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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCTD8
Full Name:
BTB/POZ domain-containing protein KCTD8
Alias:
Potassium channel tetramerisation domain containing 8
Type:
Mass (Da):
52440
Number AA:
473
UniProt ID:
Q6ZWB6
International Prot ID:
IPI00383585
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005249
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
A
L
K
D
T
G
S
G
G
S
T
I
Site 2
T12
D
T
G
S
G
G
S
T
I
L
P
I
S
E
M
Site 3
S21
L
P
I
S
E
M
V
S
S
S
S
S
P
G
A
Site 4
S22
P
I
S
E
M
V
S
S
S
S
S
P
G
A
S
Site 5
S23
I
S
E
M
V
S
S
S
S
S
P
G
A
S
A
Site 6
S24
S
E
M
V
S
S
S
S
S
P
G
A
S
A
A
Site 7
S25
E
M
V
S
S
S
S
S
P
G
A
S
A
A
A
Site 8
S29
S
S
S
S
P
G
A
S
A
A
A
A
P
G
P
Site 9
S40
A
P
G
P
C
A
P
S
P
F
P
E
V
V
E
Site 10
T61
V
Y
V
T
K
H
S
T
L
L
S
V
P
D
S
Site 11
S64
T
K
H
S
T
L
L
S
V
P
D
S
T
L
A
Site 12
S72
V
P
D
S
T
L
A
S
M
F
S
P
S
S
P
Site 13
S75
S
T
L
A
S
M
F
S
P
S
S
P
R
G
G
Site 14
S77
L
A
S
M
F
S
P
S
S
P
R
G
G
A
R
Site 15
S78
A
S
M
F
S
P
S
S
P
R
G
G
A
R
R
Site 16
S93
R
G
E
L
P
R
D
S
R
A
R
F
F
I
D
Site 17
Y108
R
D
G
F
L
F
R
Y
V
L
D
Y
L
R
D
Site 18
Y112
L
F
R
Y
V
L
D
Y
L
R
D
K
Q
L
A
Site 19
Y136
R
L
L
R
E
A
E
Y
F
Q
L
T
D
L
V
Site 20
S147
T
D
L
V
K
L
L
S
P
K
V
T
K
Q
N
Site 21
T151
K
L
L
S
P
K
V
T
K
Q
N
S
L
N
D
Site 22
S155
P
K
V
T
K
Q
N
S
L
N
D
E
G
C
Q
Site 23
S163
L
N
D
E
G
C
Q
S
D
L
E
D
N
V
S
Site 24
S170
S
D
L
E
D
N
V
S
Q
G
S
S
D
A
L
Site 25
S174
D
N
V
S
Q
G
S
S
D
A
L
L
L
R
G
Site 26
S206
G
G
A
Q
D
K
R
S
G
F
L
T
L
G
Y
Site 27
T210
D
K
R
S
G
F
L
T
L
G
Y
R
G
S
Y
Site 28
S216
L
T
L
G
Y
R
G
S
Y
T
T
V
R
D
N
Site 29
Y217
T
L
G
Y
R
G
S
Y
T
T
V
R
D
N
Q
Site 30
T218
L
G
Y
R
G
S
Y
T
T
V
R
D
N
Q
A
Site 31
T219
G
Y
R
G
S
Y
T
T
V
R
D
N
Q
A
D
Site 32
T251
A
K
E
V
F
G
D
T
L
N
E
S
R
D
P
Site 33
Y265
P
D
R
Q
P
E
K
Y
T
S
R
F
Y
L
K
Site 34
Y270
E
K
Y
T
S
R
F
Y
L
K
F
T
Y
L
E
Site 35
Y275
R
F
Y
L
K
F
T
Y
L
E
Q
A
F
D
R
Site 36
S284
E
Q
A
F
D
R
L
S
E
A
G
F
H
M
V
Site 37
Y314
D
D
K
I
W
S
S
Y
T
E
Y
I
F
F
R
Site 38
Y317
I
W
S
S
Y
T
E
Y
I
F
F
R
P
P
Q
Site 39
S328
R
P
P
Q
K
I
V
S
P
K
Q
E
H
E
D
Site 40
T342
D
R
K
H
D
K
V
T
D
K
G
S
E
S
G
Site 41
S346
D
K
V
T
D
K
G
S
E
S
G
T
S
C
N
Site 42
T350
D
K
G
S
E
S
G
T
S
C
N
E
L
S
T
Site 43
S351
K
G
S
E
S
G
T
S
C
N
E
L
S
T
S
Site 44
S356
G
T
S
C
N
E
L
S
T
S
S
C
D
S
H
Site 45
T357
T
S
C
N
E
L
S
T
S
S
C
D
S
H
S
Site 46
S358
S
C
N
E
L
S
T
S
S
C
D
S
H
S
E
Site 47
S359
C
N
E
L
S
T
S
S
C
D
S
H
S
E
A
Site 48
S362
L
S
T
S
S
C
D
S
H
S
E
A
S
T
P
Site 49
S364
T
S
S
C
D
S
H
S
E
A
S
T
P
Q
D
Site 50
T368
D
S
H
S
E
A
S
T
P
Q
D
N
P
S
S
Site 51
S375
T
P
Q
D
N
P
S
S
A
Q
Q
A
T
A
H
Site 52
T388
A
H
Q
P
N
T
L
T
L
D
R
P
S
K
K
Site 53
S393
T
L
T
L
D
R
P
S
K
K
A
P
V
Q
W
Site 54
S410
P
P
D
K
R
R
N
S
E
L
F
Q
T
L
I
Site 55
T415
R
N
S
E
L
F
Q
T
L
I
S
K
S
R
E
Site 56
S418
E
L
F
Q
T
L
I
S
K
S
R
E
T
N
L
Site 57
S420
F
Q
T
L
I
S
K
S
R
E
T
N
L
S
K
Site 58
T423
L
I
S
K
S
R
E
T
N
L
S
K
K
K
V
Site 59
S426
K
S
R
E
T
N
L
S
K
K
K
V
C
E
K
Site 60
S435
K
K
V
C
E
K
L
S
V
E
E
E
M
K
K
Site 61
Y455
K
K
I
H
I
P
D
Y
F
P
E
R
K
R
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation