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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP51
Full Name:
Ubiquitin carboxyl-terminal hydrolase 51
Alias:
Deubiquitinating enzyme 51;Ubiquitin thiolesterase 51;Ubiquitin-specific-processing protease 51
Type:
Mass (Da):
79756
Number AA:
711
UniProt ID:
Q70EK9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
A
Q
V
R
E
T
S
L
P
S
G
S
G
Site 2
S8
M
A
Q
V
R
E
T
S
L
P
S
G
S
G
V
Site 3
S11
V
R
E
T
S
L
P
S
G
S
G
V
R
W
I
Site 4
S13
E
T
S
L
P
S
G
S
G
V
R
W
I
S
G
Site 5
S19
G
S
G
V
R
W
I
S
G
G
G
G
G
A
S
Site 6
S26
S
G
G
G
G
G
A
S
P
E
E
A
V
E
K
Site 7
S48
A
A
G
A
T
K
A
S
S
R
R
E
A
E
E
Site 8
S49
A
G
A
T
K
A
S
S
R
R
E
A
E
E
M
Site 9
T73
P
A
P
E
E
N
L
T
W
S
S
S
G
G
D
Site 10
S75
P
E
E
N
L
T
W
S
S
S
G
G
D
E
K
Site 11
S77
E
N
L
T
W
S
S
S
G
G
D
E
K
V
L
Site 12
S86
G
D
E
K
V
L
P
S
I
P
L
R
C
H
S
Site 13
S93
S
I
P
L
R
C
H
S
S
S
S
P
V
C
P
Site 14
S94
I
P
L
R
C
H
S
S
S
S
P
V
C
P
R
Site 15
S95
P
L
R
C
H
S
S
S
S
P
V
C
P
R
R
Site 16
S96
L
R
C
H
S
S
S
S
P
V
C
P
R
R
K
Site 17
S114
R
P
Q
P
R
A
R
S
R
S
Q
P
G
L
S
Site 18
S116
Q
P
R
A
R
S
R
S
Q
P
G
L
S
A
P
Site 19
S121
S
R
S
Q
P
G
L
S
A
P
P
P
P
P
A
Site 20
S150
R
P
R
A
W
R
G
S
R
R
R
S
R
P
G
Site 21
S154
W
R
G
S
R
R
R
S
R
P
G
S
R
P
Q
Site 22
S158
R
R
R
S
R
P
G
S
R
P
Q
T
R
R
S
Site 23
T162
R
P
G
S
R
P
Q
T
R
R
S
C
S
G
D
Site 24
S165
S
R
P
Q
T
R
R
S
C
S
G
D
L
D
G
Site 25
S167
P
Q
T
R
R
S
C
S
G
D
L
D
G
S
G
Site 26
S173
C
S
G
D
L
D
G
S
G
D
P
G
G
L
G
Site 27
S196
G
Q
G
P
T
G
C
S
H
V
E
S
F
K
V
Site 28
Y215
Q
K
N
L
R
L
I
Y
Q
R
F
V
W
S
G
Site 29
S221
I
Y
Q
R
F
V
W
S
G
T
P
E
T
R
K
Site 30
T223
Q
R
F
V
W
S
G
T
P
E
T
R
K
R
K
Site 31
Y293
F
M
C
K
D
Y
V
Y
D
K
D
I
E
Q
I
Site 32
T313
E
K
I
L
R
L
L
T
S
T
S
T
D
V
S
Site 33
S314
K
I
L
R
L
L
T
S
T
S
T
D
V
S
H
Site 34
T315
I
L
R
L
L
T
S
T
S
T
D
V
S
H
Q
Site 35
S316
L
R
L
L
T
S
T
S
T
D
V
S
H
Q
Q
Site 36
S320
T
S
T
S
T
D
V
S
H
Q
Q
F
M
T
S
Site 37
S334
S
G
F
E
D
K
Q
S
T
C
E
T
K
E
Q
Site 38
T338
D
K
Q
S
T
C
E
T
K
E
Q
E
P
K
L
Site 39
S356
K
K
K
R
R
K
K
S
V
Y
T
V
G
L
R
Site 40
Y358
K
R
R
K
K
S
V
Y
T
V
G
L
R
G
L
Site 41
T359
R
R
K
K
S
V
Y
T
V
G
L
R
G
L
I
Site 42
T382
N
C
I
V
Q
A
L
T
H
I
P
L
L
K
D
Site 43
Y419
S
S
L
F
H
A
M
Y
S
G
S
R
T
P
H
Site 44
S420
S
L
F
H
A
M
Y
S
G
S
R
T
P
H
I
Site 45
T424
A
M
Y
S
G
S
R
T
P
H
I
P
Y
K
L
Site 46
S465
L
D
V
L
H
R
H
S
K
D
D
S
G
G
Q
Site 47
S469
H
R
H
S
K
D
D
S
G
G
Q
E
A
N
N
Site 48
T524
D
L
P
G
S
C
A
T
F
D
S
Q
N
P
E
Site 49
S527
G
S
C
A
T
F
D
S
Q
N
P
E
R
A
D
Site 50
S535
Q
N
P
E
R
A
D
S
T
V
S
R
D
D
H
Site 51
T536
N
P
E
R
A
D
S
T
V
S
R
D
D
H
I
Site 52
S564
T
R
P
E
H
L
G
S
S
A
K
I
K
C
N
Site 53
S572
S
A
K
I
K
C
N
S
C
Q
S
Y
Q
E
S
Site 54
Y576
K
C
N
S
C
Q
S
Y
Q
E
S
T
K
Q
L
Site 55
S579
S
C
Q
S
Y
Q
E
S
T
K
Q
L
T
M
K
Site 56
T611
K
Q
R
R
K
I
N
T
F
I
S
F
P
L
E
Site 57
S627
D
M
T
P
F
L
A
S
T
K
E
S
R
M
K
Site 58
S631
F
L
A
S
T
K
E
S
R
M
K
E
G
Q
P
Site 59
T640
M
K
E
G
Q
P
P
T
D
C
V
P
N
E
N
Site 60
Y666
G
T
L
E
S
G
H
Y
T
S
F
I
R
Q
Q
Site 61
T667
T
L
E
S
G
H
Y
T
S
F
I
R
Q
Q
K
Site 62
S668
L
E
S
G
H
Y
T
S
F
I
R
Q
Q
K
D
Site 63
Y699
D
L
L
Y
S
E
G
Y
L
L
F
Y
H
K
Q
Site 64
Y703
S
E
G
Y
L
L
F
Y
H
K
Q
G
L
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation