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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP53
Full Name:
Inactive ubiquitin carboxyl-terminal hydrolase 53
Alias:
Inactive ubiquitin-specific peptidase 53
Type:
Mass (Da):
120806
Number AA:
1073
UniProt ID:
Q70EK8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
G
G
N
L
G
K
V
Y
Q
P
G
S
M
L
S
Site 2
S22
G
K
V
Y
Q
P
G
S
M
L
S
L
A
P
T
Site 3
S25
Y
Q
P
G
S
M
L
S
L
A
P
T
K
G
L
Site 4
T29
S
M
L
S
L
A
P
T
K
G
L
L
N
E
P
Site 5
S59
Q
L
D
I
F
R
R
S
L
R
V
L
T
G
H
Site 6
T64
R
R
S
L
R
V
L
T
G
H
V
C
Q
G
D
Site 7
S88
I
F
A
Q
F
Q
H
S
R
E
K
A
L
P
S
Site 8
S95
S
R
E
K
A
L
P
S
D
N
I
R
H
A
L
Site 9
S105
I
R
H
A
L
A
E
S
F
K
D
E
Q
R
F
Site 10
Y160
Q
K
F
A
M
T
L
Y
E
Q
C
V
C
R
S
Site 11
S167
Y
E
Q
C
V
C
R
S
C
G
A
S
S
D
P
Site 12
S171
V
C
R
S
C
G
A
S
S
D
P
L
P
F
T
Site 13
T178
S
S
D
P
L
P
F
T
E
F
V
R
Y
I
S
Site 14
S185
T
E
F
V
R
Y
I
S
T
T
A
L
C
N
E
Site 15
Y221
A
A
N
T
T
D
D
Y
R
K
C
P
S
N
C
Site 16
S253
T
I
G
L
V
W
D
S
E
H
S
D
L
T
E
Site 17
T259
D
S
E
H
S
D
L
T
E
A
V
V
R
N
L
Site 18
Y271
R
N
L
A
T
H
L
Y
L
P
G
L
F
Y
R
Site 19
T280
P
G
L
F
Y
R
V
T
D
E
N
A
K
N
S
Site 20
S357
N
P
D
G
T
A
V
S
T
E
D
A
L
R
Q
Site 21
S367
D
A
L
R
Q
V
I
S
W
S
H
Y
K
S
V
Site 22
S369
L
R
Q
V
I
S
W
S
H
Y
K
S
V
A
E
Site 23
Y371
Q
V
I
S
W
S
H
Y
K
S
V
A
E
N
M
Site 24
S388
E
K
P
V
I
H
K
S
D
N
L
K
E
N
G
Site 25
T410
R
E
N
Q
K
F
P
T
D
N
I
S
S
S
N
Site 26
S414
K
F
P
T
D
N
I
S
S
S
N
R
S
H
S
Site 27
S415
F
P
T
D
N
I
S
S
S
N
R
S
H
S
H
Site 28
S416
P
T
D
N
I
S
S
S
N
R
S
H
S
H
T
Site 29
S419
N
I
S
S
S
N
R
S
H
S
H
T
G
V
G
Site 30
S421
S
S
S
N
R
S
H
S
H
T
G
V
G
K
G
Site 31
T423
S
N
R
S
H
S
H
T
G
V
G
K
G
P
A
Site 32
S433
G
K
G
P
A
K
L
S
H
I
D
Q
R
E
K
Site 33
S445
R
E
K
I
K
D
I
S
R
E
C
A
L
K
A
Site 34
S461
E
Q
K
N
L
L
S
S
Q
R
K
D
L
E
K
Site 35
S486
D
L
V
D
E
D
L
S
H
F
Q
S
G
S
P
Site 36
S490
E
D
L
S
H
F
Q
S
G
S
P
P
A
P
N
Site 37
S492
L
S
H
F
Q
S
G
S
P
P
A
P
N
G
F
Site 38
Y508
Q
H
G
N
P
H
L
Y
H
S
Q
G
K
G
S
Site 39
S510
G
N
P
H
L
Y
H
S
Q
G
K
G
S
Y
K
Site 40
S525
H
D
R
V
V
P
Q
S
R
A
S
A
Q
I
I
Site 41
S528
V
V
P
Q
S
R
A
S
A
Q
I
I
S
S
S
Site 42
S533
R
A
S
A
Q
I
I
S
S
S
K
S
Q
I
L
Site 43
S535
S
A
Q
I
I
S
S
S
K
S
Q
I
L
A
P
Site 44
S537
Q
I
I
S
S
S
K
S
Q
I
L
A
P
G
E
Site 45
S552
K
I
T
G
K
V
K
S
D
N
G
T
G
Y
D
Site 46
T556
K
V
K
S
D
N
G
T
G
Y
D
T
D
S
S
Site 47
Y558
K
S
D
N
G
T
G
Y
D
T
D
S
S
Q
D
Site 48
T560
D
N
G
T
G
Y
D
T
D
S
S
Q
D
S
R
Site 49
S562
G
T
G
Y
D
T
D
S
S
Q
D
S
R
D
R
Site 50
S563
T
G
Y
D
T
D
S
S
Q
D
S
R
D
R
G
Site 51
S566
D
T
D
S
S
Q
D
S
R
D
R
G
N
S
C
Site 52
S572
D
S
R
D
R
G
N
S
C
D
S
S
S
K
S
Site 53
S575
D
R
G
N
S
C
D
S
S
S
K
S
R
N
R
Site 54
S576
R
G
N
S
C
D
S
S
S
K
S
R
N
R
G
Site 55
S577
G
N
S
C
D
S
S
S
K
S
R
N
R
G
W
Site 56
S579
S
C
D
S
S
S
K
S
R
N
R
G
W
K
P
Site 57
T590
G
W
K
P
M
R
E
T
L
N
V
D
S
I
F
Site 58
S595
R
E
T
L
N
V
D
S
I
F
S
E
S
E
K
Site 59
S600
V
D
S
I
F
S
E
S
E
K
R
Q
H
S
P
Site 60
S606
E
S
E
K
R
Q
H
S
P
R
H
K
P
N
I
Site 61
S614
P
R
H
K
P
N
I
S
N
K
P
K
S
S
K
Site 62
S619
N
I
S
N
K
P
K
S
S
K
D
P
S
F
S
Site 63
S620
I
S
N
K
P
K
S
S
K
D
P
S
F
S
N
Site 64
S624
P
K
S
S
K
D
P
S
F
S
N
W
P
K
E
Site 65
S626
S
S
K
D
P
S
F
S
N
W
P
K
E
N
P
Site 66
S652
E
M
K
Q
E
I
G
S
R
S
S
L
E
S
N
Site 67
S654
K
Q
E
I
G
S
R
S
S
L
E
S
N
G
K
Site 68
S655
Q
E
I
G
S
R
S
S
L
E
S
N
G
K
G
Site 69
S658
G
S
R
S
S
L
E
S
N
G
K
G
A
E
K
Site 70
S686
W
Q
M
Q
R
T
E
S
G
Y
E
S
S
D
H
Site 71
Y688
M
Q
R
T
E
S
G
Y
E
S
S
D
H
I
S
Site 72
S690
R
T
E
S
G
Y
E
S
S
D
H
I
S
N
G
Site 73
S691
T
E
S
G
Y
E
S
S
D
H
I
S
N
G
S
Site 74
S695
Y
E
S
S
D
H
I
S
N
G
S
T
N
L
D
Site 75
T699
D
H
I
S
N
G
S
T
N
L
D
S
P
V
I
Site 76
S703
N
G
S
T
N
L
D
S
P
V
I
D
G
N
G
Site 77
T721
D
I
S
G
V
K
E
T
V
C
F
S
D
Q
I
Site 78
S725
V
K
E
T
V
C
F
S
D
Q
I
T
T
S
N
Site 79
T729
V
C
F
S
D
Q
I
T
T
S
N
L
N
K
E
Site 80
T741
N
K
E
R
G
D
C
T
S
L
Q
S
Q
H
H
Site 81
S742
K
E
R
G
D
C
T
S
L
Q
S
Q
H
H
L
Site 82
S745
G
D
C
T
S
L
Q
S
Q
H
H
L
E
G
F
Site 83
S765
N
L
E
A
G
Y
K
S
H
E
F
H
P
E
S
Site 84
S796
D
N
G
K
L
F
P
S
S
S
L
Q
I
P
K
Site 85
S797
N
G
K
L
F
P
S
S
S
L
Q
I
P
K
D
Site 86
S798
G
K
L
F
P
S
S
S
L
Q
I
P
K
D
H
Site 87
S814
A
R
E
H
I
H
Q
S
D
E
Q
K
L
E
K
Site 88
S836
E
W
L
N
I
E
N
S
E
R
T
G
L
P
F
Site 89
T839
N
I
E
N
S
E
R
T
G
L
P
F
H
V
D
Site 90
S856
A
S
G
K
R
V
N
S
N
E
P
S
S
L
W
Site 91
S860
R
V
N
S
N
E
P
S
S
L
W
S
S
H
L
Site 92
S861
V
N
S
N
E
P
S
S
L
W
S
S
H
L
R
Site 93
S864
N
E
P
S
S
L
W
S
S
H
L
R
T
V
G
Site 94
S865
E
P
S
S
L
W
S
S
H
L
R
T
V
G
L
Site 95
T869
L
W
S
S
H
L
R
T
V
G
L
K
P
E
T
Site 96
Y890
Q
N
I
M
D
Q
C
Y
F
E
N
S
L
S
T
Site 97
S896
C
Y
F
E
N
S
L
S
T
E
C
I
I
R
S
Site 98
S903
S
T
E
C
I
I
R
S
A
S
R
S
D
G
C
Site 99
S905
E
C
I
I
R
S
A
S
R
S
D
G
C
Q
M
Site 100
S907
I
I
R
S
A
S
R
S
D
G
C
Q
M
P
K
Site 101
Y929
P
P
L
P
P
K
K
Y
A
I
T
S
V
P
Q
Site 102
T932
P
P
K
K
Y
A
I
T
S
V
P
Q
S
E
K
Site 103
S933
P
K
K
Y
A
I
T
S
V
P
Q
S
E
K
S
Site 104
S937
A
I
T
S
V
P
Q
S
E
K
S
E
S
T
P
Site 105
S940
S
V
P
Q
S
E
K
S
E
S
T
P
D
V
K
Site 106
S942
P
Q
S
E
K
S
E
S
T
P
D
V
K
L
T
Site 107
T943
Q
S
E
K
S
E
S
T
P
D
V
K
L
T
E
Site 108
T949
S
T
P
D
V
K
L
T
E
V
F
K
A
T
S
Site 109
S956
T
E
V
F
K
A
T
S
H
L
P
K
H
S
L
Site 110
S962
T
S
H
L
P
K
H
S
L
S
T
A
S
E
P
Site 111
S964
H
L
P
K
H
S
L
S
T
A
S
E
P
S
L
Site 112
S967
K
H
S
L
S
T
A
S
E
P
S
L
E
V
S
Site 113
S970
L
S
T
A
S
E
P
S
L
E
V
S
T
H
M
Site 114
S974
S
E
P
S
L
E
V
S
T
H
M
N
D
E
R
Site 115
T985
N
D
E
R
H
K
E
T
F
Q
V
R
E
C
F
Site 116
T995
V
R
E
C
F
G
N
T
P
N
C
P
S
S
S
Site 117
S1000
G
N
T
P
N
C
P
S
S
S
S
T
N
D
F
Site 118
S1001
N
T
P
N
C
P
S
S
S
S
T
N
D
F
Q
Site 119
S1003
P
N
C
P
S
S
S
S
T
N
D
F
Q
A
N
Site 120
T1004
N
C
P
S
S
S
S
T
N
D
F
Q
A
N
S
Site 121
S1024
F
C
Q
P
E
L
D
S
I
S
T
C
P
N
E
Site 122
S1026
Q
P
E
L
D
S
I
S
T
C
P
N
E
T
V
Site 123
T1036
P
N
E
T
V
S
L
T
T
Y
F
S
V
D
S
Site 124
T1048
V
D
S
C
M
T
D
T
Y
R
L
K
Y
H
Q
Site 125
Y1049
D
S
C
M
T
D
T
Y
R
L
K
Y
H
Q
R
Site 126
Y1053
T
D
T
Y
R
L
K
Y
H
Q
R
P
K
L
S
Site 127
S1060
Y
H
Q
R
P
K
L
S
F
P
E
S
S
G
F
Site 128
S1064
P
K
L
S
F
P
E
S
S
G
F
C
N
N
S
Site 129
S1065
K
L
S
F
P
E
S
S
G
F
C
N
N
S
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation