site 87
S496
S
P
A
G
S
T
T
S
E
E
K
K
E
P
E
Site 88
S523
I
K
E
E
S
E
D
S
L
E
K
F
E
P
S
Site 89
T531
L
E
K
F
E
P
S
T
L
Y
P
Y
L
R
E
Site 90
Y533
K
F
E
P
S
T
L
Y
P
Y
L
R
E
E
D
Site 91
Y535
E
P
S
T
L
Y
P
Y
L
R
E
E
D
L
D
Site 92
S544
R
E
E
D
L
D
D
S
P
K
G
G
L
D
I
Site 93
S554
G
G
L
D
I
L
K
S
L
E
N
T
V
S
T
Site 94
S560
K
S
L
E
N
T
V
S
T
A
I
S
K
A
Q
Site 95
S564
N
T
V
S
T
A
I
S
K
A
Q
N
G
A
P
Site 96
S572
K
A
Q
N
G
A
P
S
W
G
G
Y
P
S
I
Site 97
Y576
G
A
P
S
W
G
G
Y
P
S
I
H
A
A
Y
Site 98
S578
P
S
W
G
G
Y
P
S
I
H
A
A
Y
Q
L
Site 99
Y583
Y
P
S
I
H
A
A
Y
Q
L
P
G
T
V
K
Site 100
S598
P
L
P
A
A
V
Q
S
V
Q
V
Q
P
S
Y
Site 101
Y605
S
V
Q
V
Q
P
S
Y
A
G
G
V
K
S
L
Site 102
S611
S
Y
A
G
G
V
K
S
L
S
S
A
E
H
N
Site 103
S613
A
G
G
V
K
S
L
S
S
A
E
H
N
A
L
Site 104
S623
E
H
N
A
L
L
H
S
P
G
S
L
T
P
P
Site 105
S626
A
L
L
H
S
P
G
S
L
T
P
P
P
H
K
Site 106
T628
L
H
S
P
G
S
L
T
P
P
P
H
K
S
N
Site 107
S634
L
T
P
P
P
H
K
S
N
V
S
A
M
E
E
Site 108
S637
P
P
H
K
S
N
V
S
A
M
E
E
L
V
E
Site 109
S664
R
P
P
E
K
E
K
S
S
L
A
K
A
A
S
Site 110
S665
P
P
E
K
E
K
S
S
L
A
K
A
A
S
P
Site 111
S671
S
S
L
A
K
A
A
S
P
I
A
K
E
N
K
Site 112
T683
E
N
K
D
F
P
K
T
E
E
V
S
G
K
P
Site 113
T712
E
G
P
L
D
V
H
T
P
N
G
T
E
P
L
Site 114
S741
M
D
H
S
P
E
P
S
F
I
N
P
L
S
A
Site 115
S751
N
P
L
S
A
L
Q
S
I
M
N
T
H
L
G
Site 116
T755
A
L
Q
S
I
M
N
T
H
L
G
K
V
S
K
Site 117
S761
N
T
H
L
G
K
V
S
K
P
V
S
P
S
L
Site 118
S765
G
K
V
S
K
P
V
S
P
S
L
D
P
L
A
Site 119
S780
M
L
Y
K
I
S
N
S
M
L
D
K
P
V
Y
Site 120
Y787
S
M
L
D
K
P
V
Y
P
A
T
P
V
K
Q
Site 121
T790
D
K
P
V
Y
P
A
T
P
V
K
Q
A
D
A
Site 122
Y801
Q
A
D
A
I
D
R
Y
Y
Y
E
N
S
D
Q
Site 123
Y802
A
D
A
I
D
R
Y
Y
Y
E
N
S
D
Q
P
Site 124
Y803
D
A
I
D
R
Y
Y
Y
E
N
S
D
Q
P
I
Site 125
S806
D
R
Y
Y
Y
E
N
S
D
Q
P
I
D
L
T
Site 126
T813
S
D
Q
P
I
D
L
T
K
S
K
N
K
P
L
Site 127
S815
Q
P
I
D
L
T
K
S
K
N
K
P
L
V
S
Site 128
S822
S
K
N
K
P
L
V
S
S
V
A
D
S
V
A
Site 129
S823
K
N
K
P
L
V
S
S
V
A
D
S
V
A
S
Site 130
S830
S
V
A
D
S
V
A
S
P
L
R
E
S
A
L
Site 131
S835
V
A
S
P
L
R
E
S
A
L
M
D
I
S
D
Site 132
S841
E
S
A
L
M
D
I
S
D
M
V
K
N
L
T
Site 133
T848
S
D
M
V
K
N
L
T
G
R
L
T
P
K
S
Site 134
T852
K
N
L
T
G
R
L
T
P
K
S
S
T
P
S
Site 135
S855
T
G
R
L
T
P
K
S
S
T
P
S
T
V
S
Site 136
S856
G
R
L
T
P
K
S
S
T
P
S
T
V
S
E
Site 137
T857
R
L
T
P
K
S
S
T
P
S
T
V
S
E
K
Site 138
S859
T
P
K
S
S
T
P
S
T
V
S
E
K
S
D
Site 139
T860
P
K
S
S
T
P
S
T
V
S
E
K
S
D
A
Site 140
S862
S
S
T
P
S
T
V
S
E
K
S
D
A
D
G
Site 141
S865
P
S
T
V
S
E
K
S
D
A
D
G
S
S
F
Site 142
S870
E
K
S
D
A
D
G
S
S
F
E
E
A
L
D
Site 143
S871
K
S
D
A
D
G
S
S
F
E
E
A
L
D
E
Site 144
S880
E
E
A
L
D
E
L
S
P
V
H
K
R
K
G
Site 145
S907
L
Q
A
Q
F
A
S
S
L
R
E
T
T
E
G
Site 146
T911
F
A
S
S
L
R
E
T
T
E
G
K
Y
I
M
Site 147
T912
A
S
S
L
R
E
T
T
E
G
K
Y
I
M
S
Site 148
Y916
R
E
T
T
E
G
K
Y
I
M
S
D
L
G
P
Site 149
S919
T
E
G
K
Y
I
M
S
D
L
G
P
Q
E
R
Site 150
Y949
H
W
L
A
N
V
K
Y
Q
L
R
R
T
G
G
Site 151
T954
V
K
Y
Q
L
R
R
T
G
G
T
K
F
L
K
Site 152
T981
D
C
A
S
Q
F
R
T
A
S
T
Y
I
S
H
Site 153
S983
A
S
Q
F
R
T
A
S
T
Y
I
S
H
L
E
Site 154
Y985
Q
F
R
T
A
S
T
Y
I
S
H
L
E
T
H
Site 155
S987
R
T
A
S
T
Y
I
S
H
L
E
T
H
L
G
Site 156
T991
T
Y
I
S
H
L
E
T
H
L
G
F
S
L
K
Site 157
S996
L
E
T
H
L
G
F
S
L
K
D
L
S
K
L
Site 158
S1001
G
F
S
L
K
D
L
S
K
L
P
L
N
Q
I
Site 159
T1019
Q
N
V
S
K
V
L
T
N
K
T
L
G
P
L
Site 160
T1022
S
K
V
L
T
N
K
T
L
G
P
L
G
A
T
Site 161
S1035
A
T
E
E
D
L
G
S
T
F
Q
C
K
L
C
Site 162
T1036
T
E
E
D
L
G
S
T
F
Q
C
K
L
C
N
Site 163
S1057
H
A
V
K
L
H
L
S
K
T
H
G
K
S
P
Site 164
T1059
V
K
L
H
L
S
K
T
H
G
K
S
P
E
D
Site 165
S1063
L
S
K
T
H
G
K
S
P
E
D
H
L
I
Y
Site 166
Y1070
S
P
E
D
H
L
I
Y
V
T
E
L
E
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation