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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FGD6
Full Name:
FYVE, RhoGEF and PH domain-containing protein 6
Alias:
FLJ11183; FYVE, RhoGEF and PH domain containing 6; ZFYVE24; Zinc finger FYVE domain-containing protein 24
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
160816
Number AA:
1430
UniProt ID:
Q6ZV73
International Prot ID:
IPI00419100
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005856
GO:0030027
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0031267
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0046847
GO:0043088
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
P
K
P
D
I
V
I
S
S
V
P
Q
S
T
K
Site 2
S40
K
P
D
I
V
I
S
S
V
P
Q
S
T
K
K
Site 3
S44
V
I
S
S
V
P
Q
S
T
K
K
M
K
P
A
Site 4
T61
P
K
P
K
V
L
K
T
S
P
V
R
E
I
G
Site 5
S62
K
P
K
V
L
K
T
S
P
V
R
E
I
G
Q
Site 6
S70
P
V
R
E
I
G
Q
S
P
S
R
K
I
M
L
Site 7
S72
R
E
I
G
Q
S
P
S
R
K
I
M
L
N
L
Site 8
Y97
T
D
N
F
N
C
K
Y
E
G
N
Q
S
N
D
Site 9
Y105
E
G
N
Q
S
N
D
Y
I
S
P
M
C
S
C
Site 10
S107
N
Q
S
N
D
Y
I
S
P
M
C
S
C
S
S
Site 11
T150
E
N
S
K
I
D
E
T
L
T
I
K
T
R
S
Site 12
T152
S
K
I
D
E
T
L
T
I
K
T
R
S
K
C
Site 13
S157
T
L
T
I
K
T
R
S
K
C
D
L
Y
G
E
Site 14
Y162
T
R
S
K
C
D
L
Y
G
E
K
A
K
N
Q
Site 15
S177
G
G
V
V
L
K
A
S
V
L
E
E
E
L
K
Site 16
T203
S
A
Q
K
H
R
P
T
D
S
P
E
M
N
G
Site 17
S205
Q
K
H
R
P
T
D
S
P
E
M
N
G
G
C
Site 18
S226
R
I
E
F
A
D
L
S
P
S
P
S
S
F
E
Site 19
S228
E
F
A
D
L
S
P
S
P
S
S
F
E
K
V
Site 20
S230
A
D
L
S
P
S
P
S
S
F
E
K
V
P
D
Site 21
S231
D
L
S
P
S
P
S
S
F
E
K
V
P
D
H
Site 22
S240
E
K
V
P
D
H
H
S
C
H
L
Q
L
P
S
Site 23
S247
S
C
H
L
Q
L
P
S
D
E
C
E
H
F
E
Site 24
S270
S
N
N
C
F
Q
S
S
E
L
E
A
L
E
N
Site 25
S281
A
L
E
N
G
K
R
S
T
L
I
S
S
D
G
Site 26
T282
L
E
N
G
K
R
S
T
L
I
S
S
D
G
V
Site 27
S285
G
K
R
S
T
L
I
S
S
D
G
V
S
K
K
Site 28
S286
K
R
S
T
L
I
S
S
D
G
V
S
K
K
S
Site 29
S290
L
I
S
S
D
G
V
S
K
K
S
E
V
K
D
Site 30
S293
S
D
G
V
S
K
K
S
E
V
K
D
L
G
P
Site 31
Y308
L
E
I
H
L
V
P
Y
T
P
K
F
P
T
P
Site 32
T309
E
I
H
L
V
P
Y
T
P
K
F
P
T
P
K
Site 33
T314
P
Y
T
P
K
F
P
T
P
K
P
R
K
T
R
Site 34
T320
P
T
P
K
P
R
K
T
R
T
A
R
L
L
R
Site 35
T322
P
K
P
R
K
T
R
T
A
R
L
L
R
Q
K
Site 36
T333
L
R
Q
K
C
V
D
T
P
S
E
S
T
E
E
Site 37
S335
Q
K
C
V
D
T
P
S
E
S
T
E
E
P
G
Site 38
S337
C
V
D
T
P
S
E
S
T
E
E
P
G
N
S
Site 39
S344
S
T
E
E
P
G
N
S
D
S
S
S
S
C
L
Site 40
S346
E
E
P
G
N
S
D
S
S
S
S
C
L
T
E
Site 41
S347
E
P
G
N
S
D
S
S
S
S
C
L
T
E
N
Site 42
S348
P
G
N
S
D
S
S
S
S
C
L
T
E
N
S
Site 43
S349
G
N
S
D
S
S
S
S
C
L
T
E
N
S
L
Site 44
T352
D
S
S
S
S
C
L
T
E
N
S
L
K
I
N
Site 45
S355
S
S
C
L
T
E
N
S
L
K
I
N
K
I
S
Site 46
S384
K
M
K
L
G
N
K
S
E
L
N
M
E
S
N
Site 47
S390
K
S
E
L
N
M
E
S
N
S
D
A
Q
D
L
Site 48
S392
E
L
N
M
E
S
N
S
D
A
Q
D
L
V
N
Site 49
S410
A
M
C
N
E
T
T
S
F
E
K
M
A
P
S
Site 50
S417
S
F
E
K
M
A
P
S
F
D
K
D
S
N
L
Site 51
S422
A
P
S
F
D
K
D
S
N
L
S
S
D
S
T
Site 52
S425
F
D
K
D
S
N
L
S
S
D
S
T
T
V
D
Site 53
S426
D
K
D
S
N
L
S
S
D
S
T
T
V
D
G
Site 54
S428
D
S
N
L
S
S
D
S
T
T
V
D
G
S
S
Site 55
T429
S
N
L
S
S
D
S
T
T
V
D
G
S
S
M
Site 56
T430
N
L
S
S
D
S
T
T
V
D
G
S
S
M
S
Site 57
S434
D
S
T
T
V
D
G
S
S
M
S
L
A
V
D
Site 58
S435
S
T
T
V
D
G
S
S
M
S
L
A
V
D
E
Site 59
S437
T
V
D
G
S
S
M
S
L
A
V
D
E
G
T
Site 60
T462
L
P
K
Q
L
K
L
T
C
N
E
H
L
Q
S
Site 61
S469
T
C
N
E
H
L
Q
S
G
R
N
L
G
V
S
Site 62
S476
S
G
R
N
L
G
V
S
A
P
Q
M
Q
K
E
Site 63
S491
S
V
I
K
E
E
N
S
L
R
I
V
P
K
K
Site 64
S503
P
K
K
P
Q
R
H
S
L
P
A
T
G
V
L
Site 65
T507
Q
R
H
S
L
P
A
T
G
V
L
K
K
A
A
Site 66
S515
G
V
L
K
K
A
A
S
E
E
L
L
E
K
S
Site 67
S522
S
E
E
L
L
E
K
S
S
Y
P
S
S
E
E
Site 68
S523
E
E
L
L
E
K
S
S
Y
P
S
S
E
E
K
Site 69
Y524
E
L
L
E
K
S
S
Y
P
S
S
E
E
K
S
Site 70
S526
L
E
K
S
S
Y
P
S
S
E
E
K
S
S
E
Site 71
S527
E
K
S
S
Y
P
S
S
E
E
K
S
S
E
K
Site 72
S531
Y
P
S
S
E
E
K
S
S
E
K
S
L
E
R
Site 73
S532
P
S
S
E
E
K
S
S
E
K
S
L
E
R
N
Site 74
S535
E
E
K
S
S
E
K
S
L
E
R
N
H
L
Q
Site 75
S552
C
A
Q
N
R
G
V
S
S
S
F
D
M
P
K
Site 76
S553
A
Q
N
R
G
V
S
S
S
F
D
M
P
K
R
Site 77
S554
Q
N
R
G
V
S
S
S
F
D
M
P
K
R
A
Site 78
S562
F
D
M
P
K
R
A
S
E
K
P
V
W
K
L
Site 79
S577
P
H
P
I
L
P
F
S
G
N
P
E
F
L
K
Site 80
S585
G
N
P
E
F
L
K
S
V
T
V
S
S
N
S
Site 81
T587
P
E
F
L
K
S
V
T
V
S
S
N
S
E
P
Site 82
S589
F
L
K
S
V
T
V
S
S
N
S
E
P
S
T
Site 83
S590
L
K
S
V
T
V
S
S
N
S
E
P
S
T
A
Site 84
S592
S
V
T
V
S
S
N
S
E
P
S
T
A
L
T
Site 85
T596
S
S
N
S
E
P
S
T
A
L
T
K
P
R
A
Site 86
T599
S
E
P
S
T
A
L
T
K
P
R
A
K
S
L
Site 87
S605
L
T
K
P
R
A
K
S
L
S
A
M
D
V
E
Site 88
S607
K
P
R
A
K
S
L
S
A
M
D
V
E
K
C
Site 89
T622
T
K
P
C
K
D
S
T
K
K
N
S
F
K
K
Site 90
S626
K
D
S
T
K
K
N
S
F
K
K
L
L
S
M
Site 91
S632
N
S
F
K
K
L
L
S
M
K
L
S
I
C
F
Site 92
S642
L
S
I
C
F
M
K
S
D
F
Q
K
F
W
S
Site 93
S649
S
D
F
Q
K
F
W
S
K
S
S
Q
L
G
D
Site 94
S651
F
Q
K
F
W
S
K
S
S
Q
L
G
D
T
T
Site 95
T657
K
S
S
Q
L
G
D
T
T
T
G
H
L
S
S
Site 96
T658
S
S
Q
L
G
D
T
T
T
G
H
L
S
S
G
Site 97
T659
S
Q
L
G
D
T
T
T
G
H
L
S
S
G
E
Site 98
S664
T
T
T
G
H
L
S
S
G
E
Q
K
G
I
E
Site 99
S672
G
E
Q
K
G
I
E
S
D
W
Q
G
L
L
V
Site 100
Y691
R
S
K
P
I
K
A
Y
S
T
E
N
Y
S
L
Site 101
S692
S
K
P
I
K
A
Y
S
T
E
N
Y
S
L
E
Site 102
T693
K
P
I
K
A
Y
S
T
E
N
Y
S
L
E
S
Site 103
Y696
K
A
Y
S
T
E
N
Y
S
L
E
S
Q
K
K
Site 104
S697
A
Y
S
T
E
N
Y
S
L
E
S
Q
K
K
R
Site 105
S707
S
Q
K
K
R
K
K
S
R
G
Q
T
S
A
A
Site 106
T711
R
K
K
S
R
G
Q
T
S
A
A
N
G
L
R
Site 107
S712
K
K
S
R
G
Q
T
S
A
A
N
G
L
R
A
Site 108
S721
A
N
G
L
R
A
E
S
L
D
D
Q
M
L
S
Site 109
S728
S
L
D
D
Q
M
L
S
R
E
S
S
S
Q
A
Site 110
S731
D
Q
M
L
S
R
E
S
S
S
Q
A
P
Y
K
Site 111
S732
Q
M
L
S
R
E
S
S
S
Q
A
P
Y
K
S
Site 112
S733
M
L
S
R
E
S
S
S
Q
A
P
Y
K
S
V
Site 113
Y737
E
S
S
S
Q
A
P
Y
K
S
V
T
S
L
C
Site 114
S739
S
S
Q
A
P
Y
K
S
V
T
S
L
C
A
P
Site 115
Y748
T
S
L
C
A
P
E
Y
E
N
I
R
H
Y
E
Site 116
Y754
E
Y
E
N
I
R
H
Y
E
E
I
P
E
Y
E
Site 117
Y760
H
Y
E
E
I
P
E
Y
E
N
L
P
F
I
M
Site 118
S780
Q
E
L
E
W
Q
N
S
S
S
M
E
D
A
D
Site 119
S782
L
E
W
Q
N
S
S
S
M
E
D
A
D
A
N
Site 120
Y791
E
D
A
D
A
N
V
Y
E
V
E
E
P
Y
E
Site 121
Y797
V
Y
E
V
E
E
P
Y
E
A
P
D
G
Q
L
Site 122
S813
L
G
P
R
H
Q
H
S
S
S
G
A
S
Q
E
Site 123
S814
G
P
R
H
Q
H
S
S
S
G
A
S
Q
E
E
Site 124
S815
P
R
H
Q
H
S
S
S
G
A
S
Q
E
E
Q
Site 125
S818
Q
H
S
S
S
G
A
S
Q
E
E
Q
N
D
L
Site 126
S832
L
G
L
G
D
L
P
S
D
E
E
E
I
I
N
Site 127
S840
D
E
E
E
I
I
N
S
S
D
E
D
D
V
S
Site 128
S841
E
E
E
I
I
N
S
S
D
E
D
D
V
S
S
Site 129
S847
S
S
D
E
D
D
V
S
S
E
S
S
K
G
E
Site 130
S848
S
D
E
D
D
V
S
S
E
S
S
K
G
E
P
Site 131
S851
D
D
V
S
S
E
S
S
K
G
E
P
D
P
L
Site 132
Y923
R
I
L
N
Q
I
L
Y
Y
L
P
Q
L
Y
E
Site 133
Y929
L
Y
Y
L
P
Q
L
Y
E
L
N
R
D
L
L
Site 134
Y962
I
F
V
K
K
G
P
Y
L
K
M
Y
S
T
Y
Site 135
Y966
K
G
P
Y
L
K
M
Y
S
T
Y
I
K
E
F
Site 136
S1000
V
V
R
E
F
E
M
S
P
R
C
A
N
L
A
Site 137
Y1011
A
N
L
A
L
K
H
Y
L
L
K
P
V
Q
R
Site 138
Y1022
P
V
Q
R
I
P
Q
Y
R
L
L
L
T
D
Y
Site 139
T1027
P
Q
Y
R
L
L
L
T
D
Y
L
K
N
L
I
Site 140
Y1029
Y
R
L
L
L
T
D
Y
L
K
N
L
I
E
D
Site 141
Y1040
L
I
E
D
A
G
D
Y
R
D
T
Q
D
A
L
Site 142
T1043
D
A
G
D
Y
R
D
T
Q
D
A
L
A
V
V
Site 143
Y1075
Q
K
L
M
Q
I
Q
Y
S
L
N
G
H
H
E
Site 144
S1100
E
G
I
L
M
K
L
S
R
K
V
M
Q
P
R
Site 145
T1120
N
D
A
L
L
Y
T
T
P
V
Q
S
G
M
Y
Site 146
S1134
Y
K
L
N
N
M
L
S
L
A
G
M
K
V
R
Site 147
T1144
G
M
K
V
R
K
P
T
Q
E
A
Y
Q
N
E
Site 148
S1156
Q
N
E
L
K
I
E
S
V
E
R
S
F
I
L
Site 149
S1160
K
I
E
S
V
E
R
S
F
I
L
S
A
S
S
Site 150
S1164
V
E
R
S
F
I
L
S
A
S
S
A
T
E
R
Site 151
Y1185
I
S
R
A
I
E
E
Y
A
K
K
R
I
T
F
Site 152
T1191
E
Y
A
K
K
R
I
T
F
C
P
S
R
S
L
Site 153
S1197
I
T
F
C
P
S
R
S
L
D
E
A
D
S
E
Site 154
S1203
R
S
L
D
E
A
D
S
E
N
K
E
E
V
S
Site 155
S1210
S
E
N
K
E
E
V
S
P
L
G
S
K
A
P
Site 156
S1214
E
E
V
S
P
L
G
S
K
A
P
I
W
I
P
Site 157
T1238
C
T
S
E
F
T
L
T
W
R
R
H
H
C
R
Site 158
Y1260
Q
A
C
S
S
N
K
Y
G
L
D
Y
L
K
N
Site 159
Y1264
S
N
K
Y
G
L
D
Y
L
K
N
Q
P
A
R
Site 160
S1288
Q
K
L
D
H
Q
H
S
P
R
I
G
S
P
G
Site 161
S1293
Q
H
S
P
R
I
G
S
P
G
N
H
K
S
P
Site 162
S1299
G
S
P
G
N
H
K
S
P
S
S
A
L
S
S
Site 163
S1301
P
G
N
H
K
S
P
S
S
A
L
S
S
V
L
Site 164
S1302
G
N
H
K
S
P
S
S
A
L
S
S
V
L
H
Site 165
S1305
K
S
P
S
S
A
L
S
S
V
L
H
S
I
P
Site 166
S1306
S
P
S
S
A
L
S
S
V
L
H
S
I
P
S
Site 167
S1310
A
L
S
S
V
L
H
S
I
P
S
G
R
K
Q
Site 168
S1313
S
V
L
H
S
I
P
S
G
R
K
Q
K
K
I
Site 169
T1331
L
K
E
V
S
A
N
T
E
D
S
S
M
S
G
Site 170
S1334
V
S
A
N
T
E
D
S
S
M
S
G
Y
L
Y
Site 171
S1335
S
A
N
T
E
D
S
S
M
S
G
Y
L
Y
R
Site 172
Y1339
E
D
S
S
M
S
G
Y
L
Y
R
S
K
G
N
Site 173
Y1341
S
S
M
S
G
Y
L
Y
R
S
K
G
N
K
K
Site 174
Y1363
V
I
K
N
K
V
L
Y
T
Y
A
A
S
E
D
Site 175
S1392
I
Q
V
K
D
E
N
S
E
S
K
V
F
Q
L
Site 176
S1394
V
K
D
E
N
S
E
S
K
V
F
Q
L
L
H
Site 177
Y1407
L
H
K
N
M
L
F
Y
V
F
K
A
E
D
A
Site 178
S1416
F
K
A
E
D
A
H
S
A
Q
K
W
I
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation