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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CSS3
Full Name:
Chondroitin sulfate synthase 3
Alias:
Carbohydrate synthase 2; Chondroitin glucuronyltransferase II; Chondroitin synthase 2; CHSS3; CHSY2; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II; N-acetylgalactosaminyltransferase II
Type:
Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; EC 2.4.1.226; EC 2.4.1.175
Mass (Da):
100284
Number AA:
882
UniProt ID:
Q70JA7
International Prot ID:
IPI00418277
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032580
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0050510
GO:0047238
GO:0046872
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
A
P
R
V
A
E
L
S
E
R
K
R
R
G
S
Site 2
S42
S
E
R
K
R
R
G
S
S
L
C
S
Y
Y
G
Site 3
S43
E
R
K
R
R
G
S
S
L
C
S
Y
Y
G
R
Site 4
S46
R
R
G
S
S
L
C
S
Y
Y
G
R
S
A
A
Site 5
Y47
R
G
S
S
L
C
S
Y
Y
G
R
S
A
A
G
Site 6
Y48
G
S
S
L
C
S
Y
Y
G
R
S
A
A
G
P
Site 7
S51
L
C
S
Y
Y
G
R
S
A
A
G
P
R
A
G
Site 8
S68
Q
P
L
P
Q
P
Q
S
R
P
R
Q
E
Q
S
Site 9
S75
S
R
P
R
Q
E
Q
S
P
P
P
A
R
Q
D
Site 10
T96
P
E
A
A
P
G
I
T
S
F
R
S
S
P
W
Site 11
S97
E
A
A
P
G
I
T
S
F
R
S
S
P
W
Q
Site 12
S100
P
G
I
T
S
F
R
S
S
P
W
Q
Q
P
P
Site 13
S101
G
I
T
S
F
R
S
S
P
W
Q
Q
P
P
P
Site 14
S152
R
R
D
G
R
P
G
S
S
H
N
G
S
G
D
Site 15
S153
R
D
G
R
P
G
S
S
H
N
G
S
G
D
G
Site 16
S157
P
G
S
S
H
N
G
S
G
D
G
G
A
A
A
Site 17
S166
D
G
G
A
A
A
P
S
A
R
P
R
D
F
L
Site 18
Y174
A
R
P
R
D
F
L
Y
V
G
V
M
T
A
Q
Site 19
T194
R
A
L
A
A
Q
R
T
W
A
R
F
I
P
G
Site 20
S207
P
G
R
V
E
F
F
S
S
Q
Q
P
P
N
A
Site 21
S208
G
R
V
E
F
F
S
S
Q
Q
P
P
N
A
G
Site 22
S232
A
L
P
G
V
D
D
S
Y
P
P
Q
K
K
S
Site 23
Y233
L
P
G
V
D
D
S
Y
P
P
Q
K
K
S
F
Site 24
Y265
M
R
A
D
D
D
V
Y
I
K
G
D
K
L
E
Site 25
S277
K
L
E
E
F
L
R
S
L
N
S
S
K
P
L
Site 26
S280
E
F
L
R
S
L
N
S
S
K
P
L
Y
L
G
Site 27
S281
F
L
R
S
L
N
S
S
K
P
L
Y
L
G
Q
Site 28
Y285
L
N
S
S
K
P
L
Y
L
G
Q
T
G
L
G
Site 29
S318
G
G
P
G
M
I
F
S
R
E
V
L
R
R
M
Site 30
Y337
G
E
C
L
R
E
M
Y
T
T
H
E
D
V
E
Site 31
T339
C
L
R
E
M
Y
T
T
H
E
D
V
E
V
G
Site 32
Y371
Q
Q
L
F
H
E
N
Y
E
H
N
R
K
G
Y
Site 33
Y378
Y
E
H
N
R
K
G
Y
I
Q
D
L
H
N
S
Site 34
T392
S
K
I
H
A
A
I
T
L
H
P
N
K
R
P
Site 35
Y401
H
P
N
K
R
P
A
Y
Q
Y
R
L
H
N
Y
Site 36
Y403
N
K
R
P
A
Y
Q
Y
R
L
H
N
Y
M
L
Site 37
S411
R
L
H
N
Y
M
L
S
R
K
I
S
E
L
R
Site 38
S415
Y
M
L
S
R
K
I
S
E
L
R
Y
R
T
I
Site 39
Y419
R
K
I
S
E
L
R
Y
R
T
I
Q
L
H
R
Site 40
T421
I
S
E
L
R
Y
R
T
I
Q
L
H
R
E
S
Site 41
S428
T
I
Q
L
H
R
E
S
A
L
M
S
K
L
S
Site 42
S432
H
R
E
S
A
L
M
S
K
L
S
N
T
E
V
Site 43
S435
S
A
L
M
S
K
L
S
N
T
E
V
S
K
E
Site 44
S451
Q
Q
L
G
V
I
P
S
F
N
H
F
Q
P
R
Site 45
T470
V
I
E
W
E
F
L
T
G
K
L
L
Y
S
A
Site 46
S476
L
T
G
K
L
L
Y
S
A
A
E
N
Q
P
P
Site 47
S486
E
N
Q
P
P
R
Q
S
L
S
S
I
L
R
T
Site 48
S488
Q
P
P
R
Q
S
L
S
S
I
L
R
T
A
L
Site 49
S489
P
P
R
Q
S
L
S
S
I
L
R
T
A
L
D
Site 50
S512
M
I
N
E
N
A
K
S
R
G
R
L
I
D
F
Site 51
Y526
F
K
E
I
Q
Y
G
Y
R
R
V
N
P
M
H
Site 52
Y545
I
L
D
L
L
L
L
Y
K
R
H
K
G
R
K
Site 53
T554
R
H
K
G
R
K
L
T
V
P
V
R
R
H
A
Site 54
Y562
V
P
V
R
R
H
A
Y
L
Q
Q
L
F
S
K
Site 55
S568
A
Y
L
Q
Q
L
F
S
K
P
F
F
R
E
T
Site 56
T575
S
K
P
F
F
R
E
T
E
E
L
D
V
N
S
Site 57
S582
T
E
E
L
D
V
N
S
L
V
E
S
I
N
S
Site 58
S586
D
V
N
S
L
V
E
S
I
N
S
E
T
Q
S
Site 59
S589
S
L
V
E
S
I
N
S
E
T
Q
S
F
S
F
Site 60
T591
V
E
S
I
N
S
E
T
Q
S
F
S
F
I
S
Site 61
S593
S
I
N
S
E
T
Q
S
F
S
F
I
S
N
S
Site 62
S595
N
S
E
T
Q
S
F
S
F
I
S
N
S
L
K
Site 63
S606
N
S
L
K
I
L
S
S
F
Q
G
A
K
E
M
Site 64
S660
K
L
V
I
I
L
F
S
R
D
S
G
Q
D
S
Site 65
S663
I
I
L
F
S
R
D
S
G
Q
D
S
S
K
H
Site 66
S667
S
R
D
S
G
Q
D
S
S
K
H
I
E
L
I
Site 67
S668
R
D
S
G
Q
D
S
S
K
H
I
E
L
I
K
Site 68
Y677
H
I
E
L
I
K
G
Y
Q
N
K
Y
P
K
A
Site 69
Y681
I
K
G
Y
Q
N
K
Y
P
K
A
E
M
T
L
Site 70
T687
K
Y
P
K
A
E
M
T
L
I
P
M
K
G
E
Site 71
T735
L
Q
R
C
R
D
N
T
I
Q
G
Q
Q
V
Y
Site 72
Y742
T
I
Q
G
Q
Q
V
Y
Y
P
I
I
F
S
Q
Site 73
Y743
I
Q
G
Q
Q
V
Y
Y
P
I
I
F
S
Q
Y
Site 74
Y750
Y
P
I
I
F
S
Q
Y
D
P
K
V
T
N
G
Site 75
T762
T
N
G
G
N
P
P
T
D
D
Y
F
I
F
S
Site 76
Y765
G
N
P
P
T
D
D
Y
F
I
F
S
K
K
T
Site 77
S799
G
A
G
G
F
D
T
S
I
Q
G
W
G
L
E
Site 78
S817
L
Y
N
K
V
I
L
S
G
L
R
P
F
R
S
Site 79
S824
S
G
L
R
P
F
R
S
Q
E
V
G
V
V
H
Site 80
Y847
P
N
L
D
P
K
Q
Y
K
M
C
L
G
S
K
Site 81
Y877
E
K
H
L
G
V
R
Y
N
R
T
L
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation