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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEK10
Full Name:
Serine/threonine-protein kinase Nek10
Alias:
Never in mitosis A-related kinase 10
Type:
Mass (Da):
133229
Number AA:
1172
UniProt ID:
Q6ZWH5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
D
Q
D
K
K
V
K
T
T
E
K
S
T
D
K
Site 2
T22
T
D
K
Q
Q
E
I
T
I
R
D
Y
S
D
L
Site 3
Y26
Q
E
I
T
I
R
D
Y
S
D
L
K
R
L
R
Site 4
S27
E
I
T
I
R
D
Y
S
D
L
K
R
L
R
C
Site 5
S40
R
C
L
L
N
V
Q
S
S
K
Q
Q
L
P
A
Site 6
S52
L
P
A
I
N
F
D
S
A
Q
N
S
M
T
K
Site 7
S56
N
F
D
S
A
Q
N
S
M
T
K
S
E
P
A
Site 8
S60
A
Q
N
S
M
T
K
S
E
P
A
I
R
A
G
Site 9
T79
R
G
Q
W
H
E
S
T
E
A
V
E
L
E
N
Site 10
S98
Y
K
N
E
R
N
F
S
K
H
P
Q
R
K
L
Site 11
S120
L
V
K
N
R
L
I
S
R
E
W
V
N
R
A
Site 12
Y164
G
I
E
N
L
A
Q
Y
M
E
I
V
A
N
E
Site 13
Y172
M
E
I
V
A
N
E
Y
L
G
Y
G
E
E
Q
Site 14
Y175
V
A
N
E
Y
L
G
Y
G
E
E
Q
H
T
V
Site 15
T181
G
Y
G
E
E
Q
H
T
V
D
K
L
V
N
M
Site 16
T207
D
Q
R
E
W
V
T
T
S
G
A
H
K
T
L
Site 17
S239
A
L
A
S
L
A
E
S
Q
E
C
R
E
K
I
Site 18
S266
L
H
E
Y
D
L
L
S
K
R
L
T
A
E
L
Site 19
T324
Q
V
C
E
D
P
E
T
S
V
E
I
R
I
W
Site 20
S349
Q
G
D
R
N
F
V
S
D
H
S
S
I
G
S
Site 21
S352
R
N
F
V
S
D
H
S
S
I
G
S
L
S
S
Site 22
S353
N
F
V
S
D
H
S
S
I
G
S
L
S
S
A
Site 23
S356
S
D
H
S
S
I
G
S
L
S
S
A
N
A
A
Site 24
S358
H
S
S
I
G
S
L
S
S
A
N
A
A
G
R
Site 25
S372
R
I
Q
Q
L
H
L
S
E
D
L
S
P
R
E
Site 26
S376
L
H
L
S
E
D
L
S
P
R
E
I
Q
E
N
Site 27
T403
T
E
L
V
L
N
D
T
N
A
H
Q
V
V
Q
Site 28
S432
K
Q
K
N
A
A
K
S
N
L
L
Q
C
Y
A
Site 29
Y438
K
S
N
L
L
Q
C
Y
A
F
R
A
L
R
F
Site 30
S448
R
A
L
R
F
L
F
S
M
E
R
N
R
P
L
Site 31
S479
G
H
Y
V
R
D
I
S
A
Y
E
E
L
V
S
Site 32
Y481
Y
V
R
D
I
S
A
Y
E
E
L
V
S
K
L
Site 33
S505
Q
I
A
E
N
I
E
S
I
N
Q
N
K
A
P
Site 34
Y534
S
G
A
F
G
C
V
Y
K
V
R
K
H
S
G
Site 35
S540
V
Y
K
V
R
K
H
S
G
Q
N
L
L
A
M
Site 36
S566
K
D
K
K
D
R
D
S
S
V
R
N
I
V
S
Site 37
S567
D
K
K
D
R
D
S
S
V
R
N
I
V
S
E
Site 38
Y583
T
I
I
K
E
Q
L
Y
H
P
N
I
V
R
Y
Site 39
Y590
Y
H
P
N
I
V
R
Y
Y
K
T
F
L
E
N
Site 40
Y591
H
P
N
I
V
R
Y
Y
K
T
F
L
E
N
D
Site 41
T593
N
I
V
R
Y
Y
K
T
F
L
E
N
D
R
L
Site 42
S617
A
P
L
G
E
H
F
S
S
L
K
E
K
H
H
Site 43
S618
P
L
G
E
H
F
S
S
L
K
E
K
H
H
H
Site 44
T657
R
I
V
H
R
D
L
T
P
N
N
I
M
L
G
Site 45
S684
A
K
Q
K
Q
E
N
S
K
L
T
S
V
V
G
Site 46
S688
Q
E
N
S
K
L
T
S
V
V
G
T
I
L
Y
Site 47
S703
S
C
P
E
V
L
K
S
E
P
Y
G
E
K
A
Site 48
S726
L
Y
Q
M
A
T
L
S
P
P
F
Y
S
T
N
Site 49
S755
P
V
P
E
G
I
Y
S
E
K
V
T
D
T
I
Site 50
T759
G
I
Y
S
E
K
V
T
D
T
I
S
R
C
L
Site 51
T761
Y
S
E
K
V
T
D
T
I
S
R
C
L
T
P
Site 52
S763
E
K
V
T
D
T
I
S
R
C
L
T
P
D
A
Site 53
T767
D
T
I
S
R
C
L
T
P
D
A
E
A
R
P
Site 54
Y790
I
S
D
V
M
M
K
Y
L
D
N
L
S
T
S
Site 55
S795
M
K
Y
L
D
N
L
S
T
S
Q
L
S
L
E
Site 56
T796
K
Y
L
D
N
L
S
T
S
Q
L
S
L
E
K
Site 57
S797
Y
L
D
N
L
S
T
S
Q
L
S
L
E
K
K
Site 58
S800
N
L
S
T
S
Q
L
S
L
E
K
K
L
E
R
Site 59
T812
L
E
R
E
R
R
R
T
Q
R
Y
F
M
E
A
Site 60
Y815
E
R
R
R
T
Q
R
Y
F
M
E
A
N
R
N
Site 61
S834
H
H
E
L
A
V
L
S
H
E
T
F
E
K
A
Site 62
S842
H
E
T
F
E
K
A
S
L
S
S
S
S
S
G
Site 63
S844
T
F
E
K
A
S
L
S
S
S
S
S
G
A
A
Site 64
S846
E
K
A
S
L
S
S
S
S
S
G
A
A
S
L
Site 65
S848
A
S
L
S
S
S
S
S
G
A
A
S
L
K
S
Site 66
S852
S
S
S
S
G
A
A
S
L
K
S
E
L
S
E
Site 67
S855
S
G
A
A
S
L
K
S
E
L
S
E
S
A
D
Site 68
S858
A
S
L
K
S
E
L
S
E
S
A
D
L
P
P
Site 69
S860
L
K
S
E
L
S
E
S
A
D
L
P
P
E
G
Site 70
S871
P
P
E
G
F
Q
A
S
Y
G
K
D
E
D
R
Site 71
S885
R
A
C
D
E
I
L
S
D
D
N
F
N
L
E
Site 72
Y899
E
N
A
E
K
D
T
Y
S
E
V
D
D
E
L
Site 73
S900
N
A
E
K
D
T
Y
S
E
V
D
D
E
L
D
Site 74
S909
V
D
D
E
L
D
I
S
D
N
S
S
S
S
S
Site 75
S912
E
L
D
I
S
D
N
S
S
S
S
S
S
S
P
Site 76
S913
L
D
I
S
D
N
S
S
S
S
S
S
S
P
L
Site 77
S914
D
I
S
D
N
S
S
S
S
S
S
S
P
L
K
Site 78
S915
I
S
D
N
S
S
S
S
S
S
S
P
L
K
E
Site 79
S916
S
D
N
S
S
S
S
S
S
S
P
L
K
E
S
Site 80
S917
D
N
S
S
S
S
S
S
S
P
L
K
E
S
T
Site 81
S918
N
S
S
S
S
S
S
S
P
L
K
E
S
T
F
Site 82
S923
S
S
S
P
L
K
E
S
T
F
N
I
L
K
R
Site 83
T924
S
S
P
L
K
E
S
T
F
N
I
L
K
R
S
Site 84
S931
T
F
N
I
L
K
R
S
F
S
A
S
G
G
E
Site 85
S933
N
I
L
K
R
S
F
S
A
S
G
G
E
R
Q
Site 86
S935
L
K
R
S
F
S
A
S
G
G
E
R
Q
S
Q
Site 87
S941
A
S
G
G
E
R
Q
S
Q
T
R
D
F
T
G
Site 88
T943
G
G
E
R
Q
S
Q
T
R
D
F
T
G
G
T
Site 89
T947
Q
S
Q
T
R
D
F
T
G
G
T
G
S
R
P
Site 90
S952
D
F
T
G
G
T
G
S
R
P
R
P
A
L
L
Site 91
S1021
A
S
A
G
I
A
V
S
Q
R
K
V
R
Q
I
Site 92
S1029
Q
R
K
V
R
Q
I
S
D
P
I
Q
Q
I
L
Site 93
S1067
V
I
E
R
F
K
K
S
L
F
S
Q
Q
S
N
Site 94
S1070
R
F
K
K
S
L
F
S
Q
Q
S
N
P
C
N
Site 95
S1073
K
S
L
F
S
Q
Q
S
N
P
C
N
L
K
S
Site 96
S1080
S
N
P
C
N
L
K
S
E
I
K
K
L
S
Q
Site 97
S1086
K
S
E
I
K
K
L
S
Q
G
S
P
E
P
I
Site 98
S1089
I
K
K
L
S
Q
G
S
P
E
P
I
E
P
N
Site 99
Y1102
P
N
F
F
T
A
D
Y
H
L
L
H
R
S
S
Site 100
S1108
D
Y
H
L
L
H
R
S
S
G
G
N
S
L
S
Site 101
S1109
Y
H
L
L
H
R
S
S
G
G
N
S
L
S
P
Site 102
S1113
H
R
S
S
G
G
N
S
L
S
P
N
D
P
T
Site 103
S1115
S
S
G
G
N
S
L
S
P
N
D
P
T
G
L
Site 104
T1120
S
L
S
P
N
D
P
T
G
L
P
T
S
I
E
Site 105
S1125
D
P
T
G
L
P
T
S
I
E
L
E
E
G
I
Site 106
T1133
I
E
L
E
E
G
I
T
Y
E
Q
M
Q
T
V
Site 107
Y1134
E
L
E
E
G
I
T
Y
E
Q
M
Q
T
V
I
Site 108
T1139
I
T
Y
E
Q
M
Q
T
V
I
E
E
V
L
E
Site 109
Y1150
E
V
L
E
E
S
G
Y
Y
N
F
T
S
N
R
Site 110
Y1151
V
L
E
E
S
G
Y
Y
N
F
T
S
N
R
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation