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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP54
Full Name:
Inactive ubiquitin carboxyl-terminal hydrolase 54
Alias:
BA137L10.3; BA137L10.4; C10orf29; FLJ37318; Inactive ubiquitin-specific peptidase 54; Ubiquitin specific peptidase 54; Ubiquitin specific protease 54; Ubiquitin specific proteinase 54
Type:
Ubiquitin conjugating system
Mass (Da):
187388
Number AA:
1684
UniProt ID:
Q70EL1
International Prot ID:
IPI00418210
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
W
K
R
N
Y
F
S
G
G
R
G
S
V
Q
Site 2
S14
Y
F
S
G
G
R
G
S
V
Q
G
M
F
A
P
Site 3
S23
Q
G
M
F
A
P
R
S
S
T
S
I
A
P
S
Site 4
S24
G
M
F
A
P
R
S
S
T
S
I
A
P
S
K
Site 5
T25
M
F
A
P
R
S
S
T
S
I
A
P
S
K
G
Site 6
S26
F
A
P
R
S
S
T
S
I
A
P
S
K
G
L
Site 7
S30
S
S
T
S
I
A
P
S
K
G
L
S
N
E
P
Site 8
S34
I
A
P
S
K
G
L
S
N
E
P
G
Q
N
S
Site 9
S60
H
L
D
I
F
R
R
S
F
R
Q
L
T
T
H
Site 10
T65
R
R
S
F
R
Q
L
T
T
H
K
C
M
G
D
Site 11
S89
I
F
N
Q
F
Q
C
S
S
E
K
V
L
P
S
Site 12
S90
F
N
Q
F
Q
C
S
S
E
K
V
L
P
S
D
Site 13
S96
S
S
E
K
V
L
P
S
D
T
L
R
S
A
L
Site 14
T98
E
K
V
L
P
S
D
T
L
R
S
A
L
A
K
Site 15
S101
L
P
S
D
T
L
R
S
A
L
A
K
T
F
Q
Site 16
T106
L
R
S
A
L
A
K
T
F
Q
D
E
Q
R
F
Site 17
S205
L
E
R
R
E
K
P
S
P
S
M
F
G
E
L
Site 18
S207
R
R
E
K
P
S
P
S
M
F
G
E
L
L
Q
Site 19
S217
G
E
L
L
Q
N
A
S
T
M
G
D
L
R
N
Site 20
S227
G
D
L
R
N
C
P
S
N
C
G
E
R
I
R
Site 21
S254
T
I
G
L
V
W
D
S
D
H
S
D
L
A
E
Site 22
S257
L
V
W
D
S
D
H
S
D
L
A
E
D
V
I
Site 23
T281
G
D
L
F
F
R
V
T
D
D
R
A
K
Q
S
Site 24
Y317
T
K
I
R
K
W
M
Y
F
D
D
A
H
V
K
Site 25
Y349
Y
Q
P
L
L
L
L
Y
A
D
P
Q
G
T
P
Site 26
T355
L
Y
A
D
P
Q
G
T
P
V
S
T
Q
D
L
Site 27
S358
D
P
Q
G
T
P
V
S
T
Q
D
L
P
P
Q
Site 28
S370
P
P
Q
A
E
F
Q
S
Y
S
R
T
C
Y
D
Site 29
Y371
P
Q
A
E
F
Q
S
Y
S
R
T
C
Y
D
S
Site 30
T374
E
F
Q
S
Y
S
R
T
C
Y
D
S
E
D
S
Site 31
Y376
Q
S
Y
S
R
T
C
Y
D
S
E
D
S
G
R
Site 32
S378
Y
S
R
T
C
Y
D
S
E
D
S
G
R
E
P
Site 33
S381
T
C
Y
D
S
E
D
S
G
R
E
P
S
I
S
Site 34
S386
E
D
S
G
R
E
P
S
I
S
S
D
T
R
T
Site 35
S388
S
G
R
E
P
S
I
S
S
D
T
R
T
D
S
Site 36
S389
G
R
E
P
S
I
S
S
D
T
R
T
D
S
S
Site 37
T391
E
P
S
I
S
S
D
T
R
T
D
S
S
T
E
Site 38
T393
S
I
S
S
D
T
R
T
D
S
S
T
E
S
Y
Site 39
S395
S
S
D
T
R
T
D
S
S
T
E
S
Y
P
Y
Site 40
S396
S
D
T
R
T
D
S
S
T
E
S
Y
P
Y
K
Site 41
T397
D
T
R
T
D
S
S
T
E
S
Y
P
Y
K
H
Site 42
S399
R
T
D
S
S
T
E
S
Y
P
Y
K
H
S
H
Site 43
Y400
T
D
S
S
T
E
S
Y
P
Y
K
H
S
H
H
Site 44
Y402
S
S
T
E
S
Y
P
Y
K
H
S
H
H
E
S
Site 45
S405
E
S
Y
P
Y
K
H
S
H
H
E
S
V
V
S
Site 46
S409
Y
K
H
S
H
H
E
S
V
V
S
H
F
S
S
Site 47
S412
S
H
H
E
S
V
V
S
H
F
S
S
D
S
Q
Site 48
S415
E
S
V
V
S
H
F
S
S
D
S
Q
G
T
V
Site 49
S418
V
S
H
F
S
S
D
S
Q
G
T
V
I
Y
N
Site 50
S430
I
Y
N
V
E
N
D
S
M
S
Q
S
S
R
D
Site 51
S432
N
V
E
N
D
S
M
S
Q
S
S
R
D
T
G
Site 52
S434
E
N
D
S
M
S
Q
S
S
R
D
T
G
H
L
Site 53
T438
M
S
Q
S
S
R
D
T
G
H
L
T
D
S
E
Site 54
T442
S
R
D
T
G
H
L
T
D
S
E
C
N
Q
K
Site 55
S444
D
T
G
H
L
T
D
S
E
C
N
Q
K
H
T
Site 56
S452
E
C
N
Q
K
H
T
S
K
K
G
S
L
I
E
Site 57
S456
K
H
T
S
K
K
G
S
L
I
E
R
K
R
S
Site 58
S463
S
L
I
E
R
K
R
S
S
G
R
V
R
R
K
Site 59
S464
L
I
E
R
K
R
S
S
G
R
V
R
R
K
G
Site 60
S477
K
G
D
E
P
Q
A
S
G
Y
H
S
E
G
E
Site 61
Y479
D
E
P
Q
A
S
G
Y
H
S
E
G
E
T
L
Site 62
S481
P
Q
A
S
G
Y
H
S
E
G
E
T
L
K
E
Site 63
T485
G
Y
H
S
E
G
E
T
L
K
E
K
Q
A
P
Site 64
S496
K
Q
A
P
R
N
A
S
K
P
S
S
S
T
N
Site 65
S500
R
N
A
S
K
P
S
S
S
T
N
R
L
R
D
Site 66
S501
N
A
S
K
P
S
S
S
T
N
R
L
R
D
F
Site 67
T511
R
L
R
D
F
K
E
T
V
S
N
M
I
H
N
Site 68
S521
N
M
I
H
N
R
P
S
L
A
S
Q
T
N
V
Site 69
S524
H
N
R
P
S
L
A
S
Q
T
N
V
G
S
H
Site 70
T526
R
P
S
L
A
S
Q
T
N
V
G
S
H
C
R
Site 71
S530
A
S
Q
T
N
V
G
S
H
C
R
G
R
G
G
Site 72
T547
P
D
K
K
P
P
R
T
L
P
L
H
S
R
D
Site 73
S559
S
R
D
W
E
I
E
S
T
S
S
E
S
K
S
Site 74
T560
R
D
W
E
I
E
S
T
S
S
E
S
K
S
S
Site 75
S561
D
W
E
I
E
S
T
S
S
E
S
K
S
S
S
Site 76
S562
W
E
I
E
S
T
S
S
E
S
K
S
S
S
S
Site 77
S564
I
E
S
T
S
S
E
S
K
S
S
S
S
S
K
Site 78
S566
S
T
S
S
E
S
K
S
S
S
S
S
K
Y
R
Site 79
S567
T
S
S
E
S
K
S
S
S
S
S
K
Y
R
P
Site 80
S568
S
S
E
S
K
S
S
S
S
S
K
Y
R
P
T
Site 81
S569
S
E
S
K
S
S
S
S
S
K
Y
R
P
T
W
Site 82
S570
E
S
K
S
S
S
S
S
K
Y
R
P
T
W
R
Site 83
T575
S
S
S
K
Y
R
P
T
W
R
P
K
R
E
S
Site 84
S582
T
W
R
P
K
R
E
S
L
N
I
D
S
I
F
Site 85
S587
R
E
S
L
N
I
D
S
I
F
S
K
D
K
R
Site 86
Y599
D
K
R
K
H
C
G
Y
T
Q
L
S
P
F
S
Site 87
S603
H
C
G
Y
T
Q
L
S
P
F
S
E
D
S
A
Site 88
S606
Y
T
Q
L
S
P
F
S
E
D
S
A
K
E
F
Site 89
S609
L
S
P
F
S
E
D
S
A
K
E
F
I
P
D
Site 90
S619
E
F
I
P
D
E
P
S
K
P
P
S
Y
D
I
Site 91
S623
D
E
P
S
K
P
P
S
Y
D
I
K
F
G
G
Site 92
Y624
E
P
S
K
P
P
S
Y
D
I
K
F
G
G
P
Site 93
S632
D
I
K
F
G
G
P
S
P
Q
Y
K
R
W
G
Site 94
Y635
F
G
G
P
S
P
Q
Y
K
R
W
G
P
A
R
Site 95
S645
W
G
P
A
R
P
G
S
H
L
L
E
Q
H
P
Site 96
S660
R
L
I
Q
R
M
E
S
G
Y
E
S
S
E
R
Site 97
Y662
I
Q
R
M
E
S
G
Y
E
S
S
E
R
N
S
Site 98
S664
R
M
E
S
G
Y
E
S
S
E
R
N
S
S
S
Site 99
S665
M
E
S
G
Y
E
S
S
E
R
N
S
S
S
P
Site 100
S669
Y
E
S
S
E
R
N
S
S
S
P
V
S
L
D
Site 101
S670
E
S
S
E
R
N
S
S
S
P
V
S
L
D
A
Site 102
S671
S
S
E
R
N
S
S
S
P
V
S
L
D
A
A
Site 103
S674
R
N
S
S
S
P
V
S
L
D
A
A
L
P
E
Site 104
Y686
L
P
E
S
S
N
V
Y
R
D
P
S
A
K
R
Site 105
S690
S
N
V
Y
R
D
P
S
A
K
R
S
A
G
L
Site 106
S694
R
D
P
S
A
K
R
S
A
G
L
V
P
S
W
Site 107
S700
R
S
A
G
L
V
P
S
W
R
H
I
P
K
S
Site 108
S707
S
W
R
H
I
P
K
S
H
S
S
S
I
L
E
Site 109
S709
R
H
I
P
K
S
H
S
S
S
I
L
E
V
D
Site 110
S711
I
P
K
S
H
S
S
S
I
L
E
V
D
S
T
Site 111
S717
S
S
I
L
E
V
D
S
T
A
S
M
G
G
W
Site 112
S727
S
M
G
G
W
T
K
S
Q
P
F
S
G
E
E
Site 113
S731
W
T
K
S
Q
P
F
S
G
E
E
I
S
S
K
Site 114
S736
P
F
S
G
E
E
I
S
S
K
S
E
L
D
E
Site 115
S737
F
S
G
E
E
I
S
S
K
S
E
L
D
E
L
Site 116
S739
G
E
E
I
S
S
K
S
E
L
D
E
L
Q
E
Site 117
S790
E
L
Q
N
Q
G
R
S
D
G
F
E
R
S
L
Site 118
S796
R
S
D
G
F
E
R
S
L
Q
E
A
E
S
V
Site 119
S802
R
S
L
Q
E
A
E
S
V
F
E
E
S
L
H
Site 120
S807
A
E
S
V
F
E
E
S
L
H
L
E
Q
K
G
Site 121
S838
R
L
A
L
H
G
A
S
C
S
T
H
S
R
A
Site 122
S854
V
D
K
K
L
Q
I
S
I
R
K
A
R
S
L
Site 123
S860
I
S
I
R
K
A
R
S
L
Q
D
R
M
Q
Q
Site 124
S870
D
R
M
Q
Q
Q
Q
S
P
Q
Q
P
S
Q
P
Site 125
S875
Q
Q
S
P
Q
Q
P
S
Q
P
S
A
C
L
P
Site 126
S889
P
T
Q
A
G
T
L
S
Q
P
T
S
E
Q
P
Site 127
S893
G
T
L
S
Q
P
T
S
E
Q
P
I
P
L
Q
Site 128
T915
Q
L
E
S
G
M
D
T
E
F
G
A
S
S
F
Site 129
S920
M
D
T
E
F
G
A
S
S
F
F
H
S
P
A
Site 130
S921
D
T
E
F
G
A
S
S
F
F
H
S
P
A
S
Site 131
S925
G
A
S
S
F
F
H
S
P
A
S
C
H
E
S
Site 132
S928
S
F
F
H
S
P
A
S
C
H
E
S
H
S
S
Site 133
S932
S
P
A
S
C
H
E
S
H
S
S
L
S
P
E
Site 134
S934
A
S
C
H
E
S
H
S
S
L
S
P
E
S
S
Site 135
S935
S
C
H
E
S
H
S
S
L
S
P
E
S
S
A
Site 136
S937
H
E
S
H
S
S
L
S
P
E
S
S
A
P
Q
Site 137
S940
H
S
S
L
S
P
E
S
S
A
P
Q
H
S
S
Site 138
S941
S
S
L
S
P
E
S
S
A
P
Q
H
S
S
P
Site 139
S946
E
S
S
A
P
Q
H
S
S
P
S
R
S
A
L
Site 140
S947
S
S
A
P
Q
H
S
S
P
S
R
S
A
L
K
Site 141
S951
Q
H
S
S
P
S
R
S
A
L
K
L
L
T
S
Site 142
S988
T
E
K
N
S
H
H
S
W
E
P
L
D
A
P
Site 143
S1002
P
E
G
K
L
Q
G
S
R
C
D
N
S
S
C
Site 144
S1007
Q
G
S
R
C
D
N
S
S
C
S
K
L
P
P
Site 145
S1008
G
S
R
C
D
N
S
S
C
S
K
L
P
P
Q
Site 146
S1010
R
C
D
N
S
S
C
S
K
L
P
P
Q
E
G
Site 147
S1036
K
K
D
P
A
N
P
S
P
V
M
P
G
I
A
Site 148
S1045
V
M
P
G
I
A
T
S
E
R
G
D
E
H
S
Site 149
S1052
S
E
R
G
D
E
H
S
L
G
C
S
P
S
N
Site 150
S1056
D
E
H
S
L
G
C
S
P
S
N
S
S
A
Q
Site 151
S1058
H
S
L
G
C
S
P
S
N
S
S
A
Q
P
S
Site 152
S1060
L
G
C
S
P
S
N
S
S
A
Q
P
S
L
P
Site 153
S1061
G
C
S
P
S
N
S
S
A
Q
P
S
L
P
L
Site 154
S1065
S
N
S
S
A
Q
P
S
L
P
L
Y
R
T
C
Site 155
Y1069
A
Q
P
S
L
P
L
Y
R
T
C
H
P
I
M
Site 156
S1101
N
Q
C
L
Q
G
Q
S
L
K
T
S
L
T
L
Site 157
S1105
Q
G
Q
S
L
K
T
S
L
T
L
K
V
D
R
Site 158
T1107
Q
S
L
K
T
S
L
T
L
K
V
D
R
G
S
Site 159
S1114
T
L
K
V
D
R
G
S
E
E
T
Y
R
P
E
Site 160
T1117
V
D
R
G
S
E
E
T
Y
R
P
E
F
P
S
Site 161
Y1118
D
R
G
S
E
E
T
Y
R
P
E
F
P
S
T
Site 162
S1124
T
Y
R
P
E
F
P
S
T
K
G
L
V
R
S
Site 163
T1125
Y
R
P
E
F
P
S
T
K
G
L
V
R
S
L
Site 164
S1131
S
T
K
G
L
V
R
S
L
A
E
Q
F
Q
R
Site 165
S1143
F
Q
R
M
Q
G
V
S
M
R
D
S
T
G
F
Site 166
S1147
Q
G
V
S
M
R
D
S
T
G
F
K
D
R
S
Site 167
T1148
G
V
S
M
R
D
S
T
G
F
K
D
R
S
L
Site 168
S1154
S
T
G
F
K
D
R
S
L
S
G
S
L
R
K
Site 169
S1156
G
F
K
D
R
S
L
S
G
S
L
R
K
N
S
Site 170
S1158
K
D
R
S
L
S
G
S
L
R
K
N
S
S
P
Site 171
S1163
S
G
S
L
R
K
N
S
S
P
S
D
S
K
P
Site 172
S1164
G
S
L
R
K
N
S
S
P
S
D
S
K
P
P
Site 173
S1166
L
R
K
N
S
S
P
S
D
S
K
P
P
F
S
Site 174
S1168
K
N
S
S
P
S
D
S
K
P
P
F
S
Q
G
Site 175
S1173
S
D
S
K
P
P
F
S
Q
G
Q
E
K
G
H
Site 176
S1189
P
W
A
K
Q
Q
S
S
L
E
G
G
D
R
P
Site 177
S1198
E
G
G
D
R
P
L
S
W
E
E
S
T
E
H
Site 178
S1202
R
P
L
S
W
E
E
S
T
E
H
S
S
L
A
Site 179
T1203
P
L
S
W
E
E
S
T
E
H
S
S
L
A
L
Site 180
S1206
W
E
E
S
T
E
H
S
S
L
A
L
N
S
G
Site 181
S1207
E
E
S
T
E
H
S
S
L
A
L
N
S
G
L
Site 182
T1219
S
G
L
P
N
G
E
T
S
S
G
G
Q
P
R
Site 183
Y1233
R
L
A
E
P
D
I
Y
Q
E
K
L
S
Q
V
Site 184
S1238
D
I
Y
Q
E
K
L
S
Q
V
R
D
V
R
S
Site 185
S1245
S
Q
V
R
D
V
R
S
K
D
L
G
S
S
T
Site 186
S1250
V
R
S
K
D
L
G
S
S
T
D
L
G
T
S
Site 187
S1251
R
S
K
D
L
G
S
S
T
D
L
G
T
S
L
Site 188
T1252
S
K
D
L
G
S
S
T
D
L
G
T
S
L
P
Site 189
T1256
G
S
S
T
D
L
G
T
S
L
P
L
D
S
W
Site 190
S1257
S
S
T
D
L
G
T
S
L
P
L
D
S
W
V
Site 191
S1262
G
T
S
L
P
L
D
S
W
V
N
I
T
R
F
Site 192
S1272
N
I
T
R
F
C
D
S
Q
L
K
H
G
A
P
Site 193
S1285
A
P
R
P
G
M
K
S
S
P
H
D
S
H
T
Site 194
S1286
P
R
P
G
M
K
S
S
P
H
D
S
H
T
C
Site 195
S1290
M
K
S
S
P
H
D
S
H
T
C
V
T
Y
P
Site 196
T1292
S
S
P
H
D
S
H
T
C
V
T
Y
P
E
R
Site 197
Y1296
D
S
H
T
C
V
T
Y
P
E
R
N
H
I
L
Site 198
T1312
H
P
H
W
N
Q
D
T
E
Q
E
T
S
E
L
Site 199
S1317
Q
D
T
E
Q
E
T
S
E
L
E
S
L
Y
Q
Site 200
S1321
Q
E
T
S
E
L
E
S
L
Y
Q
A
S
L
Q
Site 201
Y1323
T
S
E
L
E
S
L
Y
Q
A
S
L
Q
A
S
Site 202
S1326
L
E
S
L
Y
Q
A
S
L
Q
A
S
Q
A
G
Site 203
S1330
Y
Q
A
S
L
Q
A
S
Q
A
G
C
S
G
W
Site 204
S1348
D
T
A
W
H
P
L
S
Q
T
G
S
A
D
G
Site 205
S1352
H
P
L
S
Q
T
G
S
A
D
G
M
G
R
R
Site 206
S1362
G
M
G
R
R
L
H
S
A
H
D
P
G
L
S
Site 207
S1369
S
A
H
D
P
G
L
S
K
T
S
T
A
E
M
Site 208
T1373
P
G
L
S
K
T
S
T
A
E
M
E
H
G
L
Site 209
T1385
H
G
L
H
E
A
R
T
V
R
T
S
Q
A
T
Site 210
S1389
E
A
R
T
V
R
T
S
Q
A
T
P
C
R
G
Site 211
T1392
T
V
R
T
S
Q
A
T
P
C
R
G
L
S
R
Site 212
S1398
A
T
P
C
R
G
L
S
R
E
C
G
E
D
E
Site 213
Y1407
E
C
G
E
D
E
Q
Y
S
A
E
N
L
R
R
Site 214
S1416
A
E
N
L
R
R
I
S
R
S
L
S
G
T
V
Site 215
S1418
N
L
R
R
I
S
R
S
L
S
G
T
V
V
S
Site 216
S1420
R
R
I
S
R
S
L
S
G
T
V
V
S
E
R
Site 217
T1422
I
S
R
S
L
S
G
T
V
V
S
E
R
E
E
Site 218
S1425
S
L
S
G
T
V
V
S
E
R
E
E
A
P
V
Site 219
S1433
E
R
E
E
A
P
V
S
S
H
S
F
D
S
S
Site 220
S1434
R
E
E
A
P
V
S
S
H
S
F
D
S
S
N
Site 221
S1436
E
A
P
V
S
S
H
S
F
D
S
S
N
V
R
Site 222
S1439
V
S
S
H
S
F
D
S
S
N
V
R
K
P
L
Site 223
S1440
S
S
H
S
F
D
S
S
N
V
R
K
P
L
E
Site 224
T1448
N
V
R
K
P
L
E
T
G
H
R
C
S
S
S
Site 225
S1453
L
E
T
G
H
R
C
S
S
S
S
S
L
P
V
Site 226
S1454
E
T
G
H
R
C
S
S
S
S
S
L
P
V
I
Site 227
S1455
T
G
H
R
C
S
S
S
S
S
L
P
V
I
H
Site 228
S1456
G
H
R
C
S
S
S
S
S
L
P
V
I
H
D
Site 229
S1457
H
R
C
S
S
S
S
S
L
P
V
I
H
D
P
Site 230
T1489
S
P
D
V
L
M
P
T
M
A
G
E
P
N
R
Site 231
T1500
E
P
N
R
L
P
G
T
S
R
S
V
Q
Q
F
Site 232
S1501
P
N
R
L
P
G
T
S
R
S
V
Q
Q
F
L
Site 233
S1503
R
L
P
G
T
S
R
S
V
Q
Q
F
L
A
M
Site 234
T1516
A
M
C
D
R
G
E
T
S
Q
G
A
K
Y
T
Site 235
S1517
M
C
D
R
G
E
T
S
Q
G
A
K
Y
T
G
Site 236
Y1522
E
T
S
Q
G
A
K
Y
T
G
R
T
L
N
Y
Site 237
Y1529
Y
T
G
R
T
L
N
Y
Q
S
L
P
H
R
S
Site 238
S1531
G
R
T
L
N
Y
Q
S
L
P
H
R
S
R
T
Site 239
T1538
S
L
P
H
R
S
R
T
D
N
S
W
A
P
W
Site 240
S1541
H
R
S
R
T
D
N
S
W
A
P
W
S
E
T
Site 241
T1558
H
I
G
T
R
F
L
T
T
P
G
C
N
P
Q
Site 242
T1559
I
G
T
R
F
L
T
T
P
G
C
N
P
Q
L
Site 243
T1567
P
G
C
N
P
Q
L
T
Y
T
A
T
L
P
E
Site 244
T1571
P
Q
L
T
Y
T
A
T
L
P
E
R
S
K
G
Site 245
T1584
K
G
L
Q
V
P
H
T
Q
S
W
S
D
L
F
Site 246
S1586
L
Q
V
P
H
T
Q
S
W
S
D
L
F
H
S
Site 247
S1588
V
P
H
T
Q
S
W
S
D
L
F
H
S
P
S
Site 248
S1593
S
W
S
D
L
F
H
S
P
S
H
P
P
I
V
Site 249
S1595
S
D
L
F
H
S
P
S
H
P
P
I
V
H
P
Site 250
Y1604
P
P
I
V
H
P
V
Y
P
P
S
S
S
L
H
Site 251
S1608
H
P
V
Y
P
P
S
S
S
L
H
V
P
L
R
Site 252
S1609
P
V
Y
P
P
S
S
S
L
H
V
P
L
R
S
Site 253
S1616
S
L
H
V
P
L
R
S
A
W
N
S
D
P
V
Site 254
S1620
P
L
R
S
A
W
N
S
D
P
V
P
G
S
R
Site 255
S1626
N
S
D
P
V
P
G
S
R
T
P
G
P
R
R
Site 256
T1628
D
P
V
P
G
S
R
T
P
G
P
R
R
V
D
Site 257
S1645
P
D
D
D
W
R
Q
S
S
Y
A
S
H
S
G
Site 258
S1646
D
D
D
W
R
Q
S
S
Y
A
S
H
S
G
H
Site 259
Y1647
D
D
W
R
Q
S
S
Y
A
S
H
S
G
H
R
Site 260
S1649
W
R
Q
S
S
Y
A
S
H
S
G
H
R
R
T
Site 261
S1651
Q
S
S
Y
A
S
H
S
G
H
R
R
T
V
G
Site 262
T1656
S
H
S
G
H
R
R
T
V
G
E
G
F
L
F
Site 263
S1666
E
G
F
L
F
V
L
S
D
A
P
R
R
E
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation