KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
USP34
Full Name:
Ubiquitin carboxyl-terminal hydrolase 34
Alias:
Deubiquitinating enzyme 34; KIAA0570; KIAA0729; Ubiquitin specific peptidase 34; Ubiquitin thioesterase 34; Ubiquitin-specific proteinase 34; Ubiquitin-specific-processing protease 34; UBP34
Type:
Protease; EC 3.1.2.15
Mass (Da):
404233
Number AA:
3546
UniProt ID:
Q70CQ2
International Prot ID:
IPI00297593
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
V
E
V
L
N
E
I
S
D
V
E
G
G
D
G
Site 2
T31
L
Q
L
R
K
E
H
T
L
K
I
F
T
Y
I
Site 3
T36
P
T
I
E
D
I
S
T
Q
E
S
N
I
L
G
Site 4
Y37
H
T
L
K
I
F
T
Y
I
N
S
W
T
Q
R
Site 5
T93
T
T
I
N
I
D
S
T
W
Q
D
E
S
N
Q
Site 6
T116
R
E
C
N
E
G
S
T
E
R
Q
K
S
I
E
Site 7
S121
G
S
T
E
R
Q
K
S
I
E
K
K
S
N
S
Site 8
S126
Q
K
S
I
E
K
K
S
N
S
T
R
I
C
N
Site 9
S128
S
I
E
K
K
S
N
S
T
R
I
C
N
L
T
Site 10
T135
S
T
R
I
C
N
L
T
E
E
E
S
S
K
S
Site 11
S139
C
N
L
T
E
E
E
S
S
K
S
S
D
P
F
Site 12
S140
N
L
T
E
E
E
S
S
K
S
S
D
P
F
S
Site 13
S142
T
E
E
E
S
S
K
S
S
D
P
F
S
L
W
Site 14
S143
E
E
E
S
S
K
S
S
D
P
F
S
L
W
S
Site 15
S147
S
K
S
S
D
P
F
S
L
W
S
T
D
E
K
Site 16
S150
S
D
P
F
S
L
W
S
T
D
E
K
E
K
L
Site 17
T151
D
P
F
S
L
W
S
T
D
E
K
E
K
L
L
Site 18
Y172
F
Q
I
Q
F
P
L
Y
T
A
Y
K
H
N
T
Site 19
S187
H
P
T
I
E
D
I
S
T
Q
E
S
N
I
L
Site 20
T188
P
T
I
E
D
I
S
T
Q
E
S
N
I
L
G
Site 21
S191
E
D
I
S
T
Q
E
S
N
I
L
G
A
F
C
Site 22
Y231
L
M
K
D
C
F
E
Y
G
T
P
E
T
L
P
Site 23
T233
K
D
C
F
E
Y
G
T
P
E
T
L
P
F
L
Site 24
Y275
F
R
T
Y
V
I
R
Y
L
C
K
L
S
D
Q
Site 25
S280
I
R
Y
L
C
K
L
S
D
Q
E
L
R
Q
S
Site 26
S287
S
D
Q
E
L
R
Q
S
A
A
R
N
M
A
D
Site 27
T306
T
V
K
E
P
L
D
T
T
L
C
F
D
K
E
Site 28
T307
V
K
E
P
L
D
T
T
L
C
F
D
K
E
S
Site 29
Y321
S
L
D
L
A
F
K
Y
F
M
S
P
T
L
T
Site 30
S324
L
A
F
K
Y
F
M
S
P
T
L
T
M
R
L
Site 31
T326
F
K
Y
F
M
S
P
T
L
T
M
R
L
A
G
Site 32
T328
Y
F
M
S
P
T
L
T
M
R
L
A
G
L
S
Site 33
S335
T
M
R
L
A
G
L
S
Q
I
T
N
Q
L
H
Site 34
S352
N
D
V
C
N
N
E
S
L
V
S
D
T
E
T
Site 35
S355
C
N
N
E
S
L
V
S
D
T
E
T
S
I
A
Site 36
T359
S
L
V
S
D
T
E
T
S
I
A
K
E
L
A
Site 37
T406
A
A
E
G
R
L
S
T
Q
H
I
D
C
I
W
Site 38
S431
Y
I
H
D
L
F
P
S
L
I
K
N
L
D
P
Site 39
S465
E
Q
T
L
Y
L
A
S
M
L
I
K
A
L
W
Site 40
S483
L
A
A
K
A
Q
L
S
K
Q
S
S
F
A
S
Site 41
S486
K
A
Q
L
S
K
Q
S
S
F
A
S
L
L
N
Site 42
S487
A
Q
L
S
K
Q
S
S
F
A
S
L
L
N
T
Site 43
S490
S
K
Q
S
S
F
A
S
L
L
N
T
N
I
P
Site 44
T510
E
E
E
E
L
R
R
T
A
P
S
P
W
S
P
Site 45
S513
E
L
R
R
T
A
P
S
P
W
S
P
A
A
S
Site 46
S516
R
T
A
P
S
P
W
S
P
A
A
S
P
Q
S
Site 47
S520
S
P
W
S
P
A
A
S
P
Q
S
S
D
N
S
Site 48
S523
S
P
A
A
S
P
Q
S
S
D
N
S
D
T
H
Site 49
S524
P
A
A
S
P
Q
S
S
D
N
S
D
T
H
Q
Site 50
S527
S
P
Q
S
S
D
N
S
D
T
H
Q
S
G
G
Site 51
T529
Q
S
S
D
N
S
D
T
H
Q
S
G
G
S
D
Site 52
S555
K
H
V
Q
Q
R
L
S
D
T
E
E
S
M
Q
Site 53
T557
V
Q
Q
R
L
S
D
T
E
E
S
M
Q
G
S
Site 54
S560
R
L
S
D
T
E
E
S
M
Q
G
S
S
D
E
Site 55
S564
T
E
E
S
M
Q
G
S
S
D
E
T
A
N
S
Site 56
S565
E
E
S
M
Q
G
S
S
D
E
T
A
N
S
G
Site 57
T568
M
Q
G
S
S
D
E
T
A
N
S
G
E
D
G
Site 58
S571
S
S
D
E
T
A
N
S
G
E
D
G
S
S
G
Site 59
S576
A
N
S
G
E
D
G
S
S
G
P
G
S
S
S
Site 60
S577
N
S
G
E
D
G
S
S
G
P
G
S
S
S
G
Site 61
S581
D
G
S
S
G
P
G
S
S
S
G
H
S
D
G
Site 62
S582
G
S
S
G
P
G
S
S
S
G
H
S
D
G
S
Site 63
S583
S
S
G
P
G
S
S
S
G
H
S
D
G
S
S
Site 64
S586
P
G
S
S
S
G
H
S
D
G
S
S
N
E
V
Site 65
S589
S
S
G
H
S
D
G
S
S
N
E
V
N
S
S
Site 66
S590
S
G
H
S
D
G
S
S
N
E
V
N
S
S
H
Site 67
S595
G
S
S
N
E
V
N
S
S
H
A
S
Q
S
A
Site 68
S596
S
S
N
E
V
N
S
S
H
A
S
Q
S
A
G
Site 69
S599
E
V
N
S
S
H
A
S
Q
S
A
G
S
P
G
Site 70
S601
N
S
S
H
A
S
Q
S
A
G
S
P
G
S
E
Site 71
S604
H
A
S
Q
S
A
G
S
P
G
S
E
V
Q
S
Site 72
S607
Q
S
A
G
S
P
G
S
E
V
Q
S
E
D
I
Site 73
S611
S
P
G
S
E
V
Q
S
E
D
I
A
D
I
E
Site 74
S636
H
G
H
N
P
P
K
S
S
C
G
T
D
L
R
Site 75
T640
P
P
K
S
S
C
G
T
D
L
R
N
R
K
L
Site 76
S649
L
R
N
R
K
L
E
S
Q
A
G
I
C
L
G
Site 77
S658
A
G
I
C
L
G
D
S
Q
G
T
S
E
R
N
Site 78
S662
L
G
D
S
Q
G
M
S
E
R
N
G
T
S
S
Site 79
T667
G
M
S
E
R
N
G
T
S
S
G
T
G
K
D
Site 80
S668
M
S
E
R
N
G
T
S
S
G
T
G
K
D
L
Site 81
S669
S
E
R
N
G
T
S
S
G
T
G
K
D
L
V
Site 82
T679
G
K
D
L
V
F
N
T
E
S
L
P
S
V
D
Site 83
S681
D
L
V
F
N
T
E
S
L
P
S
V
D
N
R
Site 84
S684
F
N
T
E
S
L
P
S
V
D
N
R
M
R
M
Site 85
S696
M
R
M
L
D
A
C
S
H
S
E
D
P
E
H
Site 86
S698
M
L
D
A
C
S
H
S
E
D
P
E
H
D
I
Site 87
S706
E
D
P
E
H
D
I
S
G
E
M
N
A
T
H
Site 88
T712
I
S
G
E
M
N
A
T
H
I
A
Q
G
S
Q
Site 89
S718
A
T
H
I
A
Q
G
S
Q
E
S
C
I
T
R
Site 90
T724
G
S
Q
E
S
C
I
T
R
T
G
D
F
L
G
Site 91
T733
T
G
D
F
L
G
E
T
I
G
N
E
L
F
N
Site 92
S770
H
M
V
D
D
M
L
S
A
D
D
V
S
C
S
Site 93
S775
M
L
S
A
D
D
V
S
C
S
S
S
Q
V
S
Site 94
S777
S
A
D
D
V
S
C
S
S
S
Q
V
S
A
K
Site 95
S778
A
D
D
V
S
C
S
S
S
Q
V
S
A
K
S
Site 96
S779
D
D
V
S
C
S
S
S
Q
V
S
A
K
S
E
Site 97
S782
S
C
S
S
S
Q
V
S
A
K
S
E
K
N
M
Site 98
S785
S
S
Q
V
S
A
K
S
E
K
N
M
A
D
F
Site 99
S797
A
D
F
D
G
E
E
S
G
C
E
E
E
L
V
Site 100
S808
E
E
L
V
Q
I
N
S
H
A
E
L
T
S
H
Site 101
S825
Q
H
L
P
N
L
A
S
I
Y
H
E
H
L
S
Site 102
Y827
L
P
N
L
A
S
I
Y
H
E
H
L
S
Q
G
Site 103
S832
S
I
Y
H
E
H
L
S
Q
G
P
V
V
H
K
Site 104
T848
Q
F
N
S
N
A
V
T
D
I
N
L
D
N
V
Site 105
S916
E
N
L
G
N
N
R
S
V
V
I
S
L
R
L
Site 106
S920
N
N
R
S
V
V
I
S
L
R
L
L
P
K
L
Site 107
Y964
F
F
D
N
L
V
Y
Y
I
Q
T
V
R
E
G
Site 108
S979
R
Q
K
H
A
L
Y
S
H
S
A
E
V
Q
V
Site 109
S981
K
H
A
L
Y
S
H
S
A
E
V
Q
V
R
L
Site 110
S1007
S
P
D
H
F
R
L
S
L
E
Q
V
D
I
L
Site 111
T1064
M
P
Q
L
K
P
E
T
I
S
M
T
G
L
N
Site 112
Y1087
A
R
L
A
T
S
A
Y
D
G
C
S
N
S
E
Site 113
S1091
T
S
A
Y
D
G
C
S
N
S
E
L
C
G
M
Site 114
S1110
G
I
A
L
R
A
Q
S
G
D
V
S
R
A
A
Site 115
S1114
R
A
Q
S
G
D
V
S
R
A
A
I
Q
Y
I
Site 116
Y1120
V
S
R
A
A
I
Q
Y
I
N
S
Y
Y
I
N
Site 117
Y1124
A
I
Q
Y
I
N
S
Y
Y
I
N
G
K
T
G
Site 118
Y1125
I
Q
Y
I
N
S
Y
Y
I
N
G
K
T
G
L
Site 119
S1151
E
S
L
M
I
A
S
S
S
L
E
Q
E
S
H
Site 120
S1152
S
L
M
I
A
S
S
S
L
E
Q
E
S
H
S
Site 121
S1157
S
S
S
L
E
Q
E
S
H
S
S
L
M
V
I
Site 122
S1160
L
E
Q
E
S
H
S
S
L
M
V
I
E
R
G
Site 123
T1173
R
G
L
L
M
L
K
T
H
L
E
A
F
R
R
Site 124
S1204
S
S
H
L
K
A
L
S
D
K
Q
S
L
P
L
Site 125
S1208
K
A
L
S
D
K
Q
S
L
P
L
R
V
V
C
Site 126
T1225
A
G
L
P
D
K
M
T
I
E
M
Y
P
S
D
Site 127
Y1229
D
K
M
T
I
E
M
Y
P
S
D
Q
V
A
D
Site 128
S1231
M
T
I
E
M
Y
P
S
D
Q
V
A
D
L
R
Site 129
Y1245
R
A
E
V
T
H
W
Y
E
N
L
Q
K
E
Q
Site 130
S1265
Q
L
Q
E
F
G
Q
S
N
R
K
G
E
F
P
Site 131
S1283
M
G
P
V
R
M
I
S
S
G
H
E
L
T
T
Site 132
S1284
G
P
V
R
M
I
S
S
G
H
E
L
T
T
D
Site 133
Y1292
G
H
E
L
T
T
D
Y
D
E
K
A
L
H
E
Site 134
S1329
E
G
V
Q
L
P
A
S
C
L
P
P
P
Q
K
Site 135
S1362
D
L
L
E
M
L
A
S
F
K
P
P
S
G
K
Site 136
S1367
L
A
S
F
K
P
P
S
G
K
V
A
V
D
D
Site 137
S1375
G
K
V
A
V
D
D
S
E
S
L
R
C
E
E
Site 138
S1377
V
A
V
D
D
S
E
S
L
R
C
E
E
L
H
Site 139
S1391
H
L
H
A
E
N
L
S
R
R
V
W
E
L
L
Site 140
S1415
L
M
A
F
Q
N
I
S
D
E
Q
S
N
D
G
Site 141
S1433
K
E
L
L
K
I
K
S
A
H
K
L
L
Y
A
Site 142
Y1439
K
S
A
H
K
L
L
Y
A
L
E
I
I
E
A
Site 143
S1458
N
R
R
I
R
R
E
S
T
G
S
Y
S
D
L
Site 144
T1459
R
R
I
R
R
E
S
T
G
S
Y
S
D
L
Y
Site 145
S1461
I
R
R
E
S
T
G
S
Y
S
D
L
Y
P
D
Site 146
Y1462
R
R
E
S
T
G
S
Y
S
D
L
Y
P
D
S
Site 147
S1463
R
E
S
T
G
S
Y
S
D
L
Y
P
D
S
D
Site 148
Y1466
T
G
S
Y
S
D
L
Y
P
D
S
D
D
S
S
Site 149
S1469
Y
S
D
L
Y
P
D
S
D
D
S
S
E
D
Q
Site 150
S1472
L
Y
P
D
S
D
D
S
S
E
D
Q
V
E
N
Site 151
S1473
Y
P
D
S
D
D
S
S
E
D
Q
V
E
N
S
Site 152
S1480
S
E
D
Q
V
E
N
S
K
N
S
W
S
C
K
Site 153
S1503
Q
L
L
E
I
F
N
S
G
I
L
E
P
K
E
Site 154
S1537
C
Q
F
A
V
D
P
S
D
L
D
L
A
Y
H
Site 155
Y1543
P
S
D
L
D
L
A
Y
H
D
V
F
A
W
S
Site 156
T1560
A
E
S
H
R
K
R
T
W
P
G
K
S
R
K
Site 157
S1600
S
L
I
Q
R
L
M
S
V
A
Y
T
Y
D
N
Site 158
T1604
R
L
M
S
V
A
Y
T
Y
D
N
L
A
P
R
Site 159
S1617
P
R
V
L
K
A
Q
S
D
H
R
S
R
H
E
Site 160
S1621
K
A
Q
S
D
H
R
S
R
H
E
V
S
H
Y
Site 161
Y1628
S
R
H
E
V
S
H
Y
S
M
W
L
L
V
S
Site 162
S1645
H
C
C
S
L
V
K
S
S
L
A
D
S
D
H
Site 163
S1650
V
K
S
S
L
A
D
S
D
H
L
Q
D
W
L
Site 164
S1673
E
T
A
V
R
H
E
S
C
S
G
L
Y
K
L
Site 165
S1675
A
V
R
H
E
S
C
S
G
L
Y
K
L
S
L
Site 166
S1683
G
L
Y
K
L
S
L
S
G
L
D
G
G
D
S
Site 167
S1690
S
G
L
D
G
G
D
S
I
N
R
S
F
L
L
Site 168
Y1721
K
P
I
R
I
D
D
Y
E
E
E
P
I
L
K
Site 169
S1751
N
I
H
I
K
D
A
S
Q
T
T
L
L
D
L
Site 170
S1796
G
L
L
R
L
A
T
S
V
V
K
H
K
P
P
Site 171
S1826
N
L
L
F
L
L
P
S
L
K
D
R
Q
Q
P
Site 172
S1837
R
Q
Q
P
K
C
K
S
H
S
S
R
A
A
A
Site 173
S1839
Q
P
K
C
K
S
H
S
S
R
A
A
A
Y
D
Site 174
Y1859
V
K
G
S
V
E
N
Y
R
L
I
H
N
W
V
Site 175
Y1913
A
S
T
I
Q
Q
L
Y
M
I
P
E
A
R
Q
Site 176
T1924
E
A
R
Q
A
V
F
T
A
K
Y
S
E
D
M
Site 177
Y1927
Q
A
V
F
T
A
K
Y
S
E
D
M
K
H
K
Site 178
T1935
S
E
D
M
K
H
K
T
T
L
L
E
L
Q
K
Site 179
T1945
L
E
L
Q
K
M
F
T
Y
L
M
E
S
E
C
Site 180
Y1946
E
L
Q
K
M
F
T
Y
L
M
E
S
E
C
K
Site 181
S1950
M
F
T
Y
L
M
E
S
E
C
K
A
Y
N
P
Site 182
Y1955
M
E
S
E
C
K
A
Y
N
P
R
P
F
C
K
Site 183
T1963
N
P
R
P
F
C
K
T
Y
T
M
D
K
Q
P
Site 184
Y1964
P
R
P
F
C
K
T
Y
T
M
D
K
Q
P
L
Site 185
T1965
R
P
F
C
K
T
Y
T
M
D
K
Q
P
L
N
Site 186
T1980
T
G
E
Q
K
D
M
T
E
F
F
T
D
L
I
Site 187
T1988
E
F
F
T
D
L
I
T
K
I
E
E
M
S
P
Site 188
S1994
I
T
K
I
E
E
M
S
P
E
L
K
N
T
V
Site 189
T2000
M
S
P
E
L
K
N
T
V
K
S
L
F
G
G
Site 190
S2022
S
L
D
C
E
H
V
S
Q
T
A
E
E
F
Y
Site 191
T2030
Q
T
A
E
E
F
Y
T
V
R
C
Q
V
A
D
Site 192
Y2042
V
A
D
M
K
N
I
Y
E
S
L
D
E
V
T
Site 193
S2044
D
M
K
N
I
Y
E
S
L
D
E
V
T
I
K
Site 194
T2053
D
E
V
T
I
K
D
T
L
E
G
D
N
M
Y
Site 195
Y2060
T
L
E
G
D
N
M
Y
T
C
S
H
C
G
K
Site 196
S2085
K
K
L
P
R
I
L
S
F
N
T
M
R
Y
T
Site 197
Y2091
L
S
F
N
T
M
R
Y
T
F
N
M
V
T
M
Site 198
T2092
S
F
N
T
M
R
Y
T
F
N
M
V
T
M
M
Site 199
T2097
R
Y
T
F
N
M
V
T
M
M
K
E
K
V
N
Site 200
T2105
M
M
K
E
K
V
N
T
H
F
S
F
P
L
R
Site 201
S2108
E
K
V
N
T
H
F
S
F
P
L
R
L
D
M
Site 202
T2116
F
P
L
R
L
D
M
T
P
Y
T
E
D
F
L
Site 203
Y2118
L
R
L
D
M
T
P
Y
T
E
D
F
L
M
G
Site 204
T2119
R
L
D
M
T
P
Y
T
E
D
F
L
M
G
K
Site 205
S2127
E
D
F
L
M
G
K
S
E
R
K
E
G
F
K
Site 206
S2137
K
E
G
F
K
E
V
S
D
H
S
K
D
S
E
Site 207
S2140
F
K
E
V
S
D
H
S
K
D
S
E
S
Y
E
Site 208
S2143
V
S
D
H
S
K
D
S
E
S
Y
E
Y
D
L
Site 209
S2145
D
H
S
K
D
S
E
S
Y
E
Y
D
L
I
G
Site 210
Y2148
K
D
S
E
S
Y
E
Y
D
L
I
G
V
T
V
Site 211
Y2165
G
T
A
D
G
G
H
Y
Y
S
F
I
R
D
I
Site 212
Y2166
T
A
D
G
G
H
Y
Y
S
F
I
R
D
I
V
Site 213
Y2178
D
I
V
N
P
H
A
Y
K
N
N
K
W
Y
L
Site 214
S2201
F
D
S
A
Q
L
A
S
E
C
F
G
G
E
M
Site 215
T2212
G
G
E
M
T
T
K
T
Y
D
S
V
T
D
K
Site 216
Y2213
G
E
M
T
T
K
T
Y
D
S
V
T
D
K
F
Site 217
T2217
T
K
T
Y
D
S
V
T
D
K
F
M
D
F
S
Site 218
S2224
T
D
K
F
M
D
F
S
F
E
K
T
H
S
A
Site 219
Y2236
H
S
A
Y
M
L
F
Y
K
R
M
E
P
E
E
Site 220
Y2249
E
E
E
N
G
R
E
Y
K
F
D
V
S
S
E
Site 221
S2254
R
E
Y
K
F
D
V
S
S
E
L
L
E
W
I
Site 222
S2255
E
Y
K
F
D
V
S
S
E
L
L
E
W
I
W
Site 223
S2292
Q
L
C
S
C
I
P
S
T
L
P
D
P
K
A
Site 224
T2315
S
T
S
F
V
L
E
T
F
I
H
S
K
E
K
Site 225
Y2392
R
P
V
H
A
H
L
Y
L
Q
P
G
M
E
D
Site 226
S2401
Q
P
G
M
E
D
G
S
D
D
M
D
T
S
V
Site 227
T2406
D
G
S
D
D
M
D
T
S
V
E
D
I
G
G
Site 228
S2407
G
S
D
D
M
D
T
S
V
E
D
I
G
G
R
Site 229
S2436
E
H
G
V
K
P
H
S
K
H
L
T
E
Y
F
Site 230
T2440
K
P
H
S
K
H
L
T
E
Y
F
A
F
L
Y
Site 231
Y2442
H
S
K
H
L
T
E
Y
F
A
F
L
Y
E
F
Site 232
Y2447
T
E
Y
F
A
F
L
Y
E
F
A
K
M
G
E
Site 233
S2457
A
K
M
G
E
E
E
S
Q
F
L
L
S
L
Q
Site 234
S2488
N
P
Q
V
E
V
L
S
E
E
E
G
E
E
E
Site 235
S2503
E
E
E
E
D
I
L
S
L
A
E
E
K
Y
R
Site 236
Y2509
L
S
L
A
E
E
K
Y
R
P
A
A
L
E
K
Site 237
S2528
V
A
L
L
V
E
Q
S
R
S
E
R
H
L
T
Site 238
S2530
L
L
V
E
Q
S
R
S
E
R
H
L
T
L
S
Site 239
T2535
S
R
S
E
R
H
L
T
L
S
Q
T
D
M
A
Site 240
S2537
S
E
R
H
L
T
L
S
Q
T
D
M
A
A
L
Site 241
T2539
R
H
L
T
L
S
Q
T
D
M
A
A
L
T
G
Site 242
T2545
Q
T
D
M
A
A
L
T
G
G
K
G
F
P
F
Site 243
Y2576
L
I
F
S
L
C
R
Y
N
N
R
L
A
E
H
Site 244
Y2637
R
I
W
E
V
I
E
Y
N
P
S
Q
C
L
D
Site 245
T2650
L
D
W
L
A
V
Q
T
P
R
N
K
L
A
H
Site 246
Y2677
R
F
L
L
A
H
N
Y
P
R
V
R
T
S
A
Site 247
T2682
H
N
Y
P
R
V
R
T
S
A
A
Y
L
L
V
Site 248
S2683
N
Y
P
R
V
R
T
S
A
A
Y
L
L
V
S
Site 249
S2690
S
A
A
Y
L
L
V
S
L
I
P
S
N
S
F
Site 250
S2694
L
L
V
S
L
I
P
S
N
S
F
R
Q
M
F
Site 251
S2696
V
S
L
I
P
S
N
S
F
R
Q
M
F
R
S
Site 252
S2703
S
F
R
Q
M
F
R
S
T
R
S
L
H
I
P
Site 253
T2704
F
R
Q
M
F
R
S
T
R
S
L
H
I
P
T
Site 254
T2711
T
R
S
L
H
I
P
T
R
D
L
P
L
S
P
Site 255
S2717
P
T
R
D
L
P
L
S
P
D
T
T
V
V
L
Site 256
S2788
N
L
F
Q
P
K
L
S
E
P
A
I
A
T
N
Site 257
S2865
L
R
L
C
C
E
Q
S
P
A
F
T
R
Q
L
Site 258
T2886
Q
W
A
F
K
N
L
T
P
H
A
S
Q
Y
P
Site 259
S2890
K
N
L
T
P
H
A
S
Q
Y
P
G
A
V
E
Site 260
Y2892
L
T
P
H
A
S
Q
Y
P
G
A
V
E
E
L
Site 261
Y2932
K
K
T
T
I
S
C
Y
L
R
C
L
D
G
R
Site 262
S3007
I
F
L
S
V
L
K
S
T
R
P
Y
L
Q
R
Site 263
Y3011
V
L
K
S
T
R
P
Y
L
Q
R
K
D
V
K
Site 264
T3036
E
F
A
H
K
L
L
T
L
L
N
S
Y
S
P
Site 265
S3040
K
L
L
T
L
L
N
S
Y
S
P
P
E
L
R
Site 266
Y3041
L
L
T
L
L
N
S
Y
S
P
P
E
L
R
N
Site 267
S3042
L
T
L
L
N
S
Y
S
P
P
E
L
R
N
A
Site 268
T3068
S
P
H
D
F
L
H
T
L
V
P
F
L
Q
H
Site 269
Y3092
I
P
M
S
L
G
P
Y
F
P
C
R
E
N
I
Site 270
S3106
I
K
L
I
G
G
K
S
N
I
R
P
P
R
P
Site 271
Y3134
S
K
G
K
D
D
V
Y
D
R
M
L
L
D
Y
Site 272
Y3141
Y
D
R
M
L
L
D
Y
F
F
S
Y
H
Q
F
Site 273
T3195
L
W
T
E
L
C
Q
T
Q
S
A
M
S
K
N
Site 274
S3246
H
F
L
L
K
V
Q
S
Q
V
F
S
E
A
N
Site 275
S3250
K
V
Q
S
Q
V
F
S
E
A
N
C
A
N
L
Site 276
S3267
T
L
I
T
N
L
I
S
Q
Y
Q
N
L
Q
S
Site 277
S3274
S
Q
Y
Q
N
L
Q
S
D
F
S
N
R
V
E
Site 278
S3277
Q
N
L
Q
S
D
F
S
N
R
V
E
I
S
K
Site 279
S3283
F
S
N
R
V
E
I
S
K
A
S
A
S
L
N
Site 280
S3288
E
I
S
K
A
S
A
S
L
N
G
D
L
R
A
Site 281
S3321
P
T
L
Q
E
L
L
S
K
C
R
T
C
L
Q
Site 282
T3325
E
L
L
S
K
C
R
T
C
L
Q
Q
R
N
S
Site 283
S3332
T
C
L
Q
Q
R
N
S
L
Q
E
Q
E
A
K
Site 284
T3343
Q
E
A
K
E
R
K
T
K
D
D
E
G
A
T
Site 285
T3350
T
K
D
D
E
G
A
T
P
I
K
R
R
R
V
Site 286
S3358
P
I
K
R
R
R
V
S
S
D
E
E
H
T
V
Site 287
S3359
I
K
R
R
R
V
S
S
D
E
E
H
T
V
D
Site 288
T3364
V
S
S
D
E
E
H
T
V
D
S
C
I
S
D
Site 289
T3374
S
C
I
S
D
M
K
T
E
T
R
E
V
L
T
Site 290
T3381
T
E
T
R
E
V
L
T
P
T
S
T
S
D
N
Site 291
S3384
R
E
V
L
T
P
T
S
T
S
D
N
E
T
R
Site 292
T3390
T
S
T
S
D
N
E
T
R
D
S
S
I
I
D
Site 293
S3393
S
D
N
E
T
R
D
S
S
I
I
D
P
G
T
Site 294
S3394
D
N
E
T
R
D
S
S
I
I
D
P
G
T
E
Site 295
T3400
S
S
I
I
D
P
G
T
E
Q
D
L
P
S
P
Site 296
S3406
G
T
E
Q
D
L
P
S
P
E
N
S
S
V
K
Site 297
S3410
D
L
P
S
P
E
N
S
S
V
K
E
Y
R
M
Site 298
S3411
L
P
S
P
E
N
S
S
V
K
E
Y
R
M
E
Site 299
Y3415
E
N
S
S
V
K
E
Y
R
M
E
V
P
S
S
Site 300
S3421
E
Y
R
M
E
V
P
S
S
F
S
E
D
M
S
Site 301
S3422
Y
R
M
E
V
P
S
S
F
S
E
D
M
S
N
Site 302
S3424
M
E
V
P
S
S
F
S
E
D
M
S
N
I
R
Site 303
S3428
S
S
F
S
E
D
M
S
N
I
R
S
Q
H
A
Site 304
S3432
E
D
M
S
N
I
R
S
Q
H
A
E
E
Q
S
Site 305
Y3444
E
Q
S
N
N
G
R
Y
D
D
C
K
E
F
K
Site 306
T3460
L
H
C
S
K
D
S
T
L
A
E
E
E
S
E
Site 307
S3466
S
T
L
A
E
E
E
S
E
F
P
S
T
S
I
Site 308
S3470
E
E
E
S
E
F
P
S
T
S
I
S
A
V
L
Site 309
T3471
E
E
S
E
F
P
S
T
S
I
S
A
V
L
S
Site 310
S3472
E
S
E
F
P
S
T
S
I
S
A
V
L
S
D
Site 311
S3485
S
D
L
A
D
L
R
S
C
D
G
Q
A
L
P
Site 312
S3493
C
D
G
Q
A
L
P
S
Q
D
P
E
V
A
L
Site 313
S3501
Q
D
P
E
V
A
L
S
L
S
C
G
H
S
R
Site 314
S3503
P
E
V
A
L
S
L
S
C
G
H
S
R
G
L
Site 315
S3507
L
S
L
S
C
G
H
S
R
G
L
F
S
H
M
Site 316
T3522
Q
Q
H
D
I
L
D
T
L
C
R
T
I
E
S
Site 317
S3538
I
H
V
V
T
R
I
S
G
K
G
N
Q
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation