KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ZNF650
Full Name:
E3 ubiquitin-protein ligase UBR3
Alias:
E3 ubiquitin-protein ligase UBR3; E3-alpha-III; EC 6.3.2.-; N-recognin-3; Ubiquitin-protein ligase E3-alpha-3; UBR3
Type:
Enzyme, ubiquitin-protein ligase
Mass (Da):
212433
Number AA:
741
UniProt ID:
Q6ZT12
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004842
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0009790
GO:0007608
GO:0001967
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
A
V
G
G
Q
Q
P
S
Q
P
E
L
P
A
P
Site 2
S40
A
H
L
K
A
A
L
S
R
P
D
N
R
A
G
Site 3
S175
G
A
C
D
C
G
D
S
N
V
M
R
E
S
G
Site 4
S191
C
K
R
H
Q
I
K
S
S
S
N
I
P
C
V
Site 5
S193
R
H
Q
I
K
S
S
S
N
I
P
C
V
P
K
Site 6
Y225
I
Q
Y
L
R
E
G
Y
N
E
P
A
A
D
G
Site 7
S250
Q
L
L
E
P
Q
I
S
F
L
E
D
L
T
K
Site 8
T271
S
V
L
T
Q
V
L
T
N
Q
Q
N
Y
K
D
Site 9
T280
Q
Q
N
Y
K
D
L
T
S
G
L
G
E
N
A
Site 10
Y296
V
K
K
S
H
E
K
Y
L
I
A
L
K
S
S
Site 11
S302
K
Y
L
I
A
L
K
S
S
G
L
T
Y
P
E
Site 12
T306
A
L
K
S
S
G
L
T
Y
P
E
D
K
L
V
Site 13
Y307
L
K
S
S
G
L
T
Y
P
E
D
K
L
V
Y
Site 14
Y314
Y
P
E
D
K
L
V
Y
G
V
Q
E
P
S
A
Site 15
S320
V
Y
G
V
Q
E
P
S
A
G
T
S
S
L
A
Site 16
T323
V
Q
E
P
S
A
G
T
S
S
L
A
V
Q
G
Site 17
S324
Q
E
P
S
A
G
T
S
S
L
A
V
Q
G
F
Site 18
S343
G
T
L
G
Q
V
D
S
S
D
E
D
D
Q
D
Site 19
S344
T
L
G
Q
V
D
S
S
D
E
D
D
Q
D
G
Site 20
S352
D
E
D
D
Q
D
G
S
Q
G
L
G
K
R
K
Site 21
S365
R
K
R
V
K
L
S
S
G
T
K
D
Q
S
I
Site 22
S371
S
S
G
T
K
D
Q
S
I
M
D
V
L
K
H
Site 23
Y411
N
M
L
P
D
Q
E
Y
K
V
A
F
T
K
T
Site 24
T429
H
Y
A
F
I
M
K
T
L
K
K
S
H
E
S
Site 25
S433
I
M
K
T
L
K
K
S
H
E
S
D
T
M
S
Site 26
S436
T
L
K
K
S
H
E
S
D
T
M
S
N
R
I
Site 27
S440
S
H
E
S
D
T
M
S
N
R
I
V
H
I
S
Site 28
S447
S
N
R
I
V
H
I
S
V
Q
L
F
S
N
E
Site 29
T461
E
E
L
A
R
Q
V
T
E
E
C
Q
L
L
D
Site 30
S493
E
L
Q
D
E
E
N
S
L
H
V
V
V
N
C
Site 31
T509
E
A
L
L
K
N
N
T
Y
W
P
L
V
S
D
Site 32
Y510
A
L
L
K
N
N
T
Y
W
P
L
V
S
D
F
Site 33
S522
S
D
F
I
N
I
L
S
H
Q
S
V
A
K
R
Site 34
Y568
V
E
F
E
S
Q
T
Y
Y
A
A
F
A
A
E
Site 35
Y569
E
F
E
S
Q
T
Y
Y
A
A
F
A
A
E
L
Site 36
T595
S
H
C
K
V
R
E
T
Q
E
Y
T
R
N
V
Site 37
Y598
K
V
R
E
T
Q
E
Y
T
R
N
V
V
R
Y
Site 38
Y605
Y
T
R
N
V
V
R
Y
C
L
E
A
L
Q
D
Site 39
T629
E
P
A
P
N
Q
V
T
F
H
L
P
L
H
R
Site 40
Y637
F
H
L
P
L
H
R
Y
Y
A
M
F
L
S
K
Site 41
Y638
H
L
P
L
H
R
Y
Y
A
M
F
L
S
K
A
Site 42
S655
C
Q
E
L
D
L
D
S
V
L
P
D
Q
E
M
Site 43
S676
H
P
L
Q
I
Q
A
S
L
A
E
I
H
S
N
Site 44
Y699
I
K
G
Q
A
M
T
Y
V
Q
S
H
F
C
N
Site 45
Y727
A
S
R
L
D
P
D
Y
F
I
S
S
V
F
E
Site 46
S731
D
P
D
Y
F
I
S
S
V
F
E
R
F
K
V
Site 47
T743
F
K
V
V
D
L
L
T
M
A
S
Q
H
Q
N
Site 48
S760
L
D
A
E
H
E
R
S
M
L
E
G
A
L
T
Site 49
S782
L
R
L
H
L
G
M
S
D
D
E
I
L
R
A
Site 50
T801
Q
L
C
M
N
D
R
T
H
S
S
L
L
D
L
Site 51
S803
C
M
N
D
R
T
H
S
S
L
L
D
L
I
P
Site 52
S804
M
N
D
R
T
H
S
S
L
L
D
L
I
P
E
Site 53
S817
P
E
N
P
N
P
K
S
G
I
I
P
G
S
Y
Site 54
S846
P
V
F
E
P
G
G
S
M
Q
Q
G
M
Y
T
Site 55
T853
S
M
Q
Q
G
M
Y
T
P
K
A
E
V
W
D
Site 56
Y874
M
V
I
L
R
T
V
Y
R
R
D
V
Q
S
A
Site 57
S880
V
Y
R
R
D
V
Q
S
A
M
D
R
Y
T
A
Site 58
Y885
V
Q
S
A
M
D
R
Y
T
A
F
L
K
Q
S
Site 59
T886
Q
S
A
M
D
R
Y
T
A
F
L
K
Q
S
G
Site 60
Y903
P
G
N
P
W
P
P
Y
K
K
R
T
S
L
H
Site 61
S908
P
P
Y
K
K
R
T
S
L
H
P
S
Y
K
G
Site 62
S912
K
R
T
S
L
H
P
S
Y
K
G
L
M
R
L
Site 63
S962
I
E
L
G
L
E
N
S
A
E
E
E
S
D
E
Site 64
S982
G
P
E
R
C
H
D
S
W
F
P
G
S
N
L
Site 65
S991
F
P
G
S
N
L
V
S
N
M
R
H
F
I
N
Site 66
Y999
N
M
R
H
F
I
N
Y
V
R
V
R
V
P
E
Site 67
S1015
A
P
E
V
K
R
D
S
P
A
S
T
S
S
D
Site 68
S1018
V
K
R
D
S
P
A
S
T
S
S
D
N
L
G
Site 69
T1019
K
R
D
S
P
A
S
T
S
S
D
N
L
G
S
Site 70
S1020
R
D
S
P
A
S
T
S
S
D
N
L
G
S
L
Site 71
S1021
D
S
P
A
S
T
S
S
D
N
L
G
S
L
Q
Site 72
S1026
T
S
S
D
N
L
G
S
L
Q
N
S
G
T
A
Site 73
S1030
N
L
G
S
L
Q
N
S
G
T
A
Q
V
F
S
Site 74
S1037
S
G
T
A
Q
V
F
S
L
V
A
E
R
R
K
Site 75
S1054
Q
E
I
I
N
R
S
S
S
E
A
N
Q
V
V
Site 76
S1055
E
I
I
N
R
S
S
S
E
A
N
Q
V
V
R
Site 77
T1065
N
Q
V
V
R
P
K
T
S
S
K
W
S
A
P
Site 78
S1067
V
V
R
P
K
T
S
S
K
W
S
A
P
G
S
Site 79
S1070
P
K
T
S
S
K
W
S
A
P
G
S
A
P
Q
Site 80
S1074
S
K
W
S
A
P
G
S
A
P
Q
L
T
T
A
Site 81
T1080
G
S
A
P
Q
L
T
T
A
I
L
E
I
K
E
Site 82
S1101
I
K
L
H
H
K
L
S
G
K
Q
N
S
Y
Y
Site 83
S1106
K
L
S
G
K
Q
N
S
Y
Y
P
P
W
L
D
Site 84
Y1107
L
S
G
K
Q
N
S
Y
Y
P
P
W
L
D
D
Site 85
Y1108
S
G
K
Q
N
S
Y
Y
P
P
W
L
D
D
I
Site 86
Y1126
I
Q
P
E
I
P
K
Y
S
H
G
D
G
I
T
Site 87
S1144
R
I
L
L
K
A
A
S
Q
S
R
M
N
K
R
Site 88
T1161
E
E
I
C
R
K
V
T
P
P
V
P
P
K
K
Site 89
T1170
P
V
P
P
K
K
V
T
A
A
E
K
K
T
L
Site 90
S1199
K
L
L
A
E
F
A
S
R
Q
K
S
F
M
E
Site 91
S1203
E
F
A
S
R
Q
K
S
F
M
E
T
A
M
D
Site 92
T1207
R
Q
K
S
F
M
E
T
A
M
D
V
D
S
P
Site 93
S1213
E
T
A
M
D
V
D
S
P
E
N
D
I
P
M
Site 94
S1230
T
T
A
E
P
Q
V
S
E
A
V
Y
D
C
V
Site 95
S1242
D
C
V
I
C
G
Q
S
G
P
S
S
E
D
R
Site 96
S1246
C
G
Q
S
G
P
S
S
E
D
R
P
T
G
L
Site 97
T1251
P
S
S
E
D
R
P
T
G
L
V
V
L
L
Q
Site 98
S1278
E
P
K
K
L
P
I
S
E
E
E
Q
I
Y
P
Site 99
Y1284
I
S
E
E
E
Q
I
Y
P
W
D
T
C
A
A
Site 100
S1298
A
V
H
D
V
R
L
S
L
L
Q
R
Y
F
K
Site 101
Y1303
R
L
S
L
L
Q
R
Y
F
K
D
S
S
C
L
Site 102
Y1322
I
G
W
E
G
G
V
Y
V
Q
T
C
G
H
T
Site 103
Y1338
H
I
D
C
H
K
S
Y
M
E
S
L
R
N
D
Site 104
S1341
C
H
K
S
Y
M
E
S
L
R
N
D
Q
V
L
Site 105
Y1374
A
N
S
V
L
P
C
Y
P
G
S
N
V
E
N
Site 106
S1388
N
N
P
W
Q
R
P
S
N
K
S
I
Q
D
L
Site 107
S1391
W
Q
R
P
S
N
K
S
I
Q
D
L
I
K
E
Site 108
S1411
G
R
P
G
A
F
P
S
E
T
N
L
S
K
E
Site 109
S1416
F
P
S
E
T
N
L
S
K
E
M
E
S
V
M
Site 110
Y1434
K
N
T
T
Q
K
K
Y
R
D
Y
S
K
T
P
Site 111
Y1437
T
Q
K
K
Y
R
D
Y
S
K
T
P
G
S
P
Site 112
S1438
Q
K
K
Y
R
D
Y
S
K
T
P
G
S
P
D
Site 113
T1440
K
Y
R
D
Y
S
K
T
P
G
S
P
D
N
D
Site 114
S1443
D
Y
S
K
T
P
G
S
P
D
N
D
F
L
F
Site 115
Y1452
D
N
D
F
L
F
M
Y
S
V
A
R
T
N
L
Site 116
S1472
H
R
G
G
N
L
C
S
G
G
A
S
T
A
G
Site 117
S1476
N
L
C
S
G
G
A
S
T
A
G
K
R
S
C
Site 118
Y1498
L
A
L
H
M
R
L
Y
S
I
D
S
E
Y
N
Site 119
S1499
A
L
H
M
R
L
Y
S
I
D
S
E
Y
N
P
Site 120
Y1504
L
Y
S
I
D
S
E
Y
N
P
W
R
K
L
T
Site 121
T1511
Y
N
P
W
R
K
L
T
Q
L
E
E
M
N
P
Site 122
Y1522
E
M
N
P
Q
L
G
Y
E
E
Q
Q
P
E
V
Site 123
S1576
T
Q
A
L
A
A
L
S
V
K
C
S
E
E
D
Site 124
S1580
A
A
L
S
V
K
C
S
E
E
D
R
S
A
W
Site 125
S1585
K
C
S
E
E
D
R
S
A
W
K
H
A
G
A
Site 126
S1596
H
A
G
A
L
K
K
S
T
C
D
A
E
K
S
Site 127
S1603
S
T
C
D
A
E
K
S
Y
E
V
L
L
S
F
Site 128
Y1621
E
L
F
K
G
K
L
Y
H
E
E
G
T
Q
E
Site 129
S1641
P
I
A
W
S
P
E
S
M
E
K
C
L
Q
D
Site 130
S1671
L
F
G
E
D
L
P
S
C
Q
E
E
E
E
F
Site 131
S1679
C
Q
E
E
E
E
F
S
V
L
A
S
C
L
G
Site 132
T1690
S
C
L
G
L
L
P
T
F
Y
Q
T
E
H
P
Site 133
S1702
E
H
P
F
I
S
A
S
C
L
D
W
P
V
P
Site 134
S1740
K
A
L
L
I
Q
E
S
K
W
K
L
P
H
L
Site 135
Y1754
L
L
Q
L
P
E
N
Y
N
T
I
F
Q
Y
Y
Site 136
Y1761
Y
N
T
I
F
Q
Y
Y
H
R
K
T
C
S
V
Site 137
Y1856
L
R
R
G
K
P
L
Y
I
C
K
E
R
Y
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation