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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FRMD7
Full Name:
FERM domain-containing protein 7
Alias:
FERM domain containing 7; FLJ43346; NYS; NYS1; nystagmus 1
Type:
Unknown function
Mass (Da):
81595
Number AA:
714
UniProt ID:
Q6ZUT3
International Prot ID:
IPI00375566
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
K
V
Q
F
L
D
D
S
Q
K
I
F
V
V
D
Site 2
Y42
L
N
L
A
E
K
E
Y
F
G
L
E
F
C
S
Site 3
T64
L
E
L
L
K
P
I
T
K
Q
V
K
N
P
K
Site 4
T94
G
H
L
R
E
E
L
T
R
Y
L
F
T
L
Q
Site 5
Y96
L
R
E
E
L
T
R
Y
L
F
T
L
Q
I
K
Site 6
T137
L
G
D
F
H
E
E
T
D
R
K
H
L
A
Q
Site 7
Y147
K
H
L
A
Q
T
R
Y
L
P
N
Q
D
C
L
Site 8
S169
H
Q
K
H
I
G
R
S
P
A
E
S
D
I
L
Site 9
Y187
I
A
R
K
L
D
M
Y
G
I
R
P
H
P
A
Site 10
S195
G
I
R
P
H
P
A
S
D
G
E
G
M
Q
I
Site 11
T222
R
G
N
T
K
I
N
T
F
N
W
A
K
I
R
Site 12
S232
W
A
K
I
R
K
L
S
F
K
R
K
H
F
L
Site 13
S281
Y
H
A
F
F
R
L
S
E
E
P
K
S
K
P
Site 14
S286
R
L
S
E
E
P
K
S
K
P
K
T
L
L
C
Site 15
T290
E
P
K
S
K
P
K
T
L
L
C
S
K
G
S
Site 16
S294
K
P
K
T
L
L
C
S
K
G
S
S
F
R
Y
Site 17
S297
T
L
L
C
S
K
G
S
S
F
R
Y
S
G
R
Site 18
S298
L
L
C
S
K
G
S
S
F
R
Y
S
G
R
T
Site 19
Y301
S
K
G
S
S
F
R
Y
S
G
R
T
Q
R
Q
Site 20
S302
K
G
S
S
F
R
Y
S
G
R
T
Q
R
Q
L
Site 21
T305
S
F
R
Y
S
G
R
T
Q
R
Q
L
L
E
Y
Site 22
Y312
T
Q
R
Q
L
L
E
Y
G
R
K
G
R
L
K
Site 23
S320
G
R
K
G
R
L
K
S
L
P
F
E
R
K
H
Site 24
Y328
L
P
F
E
R
K
H
Y
P
S
Q
Y
H
E
R
Site 25
Y332
R
K
H
Y
P
S
Q
Y
H
E
R
Q
C
R
S
Site 26
S339
Y
H
E
R
Q
C
R
S
S
P
D
L
L
S
D
Site 27
S340
H
E
R
Q
C
R
S
S
P
D
L
L
S
D
V
Site 28
S345
R
S
S
P
D
L
L
S
D
V
S
K
Q
V
E
Site 29
S348
P
D
L
L
S
D
V
S
K
Q
V
E
D
L
R
Site 30
Y358
V
E
D
L
R
L
A
Y
G
G
G
Y
Y
Q
N
Site 31
Y362
R
L
A
Y
G
G
G
Y
Y
Q
N
V
N
G
V
Site 32
Y363
L
A
Y
G
G
G
Y
Y
Q
N
V
N
G
V
H
Site 33
S372
N
V
N
G
V
H
A
S
E
P
V
L
E
S
R
Site 34
S378
A
S
E
P
V
L
E
S
R
R
R
N
S
A
L
Site 35
S383
L
E
S
R
R
R
N
S
A
L
E
V
T
F
A
Site 36
T388
R
N
S
A
L
E
V
T
F
A
T
E
L
E
H
Site 37
S396
F
A
T
E
L
E
H
S
K
P
E
A
D
P
T
Site 38
T403
S
K
P
E
A
D
P
T
L
L
H
Q
S
Q
S
Site 39
S408
D
P
T
L
L
H
Q
S
Q
S
S
S
S
F
P
Site 40
S410
T
L
L
H
Q
S
Q
S
S
S
S
F
P
F
I
Site 41
S412
L
H
Q
S
Q
S
S
S
S
F
P
F
I
Y
M
Site 42
S413
H
Q
S
Q
S
S
S
S
F
P
F
I
Y
M
D
Site 43
S438
P
D
P
R
D
I
F
S
E
R
S
S
L
S
S
Site 44
S441
R
D
I
F
S
E
R
S
S
L
S
S
F
Q
T
Site 45
S442
D
I
F
S
E
R
S
S
L
S
S
F
Q
T
S
Site 46
S444
F
S
E
R
S
S
L
S
S
F
Q
T
S
C
K
Site 47
S445
S
E
R
S
S
L
S
S
F
Q
T
S
C
K
F
Site 48
T448
S
S
L
S
S
F
Q
T
S
C
K
F
S
G
N
Site 49
S449
S
L
S
S
F
Q
T
S
C
K
F
S
G
N
H
Site 50
S458
K
F
S
G
N
H
M
S
I
Y
S
G
L
T
S
Site 51
Y460
S
G
N
H
M
S
I
Y
S
G
L
T
S
K
V
Site 52
S465
S
I
Y
S
G
L
T
S
K
V
R
P
A
K
Q
Site 53
T474
V
R
P
A
K
Q
L
T
Y
T
D
V
P
Y
I
Site 54
T476
P
A
K
Q
L
T
Y
T
D
V
P
Y
I
P
C
Site 55
Y480
L
T
Y
T
D
V
P
Y
I
P
C
T
G
Q
Q
Site 56
Y498
M
P
P
Q
V
F
F
Y
V
D
K
P
P
Q
V
Site 57
S509
P
P
Q
V
P
R
W
S
P
I
R
A
E
E
R
Site 58
T517
P
I
R
A
E
E
R
T
S
P
H
S
Y
V
E
Site 59
S518
I
R
A
E
E
R
T
S
P
H
S
Y
V
E
P
Site 60
S521
E
E
R
T
S
P
H
S
Y
V
E
P
T
A
M
Site 61
Y522
E
R
T
S
P
H
S
Y
V
E
P
T
A
M
K
Site 62
S534
A
M
K
P
A
E
R
S
P
R
N
I
R
M
K
Site 63
S542
P
R
N
I
R
M
K
S
F
Q
Q
D
L
Q
V
Site 64
S558
Q
E
A
I
A
R
T
S
G
R
S
N
I
N
V
Site 65
S561
I
A
R
T
S
G
R
S
N
I
N
V
G
L
E
Site 66
T586
V
C
N
I
Q
E
Q
T
P
K
R
S
Q
S
Q
Site 67
S590
Q
E
Q
T
P
K
R
S
Q
S
Q
S
D
M
K
Site 68
S592
Q
T
P
K
R
S
Q
S
Q
S
D
M
K
T
I
Site 69
S594
P
K
R
S
Q
S
Q
S
D
M
K
T
I
R
F
Site 70
T598
Q
S
Q
S
D
M
K
T
I
R
F
P
F
G
S
Site 71
S605
T
I
R
F
P
F
G
S
E
F
R
P
L
G
P
Site 72
S640
P
A
V
L
M
D
Q
S
T
A
E
R
Y
V
A
Site 73
T641
A
V
L
M
D
Q
S
T
A
E
R
Y
V
A
S
Site 74
Y645
D
Q
S
T
A
E
R
Y
V
A
S
E
S
S
D
Site 75
S648
T
A
E
R
Y
V
A
S
E
S
S
D
S
E
S
Site 76
S650
E
R
Y
V
A
S
E
S
S
D
S
E
S
E
I
Site 77
S651
R
Y
V
A
S
E
S
S
D
S
E
S
E
I
L
Site 78
S653
V
A
S
E
S
S
D
S
E
S
E
I
L
K
P
Site 79
S655
S
E
S
S
D
S
E
S
E
I
L
K
P
D
Y
Site 80
Y662
S
E
I
L
K
P
D
Y
Y
A
L
Y
G
K
E
Site 81
Y663
E
I
L
K
P
D
Y
Y
A
L
Y
G
K
E
I
Site 82
Y666
K
P
D
Y
Y
A
L
Y
G
K
E
I
R
S
P
Site 83
S672
L
Y
G
K
E
I
R
S
P
M
A
R
I
R
L
Site 84
S680
P
M
A
R
I
R
L
S
S
G
S
L
Q
L
D
Site 85
S681
M
A
R
I
R
L
S
S
G
S
L
Q
L
D
E
Site 86
S683
R
I
R
L
S
S
G
S
L
Q
L
D
E
E
D
Site 87
Y694
D
E
E
D
E
D
A
Y
F
N
T
P
T
A
E
Site 88
T697
D
E
D
A
Y
F
N
T
P
T
A
E
D
R
T
Site 89
S705
P
T
A
E
D
R
T
S
L
K
P
C
N
Y
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation