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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRIN3
Full Name:
G protein-regulated inducer of neurite outgrowth 3
Alias:
FLJ42625; GPRIN family member 3
Type:
Mass (Da):
82420
Number AA:
776
UniProt ID:
Q6ZVF9
International Prot ID:
IPI00216989
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
T
V
P
D
P
L
R
S
A
K
T
S
L
I
A
Site 2
S14
P
L
R
S
A
K
T
S
L
I
A
A
S
G
K
Site 3
S32
L
G
E
P
Q
A
A
S
P
R
H
R
P
A
L
Site 4
S57
A
P
A
E
P
D
L
S
P
R
A
A
A
E
A
Site 5
T74
Q
V
C
E
H
E
T
T
Q
P
D
M
S
S
P
Site 6
S80
T
T
Q
P
D
M
S
S
P
G
V
F
N
E
V
Site 7
T93
E
V
Q
K
A
P
A
T
F
N
S
P
G
N
P
Site 8
S96
K
A
P
A
T
F
N
S
P
G
N
P
Q
L
P
Site 9
S105
G
N
P
Q
L
P
G
S
S
Q
P
A
A
S
A
Site 10
S106
N
P
Q
L
P
G
S
S
Q
P
A
A
S
A
P
Site 11
S111
G
S
S
Q
P
A
A
S
A
P
S
S
A
A
G
Site 12
T124
A
G
R
D
L
I
H
T
P
L
T
M
P
A
N
Site 13
T127
D
L
I
H
T
P
L
T
M
P
A
N
Q
H
T
Site 14
T134
T
M
P
A
N
Q
H
T
C
Q
S
I
P
G
D
Site 15
S148
D
Q
P
N
A
I
T
S
S
M
P
E
D
S
L
Site 16
S154
T
S
S
M
P
E
D
S
L
M
R
S
Q
R
T
Site 17
S158
P
E
D
S
L
M
R
S
Q
R
T
S
N
R
E
Site 18
S162
L
M
R
S
Q
R
T
S
N
R
E
Q
P
E
K
Site 19
S171
R
E
Q
P
E
K
P
S
C
P
V
G
G
V
L
Site 20
S179
C
P
V
G
G
V
L
S
S
S
K
D
Q
V
S
Site 21
S180
P
V
G
G
V
L
S
S
S
K
D
Q
V
S
C
Site 22
S181
V
G
G
V
L
S
S
S
K
D
Q
V
S
C
E
Site 23
S186
S
S
S
K
D
Q
V
S
C
E
F
P
S
P
E
Site 24
S191
Q
V
S
C
E
F
P
S
P
E
T
I
Q
G
T
Site 25
S212
A
A
R
V
V
S
H
S
S
S
P
V
G
G
P
Site 26
S213
A
R
V
V
S
H
S
S
S
P
V
G
G
P
E
Site 27
S214
R
V
V
S
H
S
S
S
P
V
G
G
P
E
G
Site 28
S230
R
Q
G
A
I
C
D
S
E
M
R
S
C
K
P
Site 29
S234
I
C
D
S
E
M
R
S
C
K
P
L
T
R
E
Site 30
T239
M
R
S
C
K
P
L
T
R
E
S
G
C
S
E
Site 31
S242
C
K
P
L
T
R
E
S
G
C
S
E
N
K
Q
Site 32
S245
L
T
R
E
S
G
C
S
E
N
K
Q
P
S
V
Site 33
S251
C
S
E
N
K
Q
P
S
V
T
A
S
G
P
Q
Site 34
S255
K
Q
P
S
V
T
A
S
G
P
Q
G
T
T
S
Site 35
S262
S
G
P
Q
G
T
T
S
V
T
P
Q
P
T
P
Site 36
T264
P
Q
G
T
T
S
V
T
P
Q
P
T
P
L
T
Site 37
T268
T
S
V
T
P
Q
P
T
P
L
T
S
E
P
S
Site 38
T271
T
P
Q
P
T
P
L
T
S
E
P
S
A
C
P
Site 39
S272
P
Q
P
T
P
L
T
S
E
P
S
A
C
P
P
Site 40
S275
T
P
L
T
S
E
P
S
A
C
P
P
G
P
E
Site 41
S293
L
P
A
Q
R
Q
M
S
R
F
K
E
A
S
T
Site 42
S299
M
S
R
F
K
E
A
S
T
M
T
N
Q
A
E
Site 43
S330
Q
A
V
A
S
V
E
S
R
S
V
S
T
S
P
Site 44
S332
V
A
S
V
E
S
R
S
V
S
T
S
P
S
I
Site 45
S334
S
V
E
S
R
S
V
S
T
S
P
S
I
L
T
Site 46
T335
V
E
S
R
S
V
S
T
S
P
S
I
L
T
A
Site 47
S336
E
S
R
S
V
S
T
S
P
S
I
L
T
A
F
Site 48
S347
L
T
A
F
L
K
E
S
R
A
P
E
H
F
E
Site 49
S364
Q
L
R
V
I
C
H
S
S
G
S
H
T
L
E
Site 50
S365
L
R
V
I
C
H
S
S
G
S
H
T
L
E
L
Site 51
S367
V
I
C
H
S
S
G
S
H
T
L
E
L
S
D
Site 52
T369
C
H
S
S
G
S
H
T
L
E
L
S
D
S
T
Site 53
S373
G
S
H
T
L
E
L
S
D
S
T
L
A
P
Q
Site 54
S375
H
T
L
E
L
S
D
S
T
L
A
P
Q
E
S
Site 55
T376
T
L
E
L
S
D
S
T
L
A
P
Q
E
S
S
Site 56
S382
S
T
L
A
P
Q
E
S
S
Q
C
P
G
I
M
Site 57
S383
T
L
A
P
Q
E
S
S
Q
C
P
G
I
M
P
Site 58
S412
Q
R
E
N
K
L
A
S
L
P
G
G
V
L
K
Site 59
S428
S
S
I
N
L
V
S
S
N
A
Q
H
T
C
K
Site 60
T444
D
G
R
L
A
G
M
T
P
V
R
E
E
S
T
Site 61
S450
M
T
P
V
R
E
E
S
T
A
K
K
L
A
G
Site 62
T458
T
A
K
K
L
A
G
T
N
S
S
S
L
K
A
Site 63
S460
K
K
L
A
G
T
N
S
S
S
L
K
A
T
A
Site 64
S462
L
A
G
T
N
S
S
S
L
K
A
T
A
I
D
Site 65
T466
N
S
S
S
L
K
A
T
A
I
D
Q
I
S
I
Site 66
S477
Q
I
S
I
S
A
C
S
Q
A
E
T
S
Y
G
Site 67
T481
S
A
C
S
Q
A
E
T
S
Y
G
L
G
K
F
Site 68
S493
G
K
F
E
T
R
P
S
E
F
A
E
K
T
T
Site 69
T499
P
S
E
F
A
E
K
T
T
N
G
H
K
T
D
Site 70
T505
K
T
T
N
G
H
K
T
D
P
D
C
K
L
S
Site 71
S512
T
D
P
D
C
K
L
S
D
S
C
G
S
I
S
Site 72
S514
P
D
C
K
L
S
D
S
C
G
S
I
S
K
A
Site 73
S517
K
L
S
D
S
C
G
S
I
S
K
A
D
H
S
Site 74
S519
S
D
S
C
G
S
I
S
K
A
D
H
S
G
S
Site 75
S524
S
I
S
K
A
D
H
S
G
S
L
D
P
T
N
Site 76
S526
S
K
A
D
H
S
G
S
L
D
P
T
N
K
G
Site 77
T530
H
S
G
S
L
D
P
T
N
K
G
D
A
R
E
Site 78
S542
A
R
E
K
K
P
A
S
P
Q
V
V
K
E
K
Site 79
T552
V
V
K
E
K
E
S
T
G
T
D
T
S
D
A
Site 80
S557
E
S
T
G
T
D
T
S
D
A
K
T
L
L
L
Site 81
T561
T
D
T
S
D
A
K
T
L
L
L
N
P
K
S
Site 82
S568
T
L
L
L
N
P
K
S
Q
E
S
G
G
T
E
Site 83
T581
T
E
S
A
A
N
P
T
P
S
P
I
R
K
N
Site 84
S583
S
A
A
N
P
T
P
S
P
I
R
K
N
Q
E
Site 85
S591
P
I
R
K
N
Q
E
S
T
L
E
E
N
R
Q
Site 86
T599
T
L
E
E
N
R
Q
T
K
T
A
T
S
L
S
Site 87
T601
E
E
N
R
Q
T
K
T
A
T
S
L
S
L
P
Site 88
S604
R
Q
T
K
T
A
T
S
L
S
L
P
S
D
P
Site 89
S606
T
K
T
A
T
S
L
S
L
P
S
D
P
M
G
Site 90
S609
A
T
S
L
S
L
P
S
D
P
M
G
D
S
S
Site 91
S615
P
S
D
P
M
G
D
S
S
P
G
S
G
K
K
Site 92
S616
S
D
P
M
G
D
S
S
P
G
S
G
K
K
T
Site 93
S619
M
G
D
S
S
P
G
S
G
K
K
T
P
S
R
Site 94
T623
S
P
G
S
G
K
K
T
P
S
R
S
V
K
A
Site 95
S625
G
S
G
K
K
T
P
S
R
S
V
K
A
S
P
Site 96
S627
G
K
K
T
P
S
R
S
V
K
A
S
P
R
R
Site 97
S631
P
S
R
S
V
K
A
S
P
R
R
P
S
R
V
Site 98
S636
K
A
S
P
R
R
P
S
R
V
S
E
F
L
K
Site 99
S639
P
R
R
P
S
R
V
S
E
F
L
K
E
Q
K
Site 100
T659
A
A
A
Q
V
G
L
T
P
G
D
K
K
K
Q
Site 101
S678
S
K
L
Q
L
K
Q
S
K
R
V
R
D
V
V
Site 102
Y696
Q
G
M
T
W
E
V
Y
G
A
S
L
D
A
E
Site 103
S699
T
W
E
V
Y
G
A
S
L
D
A
E
S
L
G
Site 104
T726
E
H
E
K
L
I
K
T
Q
N
S
Q
T
R
R
Site 105
S729
K
L
I
K
T
Q
N
S
Q
T
R
R
S
I
S
Site 106
T731
I
K
T
Q
N
S
Q
T
R
R
S
I
S
S
D
Site 107
S734
Q
N
S
Q
T
R
R
S
I
S
S
D
T
S
S
Site 108
S736
S
Q
T
R
R
S
I
S
S
D
T
S
S
N
K
Site 109
S737
Q
T
R
R
S
I
S
S
D
T
S
S
N
K
K
Site 110
T739
R
R
S
I
S
S
D
T
S
S
N
K
K
L
R
Site 111
S740
R
S
I
S
S
D
T
S
S
N
K
K
L
R
G
Site 112
S741
S
I
S
S
D
T
S
S
N
K
K
L
R
G
R
Site 113
S751
K
L
R
G
R
Q
H
S
V
F
Q
S
M
L
Q
Site 114
S755
R
Q
H
S
V
F
Q
S
M
L
Q
N
F
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation