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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PHLPP2
Full Name:
PH domain leucine-rich repeat-containing protein phosphatase 2
Alias:
PH domain leucine-rich repeat-containing protein phosphatase-like
Type:
Mass (Da):
146751
Number AA:
1323
UniProt ID:
Q6ZVD8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
K
R
N
G
S
R
N
C
L
N
R
R
Site 2
S14
R
N
C
L
N
R
R
S
R
F
G
S
R
E
R
Site 3
S18
N
R
R
S
R
F
G
S
R
E
R
D
W
L
R
Site 4
Y34
D
V
K
R
G
C
V
Y
L
Y
G
A
D
T
T
Site 5
Y36
K
R
G
C
V
Y
L
Y
G
A
D
T
T
T
A
Site 6
T40
V
Y
L
Y
G
A
D
T
T
T
A
T
T
T
T
Site 7
T46
D
T
T
T
A
T
T
T
T
T
T
S
S
S
S
Site 8
T47
T
T
T
A
T
T
T
T
T
T
S
S
S
S
S
Site 9
T48
T
T
A
T
T
T
T
T
T
S
S
S
S
S
S
Site 10
T49
T
A
T
T
T
T
T
T
S
S
S
S
S
S
S
Site 11
S50
A
T
T
T
T
T
T
S
S
S
S
S
S
S
S
Site 12
S51
T
T
T
T
T
T
S
S
S
S
S
S
S
S
S
Site 13
S52
T
T
T
T
T
S
S
S
S
S
S
S
S
S
S
Site 14
S53
T
T
T
T
S
S
S
S
S
S
S
S
S
S
S
Site 15
S54
T
T
T
S
S
S
S
S
S
S
S
S
S
S
D
Site 16
S55
T
T
S
S
S
S
S
S
S
S
S
S
S
D
L
Site 17
S56
T
S
S
S
S
S
S
S
S
S
S
S
D
L
H
Site 18
S57
S
S
S
S
S
S
S
S
S
S
S
D
L
H
L
Site 19
S58
S
S
S
S
S
S
S
S
S
S
D
L
H
L
V
Site 20
S59
S
S
S
S
S
S
S
S
S
D
L
H
L
V
L
Site 21
S60
S
S
S
S
S
S
S
S
D
L
H
L
V
L
C
Site 22
S84
C
A
G
E
G
R
E
S
L
Y
L
Q
L
H
G
Site 23
Y86
G
E
G
R
E
S
L
Y
L
Q
L
H
G
D
L
Site 24
T100
L
V
R
R
L
E
P
T
E
R
P
L
Q
I
V
Site 25
Y108
E
R
P
L
Q
I
V
Y
D
Y
L
S
R
L
G
Site 26
S112
Q
I
V
Y
D
Y
L
S
R
L
G
F
D
D
P
Site 27
S154
R
L
D
R
I
L
L
S
G
I
Y
N
V
R
K
Site 28
Y157
R
I
L
L
S
G
I
Y
N
V
R
K
G
K
T
Site 29
T191
S
S
V
K
D
C
Q
T
G
K
M
H
I
L
P
Site 30
Y212
E
E
V
K
R
R
Q
Y
S
L
A
F
S
S
A
Site 31
S213
E
V
K
R
R
Q
Y
S
L
A
F
S
S
A
G
Site 32
S217
R
Q
Y
S
L
A
F
S
S
A
G
A
Q
A
Q
Site 33
T225
S
A
G
A
Q
A
Q
T
Y
H
V
S
F
E
T
Site 34
Y226
A
G
A
Q
A
Q
T
Y
H
V
S
F
E
T
L
Site 35
S229
Q
A
Q
T
Y
H
V
S
F
E
T
L
A
E
Y
Site 36
Y236
S
F
E
T
L
A
E
Y
Q
R
W
Q
R
Q
A
Site 37
S244
Q
R
W
Q
R
Q
A
S
K
V
V
S
Q
R
I
Site 38
S248
R
Q
A
S
K
V
V
S
Q
R
I
S
T
V
D
Site 39
S260
T
V
D
L
S
C
Y
S
L
E
E
V
P
E
H
Site 40
Y270
E
V
P
E
H
L
F
Y
S
Q
D
I
T
Y
L
Site 41
Y276
F
Y
S
Q
D
I
T
Y
L
N
L
R
H
N
F
Site 42
T294
E
R
P
G
G
L
D
T
L
Y
K
F
S
Q
L
Site 43
Y296
P
G
G
L
D
T
L
Y
K
F
S
Q
L
K
G
Site 44
S299
L
D
T
L
Y
K
F
S
Q
L
K
G
L
N
L
Site 45
S307
Q
L
K
G
L
N
L
S
H
N
K
L
G
L
F
Site 46
S330
T
L
T
E
L
N
L
S
C
N
G
F
H
D
L
Site 47
S339
N
G
F
H
D
L
P
S
Q
I
G
N
L
L
N
Site 48
T359
L
D
G
N
F
L
T
T
L
P
E
E
L
G
N
Site 49
S372
G
N
L
Q
Q
L
S
S
L
G
I
S
F
N
N
Site 50
S376
Q
L
S
S
L
G
I
S
F
N
N
F
S
Q
I
Site 51
S381
G
I
S
F
N
N
F
S
Q
I
P
E
V
Y
E
Site 52
T429
L
R
M
N
H
L
K
T
M
V
I
E
N
L
E
Site 53
T452
D
L
R
D
N
R
L
T
D
L
D
L
S
S
L
Site 54
S457
R
L
T
D
L
D
L
S
S
L
C
S
L
E
Q
Site 55
T476
R
N
Q
L
R
E
L
T
L
S
G
F
S
L
R
Site 56
T484
L
S
G
F
S
L
R
T
L
Y
A
S
S
N
R
Site 57
Y486
G
F
S
L
R
T
L
Y
A
S
S
N
R
L
T
Site 58
S488
S
L
R
T
L
Y
A
S
S
N
R
L
T
A
V
Site 59
S489
L
R
T
L
Y
A
S
S
N
R
L
T
A
V
N
Site 60
T493
Y
A
S
S
N
R
L
T
A
V
N
V
Y
P
V
Site 61
Y598
S
K
A
L
N
L
R
Y
L
N
A
S
A
N
S
Site 62
S602
N
L
R
Y
L
N
A
S
A
N
S
L
E
S
L
Site 63
S605
Y
L
N
A
S
A
N
S
L
E
S
L
P
S
A
Site 64
S608
A
S
A
N
S
L
E
S
L
P
S
A
C
T
G
Site 65
S611
N
S
L
E
S
L
P
S
A
C
T
G
E
E
S
Site 66
T614
E
S
L
P
S
A
C
T
G
E
E
S
L
S
M
Site 67
T658
L
A
N
N
Q
L
Q
T
F
P
A
S
K
L
N
Site 68
S662
Q
L
Q
T
F
P
A
S
K
L
N
K
L
E
Q
Site 69
S676
Q
L
E
E
L
N
L
S
G
N
K
L
K
T
I
Site 70
T682
L
S
G
N
K
L
K
T
I
P
T
T
I
A
N
Site 71
T695
A
N
C
K
R
L
H
T
L
V
A
H
S
N
N
Site 72
T764
D
I
F
S
H
I
T
T
L
K
I
D
Q
K
P
Site 73
T775
D
Q
K
P
L
P
T
T
D
S
T
V
T
S
T
Site 74
S777
K
P
L
P
T
T
D
S
T
V
T
S
T
F
W
Site 75
T778
P
L
P
T
T
D
S
T
V
T
S
T
F
W
S
Site 76
S781
T
T
D
S
T
V
T
S
T
F
W
S
H
G
L
Site 77
T782
T
D
S
T
V
T
S
T
F
W
S
H
G
L
A
Site 78
Y816
A
E
G
V
G
A
V
Y
G
M
F
D
G
D
R
Site 79
T850
V
Q
Q
S
T
N
D
T
V
F
M
A
N
T
F
Site 80
T856
D
T
V
F
M
A
N
T
F
L
V
S
H
R
K
Site 81
Y879
G
S
S
A
L
L
C
Y
I
R
P
D
T
A
D
Site 82
T884
L
C
Y
I
R
P
D
T
A
D
P
A
S
S
F
Site 83
S889
P
D
T
A
D
P
A
S
S
F
S
L
T
V
A
Site 84
S890
D
T
A
D
P
A
S
S
F
S
L
T
V
A
N
Site 85
S915
G
G
K
P
V
P
L
S
K
V
F
S
L
E
Q
Site 86
S919
V
P
L
S
K
V
F
S
L
E
Q
D
P
E
E
Site 87
T971
P
K
P
H
I
S
S
T
P
L
T
I
Q
D
E
Site 88
S992
K
A
L
W
E
H
L
S
Y
T
E
A
V
N
A
Site 89
T1069
K
D
A
P
K
P
A
T
P
S
S
S
S
G
I
Site 90
S1071
A
P
K
P
A
T
P
S
S
S
S
G
I
A
S
Site 91
S1072
P
K
P
A
T
P
S
S
S
S
G
I
A
S
E
Site 92
S1073
K
P
A
T
P
S
S
S
S
G
I
A
S
E
F
Site 93
S1074
P
A
T
P
S
S
S
S
G
I
A
S
E
F
S
Site 94
S1078
S
S
S
S
G
I
A
S
E
F
S
S
E
M
S
Site 95
S1081
S
G
I
A
S
E
F
S
S
E
M
S
T
S
E
Site 96
S1082
G
I
A
S
E
F
S
S
E
M
S
T
S
E
V
Site 97
S1085
S
E
F
S
S
E
M
S
T
S
E
V
S
S
E
Site 98
T1086
E
F
S
S
E
M
S
T
S
E
V
S
S
E
V
Site 99
S1087
F
S
S
E
M
S
T
S
E
V
S
S
E
V
G
Site 100
S1091
M
S
T
S
E
V
S
S
E
V
G
S
T
A
S
Site 101
S1095
E
V
S
S
E
V
G
S
T
A
S
D
E
H
N
Site 102
T1096
V
S
S
E
V
G
S
T
A
S
D
E
H
N
A
Site 103
S1098
S
E
V
G
S
T
A
S
D
E
H
N
A
G
G
Site 104
S1119
P
R
P
E
R
R
C
S
L
H
P
T
P
T
S
Site 105
T1123
R
R
C
S
L
H
P
T
P
T
S
G
L
F
Q
Site 106
T1125
C
S
L
H
P
T
P
T
S
G
L
F
Q
R
Q
Site 107
S1126
S
L
H
P
T
P
T
S
G
L
F
Q
R
Q
P
Site 108
S1134
G
L
F
Q
R
Q
P
S
S
A
T
F
S
S
N
Site 109
S1135
L
F
Q
R
Q
P
S
S
A
T
F
S
S
N
Q
Site 110
T1137
Q
R
Q
P
S
S
A
T
F
S
S
N
Q
S
D
Site 111
S1139
Q
P
S
S
A
T
F
S
S
N
Q
S
D
N
G
Site 112
S1140
P
S
S
A
T
F
S
S
N
Q
S
D
N
G
L
Site 113
S1143
A
T
F
S
S
N
Q
S
D
N
G
L
D
S
D
Site 114
S1149
Q
S
D
N
G
L
D
S
D
D
D
Q
P
V
E
Site 115
T1160
Q
P
V
E
G
V
I
T
N
G
S
K
V
E
V
Site 116
S1163
E
G
V
I
T
N
G
S
K
V
E
V
E
V
D
Site 117
S1182
R
G
R
D
L
E
N
S
P
P
L
I
E
S
S
Site 118
S1188
N
S
P
P
L
I
E
S
S
P
T
L
C
S
E
Site 119
S1189
S
P
P
L
I
E
S
S
P
T
L
C
S
E
E
Site 120
T1191
P
L
I
E
S
S
P
T
L
C
S
E
E
H
A
Site 121
S1194
E
S
S
P
T
L
C
S
E
E
H
A
R
G
S
Site 122
S1201
S
E
E
H
A
R
G
S
C
F
G
I
R
R
Q
Site 123
S1210
F
G
I
R
R
Q
N
S
V
N
S
G
M
L
L
Site 124
S1220
S
G
M
L
L
P
M
S
K
D
R
M
E
L
Q
Site 125
S1229
D
R
M
E
L
Q
K
S
P
S
T
S
C
L
Y
Site 126
S1231
M
E
L
Q
K
S
P
S
T
S
C
L
Y
G
K
Site 127
S1233
L
Q
K
S
P
S
T
S
C
L
Y
G
K
K
L
Site 128
Y1236
S
P
S
T
S
C
L
Y
G
K
K
L
S
N
G
Site 129
S1241
C
L
Y
G
K
K
L
S
N
G
S
I
V
P
L
Site 130
T1259
L
N
L
I
E
V
A
T
E
V
P
K
R
K
T
Site 131
T1266
T
E
V
P
K
R
K
T
G
Y
F
A
A
P
T
Site 132
Y1268
V
P
K
R
K
T
G
Y
F
A
A
P
T
Q
M
Site 133
S1301
Q
M
K
Q
H
Q
D
S
R
L
E
P
E
P
H
Site 134
T1313
E
P
H
E
E
D
R
T
E
P
P
E
E
F
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation