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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANKS3
Full Name:
Ankyrin repeat and SAM domain-containing protein 3
Alias:
Ankyrin repeat and sterile alpha motif domain containing 3; FLJ32345; FLJ32767; KIAA1977
Type:
Mass (Da):
72038
Number AA:
656
UniProt ID:
Q6ZW76
International Prot ID:
IPI00401758
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
E
L
S
D
E
A
S
Site 2
S5
_
_
_
M
S
E
L
S
D
E
A
S
E
P
E
Site 3
S9
S
E
L
S
D
E
A
S
E
P
E
L
L
N
R
Site 4
S17
E
P
E
L
L
N
R
S
L
S
M
W
H
G
L
Site 5
S19
E
L
L
N
R
S
L
S
M
W
H
G
L
G
T
Site 6
T26
S
M
W
H
G
L
G
T
Q
V
S
G
E
E
L
Site 7
S29
H
G
L
G
T
Q
V
S
G
E
E
L
D
V
P
Site 8
T71
K
K
N
G
G
G
W
T
P
L
M
Y
A
S
Y
Site 9
Y75
G
G
W
T
P
L
M
Y
A
S
Y
I
G
H
D
Site 10
T99
G
V
S
V
N
V
P
T
P
E
G
Q
T
P
L
Site 11
T104
V
P
T
P
E
G
Q
T
P
L
M
L
A
S
S
Site 12
S110
Q
T
P
L
M
L
A
S
S
C
G
N
E
S
I
Site 13
S201
K
V
D
A
R
D
H
S
G
A
T
A
R
M
L
Site 14
Y212
A
R
M
L
A
K
Q
Y
G
H
M
K
I
V
A
Site 15
T223
K
I
V
A
L
M
D
T
Y
S
P
S
L
P
K
Site 16
S225
V
A
L
M
D
T
Y
S
P
S
L
P
K
S
L
Site 17
S227
L
M
D
T
Y
S
P
S
L
P
K
S
L
Y
R
Site 18
S231
Y
S
P
S
L
P
K
S
L
Y
R
S
P
E
K
Site 19
Y233
P
S
L
P
K
S
L
Y
R
S
P
E
K
Y
E
Site 20
S235
L
P
K
S
L
Y
R
S
P
E
K
Y
E
D
L
Site 21
Y239
L
Y
R
S
P
E
K
Y
E
D
L
S
S
S
D
Site 22
S243
P
E
K
Y
E
D
L
S
S
S
D
E
S
C
P
Site 23
S244
E
K
Y
E
D
L
S
S
S
D
E
S
C
P
A
Site 24
S245
K
Y
E
D
L
S
S
S
D
E
S
C
P
A
P
Site 25
S248
D
L
S
S
S
D
E
S
C
P
A
P
Q
R
Q
Site 26
S264
P
C
R
K
K
G
V
S
I
H
E
G
P
R
A
Site 27
Y289
G
R
A
P
R
P
R
Y
E
Q
A
P
P
R
G
Site 28
Y297
E
Q
A
P
P
R
G
Y
V
T
F
N
S
S
G
Site 29
T299
A
P
P
R
G
Y
V
T
F
N
S
S
G
E
N
Site 30
T319
G
L
C
C
R
D
V
T
S
P
I
N
E
R
D
Site 31
S320
L
C
C
R
D
V
T
S
P
I
N
E
R
D
V
Site 32
S329
I
N
E
R
D
V
E
S
S
S
S
S
S
S
R
Site 33
S330
N
E
R
D
V
E
S
S
S
S
S
S
S
R
E
Site 34
S331
E
R
D
V
E
S
S
S
S
S
S
S
R
E
E
Site 35
S332
R
D
V
E
S
S
S
S
S
S
S
R
E
E
H
Site 36
S333
D
V
E
S
S
S
S
S
S
S
R
E
E
H
A
Site 37
S334
V
E
S
S
S
S
S
S
S
R
E
E
H
A
F
Site 38
S335
E
S
S
S
S
S
S
S
R
E
E
H
A
F
C
Site 39
S350
A
N
L
G
P
V
Q
S
S
S
S
S
E
G
L
Site 40
S351
N
L
G
P
V
Q
S
S
S
S
S
E
G
L
A
Site 41
S352
L
G
P
V
Q
S
S
S
S
S
E
G
L
A
R
Site 42
S354
P
V
Q
S
S
S
S
S
E
G
L
A
R
A
Q
Site 43
S364
L
A
R
A
Q
G
L
S
S
E
A
S
V
E
S
Site 44
S365
A
R
A
Q
G
L
S
S
E
A
S
V
E
S
N
Site 45
S368
Q
G
L
S
S
E
A
S
V
E
S
N
E
D
S
Site 46
S371
S
S
E
A
S
V
E
S
N
E
D
S
D
H
A
Site 47
S375
S
V
E
S
N
E
D
S
D
H
A
C
K
S
S
Site 48
S381
D
S
D
H
A
C
K
S
S
A
R
K
Q
A
K
Site 49
S382
S
D
H
A
C
K
S
S
A
R
K
Q
A
K
S
Site 50
S389
S
A
R
K
Q
A
K
S
Y
M
K
T
K
N
P
Site 51
T393
Q
A
K
S
Y
M
K
T
K
N
P
D
S
Q
W
Site 52
S398
M
K
T
K
N
P
D
S
Q
W
P
P
R
A
A
Site 53
T406
Q
W
P
P
R
A
A
T
D
R
E
G
F
L
A
Site 54
S415
R
E
G
F
L
A
E
S
S
P
Q
T
Q
R
A
Site 55
S416
E
G
F
L
A
E
S
S
P
Q
T
Q
R
A
P
Site 56
T419
L
A
E
S
S
P
Q
T
Q
R
A
P
Y
S
G
Site 57
Y424
P
Q
T
Q
R
A
P
Y
S
G
P
Q
D
L
A
Site 58
S425
Q
T
Q
R
A
P
Y
S
G
P
Q
D
L
A
A
Site 59
Y442
E
Q
I
G
C
L
K
Y
L
Q
V
F
E
E
Q
Site 60
T470
D
L
K
E
I
G
I
T
L
F
G
P
K
R
K
Site 61
T479
F
G
P
K
R
K
M
T
S
A
I
A
R
W
H
Site 62
S480
G
P
K
R
K
M
T
S
A
I
A
R
W
H
S
Site 63
S487
S
A
I
A
R
W
H
S
S
A
R
P
P
G
D
Site 64
S488
A
I
A
R
W
H
S
S
A
R
P
P
G
D
A
Site 65
T525
R
C
E
E
V
E
A
T
R
G
Q
V
C
Q
E
Site 66
S541
E
L
R
A
V
V
E
S
C
L
L
E
Q
D
R
Site 67
T560
L
Q
A
R
L
R
E
T
W
A
L
A
R
D
A
Site 68
S582
R
A
C
Q
A
E
L
S
S
R
V
R
Q
D
Q
Site 69
S605
L
A
V
P
P
A
D
S
K
G
W
Q
A
S
L
Site 70
S611
D
S
K
G
W
Q
A
S
L
Q
A
M
S
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation