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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ESPNL
Full Name:
Espin-like protein
Alias:
Type:
Mass (Da):
108132
Number AA:
1005
UniProt ID:
Q6ZVH7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
A
K
D
G
D
V
A
T
L
E
R
L
L
E
A
Site 2
T72
Q
R
A
H
N
G
A
T
P
A
H
D
A
A
A
Site 3
S103
G
L
Q
D
Q
D
A
S
G
V
S
P
L
H
L
Site 4
S106
D
Q
D
A
S
G
V
S
P
L
H
L
A
A
R
Site 5
S162
L
L
T
A
A
H
G
S
S
V
N
R
R
T
R
Site 6
S163
L
T
A
A
H
G
S
S
V
N
R
R
T
R
S
Site 7
T168
G
S
S
V
N
R
R
T
R
S
G
A
S
P
L
Site 8
S170
S
V
N
R
R
T
R
S
G
A
S
P
L
Y
L
Site 9
S173
R
R
T
R
S
G
A
S
P
L
Y
L
A
C
Q
Site 10
Y176
R
S
G
A
S
P
L
Y
L
A
C
Q
E
G
H
Site 11
T252
F
A
A
R
G
G
H
T
P
I
L
D
R
L
L
Site 12
T263
D
R
L
L
L
M
G
T
P
I
L
R
D
S
W
Site 13
S269
G
T
P
I
L
R
D
S
W
G
G
T
P
L
H
Site 14
T273
L
R
D
S
W
G
G
T
P
L
H
D
A
A
E
Site 15
S298
V
S
H
H
V
D
P
S
L
R
D
E
D
G
Y
Site 16
Y305
S
L
R
D
E
D
G
Y
T
A
A
D
L
A
E
Site 17
T306
L
R
D
E
D
G
Y
T
A
A
D
L
A
E
Y
Site 18
Y322
G
H
R
D
C
A
Q
Y
L
R
E
V
A
Q
P
Site 19
T335
Q
P
V
P
L
L
M
T
P
P
P
P
P
F
P
Site 20
T349
P
P
P
P
L
L
A
T
R
R
S
L
E
D
G
Site 21
S352
P
L
L
A
T
R
R
S
L
E
D
G
R
R
G
Site 22
S367
G
P
G
P
G
N
P
S
P
M
S
L
S
P
A
Site 23
S370
P
G
N
P
S
P
M
S
L
S
P
A
W
P
G
Site 24
S372
N
P
S
P
M
S
L
S
P
A
W
P
G
H
P
Site 25
S390
L
P
R
E
Q
M
T
S
P
A
P
P
R
I
I
Site 26
T398
P
A
P
P
R
I
I
T
S
A
T
A
D
P
E
Site 27
T401
P
R
I
I
T
S
A
T
A
D
P
E
G
T
E
Site 28
T409
A
D
P
E
G
T
E
T
A
L
A
G
D
T
S
Site 29
S466
Q
A
R
L
G
A
E
S
S
A
E
A
Q
D
N
Site 30
S467
A
R
L
G
A
E
S
S
A
E
A
Q
D
N
G
Site 31
T480
N
G
G
S
S
G
P
T
E
Q
A
A
W
R
Y
Site 32
Y509
L
T
E
D
D
L
V
Y
L
E
K
Q
I
A
D
Site 33
Y526
L
R
R
R
C
Q
E
Y
E
S
E
L
G
R
L
Site 34
S576
P
A
A
E
P
A
G
S
A
E
A
S
E
V
A
Site 35
S580
P
A
G
S
A
E
A
S
E
V
A
P
G
V
Q
Site 36
S597
P
F
W
C
S
H
I
S
R
L
V
R
S
L
S
Site 37
T622
Q
G
D
E
K
P
S
T
R
P
L
Q
D
T
C
Site 38
T628
S
T
R
P
L
Q
D
T
C
R
E
A
S
A
S
Site 39
S633
Q
D
T
C
R
E
A
S
A
S
P
P
R
S
E
Site 40
S635
T
C
R
E
A
S
A
S
P
P
R
S
E
A
Q
Site 41
S639
A
S
A
S
P
P
R
S
E
A
Q
R
Q
I
Q
Site 42
S651
Q
I
Q
E
W
G
V
S
V
R
T
L
R
G
N
Site 43
T654
E
W
G
V
S
V
R
T
L
R
G
N
F
E
S
Site 44
S661
T
L
R
G
N
F
E
S
A
S
G
P
L
C
G
Site 45
S663
R
G
N
F
E
S
A
S
G
P
L
C
G
F
N
Site 46
S696
P
A
L
P
K
P
R
S
G
L
A
S
G
E
P
Site 47
S700
K
P
R
S
G
L
A
S
G
E
P
R
P
G
D
Site 48
T708
G
E
P
R
P
G
D
T
E
E
A
S
D
S
G
Site 49
S712
P
G
D
T
E
E
A
S
D
S
G
I
S
C
E
Site 50
S714
D
T
E
E
A
S
D
S
G
I
S
C
E
E
V
Site 51
S717
E
A
S
D
S
G
I
S
C
E
E
V
P
S
E
Site 52
S735
A
A
G
P
D
L
A
S
L
R
K
E
R
I
I
Site 53
S752
F
L
S
H
W
R
R
S
A
Y
T
P
A
L
K
Site 54
Y754
S
H
W
R
R
S
A
Y
T
P
A
L
K
T
A
Site 55
T755
H
W
R
R
S
A
Y
T
P
A
L
K
T
A
A
Site 56
S781
R
G
Q
E
A
A
R
S
P
G
P
P
S
P
P
Site 57
S786
A
R
S
P
G
P
P
S
P
P
S
E
G
P
R
Site 58
S789
P
G
P
P
S
P
P
S
E
G
P
R
L
G
H
Site 59
T803
H
L
W
Q
Q
R
S
T
I
T
H
L
L
G
N
Site 60
S827
A
R
Q
L
R
R
L
S
R
Q
P
R
G
A
L
Site 61
S835
R
Q
P
R
G
A
L
S
P
E
Q
F
L
P
H
Site 62
T891
E
V
F
E
H
L
G
T
H
G
W
E
A
V
R
Site 63
T916
A
A
G
R
R
A
W
T
D
G
F
E
D
I
K
Site 64
S929
I
K
A
R
F
F
G
S
S
Q
R
P
A
W
D
Site 65
S930
K
A
R
F
F
G
S
S
Q
R
P
A
W
D
T
Site 66
T937
S
Q
R
P
A
W
D
T
E
P
G
R
K
S
G
Site 67
S943
D
T
E
P
G
R
K
S
G
L
T
L
L
G
P
Site 68
T946
P
G
R
K
S
G
L
T
L
L
G
P
L
P
H
Site 69
S959
P
H
A
A
V
P
C
S
G
P
E
P
T
A
Q
Site 70
T964
P
C
S
G
P
E
P
T
A
Q
R
L
G
S
R
Site 71
S970
P
T
A
Q
R
L
G
S
R
S
Q
Q
G
S
F
Site 72
S972
A
Q
R
L
G
S
R
S
Q
Q
G
S
F
N
G
Site 73
S976
G
S
R
S
Q
Q
G
S
F
N
G
E
D
I
C
Site 74
Y985
N
G
E
D
I
C
G
Y
I
N
R
S
F
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation