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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SSH2
Full Name:
Protein phosphatase Slingshot homolog 2
Alias:
EC 3.1.3.16; EC 3.1.3.48; HSSH-2L; KIAA1725; SSH-2L
Type:
Protein-serine phosphatase
Mass (Da):
158216
Number AA:
1423
UniProt ID:
Q76I76
International Prot ID:
IPI00377071
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0003824
GO:0004721
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0006470
GO:0006793
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
L
V
T
V
Q
R
S
P
T
P
S
T
T
S
Site 2
T11
V
T
V
Q
R
S
P
T
P
S
T
T
S
S
P
Site 3
S13
V
Q
R
S
P
T
P
S
T
T
S
S
P
C
A
Site 4
T14
Q
R
S
P
T
P
S
T
T
S
S
P
C
A
S
Site 5
T15
R
S
P
T
P
S
T
T
S
S
P
C
A
S
E
Site 6
S17
P
T
P
S
T
T
S
S
P
C
A
S
E
A
D
Site 7
S21
T
T
S
S
P
C
A
S
E
A
D
S
G
E
E
Site 8
S25
P
C
A
S
E
A
D
S
G
E
E
E
C
R
S
Site 9
S32
S
G
E
E
E
C
R
S
Q
P
R
S
I
S
E
Site 10
S36
E
C
R
S
Q
P
R
S
I
S
E
S
F
L
T
Site 11
S38
R
S
Q
P
R
S
I
S
E
S
F
L
T
V
K
Site 12
S40
Q
P
R
S
I
S
E
S
F
L
T
V
K
G
A
Site 13
S57
F
L
P
R
G
N
G
S
S
T
P
R
I
S
H
Site 14
S58
L
P
R
G
N
G
S
S
T
P
R
I
S
H
R
Site 15
T59
P
R
G
N
G
S
S
T
P
R
I
S
H
R
R
Site 16
S63
G
S
S
T
P
R
I
S
H
R
R
N
K
H
A
Site 17
S98
R
L
A
V
R
L
E
S
T
Y
Q
N
R
T
R
Site 18
Y100
A
V
R
L
E
S
T
Y
Q
N
R
T
R
Y
M
Site 19
Y106
T
Y
Q
N
R
T
R
Y
M
V
V
V
S
T
N
Site 20
T118
S
T
N
G
R
Q
D
T
E
E
S
I
V
L
G
Site 21
S121
G
R
Q
D
T
E
E
S
I
V
L
G
M
D
F
Site 22
S130
V
L
G
M
D
F
S
S
N
D
S
S
T
C
T
Site 23
S133
M
D
F
S
S
N
D
S
S
T
C
T
M
G
L
Site 24
S134
D
F
S
S
N
D
S
S
T
C
T
M
G
L
V
Site 25
S159
L
D
G
D
G
G
F
S
V
S
T
D
N
R
V
Site 26
S161
G
D
G
G
F
S
V
S
T
D
N
R
V
H
I
Site 27
T162
D
G
G
F
S
V
S
T
D
N
R
V
H
I
F
Site 28
Y196
E
V
A
R
A
H
N
Y
Y
P
G
S
L
F
L
Site 29
Y197
V
A
R
A
H
N
Y
Y
P
G
S
L
F
L
T
Site 30
T204
Y
P
G
S
L
F
L
T
W
V
S
Y
Y
E
S
Site 31
Y208
L
F
L
T
W
V
S
Y
Y
E
S
H
I
N
S
Site 32
Y209
F
L
T
W
V
S
Y
Y
E
S
H
I
N
S
D
Site 33
S215
Y
Y
E
S
H
I
N
S
D
Q
S
S
V
N
E
Site 34
S231
N
A
M
Q
D
V
Q
S
H
R
P
D
S
P
A
Site 35
S236
V
Q
S
H
R
P
D
S
P
A
L
F
T
D
I
Site 36
T241
P
D
S
P
A
L
F
T
D
I
P
T
E
R
E
Site 37
T245
A
L
F
T
D
I
P
T
E
R
E
R
T
E
R
Site 38
T250
I
P
T
E
R
E
R
T
E
R
L
I
K
T
K
Site 39
T256
R
T
E
R
L
I
K
T
K
L
R
E
I
M
M
Site 40
S272
K
D
L
E
N
I
T
S
K
E
I
R
T
E
L
Site 41
S307
V
I
L
G
Q
M
D
S
P
T
Q
I
F
E
H
Site 42
T309
L
G
Q
M
D
S
P
T
Q
I
F
E
H
V
F
Site 43
S324
L
G
S
E
W
N
A
S
N
L
E
D
L
Q
N
Site 44
Y354
F
F
P
G
V
F
E
Y
H
N
I
R
V
Y
D
Site 45
Y360
E
Y
H
N
I
R
V
Y
D
E
E
A
T
D
L
Site 46
Y370
E
A
T
D
L
L
A
Y
W
N
D
T
Y
K
F
Site 47
Y375
L
A
Y
W
N
D
T
Y
K
F
I
S
K
A
K
Site 48
S386
S
K
A
K
K
H
G
S
K
C
L
V
H
C
K
Site 49
S401
M
G
V
S
R
S
A
S
T
V
I
A
Y
A
M
Site 50
T402
G
V
S
R
S
A
S
T
V
I
A
Y
A
M
K
Site 51
Y406
S
A
S
T
V
I
A
Y
A
M
K
E
Y
G
W
Site 52
Y411
I
A
Y
A
M
K
E
Y
G
W
N
L
D
R
A
Site 53
Y419
G
W
N
L
D
R
A
Y
D
Y
V
K
E
R
R
Site 54
Y421
N
L
D
R
A
Y
D
Y
V
K
E
R
R
T
V
Site 55
T427
D
Y
V
K
E
R
R
T
V
T
K
P
N
P
S
Site 56
T429
V
K
E
R
R
T
V
T
K
P
N
P
S
F
M
Site 57
S434
T
V
T
K
P
N
P
S
F
M
R
Q
L
E
E
Site 58
S459
R
H
N
K
L
W
R
S
H
S
D
S
D
L
S
Site 59
S461
N
K
L
W
R
S
H
S
D
S
D
L
S
D
H
Site 60
S463
L
W
R
S
H
S
D
S
D
L
S
D
H
H
E
Site 61
S466
S
H
S
D
S
D
L
S
D
H
H
E
P
I
C
Site 62
T485
E
L
N
K
K
D
I
T
T
S
A
D
Q
I
A
Site 63
S487
N
K
K
D
I
T
T
S
A
D
Q
I
A
E
V
Site 64
T496
D
Q
I
A
E
V
K
T
M
E
S
H
P
P
I
Site 65
S499
A
E
V
K
T
M
E
S
H
P
P
I
P
P
V
Site 66
T593
A
N
K
F
P
D
L
T
V
E
D
L
E
T
D
Site 67
T599
L
T
V
E
D
L
E
T
D
A
L
K
A
D
M
Site 68
S618
L
P
M
E
E
L
T
S
P
L
K
D
P
P
M
Site 69
S626
P
L
K
D
P
P
M
S
P
D
P
E
S
P
S
Site 70
S631
P
M
S
P
D
P
E
S
P
S
P
Q
P
S
C
Site 71
S633
S
P
D
P
E
S
P
S
P
Q
P
S
C
Q
T
Site 72
S637
E
S
P
S
P
Q
P
S
C
Q
T
E
I
S
D
Site 73
S643
P
S
C
Q
T
E
I
S
D
F
S
T
D
R
I
Site 74
S646
Q
T
E
I
S
D
F
S
T
D
R
I
D
F
F
Site 75
T647
T
E
I
S
D
F
S
T
D
R
I
D
F
F
S
Site 76
S654
T
D
R
I
D
F
F
S
A
L
E
K
F
V
E
Site 77
S663
L
E
K
F
V
E
L
S
Q
E
T
R
S
R
S
Site 78
T666
F
V
E
L
S
Q
E
T
R
S
R
S
F
S
H
Site 79
S668
E
L
S
Q
E
T
R
S
R
S
F
S
H
S
R
Site 80
S670
S
Q
E
T
R
S
R
S
F
S
H
S
R
M
E
Site 81
S672
E
T
R
S
R
S
F
S
H
S
R
M
E
E
L
Site 82
S674
R
S
R
S
F
S
H
S
R
M
E
E
L
G
G
Site 83
S686
L
G
G
G
R
N
E
S
C
R
L
S
V
V
E
Site 84
S690
R
N
E
S
C
R
L
S
V
V
E
V
A
P
S
Site 85
S697
S
V
V
E
V
A
P
S
K
V
T
A
D
D
Q
Site 86
S706
V
T
A
D
D
Q
R
S
S
S
L
S
N
T
P
Site 87
S707
T
A
D
D
Q
R
S
S
S
L
S
N
T
P
H
Site 88
S708
A
D
D
Q
R
S
S
S
L
S
N
T
P
H
A
Site 89
S710
D
Q
R
S
S
S
L
S
N
T
P
H
A
S
E
Site 90
T712
R
S
S
S
L
S
N
T
P
H
A
S
E
E
S
Site 91
S716
L
S
N
T
P
H
A
S
E
E
S
S
M
D
E
Site 92
S720
P
H
A
S
E
E
S
S
M
D
E
E
Q
S
K
Site 93
S726
S
S
M
D
E
E
Q
S
K
A
I
S
E
L
V
Site 94
S730
E
E
Q
S
K
A
I
S
E
L
V
S
P
D
I
Site 95
S734
K
A
I
S
E
L
V
S
P
D
I
F
M
Q
S
Site 96
S741
S
P
D
I
F
M
Q
S
H
S
E
N
A
I
S
Site 97
S743
D
I
F
M
Q
S
H
S
E
N
A
I
S
V
K
Site 98
S748
S
H
S
E
N
A
I
S
V
K
E
I
V
T
E
Site 99
T754
I
S
V
K
E
I
V
T
E
I
E
S
I
S
Q
Site 100
S758
E
I
V
T
E
I
E
S
I
S
Q
G
V
G
Q
Site 101
S760
V
T
E
I
E
S
I
S
Q
G
V
G
Q
I
Q
Site 102
T779
I
L
P
N
P
C
H
T
P
K
K
N
S
I
H
Site 103
S784
C
H
T
P
K
K
N
S
I
H
E
L
L
L
E
Site 104
T795
L
L
L
E
R
A
Q
T
P
E
N
K
P
G
H
Site 105
S809
H
M
E
Q
D
E
D
S
C
T
A
Q
P
E
L
Site 106
T811
E
Q
D
E
D
S
C
T
A
Q
P
E
L
A
K
Site 107
S820
Q
P
E
L
A
K
D
S
G
M
C
N
P
E
G
Site 108
T830
C
N
P
E
G
C
L
T
T
H
S
S
I
A
D
Site 109
S833
E
G
C
L
T
T
H
S
S
I
A
D
L
E
E
Site 110
S834
G
C
L
T
T
H
S
S
I
A
D
L
E
E
G
Site 111
S853
G
E
Q
E
L
Q
G
S
G
M
H
P
G
A
K
Site 112
Y862
M
H
P
G
A
K
W
Y
P
G
S
V
R
R
A
Site 113
S865
G
A
K
W
Y
P
G
S
V
R
R
A
T
L
E
Site 114
T870
P
G
S
V
R
R
A
T
L
E
F
E
E
R
L
Site 115
S892
G
A
A
P
T
C
T
S
L
S
T
R
K
N
S
Site 116
S894
A
P
T
C
T
S
L
S
T
R
K
N
S
K
N
Site 117
S899
S
L
S
T
R
K
N
S
K
N
D
S
S
V
A
Site 118
S903
R
K
N
S
K
N
D
S
S
V
A
D
L
A
P
Site 119
S904
K
N
S
K
N
D
S
S
V
A
D
L
A
P
K
Site 120
S914
D
L
A
P
K
G
K
S
D
E
A
P
P
E
H
Site 121
S938
S
K
G
K
G
K
Y
S
G
S
E
A
G
S
L
Site 122
S940
G
K
G
K
Y
S
G
S
E
A
G
S
L
S
H
Site 123
S944
Y
S
G
S
E
A
G
S
L
S
H
S
E
Q
N
Site 124
S946
G
S
E
A
G
S
L
S
H
S
E
Q
N
A
T
Site 125
S948
E
A
G
S
L
S
H
S
E
Q
N
A
T
V
P
Site 126
T953
S
H
S
E
Q
N
A
T
V
P
A
P
R
V
L
Site 127
S974
D
P
Q
E
G
P
G
S
D
T
G
T
Q
Q
E
Site 128
T978
G
P
G
S
D
T
G
T
Q
Q
E
G
V
L
K
Site 129
T989
G
V
L
K
D
L
R
T
V
I
P
Y
Q
E
S
Site 130
Y993
D
L
R
T
V
I
P
Y
Q
E
S
E
T
Q
A
Site 131
Y1014
K
R
V
E
I
I
E
Y
T
H
I
V
T
S
P
Site 132
T1015
R
V
E
I
I
E
Y
T
H
I
V
T
S
P
N
Site 133
S1020
E
Y
T
H
I
V
T
S
P
N
H
T
G
P
G
Site 134
T1024
I
V
T
S
P
N
H
T
G
P
G
S
E
I
A
Site 135
S1028
P
N
H
T
G
P
G
S
E
I
A
T
S
E
K
Site 136
T1032
G
P
G
S
E
I
A
T
S
E
K
S
G
E
Q
Site 137
S1033
P
G
S
E
I
A
T
S
E
K
S
G
E
Q
G
Site 138
T1055
K
S
V
T
V
L
C
T
L
D
E
N
L
N
R
Site 139
T1063
L
D
E
N
L
N
R
T
L
D
P
N
Q
V
S
Site 140
S1070
T
L
D
P
N
Q
V
S
L
H
P
Q
V
L
P
Site 141
S1081
Q
V
L
P
L
P
H
S
S
S
P
E
H
N
R
Site 142
S1083
L
P
L
P
H
S
S
S
P
E
H
N
R
P
T
Site 143
T1090
S
P
E
H
N
R
P
T
D
H
P
T
S
I
L
Site 144
T1094
N
R
P
T
D
H
P
T
S
I
L
S
S
P
E
Site 145
S1095
R
P
T
D
H
P
T
S
I
L
S
S
P
E
D
Site 146
S1098
D
H
P
T
S
I
L
S
S
P
E
D
R
G
S
Site 147
S1099
H
P
T
S
I
L
S
S
P
E
D
R
G
S
S
Site 148
S1105
S
S
P
E
D
R
G
S
S
L
S
T
A
L
E
Site 149
S1106
S
P
E
D
R
G
S
S
L
S
T
A
L
E
T
Site 150
S1108
E
D
R
G
S
S
L
S
T
A
L
E
T
A
A
Site 151
S1126
S
H
T
T
H
L
L
S
A
S
L
D
Y
L
H
Site 152
S1128
T
T
H
L
L
S
A
S
L
D
Y
L
H
P
Q
Site 153
S1148
E
G
F
T
E
Q
S
S
T
T
D
E
P
S
A
Site 154
T1149
G
F
T
E
Q
S
S
T
T
D
E
P
S
A
E
Site 155
T1150
F
T
E
Q
S
S
T
T
D
E
P
S
A
E
Q
Site 156
S1154
S
S
T
T
D
E
P
S
A
E
Q
V
S
W
E
Site 157
S1159
E
P
S
A
E
Q
V
S
W
E
E
S
Q
E
S
Site 158
S1163
E
Q
V
S
W
E
E
S
Q
E
S
P
L
S
S
Site 159
S1166
S
W
E
E
S
Q
E
S
P
L
S
S
G
S
E
Site 160
S1169
E
S
Q
E
S
P
L
S
S
G
S
E
V
P
Y
Site 161
S1170
S
Q
E
S
P
L
S
S
G
S
E
V
P
Y
K
Site 162
S1172
E
S
P
L
S
S
G
S
E
V
P
Y
K
D
S
Site 163
Y1176
S
S
G
S
E
V
P
Y
K
D
S
Q
L
S
S
Site 164
S1179
S
E
V
P
Y
K
D
S
Q
L
S
S
A
D
L
Site 165
S1182
P
Y
K
D
S
Q
L
S
S
A
D
L
S
L
I
Site 166
S1183
Y
K
D
S
Q
L
S
S
A
D
L
S
L
I
S
Site 167
S1187
Q
L
S
S
A
D
L
S
L
I
S
K
L
G
D
Site 168
S1215
V
A
C
R
L
P
H
S
S
S
S
E
N
I
K
Site 169
S1216
A
C
R
L
P
H
S
S
S
S
E
N
I
K
S
Site 170
S1217
C
R
L
P
H
S
S
S
S
E
N
I
K
S
L
Site 171
S1218
R
L
P
H
S
S
S
S
E
N
I
K
S
L
S
Site 172
S1223
S
S
S
E
N
I
K
S
L
S
H
S
P
G
V
Site 173
S1225
S
E
N
I
K
S
L
S
H
S
P
G
V
V
K
Site 174
S1227
N
I
K
S
L
S
H
S
P
G
V
V
K
E
R
Site 175
T1249
V
V
F
Q
A
G
L
T
K
P
S
Q
M
R
R
Site 176
S1252
Q
A
G
L
T
K
P
S
Q
M
R
R
S
A
S
Site 177
S1257
K
P
S
Q
M
R
R
S
A
S
L
A
K
L
G
Site 178
S1259
S
Q
M
R
R
S
A
S
L
A
K
L
G
Y
L
Site 179
S1280
L
P
E
R
E
P
A
S
C
E
S
P
H
L
K
Site 180
S1283
R
E
P
A
S
C
E
S
P
H
L
K
L
L
Q
Site 181
S1297
Q
P
F
L
R
T
D
S
G
M
H
A
M
E
D
Site 182
S1307
H
A
M
E
D
Q
E
S
L
E
N
P
G
A
P
Site 183
S1322
H
N
P
E
P
T
K
S
F
V
E
Q
L
T
T
Site 184
Y1346
V
E
R
P
L
V
Q
Y
A
K
E
F
G
S
S
Site 185
S1352
Q
Y
A
K
E
F
G
S
S
Q
Q
Y
L
L
P
Site 186
S1353
Y
A
K
E
F
G
S
S
Q
Q
Y
L
L
P
R
Site 187
Y1356
E
F
G
S
S
Q
Q
Y
L
L
P
R
A
G
L
Site 188
T1366
P
R
A
G
L
E
L
T
S
S
E
G
G
L
P
Site 189
S1367
R
A
G
L
E
L
T
S
S
E
G
G
L
P
V
Site 190
T1415
K
A
N
D
K
K
R
T
T
N
P
F
Y
N
T
Site 191
T1422
T
T
N
P
F
Y
N
T
M
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation