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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PNPLA7
Full Name:
Patatin-like phospholipase domain-containing protein 7
Alias:
Type:
Mass (Da):
145733
Number AA:
1317
UniProt ID:
Q6ZV29
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
E
E
K
D
D
S
P
Q
L
T
G
I
A
Site 2
T45
Q
F
R
Q
A
Q
P
T
P
Q
Y
R
F
R
K
Site 3
Y48
Q
A
Q
P
T
P
Q
Y
R
F
R
K
R
D
K
Site 4
Y59
K
R
D
K
V
M
F
Y
G
R
K
I
M
R
K
Site 5
T68
R
K
I
M
R
K
V
T
T
L
P
N
T
L
V
Site 6
T89
R
Q
R
A
R
K
R
T
K
V
L
S
L
A
K
Site 7
S93
R
K
R
T
K
V
L
S
L
A
K
R
I
L
R
Site 8
Y105
I
L
R
F
K
K
E
Y
P
A
L
Q
P
K
E
Site 9
S116
Q
P
K
E
P
P
P
S
L
L
E
A
D
L
T
Site 10
T123
S
L
L
E
A
D
L
T
E
F
D
V
K
N
S
Site 11
S134
V
K
N
S
H
L
P
S
E
V
L
Y
M
L
K
Site 12
S181
Q
P
R
E
P
D
P
S
I
C
V
V
Q
D
G
Site 13
S215
L
A
G
D
S
V
H
S
L
L
S
I
L
D
I
Site 14
Y230
I
T
G
H
A
A
P
Y
K
T
V
S
V
R
A
Site 15
Y258
F
H
G
V
F
E
K
Y
P
E
T
L
V
R
V
Site 16
S333
K
P
P
R
L
Q
E
S
C
D
S
D
H
G
G
Site 17
S336
R
L
Q
E
S
C
D
S
D
H
G
G
G
R
P
Site 18
S353
A
G
P
L
L
K
R
S
H
S
V
P
A
P
S
Site 19
S355
P
L
L
K
R
S
H
S
V
P
A
P
S
I
R
Site 20
S360
S
H
S
V
P
A
P
S
I
R
K
Q
I
L
E
Site 21
S380
G
A
G
D
P
D
P
S
A
P
Q
G
G
P
G
Site 22
S388
A
P
Q
G
G
P
G
S
A
T
S
D
L
G
M
Site 23
S391
G
G
P
G
S
A
T
S
D
L
G
M
A
C
D
Site 24
S406
R
A
R
V
F
L
H
S
D
E
H
P
G
S
S
Site 25
S412
H
S
D
E
H
P
G
S
S
V
A
S
K
S
R
Site 26
S413
S
D
E
H
P
G
S
S
V
A
S
K
S
R
K
Site 27
S416
H
P
G
S
S
V
A
S
K
S
R
K
S
V
M
Site 28
S418
G
S
S
V
A
S
K
S
R
K
S
V
M
V
A
Site 29
S421
V
A
S
K
S
R
K
S
V
M
V
A
E
I
P
Site 30
T430
M
V
A
E
I
P
S
T
V
S
Q
H
S
E
S
Site 31
S432
A
E
I
P
S
T
V
S
Q
H
S
E
S
H
T
Site 32
S435
P
S
T
V
S
Q
H
S
E
S
H
T
D
E
T
Site 33
S437
T
V
S
Q
H
S
E
S
H
T
D
E
T
L
A
Site 34
T439
S
Q
H
S
E
S
H
T
D
E
T
L
A
S
R
Site 35
T442
S
E
S
H
T
D
E
T
L
A
S
R
K
S
D
Site 36
S445
H
T
D
E
T
L
A
S
R
K
S
D
A
I
F
Site 37
S448
E
T
L
A
S
R
K
S
D
A
I
F
R
A
A
Site 38
T461
A
A
K
K
D
L
L
T
L
M
K
L
E
D
S
Site 39
S469
L
M
K
L
E
D
S
S
L
L
D
G
R
V
A
Site 40
S495
R
Q
G
D
Q
D
A
S
I
L
F
V
V
S
G
Site 41
Y507
V
S
G
L
L
H
V
Y
Q
R
K
I
G
S
Q
Site 42
S513
V
Y
Q
R
K
I
G
S
Q
E
D
T
C
L
F
Site 43
T517
K
I
G
S
Q
E
D
T
C
L
F
L
T
R
P
Site 44
T542
T
G
E
P
L
I
F
T
V
K
A
N
R
D
C
Site 45
S550
V
K
A
N
R
D
C
S
F
L
S
I
S
K
A
Site 46
S553
N
R
D
C
S
F
L
S
I
S
K
A
H
F
Y
Site 47
Y560
S
I
S
K
A
H
F
Y
E
I
M
R
K
Q
P
Site 48
S582
H
T
V
V
K
R
M
S
S
F
V
R
Q
I
D
Site 49
Y604
V
E
A
G
R
A
I
Y
R
Q
G
D
K
S
D
Site 50
T613
Q
G
D
K
S
D
C
T
Y
I
M
L
S
G
R
Site 51
Y614
G
D
K
S
D
C
T
Y
I
M
L
S
G
R
L
Site 52
S623
M
L
S
G
R
L
R
S
V
I
R
K
D
D
G
Site 53
Y638
K
K
R
L
A
G
E
Y
G
R
G
D
L
V
G
Site 54
T657
L
T
H
Q
A
R
A
T
T
V
H
A
V
R
D
Site 55
T658
T
H
Q
A
R
A
T
T
V
H
A
V
R
D
S
Site 56
S665
T
V
H
A
V
R
D
S
E
L
A
K
L
P
A
Site 57
S677
L
P
A
G
A
L
T
S
I
K
R
R
Y
P
Q
Site 58
Y682
L
T
S
I
K
R
R
Y
P
Q
V
V
T
R
L
Site 59
T707
S
L
Q
Q
G
P
V
T
G
H
Q
L
G
L
P
Site 60
S718
L
G
L
P
T
E
G
S
K
W
D
L
G
N
P
Site 61
T764
I
G
P
T
L
L
L
T
S
D
N
I
K
R
R
Site 62
S774
N
I
K
R
R
L
G
S
A
A
L
D
S
V
H
Site 63
S779
L
G
S
A
A
L
D
S
V
H
E
Y
R
L
S
Site 64
Y783
A
L
D
S
V
H
E
Y
R
L
S
S
W
L
G
Site 65
S786
S
V
H
E
Y
R
L
S
S
W
L
G
Q
Q
E
Site 66
S787
V
H
E
Y
R
L
S
S
W
L
G
Q
Q
E
D
Site 67
Y801
D
T
H
R
I
V
L
Y
Q
V
D
G
T
L
T
Site 68
T806
V
L
Y
Q
V
D
G
T
L
T
P
W
T
Q
R
Site 69
T811
D
G
T
L
T
P
W
T
Q
R
C
V
R
Q
A
Site 70
T843
L
E
R
M
L
E
S
T
A
V
R
A
Q
K
Q
Site 71
T865
E
G
P
A
P
A
R
T
V
E
W
L
N
M
R
Site 72
S889
C
C
P
R
R
V
F
S
R
R
S
L
P
K
L
Site 73
S892
R
R
V
F
S
R
R
S
L
P
K
L
V
E
M
Site 74
S912
Q
R
P
P
D
R
H
S
D
F
S
R
L
A
R
Site 75
S915
P
D
R
H
S
D
F
S
R
L
A
R
V
L
T
Site 76
Y970
G
A
F
V
G
A
L
Y
S
E
E
R
N
Y
S
Site 77
S971
A
F
V
G
A
L
Y
S
E
E
R
N
Y
S
Q
Site 78
Y976
L
Y
S
E
E
R
N
Y
S
Q
M
R
I
R
A
Site 79
S977
Y
S
E
E
R
N
Y
S
Q
M
R
I
R
A
K
Site 80
T991
K
Q
W
A
E
G
M
T
S
L
M
K
A
A
L
Site 81
S992
Q
W
A
E
G
M
T
S
L
M
K
A
A
L
D
Site 82
S1009
Y
P
I
T
S
M
F
S
G
A
G
F
N
S
S
Site 83
S1019
G
F
N
S
S
I
F
S
V
F
K
D
Q
Q
I
Site 84
T1049
A
S
A
M
R
V
H
T
D
G
S
L
W
R
Y
Site 85
Y1056
T
D
G
S
L
W
R
Y
V
R
A
S
M
S
L
Site 86
S1060
L
W
R
Y
V
R
A
S
M
S
L
S
G
Y
M
Site 87
S1062
R
Y
V
R
A
S
M
S
L
S
G
Y
M
P
P
Site 88
Y1084
H
L
L
M
D
G
G
Y
I
N
N
L
P
A
D
Site 89
T1112
D
V
G
S
R
D
E
T
D
L
T
N
Y
G
D
Site 90
T1115
S
R
D
E
T
D
L
T
N
Y
G
D
A
L
S
Site 91
Y1117
D
E
T
D
L
T
N
Y
G
D
A
L
S
G
W
Site 92
Y1152
E
I
Q
T
R
L
A
Y
V
C
C
V
R
Q
L
Site 93
S1164
R
Q
L
E
V
V
K
S
S
D
Y
C
E
Y
L
Site 94
Y1167
E
V
V
K
S
S
D
Y
C
E
Y
L
R
P
P
Site 95
Y1170
K
S
S
D
Y
C
E
Y
L
R
P
P
I
D
S
Site 96
S1177
Y
L
R
P
P
I
D
S
Y
S
T
L
D
F
G
Site 97
Y1178
L
R
P
P
I
D
S
Y
S
T
L
D
F
G
K
Site 98
S1179
R
P
P
I
D
S
Y
S
T
L
D
F
G
K
F
Site 99
S1221
L
R
D
Q
Q
G
P
S
K
K
P
A
S
A
V
Site 100
S1226
G
P
S
K
K
P
A
S
A
V
L
T
C
P
N
Site 101
S1258
P
A
M
V
D
D
E
S
D
Y
Q
T
E
Y
E
Site 102
Y1260
M
V
D
D
E
S
D
Y
Q
T
E
Y
E
E
E
Site 103
T1262
D
D
E
S
D
Y
Q
T
E
Y
E
E
E
L
L
Site 104
Y1264
E
S
D
Y
Q
T
E
Y
E
E
E
L
L
D
V
Site 105
Y1276
L
D
V
P
R
D
A
Y
A
D
F
Q
S
T
S
Site 106
S1281
D
A
Y
A
D
F
Q
S
T
S
A
Q
Q
G
S
Site 107
S1288
S
T
S
A
Q
Q
G
S
D
L
E
D
E
S
S
Site 108
S1294
G
S
D
L
E
D
E
S
S
L
R
H
R
H
P
Site 109
S1295
S
D
L
E
D
E
S
S
L
R
H
R
H
P
S
Site 110
S1302
S
L
R
H
R
H
P
S
L
A
F
P
K
L
S
Site 111
S1309
S
L
A
F
P
K
L
S
E
G
S
S
D
Q
D
Site 112
S1313
P
K
L
S
E
G
S
S
D
Q
D
G
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation