KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
USP31
Full Name:
Ubiquitin carboxyl-terminal hydrolase 31
Alias:
Deubiquitinating enzyme 31; KIAA1203; Ubiquitin specific peptidase 31; Ubiquitin thioesterase 31; Ubiquitin-specific-processing protease 31; UBP31
Type:
EC 3.1.2.15; Protease
Mass (Da):
146651
Number AA:
1352
UniProt ID:
Q70CQ4
International Prot ID:
IPI00297289
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
S
K
V
T
A
P
G
S
G
P
P
Site 2
S9
S
K
V
T
A
P
G
S
G
P
P
A
A
A
S
Site 3
S16
S
G
P
P
A
A
A
S
G
K
E
K
R
S
F
Site 4
S22
A
S
G
K
E
K
R
S
F
S
K
R
L
F
R
Site 5
S24
G
K
E
K
R
S
F
S
K
R
L
F
R
S
G
Site 6
S30
F
S
K
R
L
F
R
S
G
R
A
G
G
G
G
Site 7
S44
G
A
G
G
P
G
A
S
G
P
A
A
P
S
S
Site 8
S50
A
S
G
P
A
A
P
S
S
P
S
S
P
S
S
Site 9
S51
S
G
P
A
A
P
S
S
P
S
S
P
S
S
A
Site 10
S53
P
A
A
P
S
S
P
S
S
P
S
S
A
R
S
Site 11
S54
A
A
P
S
S
P
S
S
P
S
S
A
R
S
V
Site 12
S56
P
S
S
P
S
S
P
S
S
A
R
S
V
G
S
Site 13
S57
S
S
P
S
S
P
S
S
A
R
S
V
G
S
F
Site 14
S60
S
S
P
S
S
A
R
S
V
G
S
F
M
S
R
Site 15
S63
S
S
A
R
S
V
G
S
F
M
S
R
V
L
K
Site 16
S66
R
S
V
G
S
F
M
S
R
V
L
K
T
L
S
Site 17
S73
S
R
V
L
K
T
L
S
T
L
S
H
L
S
S
Site 18
T74
R
V
L
K
T
L
S
T
L
S
H
L
S
S
E
Site 19
S76
L
K
T
L
S
T
L
S
H
L
S
S
E
G
A
Site 20
S80
S
T
L
S
H
L
S
S
E
G
A
A
P
D
R
Site 21
S92
P
D
R
G
G
L
R
S
C
F
P
P
G
P
A
Site 22
T103
P
G
P
A
A
A
P
T
P
P
P
C
P
P
P
Site 23
S113
P
C
P
P
P
P
A
S
P
A
P
P
A
C
A
Site 24
Y155
N
T
E
L
F
A
E
Y
L
A
L
G
Q
Y
R
Site 25
Y161
E
Y
L
A
L
G
Q
Y
R
A
G
R
P
E
P
Site 26
S169
R
A
G
R
P
E
P
S
P
D
P
E
Q
P
A
Site 27
T199
H
L
V
R
A
L
W
T
L
E
Y
T
P
Q
H
Site 28
Y202
R
A
L
W
T
L
E
Y
T
P
Q
H
S
R
D
Site 29
T203
A
L
W
T
L
E
Y
T
P
Q
H
S
R
D
F
Site 30
T212
Q
H
S
R
D
F
K
T
I
V
S
K
N
A
L
Site 31
Y221
V
S
K
N
A
L
Q
Y
R
G
N
S
Q
H
D
Site 32
S225
A
L
Q
Y
R
G
N
S
Q
H
D
A
Q
E
F
Site 33
S247
V
H
E
D
L
N
H
S
V
K
Q
S
G
Q
P
Site 34
S251
L
N
H
S
V
K
Q
S
G
Q
P
P
L
K
P
Site 35
S260
Q
P
P
L
K
P
P
S
E
T
D
M
M
P
E
Site 36
S270
D
M
M
P
E
G
P
S
F
P
V
C
S
T
F
Site 37
Y286
Q
E
L
F
Q
A
Q
Y
R
S
S
L
T
C
P
Site 38
T323
H
T
R
P
L
Y
V
T
V
V
Y
Q
G
K
C
Site 39
S343
I
G
V
A
V
P
L
S
G
T
V
A
R
L
R
Site 40
T345
V
A
V
P
L
S
G
T
V
A
R
L
R
E
A
Site 41
S354
A
R
L
R
E
A
V
S
M
E
T
K
I
P
T
Site 42
T367
P
T
D
Q
I
V
L
T
E
M
Y
Y
D
G
F
Site 43
Y370
Q
I
V
L
T
E
M
Y
Y
D
G
F
H
R
S
Site 44
Y371
I
V
L
T
E
M
Y
Y
D
G
F
H
R
S
F
Site 45
T398
D
C
I
F
A
F
E
T
P
E
I
F
R
P
E
Site 46
S409
F
R
P
E
G
I
L
S
Q
R
G
I
H
L
N
Site 47
Y428
H
L
K
F
G
L
D
Y
H
R
L
S
S
P
T
Site 48
S432
G
L
D
Y
H
R
L
S
S
P
T
Q
T
A
A
Site 49
S433
L
D
Y
H
R
L
S
S
P
T
Q
T
A
A
K
Site 50
T437
R
L
S
S
P
T
Q
T
A
A
K
Q
G
K
M
Site 51
S446
A
K
Q
G
K
M
D
S
P
T
S
R
A
G
S
Site 52
T448
Q
G
K
M
D
S
P
T
S
R
A
G
S
D
K
Site 53
S449
G
K
M
D
S
P
T
S
R
A
G
S
D
K
I
Site 54
T466
L
V
C
N
R
A
C
T
G
Q
Q
G
K
R
F
Site 55
Y576
F
V
N
T
E
D
E
Y
I
P
D
A
E
S
V
Site 56
S582
E
Y
I
P
D
A
E
S
V
R
L
Q
R
E
R
Site 57
T595
E
R
H
H
Q
P
Q
T
C
T
L
S
Q
C
F
Site 58
S629
C
K
Q
L
Q
Q
G
S
I
T
L
S
L
W
T
Site 59
T667
N
M
V
K
F
P
L
T
G
L
D
M
T
P
H
Site 60
T672
P
L
T
G
L
D
M
T
P
H
V
V
K
R
S
Site 61
S679
T
P
H
V
V
K
R
S
Q
S
S
W
S
L
P
Site 62
S681
H
V
V
K
R
S
Q
S
S
W
S
L
P
S
H
Site 63
S682
V
V
K
R
S
Q
S
S
W
S
L
P
S
H
W
Site 64
S684
K
R
S
Q
S
S
W
S
L
P
S
H
W
S
P
Site 65
S687
Q
S
S
W
S
L
P
S
H
W
S
P
W
R
R
Site 66
Y696
W
S
P
W
R
R
P
Y
G
L
G
R
D
P
E
Site 67
Y705
L
G
R
D
P
E
D
Y
I
Y
D
L
Y
A
V
Site 68
Y707
R
D
P
E
D
Y
I
Y
D
L
Y
A
V
C
N
Site 69
Y710
E
D
Y
I
Y
D
L
Y
A
V
C
N
H
H
G
Site 70
Y727
Q
G
G
H
Y
T
A
Y
C
K
N
S
V
D
G
Site 71
S748
D
S
D
V
Q
Q
L
S
E
D
E
V
C
T
Q
Site 72
Y762
Q
T
A
Y
I
L
F
Y
Q
R
R
T
A
I
P
Site 73
T766
I
L
F
Y
Q
R
R
T
A
I
P
S
W
S
A
Site 74
S770
Q
R
R
T
A
I
P
S
W
S
A
N
S
S
V
Site 75
S772
R
T
A
I
P
S
W
S
A
N
S
S
V
A
G
Site 76
S776
P
S
W
S
A
N
S
S
V
A
G
S
T
S
S
Site 77
S780
A
N
S
S
V
A
G
S
T
S
S
S
L
C
E
Site 78
S782
S
S
V
A
G
S
T
S
S
S
L
C
E
H
W
Site 79
S783
S
V
A
G
S
T
S
S
S
L
C
E
H
W
V
Site 80
S784
V
A
G
S
T
S
S
S
L
C
E
H
W
V
S
Site 81
S791
S
L
C
E
H
W
V
S
R
L
P
G
S
K
P
Site 82
S796
W
V
S
R
L
P
G
S
K
P
A
S
V
T
S
Site 83
S800
L
P
G
S
K
P
A
S
V
T
S
A
A
S
S
Site 84
T802
G
S
K
P
A
S
V
T
S
A
A
S
S
R
R
Site 85
S803
S
K
P
A
S
V
T
S
A
A
S
S
R
R
T
Site 86
S806
A
S
V
T
S
A
A
S
S
R
R
T
S
L
A
Site 87
S807
S
V
T
S
A
A
S
S
R
R
T
S
L
A
S
Site 88
T810
S
A
A
S
S
R
R
T
S
L
A
S
L
S
E
Site 89
S811
A
A
S
S
R
R
T
S
L
A
S
L
S
E
S
Site 90
S814
S
R
R
T
S
L
A
S
L
S
E
S
V
E
M
Site 91
S816
R
T
S
L
A
S
L
S
E
S
V
E
M
T
G
Site 92
S818
S
L
A
S
L
S
E
S
V
E
M
T
G
E
R
Site 93
T822
L
S
E
S
V
E
M
T
G
E
R
S
E
D
D
Site 94
S826
V
E
M
T
G
E
R
S
E
D
D
G
G
F
S
Site 95
S833
S
E
D
D
G
G
F
S
T
R
P
F
V
R
S
Site 96
S840
S
T
R
P
F
V
R
S
V
Q
R
Q
S
L
S
Site 97
S845
V
R
S
V
Q
R
Q
S
L
S
S
R
S
S
V
Site 98
S847
S
V
Q
R
Q
S
L
S
S
R
S
S
V
T
S
Site 99
S848
V
Q
R
Q
S
L
S
S
R
S
S
V
T
S
P
Site 100
S850
R
Q
S
L
S
S
R
S
S
V
T
S
P
L
A
Site 101
S851
Q
S
L
S
S
R
S
S
V
T
S
P
L
A
V
Site 102
S854
S
S
R
S
S
V
T
S
P
L
A
V
N
E
N
Site 103
S866
N
E
N
C
M
R
P
S
W
S
L
S
A
K
L
Site 104
S868
N
C
M
R
P
S
W
S
L
S
A
K
L
Q
M
Site 105
S870
M
R
P
S
W
S
L
S
A
K
L
Q
M
R
S
Site 106
S877
S
A
K
L
Q
M
R
S
N
S
P
S
R
F
S
Site 107
S879
K
L
Q
M
R
S
N
S
P
S
R
F
S
G
D
Site 108
S881
Q
M
R
S
N
S
P
S
R
F
S
G
D
S
P
Site 109
S884
S
N
S
P
S
R
F
S
G
D
S
P
I
H
S
Site 110
S887
P
S
R
F
S
G
D
S
P
I
H
S
S
A
S
Site 111
S891
S
G
D
S
P
I
H
S
S
A
S
T
L
E
K
Site 112
T895
P
I
H
S
S
A
S
T
L
E
K
I
G
E
A
Site 113
S910
A
D
D
K
V
S
I
S
C
F
G
S
L
R
N
Site 114
S919
F
G
S
L
R
N
L
S
S
S
Y
Q
E
P
S
Site 115
S920
G
S
L
R
N
L
S
S
S
Y
Q
E
P
S
D
Site 116
S921
S
L
R
N
L
S
S
S
Y
Q
E
P
S
D
S
Site 117
Y922
L
R
N
L
S
S
S
Y
Q
E
P
S
D
S
H
Site 118
S926
S
S
S
Y
Q
E
P
S
D
S
H
S
R
R
E
Site 119
S928
S
Y
Q
E
P
S
D
S
H
S
R
R
E
H
K
Site 120
S930
Q
E
P
S
D
S
H
S
R
R
E
H
K
A
V
Site 121
S953
E
G
V
F
K
D
E
S
D
T
R
R
L
N
S
Site 122
T955
V
F
K
D
E
S
D
T
R
R
L
N
S
S
V
Site 123
S960
S
D
T
R
R
L
N
S
S
V
V
D
T
Q
S
Site 124
S961
D
T
R
R
L
N
S
S
V
V
D
T
Q
S
K
Site 125
T965
L
N
S
S
V
V
D
T
Q
S
K
H
S
A
Q
Site 126
S967
S
S
V
V
D
T
Q
S
K
H
S
A
Q
G
D
Site 127
S980
G
D
R
L
P
P
L
S
G
P
F
D
N
N
N
Site 128
Y991
D
N
N
N
Q
I
A
Y
V
D
Q
S
D
S
V
Site 129
S995
Q
I
A
Y
V
D
Q
S
D
S
V
D
S
S
P
Site 130
S997
A
Y
V
D
Q
S
D
S
V
D
S
S
P
V
K
Site 131
S1001
Q
S
D
S
V
D
S
S
P
V
K
E
V
K
A
Site 132
S1010
V
K
E
V
K
A
P
S
H
P
G
S
L
A
K
Site 133
S1014
K
A
P
S
H
P
G
S
L
A
K
K
P
E
S
Site 134
S1021
S
L
A
K
K
P
E
S
T
T
K
R
S
P
S
Site 135
T1022
L
A
K
K
P
E
S
T
T
K
R
S
P
S
S
Site 136
T1023
A
K
K
P
E
S
T
T
K
R
S
P
S
S
K
Site 137
S1026
P
E
S
T
T
K
R
S
P
S
S
K
G
T
S
Site 138
S1028
S
T
T
K
R
S
P
S
S
K
G
T
S
E
P
Site 139
S1029
T
T
K
R
S
P
S
S
K
G
T
S
E
P
E
Site 140
T1032
R
S
P
S
S
K
G
T
S
E
P
E
K
S
L
Site 141
S1033
S
P
S
S
K
G
T
S
E
P
E
K
S
L
R
Site 142
S1038
G
T
S
E
P
E
K
S
L
R
K
G
R
P
A
Site 143
S1048
K
G
R
P
A
L
A
S
Q
E
S
S
L
S
S
Site 144
S1051
P
A
L
A
S
Q
E
S
S
L
S
S
T
S
P
Site 145
S1052
A
L
A
S
Q
E
S
S
L
S
S
T
S
P
S
Site 146
S1054
A
S
Q
E
S
S
L
S
S
T
S
P
S
S
P
Site 147
S1055
S
Q
E
S
S
L
S
S
T
S
P
S
S
P
L
Site 148
T1056
Q
E
S
S
L
S
S
T
S
P
S
S
P
L
P
Site 149
S1057
E
S
S
L
S
S
T
S
P
S
S
P
L
P
V
Site 150
S1059
S
L
S
S
T
S
P
S
S
P
L
P
V
K
V
Site 151
S1060
L
S
S
T
S
P
S
S
P
L
P
V
K
V
S
Site 152
S1067
S
P
L
P
V
K
V
S
L
K
P
S
R
S
R
Site 153
S1071
V
K
V
S
L
K
P
S
R
S
R
S
K
A
D
Site 154
S1073
V
S
L
K
P
S
R
S
R
S
K
A
D
S
S
Site 155
S1075
L
K
P
S
R
S
R
S
K
A
D
S
S
S
R
Site 156
S1079
R
S
R
S
K
A
D
S
S
S
R
G
S
G
R
Site 157
S1080
S
R
S
K
A
D
S
S
S
R
G
S
G
R
H
Site 158
S1081
R
S
K
A
D
S
S
S
R
G
S
G
R
H
S
Site 159
S1084
A
D
S
S
S
R
G
S
G
R
H
S
S
P
A
Site 160
S1088
S
R
G
S
G
R
H
S
S
P
A
P
A
Q
P
Site 161
S1089
R
G
S
G
R
H
S
S
P
A
P
A
Q
P
K
Site 162
S1099
P
A
Q
P
K
K
E
S
S
P
K
S
Q
D
S
Site 163
S1100
A
Q
P
K
K
E
S
S
P
K
S
Q
D
S
V
Site 164
S1103
K
K
E
S
S
P
K
S
Q
D
S
V
S
S
P
Site 165
S1106
S
S
P
K
S
Q
D
S
V
S
S
P
S
P
Q
Site 166
S1108
P
K
S
Q
D
S
V
S
S
P
S
P
Q
K
Q
Site 167
S1109
K
S
Q
D
S
V
S
S
P
S
P
Q
K
Q
K
Site 168
S1111
Q
D
S
V
S
S
P
S
P
Q
K
Q
K
S
A
Site 169
S1117
P
S
P
Q
K
Q
K
S
A
S
A
L
T
Y
T
Site 170
S1119
P
Q
K
Q
K
S
A
S
A
L
T
Y
T
A
S
Site 171
T1122
Q
K
S
A
S
A
L
T
Y
T
A
S
S
T
S
Site 172
Y1123
K
S
A
S
A
L
T
Y
T
A
S
S
T
S
A
Site 173
T1124
S
A
S
A
L
T
Y
T
A
S
S
T
S
A
K
Site 174
S1126
S
A
L
T
Y
T
A
S
S
T
S
A
K
K
A
Site 175
S1127
A
L
T
Y
T
A
S
S
T
S
A
K
K
A
S
Site 176
S1134
S
T
S
A
K
K
A
S
G
P
A
T
R
S
P
Site 177
T1138
K
K
A
S
G
P
A
T
R
S
P
F
P
P
G
Site 178
S1140
A
S
G
P
A
T
R
S
P
F
P
P
G
K
S
Site 179
S1147
S
P
F
P
P
G
K
S
R
T
S
D
H
S
L
Site 180
T1149
F
P
P
G
K
S
R
T
S
D
H
S
L
S
R
Site 181
S1150
P
P
G
K
S
R
T
S
D
H
S
L
S
R
E
Site 182
S1153
K
S
R
T
S
D
H
S
L
S
R
E
G
S
R
Site 183
S1155
R
T
S
D
H
S
L
S
R
E
G
S
R
Q
S
Site 184
S1159
H
S
L
S
R
E
G
S
R
Q
S
L
G
S
D
Site 185
S1162
S
R
E
G
S
R
Q
S
L
G
S
D
R
A
S
Site 186
S1165
G
S
R
Q
S
L
G
S
D
R
A
S
A
T
S
Site 187
S1169
S
L
G
S
D
R
A
S
A
T
S
T
S
K
P
Site 188
T1171
G
S
D
R
A
S
A
T
S
T
S
K
P
N
S
Site 189
S1172
S
D
R
A
S
A
T
S
T
S
K
P
N
S
P
Site 190
T1173
D
R
A
S
A
T
S
T
S
K
P
N
S
P
R
Site 191
S1174
R
A
S
A
T
S
T
S
K
P
N
S
P
R
V
Site 192
S1178
T
S
T
S
K
P
N
S
P
R
V
S
Q
A
R
Site 193
S1182
K
P
N
S
P
R
V
S
Q
A
R
A
G
E
G
Site 194
S1198
G
A
G
K
H
V
R
S
S
S
M
A
S
L
R
Site 195
S1199
A
G
K
H
V
R
S
S
S
M
A
S
L
R
S
Site 196
S1200
G
K
H
V
R
S
S
S
M
A
S
L
R
S
P
Site 197
S1203
V
R
S
S
S
M
A
S
L
R
S
P
S
T
S
Site 198
S1206
S
S
M
A
S
L
R
S
P
S
T
S
I
K
S
Site 199
S1208
M
A
S
L
R
S
P
S
T
S
I
K
S
G
L
Site 200
T1209
A
S
L
R
S
P
S
T
S
I
K
S
G
L
K
Site 201
S1210
S
L
R
S
P
S
T
S
I
K
S
G
L
K
R
Site 202
S1213
S
P
S
T
S
I
K
S
G
L
K
R
D
S
K
Site 203
S1219
K
S
G
L
K
R
D
S
K
S
E
D
K
G
L
Site 204
S1221
G
L
K
R
D
S
K
S
E
D
K
G
L
S
F
Site 205
S1227
K
S
E
D
K
G
L
S
F
F
K
S
A
L
R
Site 206
S1231
K
G
L
S
F
F
K
S
A
L
R
Q
K
E
T
Site 207
T1238
S
A
L
R
Q
K
E
T
R
R
S
T
D
L
G
Site 208
S1241
R
Q
K
E
T
R
R
S
T
D
L
G
K
T
A
Site 209
T1242
Q
K
E
T
R
R
S
T
D
L
G
K
T
A
L
Site 210
S1251
L
G
K
T
A
L
L
S
K
K
A
G
G
S
S
Site 211
S1257
L
S
K
K
A
G
G
S
S
V
K
S
V
C
K
Site 212
S1258
S
K
K
A
G
G
S
S
V
K
S
V
C
K
N
Site 213
S1261
A
G
G
S
S
V
K
S
V
C
K
N
T
G
D
Site 214
S1280
R
G
H
Q
P
P
A
S
Q
Q
P
N
A
N
T
Site 215
T1295
T
G
K
E
Q
L
V
T
K
D
P
A
S
A
K
Site 216
S1300
L
V
T
K
D
P
A
S
A
K
H
S
L
L
S
Site 217
S1304
D
P
A
S
A
K
H
S
L
L
S
A
R
K
S
Site 218
S1307
S
A
K
H
S
L
L
S
A
R
K
S
K
S
S
Site 219
S1311
S
L
L
S
A
R
K
S
K
S
S
Q
L
D
S
Site 220
S1313
L
S
A
R
K
S
K
S
S
Q
L
D
S
G
V
Site 221
S1314
S
A
R
K
S
K
S
S
Q
L
D
S
G
V
P
Site 222
S1318
S
K
S
S
Q
L
D
S
G
V
P
S
S
P
G
Site 223
S1322
Q
L
D
S
G
V
P
S
S
P
G
G
R
Q
S
Site 224
S1323
L
D
S
G
V
P
S
S
P
G
G
R
Q
S
A
Site 225
S1329
S
S
P
G
G
R
Q
S
A
E
K
S
S
K
K
Site 226
S1333
G
R
Q
S
A
E
K
S
S
K
K
L
S
S
S
Site 227
S1334
R
Q
S
A
E
K
S
S
K
K
L
S
S
S
M
Site 228
S1338
E
K
S
S
K
K
L
S
S
S
M
Q
T
S
A
Site 229
S1339
K
S
S
K
K
L
S
S
S
M
Q
T
S
A
R
Site 230
S1340
S
S
K
K
L
S
S
S
M
Q
T
S
A
R
P
Site 231
T1343
K
L
S
S
S
M
Q
T
S
A
R
P
S
Q
K
Site 232
S1344
L
S
S
S
M
Q
T
S
A
R
P
S
Q
K
P
Site 233
S1348
M
Q
T
S
A
R
P
S
Q
K
P
Q
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation