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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANO5
Full Name:
Anoctamin-5
Alias:
Ano5; Anoctamin 5; Gdd1; Tmem16e
Type:
Membrane, Endoplasmic reticulum, Endoplasmic reticulum membrane, Integral membrane protein
Mass (Da):
107188
Number AA:
913
UniProt ID:
Q75V66
International Prot ID:
IPI00412694
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034707
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005254
GO:0031404
PhosphoSite+
KinaseNET
Biological Process:
GO:0006811
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y23
K
V
N
K
H
I
D
Y
S
F
Q
M
S
E
Q
Site 2
S24
V
N
K
H
I
D
Y
S
F
Q
M
S
E
Q
S
Site 3
S28
I
D
Y
S
F
Q
M
S
E
Q
S
L
S
S
R
Site 4
S31
S
F
Q
M
S
E
Q
S
L
S
S
R
E
T
S
Site 5
S33
Q
M
S
E
Q
S
L
S
S
R
E
T
S
F
L
Site 6
S34
M
S
E
Q
S
L
S
S
R
E
T
S
F
L
I
Site 7
T37
Q
S
L
S
S
R
E
T
S
F
L
I
N
E
E
Site 8
S38
S
L
S
S
R
E
T
S
F
L
I
N
E
E
T
Site 9
T45
S
F
L
I
N
E
E
T
M
P
A
K
R
F
N
Site 10
Y86
Q
I
D
F
V
L
S
Y
V
D
D
V
K
K
D
Site 11
T106
E
R
R
K
E
F
E
T
N
L
R
K
T
G
L
Site 12
T111
F
E
T
N
L
R
K
T
G
L
E
L
E
I
E
Site 13
S123
E
I
E
D
K
R
D
S
E
D
G
R
T
Y
F
Site 14
T128
R
D
S
E
D
G
R
T
Y
F
V
K
I
H
A
Site 15
Y129
D
S
E
D
G
R
T
Y
F
V
K
I
H
A
P
Site 16
S156
I
K
M
P
I
K
E
S
D
I
P
R
P
K
H
Site 17
T164
D
I
P
R
P
K
H
T
P
I
S
Y
V
L
G
Site 18
S167
R
P
K
H
T
P
I
S
Y
V
L
G
P
V
R
Site 19
Y168
P
K
H
T
P
I
S
Y
V
L
G
P
V
R
L
Site 20
S178
G
P
V
R
L
P
L
S
V
K
Y
P
H
P
E
Site 21
Y181
R
L
P
L
S
V
K
Y
P
H
P
E
Y
F
T
Site 22
Y186
V
K
Y
P
H
P
E
Y
F
T
A
Q
F
S
R
Site 23
T206
F
L
I
E
D
Q
A
T
F
F
P
S
S
S
R
Site 24
S210
D
Q
A
T
F
F
P
S
S
S
R
N
R
I
V
Site 25
S211
Q
A
T
F
F
P
S
S
S
R
N
R
I
V
Y
Site 26
S212
A
T
F
F
P
S
S
S
R
N
R
I
V
Y
Y
Site 27
Y218
S
S
R
N
R
I
V
Y
Y
I
L
S
R
C
P
Site 28
Y219
S
R
N
R
I
V
Y
Y
I
L
S
R
C
P
F
Site 29
S243
G
I
E
R
L
L
N
S
N
T
Y
S
S
A
Y
Site 30
T245
E
R
L
L
N
S
N
T
Y
S
S
A
Y
P
L
Site 31
Y246
R
L
L
N
S
N
T
Y
S
S
A
Y
P
L
H
Site 32
S247
L
L
N
S
N
T
Y
S
S
A
Y
P
L
H
D
Site 33
Y250
S
N
T
Y
S
S
A
Y
P
L
H
D
G
Q
Y
Site 34
Y257
Y
P
L
H
D
G
Q
Y
W
K
P
S
E
P
P
Site 35
S261
D
G
Q
Y
W
K
P
S
E
P
P
N
P
T
N
Site 36
T267
P
S
E
P
P
N
P
T
N
E
R
Y
T
L
H
Site 37
Y282
Q
N
W
A
R
F
S
Y
F
Y
K
E
Q
P
L
Site 38
Y284
W
A
R
F
S
Y
F
Y
K
E
Q
P
L
D
L
Site 39
Y295
P
L
D
L
I
K
N
Y
Y
G
E
K
I
G
I
Site 40
Y296
L
D
L
I
K
N
Y
Y
G
E
K
I
G
I
Y
Site 41
T368
D
Y
W
R
L
N
S
T
C
L
A
S
K
F
S
Site 42
S375
T
C
L
A
S
K
F
S
H
L
F
D
N
E
S
Site 43
Y410
Q
R
Q
A
R
L
E
Y
E
W
D
L
V
D
F
Site 44
Y449
V
T
K
E
M
E
P
Y
M
P
L
Y
T
R
I
Site 45
S497
T
F
A
S
F
M
E
S
D
A
S
L
K
Q
V
Site 46
S500
S
F
M
E
S
D
A
S
L
K
Q
V
K
S
F
Site 47
S506
A
S
L
K
Q
V
K
S
F
L
T
P
Q
I
T
Site 48
T509
K
Q
V
K
S
F
L
T
P
Q
I
T
T
S
L
Site 49
T541
E
K
I
S
A
W
I
T
K
M
E
I
P
R
T
Site 50
T548
T
K
M
E
I
P
R
T
Y
Q
E
Y
E
S
S
Site 51
Y549
K
M
E
I
P
R
T
Y
Q
E
Y
E
S
S
L
Site 52
Y552
I
P
R
T
Y
Q
E
Y
E
S
S
L
T
L
K
Site 53
S555
T
Y
Q
E
Y
E
S
S
L
T
L
K
M
F
L
Site 54
T557
Q
E
Y
E
S
S
L
T
L
K
M
F
L
F
Q
Site 55
Y585
F
K
G
K
F
V
G
Y
P
G
K
Y
T
Y
L
Site 56
Y589
F
V
G
Y
P
G
K
Y
T
Y
L
F
N
E
W
Site 57
Y591
G
Y
P
G
K
Y
T
Y
L
F
N
E
W
R
S
Site 58
T646
W
R
R
R
K
A
R
T
N
S
E
K
L
Y
S
Site 59
S648
R
R
K
A
R
T
N
S
E
K
L
Y
S
R
W
Site 60
Y652
R
T
N
S
E
K
L
Y
S
R
W
E
Q
D
H
Site 61
S653
T
N
S
E
K
L
Y
S
R
W
E
Q
D
H
D
Site 62
S663
E
Q
D
H
D
L
E
S
F
G
P
L
G
L
F
Site 63
Y716
A
W
K
L
T
T
Q
Y
R
R
T
V
A
S
K
Site 64
T719
L
T
T
Q
Y
R
R
T
V
A
S
K
A
H
S
Site 65
S722
Q
Y
R
R
T
V
A
S
K
A
H
S
I
G
V
Site 66
Y761
D
I
I
P
R
L
V
Y
Y
Y
A
Y
S
T
N
Site 67
Y763
I
P
R
L
V
Y
Y
Y
A
Y
S
T
N
A
T
Site 68
T770
Y
A
Y
S
T
N
A
T
Q
P
M
T
G
Y
V
Site 69
Y776
A
T
Q
P
M
T
G
Y
V
N
N
S
L
S
V
Site 70
T803
S
E
K
R
D
F
I
T
C
R
Y
R
D
Y
R
Site 71
Y809
I
T
C
R
Y
R
D
Y
R
Y
P
P
D
D
E
Site 72
Y811
C
R
Y
R
D
Y
R
Y
P
P
D
D
E
N
K
Site 73
T872
I
K
R
E
K
L
M
T
I
K
I
L
H
D
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation