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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK3AP1
Full Name:
Phosphoinositide 3-kinase adapter protein 1
Alias:
B cell phosphoinositide 3-kinase adaptor; BCAP; B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1; FLJ35564; Phosphoinositide-3-kinase adaptor protein 1
Type:
Adaptor/scaffold
Mass (Da):
90398
Number AA:
805
UniProt ID:
Q6ZUJ8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y26
D
A
E
E
W
C
Q
Y
L
Q
T
L
F
L
S
Site 2
S33
Y
L
Q
T
L
F
L
S
S
R
Q
V
R
S
Q
Site 3
S39
L
S
S
R
Q
V
R
S
Q
K
I
L
T
H
R
Site 4
T44
V
R
S
Q
K
I
L
T
H
R
L
G
P
E
A
Site 5
S52
H
R
L
G
P
E
A
S
F
S
A
E
D
L
S
Site 6
Y133
C
D
D
E
P
E
T
Y
V
A
A
V
K
K
A
Site 7
S145
K
K
A
I
S
E
D
S
G
C
D
S
V
T
D
Site 8
S149
S
E
D
S
G
C
D
S
V
T
D
T
E
P
E
Site 9
T153
G
C
D
S
V
T
D
T
E
P
E
D
E
K
V
Site 10
S162
P
E
D
E
K
V
V
S
Y
S
K
Q
Q
N
L
Site 11
Y163
E
D
E
K
V
V
S
Y
S
K
Q
Q
N
L
P
Site 12
T171
S
K
Q
Q
N
L
P
T
V
T
S
P
G
N
L
Site 13
Y195
C
G
A
E
T
T
V
Y
V
I
V
R
C
K
L
Site 14
T208
K
L
D
D
R
V
A
T
E
A
E
F
S
P
E
Site 15
S213
V
A
T
E
A
E
F
S
P
E
D
S
P
S
V
Site 16
S217
A
E
F
S
P
E
D
S
P
S
V
R
M
E
A
Site 17
S219
F
S
P
E
D
S
P
S
V
R
M
E
A
K
V
Site 18
Y230
E
A
K
V
E
N
E
Y
T
I
S
V
K
A
P
Site 19
T231
A
K
V
E
N
E
Y
T
I
S
V
K
A
P
N
Site 20
S233
V
E
N
E
Y
T
I
S
V
K
A
P
N
L
S
Site 21
S240
S
V
K
A
P
N
L
S
S
G
N
V
S
L
K
Site 22
S245
N
L
S
S
G
N
V
S
L
K
I
Y
S
G
D
Site 23
Y263
C
E
T
V
I
S
Y
Y
T
D
M
E
E
I
G
Site 24
S274
E
E
I
G
N
L
L
S
N
A
A
N
P
V
E
Site 25
T302
E
T
L
D
K
L
L
T
E
S
L
K
N
N
I
Site 26
S304
L
D
K
L
L
T
E
S
L
K
N
N
I
P
A
Site 27
T329
L
E
E
E
D
M
M
T
N
Q
R
D
E
E
L
Site 28
T338
Q
R
D
E
E
L
P
T
L
L
H
F
A
A
K
Site 29
S366
P
G
A
L
Q
A
Y
S
V
A
N
K
H
G
H
Site 30
Y374
V
A
N
K
H
G
H
Y
P
N
T
I
A
E
K
Site 31
T397
F
I
D
E
Y
V
E
T
V
D
M
L
K
S
H
Site 32
S403
E
T
V
D
M
L
K
S
H
I
K
E
E
L
M
Site 33
Y419
G
E
E
A
D
A
V
Y
E
S
M
A
H
L
S
Site 34
S434
T
D
L
L
M
K
C
S
L
N
P
G
C
D
E
Site 35
Y444
P
G
C
D
E
D
L
Y
E
S
M
A
A
F
V
Site 36
Y459
P
A
A
T
E
D
L
Y
V
E
M
L
Q
A
S
Site 37
S466
Y
V
E
M
L
Q
A
S
T
S
N
P
I
P
G
Site 38
T467
V
E
M
L
Q
A
S
T
S
N
P
I
P
G
D
Site 39
S468
E
M
L
Q
A
S
T
S
N
P
I
P
G
D
G
Site 40
S477
P
I
P
G
D
G
F
S
R
A
T
K
D
S
M
Site 41
T480
G
D
G
F
S
R
A
T
K
D
S
M
I
R
K
Site 42
S483
F
S
R
A
T
K
D
S
M
I
R
K
F
L
E
Site 43
T497
E
G
N
S
M
G
M
T
N
L
E
R
D
Q
C
Site 44
Y513
L
G
Q
E
E
D
V
Y
H
T
V
D
D
D
E
Site 45
T539
V
P
V
P
R
P
E
T
T
A
P
G
A
H
Q
Site 46
Y553
Q
L
P
D
N
E
P
Y
I
F
K
V
F
A
E
Site 47
S562
F
K
V
F
A
E
K
S
Q
E
R
P
G
N
F
Site 48
Y570
Q
E
R
P
G
N
F
Y
V
S
S
E
S
I
R
Site 49
S573
P
G
N
F
Y
V
S
S
E
S
I
R
K
G
P
Site 50
S575
N
F
Y
V
S
S
E
S
I
R
K
G
P
P
V
Site 51
S591
P
W
R
D
R
P
Q
S
S
I
Y
D
P
F
A
Site 52
S592
W
R
D
R
P
Q
S
S
I
Y
D
P
F
A
G
Site 53
Y594
D
R
P
Q
S
S
I
Y
D
P
F
A
G
M
K
Site 54
T602
D
P
F
A
G
M
K
T
P
G
Q
R
Q
L
I
Site 55
S642
N
Q
K
K
R
S
E
S
F
R
F
Q
Q
E
N
Site 56
S656
N
L
K
R
L
R
D
S
I
T
R
R
Q
R
E
Site 57
T658
K
R
L
R
D
S
I
T
R
R
Q
R
E
K
Q
Site 58
S667
R
Q
R
E
K
Q
K
S
G
K
Q
T
D
L
E
Site 59
T671
K
Q
K
S
G
K
Q
T
D
L
E
I
T
V
P
Site 60
T676
K
Q
T
D
L
E
I
T
V
P
I
R
H
S
Q
Site 61
S682
I
T
V
P
I
R
H
S
Q
H
L
P
A
K
V
Site 62
Y694
A
K
V
E
F
G
V
Y
E
S
G
P
R
K
S
Site 63
S696
V
E
F
G
V
Y
E
S
G
P
R
K
S
V
I
Site 64
S701
Y
E
S
G
P
R
K
S
V
I
P
P
R
T
E
Site 65
T707
K
S
V
I
P
P
R
T
E
L
R
R
G
D
W
Site 66
T716
L
R
R
G
D
W
K
T
D
S
T
S
S
T
A
Site 67
S718
R
G
D
W
K
T
D
S
T
S
S
T
A
S
S
Site 68
S720
D
W
K
T
D
S
T
S
S
T
A
S
S
T
S
Site 69
S721
W
K
T
D
S
T
S
S
T
A
S
S
T
S
N
Site 70
T722
K
T
D
S
T
S
S
T
A
S
S
T
S
N
R
Site 71
S724
D
S
T
S
S
T
A
S
S
T
S
N
R
S
S
Site 72
S725
S
T
S
S
T
A
S
S
T
S
N
R
S
S
T
Site 73
T726
T
S
S
T
A
S
S
T
S
N
R
S
S
T
R
Site 74
S727
S
S
T
A
S
S
T
S
N
R
S
S
T
R
S
Site 75
S730
A
S
S
T
S
N
R
S
S
T
R
S
L
L
S
Site 76
S731
S
S
T
S
N
R
S
S
T
R
S
L
L
S
V
Site 77
T732
S
T
S
N
R
S
S
T
R
S
L
L
S
V
S
Site 78
S734
S
N
R
S
S
T
R
S
L
L
S
V
S
S
G
Site 79
S737
S
S
T
R
S
L
L
S
V
S
S
G
M
E
G
Site 80
T755
D
N
E
V
P
E
V
T
R
S
R
S
P
G
P
Site 81
S757
E
V
P
E
V
T
R
S
R
S
P
G
P
P
Q
Site 82
S759
P
E
V
T
R
S
R
S
P
G
P
P
Q
V
D
Site 83
T768
G
P
P
Q
V
D
G
T
P
T
M
S
L
E
R
Site 84
S772
V
D
G
T
P
T
M
S
L
E
R
P
P
R
V
Site 85
S785
R
V
P
P
R
A
A
S
Q
R
P
P
T
R
E
Site 86
T790
A
A
S
Q
R
P
P
T
R
E
T
F
H
P
P
Site 87
T793
Q
R
P
P
T
R
E
T
F
H
P
P
P
P
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation