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Updated November 2019
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Protein Info
Short Name:
FBN3
Full Name:
Fibrillin-3
Alias:
Type:
Mass (Da):
300356
Number AA:
2809
UniProt ID:
Q75N90
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S50
G
R
V
R
R
R
G
S
P
G
I
L
Q
G
P
Site 2
Y67
C
G
S
R
F
H
A
Y
C
C
P
G
W
R
T
Site 3
S111
A
D
G
T
L
A
P
S
C
G
V
S
R
G
S
Site 4
S121
V
S
R
G
S
G
C
S
V
S
C
M
N
G
G
Site 5
Y141
S
C
L
C
Q
K
G
Y
T
G
T
V
C
G
Q
Site 6
T144
C
Q
K
G
Y
T
G
T
V
C
G
Q
P
I
C
Site 7
Y182
G
P
Q
C
E
R
D
Y
R
T
G
P
C
F
G
Site 8
T184
Q
C
E
R
D
Y
R
T
G
P
C
F
G
Q
V
Site 9
T201
E
G
C
Q
H
Q
L
T
G
L
V
C
T
K
A
Site 10
S281
C
P
V
G
H
R
L
S
D
S
S
A
A
C
E
Site 11
S283
V
G
H
R
L
S
D
S
S
A
A
C
E
D
Y
Site 12
S284
G
H
R
L
S
D
S
S
A
A
C
E
D
Y
R
Site 13
Y290
S
S
A
A
C
E
D
Y
R
A
G
A
C
F
S
Site 14
Y312
A
G
D
L
A
G
H
Y
T
R
R
Q
C
C
C
Site 15
S339
E
L
C
P
P
R
G
S
N
E
F
Q
Q
L
C
Site 16
S385
A
R
L
N
P
H
G
S
D
A
R
G
I
P
S
Site 17
S392
S
D
A
R
G
I
P
S
L
G
P
G
N
S
N
Site 18
S398
P
S
L
G
P
G
N
S
N
I
G
T
A
T
L
Site 19
T402
P
G
N
S
N
I
G
T
A
T
L
N
Q
T
I
Site 20
T427
L
N
G
R
C
L
P
T
P
S
S
Y
R
C
E
Site 21
T481
C
Y
P
G
F
Q
A
T
P
T
R
Q
A
C
V
Site 22
S523
C
N
A
G
F
E
L
S
P
D
G
K
N
C
V
Site 23
T614
D
G
R
V
C
V
D
T
H
V
R
S
T
C
Y
Site 24
S618
C
V
D
T
H
V
R
S
T
C
Y
G
A
I
E
Site 25
T619
V
D
T
H
V
R
S
T
C
Y
G
A
I
E
K
Site 26
Y621
T
H
V
R
S
T
C
Y
G
A
I
E
K
G
S
Site 27
S628
Y
G
A
I
E
K
G
S
C
A
R
P
F
P
G
Site 28
T636
C
A
R
P
F
P
G
T
V
T
K
S
E
C
C
Site 29
Y705
C
E
N
L
R
G
S
Y
R
C
V
C
N
L
G
Site 30
Y713
R
C
V
C
N
L
G
Y
E
A
G
A
S
G
K
Site 31
S718
L
G
Y
E
A
G
A
S
G
K
D
C
T
D
V
Site 32
T723
G
A
S
G
K
D
C
T
D
V
D
E
C
A
L
Site 33
Y747
C
Q
N
S
P
G
S
Y
S
C
S
C
P
P
G
Site 34
S748
Q
N
S
P
G
S
Y
S
C
S
C
P
P
G
F
Site 35
S750
S
P
G
S
Y
S
C
S
C
P
P
G
F
H
F
Site 36
T788
R
N
L
A
G
S
Y
T
C
K
C
G
P
G
S
Site 37
S795
T
C
K
C
G
P
G
S
R
L
D
P
S
G
T
Site 38
S800
P
G
S
R
L
D
P
S
G
T
F
C
L
D
S
Site 39
T802
S
R
L
D
P
S
G
T
F
C
L
D
S
T
K
Site 40
S829
E
V
N
L
Q
G
A
S
L
R
S
E
C
C
A
Site 41
S844
T
L
G
A
A
W
G
S
P
C
E
R
C
E
I
Site 42
T866
F
A
R
M
T
G
V
T
C
D
D
V
N
E
C
Site 43
T929
D
E
D
E
C
G
V
T
L
P
G
K
Y
R
M
Site 44
S959
E
A
C
P
D
P
E
S
L
E
F
A
S
L
C
Site 45
S964
P
E
S
L
E
F
A
S
L
C
P
R
G
L
G
Site 46
S974
P
R
G
L
G
F
A
S
R
D
F
L
S
G
R
Site 47
S979
F
A
S
R
D
F
L
S
G
R
P
F
Y
K
D
Site 48
Y984
F
L
S
G
R
P
F
Y
K
D
V
N
E
C
K
Site 49
T1001
P
G
L
C
T
H
G
T
C
R
N
T
V
G
S
Site 50
S1035
D
I
D
E
C
R
I
S
P
D
L
C
G
Q
G
Site 51
T1043
P
D
L
C
G
Q
G
T
C
V
N
T
P
G
S
Site 52
T1047
G
Q
G
T
C
V
N
T
P
G
S
F
E
C
E
Site 53
T1086
P
L
L
C
R
G
G
T
C
T
N
T
D
G
S
Site 54
T1088
L
C
R
G
G
T
C
T
N
T
D
G
S
Y
K
Site 55
T1090
R
G
G
T
C
T
N
T
D
G
S
Y
K
C
Q
Site 56
Y1094
C
T
N
T
D
G
S
Y
K
C
Q
C
P
P
G
Site 57
S1118
C
E
D
I
D
E
C
S
L
S
D
G
L
C
P
Site 58
S1120
D
I
D
E
C
S
L
S
D
G
L
C
P
H
G
Site 59
T1147
C
H
A
G
F
Q
S
T
P
D
R
Q
G
C
V
Site 60
Y1177
C
I
N
T
E
G
S
Y
R
C
S
C
G
Q
G
Site 61
S1180
T
E
G
S
Y
R
C
S
C
G
Q
G
Y
S
L
Site 62
S1186
C
S
C
G
Q
G
Y
S
L
M
P
D
G
R
A
Site 63
S1279
R
K
G
A
T
G
C
S
D
V
D
E
C
E
V
Site 64
S1327
H
D
L
D
E
C
V
S
Q
E
H
R
C
S
P
Site 65
S1333
V
S
Q
E
H
R
C
S
P
R
G
D
C
L
N
Site 66
Y1434
R
C
I
C
N
G
G
Y
E
L
D
R
G
G
G
Site 67
Y1467
C
I
N
T
P
G
S
Y
L
C
S
C
P
Q
D
Site 68
S1470
T
P
G
S
Y
L
C
S
C
P
Q
D
F
E
L
Site 69
S1480
Q
D
F
E
L
N
P
S
G
V
G
C
V
D
T
Site 70
T1496
A
G
N
C
F
L
E
T
H
D
R
G
D
S
G
Site 71
S1502
E
T
H
D
R
G
D
S
G
I
S
C
S
A
E
Site 72
Y1542
P
M
A
N
T
T
E
Y
R
T
L
C
P
G
G
Site 73
T1544
A
N
T
T
E
Y
R
T
L
C
P
G
G
E
G
Site 74
T1558
G
F
Q
P
N
R
I
T
V
I
L
E
D
I
D
Site 75
Y1594
Q
C
E
C
P
P
G
Y
H
L
S
E
H
T
R
Site 76
T1620
S
S
I
C
G
P
G
T
C
Y
N
T
L
G
N
Site 77
Y1622
I
C
G
P
G
T
C
Y
N
T
L
G
N
Y
T
Site 78
Y1657
K
S
V
C
F
R
H
Y
N
G
T
C
Q
N
E
Site 79
T1693
R
P
C
E
A
C
P
T
P
I
S
P
D
Y
Q
Site 80
Y1699
P
T
P
I
S
P
D
Y
Q
I
L
C
G
N
Q
Site 81
T1716
G
F
L
T
D
I
H
T
G
K
P
L
D
I
D
Site 82
S1772
D
E
C
G
S
R
E
S
P
C
Q
Q
N
A
D
Site 83
Y1795
R
C
K
C
T
R
G
Y
K
L
S
P
G
G
A
Site 84
S1798
C
T
R
G
Y
K
L
S
P
G
G
A
C
V
G
Site 85
T1843
F
Q
A
S
A
D
Q
T
L
C
M
D
I
D
E
Site 86
T1930
D
G
K
N
C
V
D
T
N
E
C
L
S
L
A
Site 87
T1944
A
G
T
C
L
P
G
T
C
Q
N
L
E
G
S
Site 88
T1984
P
N
L
C
L
F
G
T
C
T
N
S
P
G
S
Site 89
S1991
T
C
T
N
S
P
G
S
F
Q
C
L
C
P
P
Site 90
T2019
T
R
Q
S
F
C
F
T
R
F
E
A
G
K
C
Site 91
S2027
R
F
E
A
G
K
C
S
V
P
K
A
F
N
T
Site 92
S2081
A
V
P
G
P
D
D
S
R
E
D
V
N
E
C
Site 93
T2127
T
G
I
N
C
V
D
T
D
E
C
S
V
G
H
Site 94
T2184
C
A
F
R
C
H
N
T
E
G
S
Y
L
C
T
Site 95
Y2188
C
H
N
T
E
G
S
Y
L
C
T
C
P
A
G
Site 96
S2246
G
M
R
P
L
P
G
S
G
E
G
C
T
D
D
Site 97
T2251
P
G
S
G
E
G
C
T
D
D
N
E
C
H
A
Site 98
S2286
C
D
E
G
F
Q
P
S
P
T
L
T
E
C
H
Site 99
T2290
F
Q
P
S
P
T
L
T
E
C
H
D
I
R
Q
Site 100
S2311
V
L
Q
T
M
C
R
S
L
S
S
S
S
E
A
Site 101
S2313
Q
T
M
C
R
S
L
S
S
S
S
E
A
V
T
Site 102
S2315
M
C
R
S
L
S
S
S
S
E
A
V
T
R
A
Site 103
T2320
S
S
S
S
E
A
V
T
R
A
E
C
C
C
G
Site 104
Y2347
P
L
P
G
T
S
A
Y
R
K
L
C
P
H
G
Site 105
S2355
R
K
L
C
P
H
G
S
G
Y
T
A
E
G
R
Site 106
T2395
C
H
C
Q
A
G
Y
T
P
D
A
T
A
T
T
Site 107
T2399
A
G
Y
T
P
D
A
T
A
T
T
C
L
D
M
Site 108
T2417
S
Q
V
P
K
P
C
T
F
L
C
K
N
T
K
Site 109
S2426
L
C
K
N
T
K
G
S
F
L
C
S
C
P
R
Site 110
Y2435
L
C
S
C
P
R
G
Y
L
L
E
E
D
G
R
Site 111
T2443
L
L
E
E
D
G
R
T
C
K
D
L
D
E
C
Site 112
Y2549
C
Q
N
Q
L
G
G
Y
R
C
S
C
P
Q
G
Site 113
S2575
D
E
N
E
C
A
L
S
P
P
T
C
G
S
A
Site 114
T2578
E
C
A
L
S
P
P
T
C
G
S
A
S
C
R
Site 115
S2581
L
S
P
P
T
C
G
S
A
S
C
R
N
T
L
Site 116
S2583
P
P
T
C
G
S
A
S
C
R
N
T
L
G
G
Site 117
T2587
G
S
A
S
C
R
N
T
L
G
G
F
R
C
V
Site 118
S2622
A
G
R
R
G
P
C
S
Y
S
C
A
N
T
P
Site 119
Y2623
G
R
R
G
P
C
S
Y
S
C
A
N
T
P
G
Site 120
S2624
R
R
G
P
C
S
Y
S
C
A
N
T
P
G
G
Site 121
Y2640
L
C
G
C
P
Q
G
Y
F
R
A
G
Q
G
H
Site 122
S2655
C
V
S
G
L
G
F
S
P
G
P
Q
D
T
P
Site 123
T2661
F
S
P
G
P
Q
D
T
P
D
K
E
E
L
L
Site 124
S2669
P
D
K
E
E
L
L
S
S
E
A
C
Y
E
C
Site 125
S2670
D
K
E
E
L
L
S
S
E
A
C
Y
E
C
K
Site 126
S2682
E
C
K
I
N
G
L
S
P
R
D
R
P
R
R
Site 127
S2690
P
R
D
R
P
R
R
S
A
H
R
D
H
Q
V
Site 128
S2715
L
T
L
G
L
N
L
S
H
L
G
R
A
E
R
Site 129
Y2739
G
L
E
G
R
I
R
Y
V
I
V
R
G
N
E
Site 130
S2759
M
H
H
L
R
G
V
S
S
L
Q
L
G
R
R
Site 131
S2760
H
H
L
R
G
V
S
S
L
Q
L
G
R
R
R
Site 132
T2772
R
R
R
P
G
P
G
T
Y
R
L
E
V
V
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation