KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
USP49
Full Name:
Ubiquitin carboxyl-terminal hydrolase 49
Alias:
Deubiquitinating enzyme 49;Ubiquitin thiolesterase 49;Ubiquitin-specific-processing protease 49
Type:
Mass (Da):
79198
Number AA:
688
UniProt ID:
Q70CQ1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
L
R
L
A
Q
D
H
S
I
L
N
P
Q
K
W
Site 2
Y82
F
C
Y
L
C
K
D
Y
V
L
N
D
N
P
E
Site 3
T109
V
R
G
Q
K
Q
D
T
P
V
R
R
G
R
T
Site 4
T116
T
P
V
R
R
G
R
T
L
R
S
M
A
S
G
Site 5
S122
R
T
L
R
S
M
A
S
G
E
D
V
V
L
P
Site 6
Y145
Q
M
L
T
A
L
W
Y
R
R
Q
R
L
L
A
Site 7
T154
R
Q
R
L
L
A
R
T
L
R
L
W
F
E
K
Site 8
S162
L
R
L
W
F
E
K
S
S
R
G
Q
A
K
L
Site 9
S202
R
L
L
E
E
L
A
S
T
P
P
R
K
S
A
Site 10
T203
L
L
E
E
L
A
S
T
P
P
R
K
S
A
R
Site 11
S208
A
S
T
P
P
R
K
S
A
R
L
L
L
H
T
Site 12
T215
S
A
R
L
L
L
H
T
P
R
D
A
G
P
A
Site 13
T231
S
R
P
A
A
L
P
T
S
R
R
V
P
A
A
Site 14
S232
R
P
A
A
L
P
T
S
R
R
V
P
A
A
T
Site 15
T239
S
R
R
V
P
A
A
T
L
K
L
R
R
Q
P
Site 16
Y263
R
N
L
G
N
T
C
Y
M
N
S
I
L
Q
V
Site 17
S272
N
S
I
L
Q
V
L
S
H
L
Q
K
F
R
E
Site 18
S287
C
F
L
N
L
D
P
S
K
T
E
H
L
F
P
Site 19
T289
L
N
L
D
P
S
K
T
E
H
L
F
P
K
A
Site 20
S304
T
N
G
K
T
Q
L
S
G
K
P
T
N
S
S
Site 21
T308
T
Q
L
S
G
K
P
T
N
S
S
A
T
E
L
Site 22
S310
L
S
G
K
P
T
N
S
S
A
T
E
L
S
L
Site 23
S316
N
S
S
A
T
E
L
S
L
R
N
D
R
A
E
Site 24
S337
F
C
W
N
G
R
A
S
I
S
R
S
L
E
L
Site 25
S341
G
R
A
S
I
S
R
S
L
E
L
I
Q
N
K
Site 26
S351
L
I
Q
N
K
E
P
S
S
K
H
I
S
L
C
Site 27
S352
I
Q
N
K
E
P
S
S
K
H
I
S
L
C
R
Site 28
S356
E
P
S
S
K
H
I
S
L
C
R
E
L
H
T
Site 29
Y395
L
I
P
A
F
R
G
Y
D
Q
Q
D
A
Q
E
Site 30
T420
Q
E
L
E
S
E
G
T
T
R
R
I
L
I
P
Site 31
T421
E
L
E
S
E
G
T
T
R
R
I
L
I
P
F
Site 32
S429
R
R
I
L
I
P
F
S
Q
R
K
L
T
K
Q
Site 33
T434
P
F
S
Q
R
K
L
T
K
Q
V
L
K
V
V
Site 34
S472
I
E
P
F
W
D
L
S
L
E
F
P
E
R
Y
Site 35
Y479
S
L
E
F
P
E
R
Y
H
C
I
E
K
G
F
Site 36
T497
N
Q
T
E
C
L
L
T
E
M
L
A
K
F
T
Site 37
Y514
E
A
L
E
G
R
I
Y
A
C
D
Q
C
N
S
Site 38
S526
C
N
S
K
R
R
K
S
N
P
K
P
L
V
L
Site 39
S534
N
P
K
P
L
V
L
S
E
A
R
K
Q
L
M
Site 40
Y543
A
R
K
Q
L
M
I
Y
R
L
P
Q
V
L
R
Site 41
S559
H
L
K
R
F
R
W
S
G
R
N
H
R
E
K
Site 42
Y582
Q
V
L
T
M
E
P
Y
C
C
R
D
M
L
S
Site 43
S590
C
C
R
D
M
L
S
S
L
D
K
E
T
F
A
Site 44
T595
L
S
S
L
D
K
E
T
F
A
Y
D
L
S
A
Site 45
Y616
K
G
F
G
S
G
H
Y
T
A
Y
C
Y
N
T
Site 46
Y619
G
S
G
H
Y
T
A
Y
C
Y
N
T
E
G
G
Site 47
S666
V
Q
G
N
A
R
I
S
E
T
H
L
Q
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation