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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SYDE1
Full Name:
Rho GTPase-activating protein SYDE1
Alias:
7h3; FLJ13511; synapse defective 1, Rho GTPase 1; synapse defective 1, Rho GTPase, 1
Type:
Mass (Da):
79790
Number AA:
UniProt ID:
Q6ZW31
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005100
PhosphoSite+
KinaseNET
Biological Process:
GO:0032862
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
E
P
L
L
R
K
T
F
S
R
L
R
G
R
Site 2
S11
P
L
L
R
K
T
F
S
R
L
R
G
R
E
K
Site 3
S24
E
K
L
P
R
K
K
S
D
A
K
E
R
G
H
Site 4
S39
P
A
Q
R
P
E
P
S
P
P
E
P
E
P
Q
Site 5
S60
A
G
A
E
G
P
S
S
P
E
A
S
R
S
P
Site 6
S64
G
P
S
S
P
E
A
S
R
S
P
A
R
G
A
Site 7
S66
S
S
P
E
A
S
R
S
P
A
R
G
A
Y
L
Site 8
Y72
R
S
P
A
R
G
A
Y
L
Q
S
L
E
P
S
Site 9
S75
A
R
G
A
Y
L
Q
S
L
E
P
S
S
R
R
Site 10
S79
Y
L
Q
S
L
E
P
S
S
R
R
W
V
L
G
Site 11
S80
L
Q
S
L
E
P
S
S
R
R
W
V
L
G
G
Site 12
S95
A
K
P
A
E
D
T
S
L
G
P
G
V
P
G
Site 13
T103
L
G
P
G
V
P
G
T
G
E
P
A
G
E
I
Site 14
S134
P
P
G
P
Q
P
G
S
A
E
S
E
G
L
A
Site 15
S137
P
Q
P
G
S
A
E
S
E
G
L
A
P
Q
G
Site 16
S149
P
Q
G
A
A
P
A
S
P
P
T
K
A
S
R
Site 17
S155
A
S
P
P
T
K
A
S
R
T
K
S
P
G
P
Site 18
T157
P
P
T
K
A
S
R
T
K
S
P
G
P
A
R
Site 19
S159
T
K
A
S
R
T
K
S
P
G
P
A
R
R
L
Site 20
S167
P
G
P
A
R
R
L
S
I
K
M
K
K
L
P
Site 21
S181
P
E
L
R
R
R
L
S
L
R
G
P
R
A
G
Site 22
S199
E
R
A
A
P
A
G
S
V
I
S
R
Y
H
L
Site 23
Y204
A
G
S
V
I
S
R
Y
H
L
D
S
S
V
G
Site 24
S208
I
S
R
Y
H
L
D
S
S
V
G
G
P
G
P
Site 25
S209
S
R
Y
H
L
D
S
S
V
G
G
P
G
P
A
Site 26
T222
P
A
A
G
P
G
G
T
R
S
P
R
A
G
Y
Site 27
S224
A
G
P
G
G
T
R
S
P
R
A
G
Y
L
S
Site 28
Y229
T
R
S
P
R
A
G
Y
L
S
D
G
D
S
P
Site 29
S231
S
P
R
A
G
Y
L
S
D
G
D
S
P
E
R
Site 30
S235
G
Y
L
S
D
G
D
S
P
E
R
P
A
G
P
Site 31
S244
E
R
P
A
G
P
P
S
P
T
S
F
R
P
Y
Site 32
T246
P
A
G
P
P
S
P
T
S
F
R
P
Y
E
V
Site 33
S247
A
G
P
P
S
P
T
S
F
R
P
Y
E
V
G
Site 34
Y251
S
P
T
S
F
R
P
Y
E
V
G
P
A
A
R
Site 35
T303
D
G
E
A
R
A
R
T
G
P
L
R
G
G
P
Site 36
T318
D
F
L
R
L
D
H
T
F
H
L
E
L
E
A
Site 37
T380
G
L
L
Y
A
K
L
T
L
S
E
Q
Q
E
A
Site 38
S382
L
Y
A
K
L
T
L
S
E
Q
Q
E
A
P
A
Site 39
T390
E
Q
Q
E
A
P
A
T
A
E
P
R
V
F
G
Site 40
S455
R
D
A
F
E
R
D
S
A
A
V
C
L
S
E
Site 41
Y478
I
T
G
I
L
K
D
Y
L
R
E
L
P
T
P
Site 42
T484
D
Y
L
R
E
L
P
T
P
L
I
T
Q
P
L
Site 43
T510
P
P
N
R
V
P
P
T
T
E
G
T
R
G
L
Site 44
T511
P
N
R
V
P
P
T
T
E
G
T
R
G
L
L
Site 45
S519
E
G
T
R
G
L
L
S
C
L
P
D
V
E
R
Site 46
S540
L
D
H
L
R
L
V
S
S
F
H
A
Y
N
R
Site 47
S541
D
H
L
R
L
V
S
S
F
H
A
Y
N
R
M
Site 48
Y545
L
V
S
S
F
H
A
Y
N
R
M
T
P
Q
N
Site 49
T549
F
H
A
Y
N
R
M
T
P
Q
N
L
A
V
C
Site 50
S575
P
T
R
P
R
A
R
S
S
G
P
G
L
A
S
Site 51
S576
T
R
P
R
A
R
S
S
G
P
G
L
A
S
A
Site 52
S582
S
S
G
P
G
L
A
S
A
V
D
F
K
H
H
Site 53
Y595
H
H
I
E
V
L
H
Y
L
L
Q
S
W
P
D
Site 54
S599
V
L
H
Y
L
L
Q
S
W
P
D
P
R
L
P
Site 55
S609
D
P
R
L
P
R
Q
S
P
D
V
A
P
Y
L
Site 56
Y615
Q
S
P
D
V
A
P
Y
L
R
P
K
R
Q
P
Site 57
S645
R
G
R
G
G
P
E
S
P
P
S
N
R
Y
A
Site 58
S648
G
G
P
E
S
P
P
S
N
R
Y
A
G
D
W
Site 59
S671
P
C
G
R
D
F
L
S
G
P
D
Y
D
H
V
Site 60
Y675
D
F
L
S
G
P
D
Y
D
H
V
T
G
S
D
Site 61
T679
G
P
D
Y
D
H
V
T
G
S
D
S
E
D
E
Site 62
S681
D
Y
D
H
V
T
G
S
D
S
E
D
E
D
E
Site 63
S683
D
H
V
T
G
S
D
S
E
D
E
D
E
E
V
Site 64
T696
E
V
G
E
P
R
V
T
G
D
F
E
D
D
F
Site 65
S728
L
D
L
E
R
E
L
S
K
Q
I
N
V
C
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation