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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHM3
Full Name:
Pleckstrin homology domain-containing family M member 3
Alias:
Type:
Mass (Da):
87166
Number AA:
761
UniProt ID:
Q6ZWE6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
E
V
T
E
E
F
F
S
T
L
D
S
N
L
E
Site 2
T22
V
T
E
E
F
F
S
T
L
D
S
N
L
E
K
Site 3
S25
E
F
F
S
T
L
D
S
N
L
E
K
A
V
Q
Site 4
T64
N
G
A
M
R
N
V
T
S
L
G
K
G
G
M
Site 5
T101
Q
F
M
V
Q
R
G
T
T
P
D
N
L
S
W
Site 6
T102
F
M
V
Q
R
G
T
T
P
D
N
L
S
W
M
Site 7
S107
G
T
T
P
D
N
L
S
W
M
E
Q
K
E
A
Site 8
S132
R
R
R
D
R
P
R
S
V
N
D
L
L
D
E
Site 9
T140
V
N
D
L
L
D
E
T
S
T
F
K
P
G
H
Site 10
S141
N
D
L
L
D
E
T
S
T
F
K
P
G
H
A
Site 11
T142
D
L
L
D
E
T
S
T
F
K
P
G
H
A
R
Site 12
S150
F
K
P
G
H
A
R
S
R
S
D
I
T
Q
V
Site 13
S152
P
G
H
A
R
S
R
S
D
I
T
Q
V
D
W
Site 14
T155
A
R
S
R
S
D
I
T
Q
V
D
W
R
V
V
Site 15
T165
D
W
R
V
V
L
K
T
T
P
L
Q
Q
Q
Q
Site 16
T166
W
R
V
V
L
K
T
T
P
L
Q
Q
Q
Q
Q
Site 17
S187
G
P
H
V
T
R
P
S
F
L
L
P
S
P
N
Site 18
S192
R
P
S
F
L
L
P
S
P
N
K
I
E
D
A
Site 19
T203
I
E
D
A
Q
G
N
T
E
H
K
Q
T
F
P
Site 20
T208
G
N
T
E
H
K
Q
T
F
P
N
I
L
K
K
Site 21
Y227
I
R
K
D
H
D
S
Y
W
Q
S
C
Y
A
E
Site 22
Y232
D
S
Y
W
Q
S
C
Y
A
E
L
S
P
Y
N
Site 23
Y241
E
L
S
P
Y
N
L
Y
F
Y
S
L
D
S
S
Site 24
Y243
S
P
Y
N
L
Y
F
Y
S
L
D
S
S
G
N
Site 25
S244
P
Y
N
L
Y
F
Y
S
L
D
S
S
G
N
Q
Site 26
S247
L
Y
F
Y
S
L
D
S
S
G
N
Q
N
L
Y
Site 27
S248
Y
F
Y
S
L
D
S
S
G
N
Q
N
L
Y
A
Site 28
Y254
S
S
G
N
Q
N
L
Y
A
T
Y
Q
L
S
H
Site 29
T278
L
E
A
R
M
V
D
T
V
L
Y
D
N
T
Q
Site 30
Y281
R
M
V
D
T
V
L
Y
D
N
T
Q
L
Q
L
Site 31
S292
Q
L
Q
L
K
A
E
S
P
W
E
A
L
D
W
Site 32
Y314
V
H
A
A
V
P
G
Y
M
G
R
Q
N
E
L
Site 33
T322
M
G
R
Q
N
E
L
T
I
S
P
G
L
G
H
Site 34
S324
R
Q
N
E
L
T
I
S
P
G
L
G
H
H
D
Site 35
Y333
G
L
G
H
H
D
D
Y
T
Q
N
H
S
F
Q
Site 36
T334
L
G
H
H
D
D
Y
T
Q
N
H
S
F
Q
K
Site 37
S338
D
D
Y
T
Q
N
H
S
F
Q
K
K
T
S
G
Site 38
S344
H
S
F
Q
K
K
T
S
G
L
L
P
P
S
P
Site 39
S350
T
S
G
L
L
P
P
S
P
V
L
D
S
S
K
Site 40
S355
P
P
S
P
V
L
D
S
S
K
Q
Y
Q
N
I
Site 41
S356
P
S
P
V
L
D
S
S
K
Q
Y
Q
N
I
L
Site 42
Y359
V
L
D
S
S
K
Q
Y
Q
N
I
L
K
S
G
Site 43
S365
Q
Y
Q
N
I
L
K
S
G
T
L
Y
R
L
T
Site 44
T367
Q
N
I
L
K
S
G
T
L
Y
R
L
T
V
Q
Site 45
Y369
I
L
K
S
G
T
L
Y
R
L
T
V
Q
N
N
Site 46
T372
S
G
T
L
Y
R
L
T
V
Q
N
N
W
K
A
Site 47
T440
V
L
R
L
R
A
E
T
R
Q
R
A
Q
E
W
Site 48
S461
A
A
N
V
A
R
S
S
E
Q
N
L
Q
V
T
Site 49
T468
S
E
Q
N
L
Q
V
T
L
R
N
K
P
K
D
Site 50
S489
L
R
K
N
K
R
Q
S
V
T
T
S
F
L
S
Site 51
T491
K
N
K
R
Q
S
V
T
T
S
F
L
S
I
L
Site 52
T492
N
K
R
Q
S
V
T
T
S
F
L
S
I
L
T
Site 53
S493
K
R
Q
S
V
T
T
S
F
L
S
I
L
T
T
Site 54
S511
E
R
G
L
T
A
Q
S
F
K
C
A
G
C
Q
Site 55
S520
K
C
A
G
C
Q
R
S
I
G
L
S
N
G
K
Site 56
S524
C
Q
R
S
I
G
L
S
N
G
K
A
K
V
C
Site 57
T560
R
I
V
H
N
W
D
T
S
K
Y
K
V
S
K
Site 58
Y563
H
N
W
D
T
S
K
Y
K
V
S
K
Q
A
K
Site 59
Y575
Q
A
K
E
F
L
E
Y
V
Y
E
E
P
L
I
Site 60
Y577
K
E
F
L
E
Y
V
Y
E
E
P
L
I
D
I
Site 61
Y592
Q
Q
E
N
A
M
L
Y
H
H
A
E
P
L
A
Site 62
S610
R
L
R
Q
R
L
K
S
L
R
A
Y
L
F
S
Site 63
Y614
R
L
K
S
L
R
A
Y
L
F
S
C
R
A
A
Site 64
Y635
R
R
I
F
P
R
E
Y
L
L
Q
Q
I
H
L
Site 65
Y672
K
F
A
T
S
H
V
Y
S
C
S
L
C
S
Q
Site 66
S673
F
A
T
S
H
V
Y
S
C
S
L
C
S
Q
K
Site 67
S675
T
S
H
V
Y
S
C
S
L
C
S
Q
K
G
F
Site 68
Y694
C
N
N
G
E
I
L
Y
P
F
E
D
I
S
T
Site 69
S700
L
Y
P
F
E
D
I
S
T
S
R
C
E
S
C
Site 70
T701
Y
P
F
E
D
I
S
T
S
R
C
E
S
C
G
Site 71
S702
P
F
E
D
I
S
T
S
R
C
E
S
C
G
A
Site 72
S706
I
S
T
S
R
C
E
S
C
G
A
V
F
H
S
Site 73
S713
S
C
G
A
V
F
H
S
E
C
K
E
K
S
V
Site 74
S746
Q
R
L
N
M
D
E
S
L
E
E
A
C
T
M
Site 75
T752
E
S
L
E
E
A
C
T
M
F
E
L
S
Y
Q
Site 76
T761
F
E
L
S
Y
Q
N
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation