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Updated November 2019
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Protein Info
Short Name:
ASXL2
Full Name:
Putative Polycomb group protein ASXL2
Alias:
Additional sex combs like 2; ASXH2; FLJ10898; KIAA1685; Polycomb group protein ASXH2
Type:
DNA binding protein
Mass (Da):
153820
Number AA:
1435
UniProt ID:
Q76L83
International Prot ID:
IPI00384569
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0008270
GO:0008270
GO:0043167
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
G
R
R
K
K
G
R
T
W
A
E
A
A
K
T
Site 2
T19
T
W
A
E
A
A
K
T
V
L
E
K
Y
P
N
Site 3
Y24
A
K
T
V
L
E
K
Y
P
N
T
P
M
S
H
Site 4
T27
V
L
E
K
Y
P
N
T
P
M
S
H
K
E
I
Site 5
S30
K
Y
P
N
T
P
M
S
H
K
E
I
L
Q
V
Site 6
S48
E
G
L
K
E
I
R
S
G
T
S
P
L
A
C
Site 7
T50
L
K
E
I
R
S
G
T
S
P
L
A
C
L
N
Site 8
S51
K
E
I
R
S
G
T
S
P
L
A
C
L
N
A
Site 9
S64
N
A
M
L
H
T
N
S
R
G
E
E
G
I
F
Site 10
Y72
R
G
E
E
G
I
F
Y
K
V
P
G
R
M
G
Site 11
T82
P
G
R
M
G
V
Y
T
L
K
K
D
V
P
D
Site 12
S95
P
D
G
V
K
E
L
S
E
G
S
E
E
S
S
Site 13
S98
V
K
E
L
S
E
G
S
E
E
S
S
D
G
Q
Site 14
S102
S
E
G
S
E
E
S
S
D
G
Q
S
D
S
Q
Site 15
S106
E
E
S
S
D
G
Q
S
D
S
Q
S
S
E
N
Site 16
S108
S
S
D
G
Q
S
D
S
Q
S
S
E
N
S
S
Site 17
S110
D
G
Q
S
D
S
Q
S
S
E
N
S
S
S
S
Site 18
S111
G
Q
S
D
S
Q
S
S
E
N
S
S
S
S
S
Site 19
S114
D
S
Q
S
S
E
N
S
S
S
S
S
D
G
G
Site 20
S115
S
Q
S
S
E
N
S
S
S
S
S
D
G
G
S
Site 21
S116
Q
S
S
E
N
S
S
S
S
S
D
G
G
S
N
Site 22
S117
S
S
E
N
S
S
S
S
S
D
G
G
S
N
K
Site 23
S118
S
E
N
S
S
S
S
S
D
G
G
S
N
K
E
Site 24
S122
S
S
S
S
D
G
G
S
N
K
E
G
K
K
S
Site 25
S129
S
N
K
E
G
K
K
S
R
W
K
R
K
V
S
Site 26
S136
S
R
W
K
R
K
V
S
S
S
S
P
Q
S
G
Site 27
S137
R
W
K
R
K
V
S
S
S
S
P
Q
S
G
C
Site 28
S138
W
K
R
K
V
S
S
S
S
P
Q
S
G
C
P
Site 29
S139
K
R
K
V
S
S
S
S
P
Q
S
G
C
P
S
Site 30
S142
V
S
S
S
S
P
Q
S
G
C
P
S
P
T
I
Site 31
S146
S
P
Q
S
G
C
P
S
P
T
I
P
A
G
K
Site 32
S156
I
P
A
G
K
V
I
S
P
S
Q
K
H
S
K
Site 33
S158
A
G
K
V
I
S
P
S
Q
K
H
S
K
K
A
Site 34
S162
I
S
P
S
Q
K
H
S
K
K
A
L
K
Q
A
Site 35
S185
Q
Q
Q
Q
C
R
P
S
I
S
I
S
S
N
Q
Site 36
S187
Q
Q
C
R
P
S
I
S
I
S
S
N
Q
H
L
Site 37
S189
C
R
P
S
I
S
I
S
S
N
Q
H
L
S
L
Site 38
S190
R
P
S
I
S
I
S
S
N
Q
H
L
S
L
K
Site 39
S195
I
S
S
N
Q
H
L
S
L
K
T
V
K
A
A
Site 40
T198
N
Q
H
L
S
L
K
T
V
K
A
A
S
D
S
Site 41
S205
T
V
K
A
A
S
D
S
V
P
A
K
P
A
T
Site 42
T212
S
V
P
A
K
P
A
T
W
E
G
K
Q
S
D
Site 43
S218
A
T
W
E
G
K
Q
S
D
G
Q
T
G
S
P
Site 44
T222
G
K
Q
S
D
G
Q
T
G
S
P
Q
N
S
N
Site 45
S224
Q
S
D
G
Q
T
G
S
P
Q
N
S
N
S
S
Site 46
S228
Q
T
G
S
P
Q
N
S
N
S
S
F
S
S
S
Site 47
S230
G
S
P
Q
N
S
N
S
S
F
S
S
S
V
K
Site 48
S231
S
P
Q
N
S
N
S
S
F
S
S
S
V
K
V
Site 49
S233
Q
N
S
N
S
S
F
S
S
S
V
K
V
E
N
Site 50
S234
N
S
N
S
S
F
S
S
S
V
K
V
E
N
T
Site 51
S235
S
N
S
S
F
S
S
S
V
K
V
E
N
T
L
Site 52
T241
S
S
V
K
V
E
N
T
L
L
G
L
G
K
K
Site 53
S249
L
L
G
L
G
K
K
S
F
Q
R
S
E
R
L
Site 54
S253
G
K
K
S
F
Q
R
S
E
R
L
H
T
R
Q
Site 55
T258
Q
R
S
E
R
L
H
T
R
Q
M
K
R
T
K
Site 56
T264
H
T
R
Q
M
K
R
T
K
C
A
D
I
D
V
Site 57
T291
R
A
L
I
N
K
H
T
F
S
V
L
P
G
D
Site 58
S293
L
I
N
K
H
T
F
S
V
L
P
G
D
C
Q
Site 59
S344
Q
G
W
K
E
R
L
S
E
G
E
F
T
P
E
Site 60
T349
R
L
S
E
G
E
F
T
P
E
M
Q
V
R
I
Site 61
S376
W
K
E
Q
F
F
E
S
Y
Y
G
Q
S
S
G
Site 62
Y377
K
E
Q
F
F
E
S
Y
Y
G
Q
S
S
G
L
Site 63
Y378
E
Q
F
F
E
S
Y
Y
G
Q
S
S
G
L
S
Site 64
S382
E
S
Y
Y
G
Q
S
S
G
L
S
L
E
D
S
Site 65
S385
Y
G
Q
S
S
G
L
S
L
E
D
S
K
K
L
Site 66
S389
S
G
L
S
L
E
D
S
K
K
L
T
A
S
P
Site 67
T393
L
E
D
S
K
K
L
T
A
S
P
S
D
P
K
Site 68
S395
D
S
K
K
L
T
A
S
P
S
D
P
K
V
K
Site 69
S397
K
K
L
T
A
S
P
S
D
P
K
V
K
K
T
Site 70
T404
S
D
P
K
V
K
K
T
P
A
E
Q
P
K
S
Site 71
S411
T
P
A
E
Q
P
K
S
M
P
V
S
E
A
S
Site 72
S415
Q
P
K
S
M
P
V
S
E
A
S
L
I
R
I
Site 73
S427
I
R
I
V
P
V
V
S
Q
S
E
C
K
E
E
Site 74
S440
E
E
A
L
Q
M
S
S
P
G
R
K
E
E
C
Site 75
S449
G
R
K
E
E
C
E
S
Q
G
E
V
Q
P
N
Site 76
S458
G
E
V
Q
P
N
F
S
T
S
S
E
P
L
L
Site 77
S460
V
Q
P
N
F
S
T
S
S
E
P
L
L
S
S
Site 78
S461
Q
P
N
F
S
T
S
S
E
P
L
L
S
S
A
Site 79
S466
T
S
S
E
P
L
L
S
S
A
L
N
T
H
E
Site 80
S467
S
S
E
P
L
L
S
S
A
L
N
T
H
E
L
Site 81
S496
L
E
Q
K
P
V
T
S
A
E
Q
E
S
E
K
Site 82
T507
E
S
E
K
N
H
L
T
T
A
S
N
Y
N
K
Site 83
S510
K
N
H
L
T
T
A
S
N
Y
N
K
S
E
S
Site 84
S515
T
A
S
N
Y
N
K
S
E
S
Q
E
S
L
V
Site 85
S517
S
N
Y
N
K
S
E
S
Q
E
S
L
V
T
S
Site 86
S520
N
K
S
E
S
Q
E
S
L
V
T
S
P
S
K
Site 87
T523
E
S
Q
E
S
L
V
T
S
P
S
K
P
K
S
Site 88
S524
S
Q
E
S
L
V
T
S
P
S
K
P
K
S
P
Site 89
S526
E
S
L
V
T
S
P
S
K
P
K
S
P
G
V
Site 90
S530
T
S
P
S
K
P
K
S
P
G
V
E
K
P
I
Site 91
T557
N
M
K
E
P
L
A
T
L
V
D
Q
S
P
E
Site 92
S562
L
A
T
L
V
D
Q
S
P
E
S
L
K
R
K
Site 93
S565
L
V
D
Q
S
P
E
S
L
K
R
K
S
S
L
Site 94
S570
P
E
S
L
K
R
K
S
S
L
T
Q
E
E
A
Site 95
S571
E
S
L
K
R
K
S
S
L
T
Q
E
E
A
P
Site 96
T573
L
K
R
K
S
S
L
T
Q
E
E
A
P
V
S
Site 97
S580
T
Q
E
E
A
P
V
S
W
E
K
R
P
R
V
Site 98
T588
W
E
K
R
P
R
V
T
E
N
R
Q
H
Q
Q
Site 99
S600
H
Q
Q
P
F
Q
V
S
P
Q
P
F
L
N
R
Site 100
S627
K
I
P
V
S
R
I
S
P
M
P
F
H
P
S
Site 101
S634
S
P
M
P
F
H
P
S
Q
V
S
P
R
A
R
Site 102
S637
P
F
H
P
S
Q
V
S
P
R
A
R
F
P
V
Site 103
S645
P
R
A
R
F
P
V
S
I
T
S
P
N
R
T
Site 104
S648
R
F
P
V
S
I
T
S
P
N
R
T
G
A
R
Site 105
T652
S
I
T
S
P
N
R
T
G
A
R
T
L
A
D
Site 106
T656
P
N
R
T
G
A
R
T
L
A
D
I
K
A
K
Site 107
T709
G
E
G
G
E
G
Q
T
A
R
G
G
S
P
G
Site 108
S714
G
Q
T
A
R
G
G
S
P
G
S
D
R
V
S
Site 109
S717
A
R
G
G
S
P
G
S
D
R
V
S
E
T
G
Site 110
S721
S
P
G
S
D
R
V
S
E
T
G
K
G
P
T
Site 111
T734
P
T
L
E
L
A
G
T
G
S
R
G
G
T
R
Site 112
S736
L
E
L
A
G
T
G
S
R
G
G
T
R
E
L
Site 113
T740
G
T
G
S
R
G
G
T
R
E
L
L
P
C
G
Site 114
T750
L
L
P
C
G
P
E
T
Q
P
Q
S
E
T
K
Site 115
S754
G
P
E
T
Q
P
Q
S
E
T
K
T
T
P
S
Site 116
T758
Q
P
Q
S
E
T
K
T
T
P
S
Q
A
Q
P
Site 117
T759
P
Q
S
E
T
K
T
T
P
S
Q
A
Q
P
H
Site 118
S761
S
E
T
K
T
T
P
S
Q
A
Q
P
H
S
V
Site 119
S767
P
S
Q
A
Q
P
H
S
V
S
G
A
Q
L
Q
Site 120
T776
S
G
A
Q
L
Q
Q
T
P
P
V
P
P
T
P
Site 121
T782
Q
T
P
P
V
P
P
T
P
A
V
S
G
A
C
Site 122
S794
G
A
C
T
S
V
P
S
P
A
H
I
E
K
L
Site 123
T812
K
L
N
P
T
R
A
T
A
T
V
A
S
V
S
Site 124
T814
N
P
T
R
A
T
A
T
V
A
S
V
S
H
P
Site 125
S819
T
A
T
V
A
S
V
S
H
P
Q
G
P
S
S
Site 126
S826
S
H
P
Q
G
P
S
S
C
R
Q
E
K
A
P
Site 127
S834
C
R
Q
E
K
A
P
S
P
T
G
P
A
L
I
Site 128
T836
Q
E
K
A
P
S
P
T
G
P
A
L
I
S
G
Site 129
S845
P
A
L
I
S
G
A
S
P
V
H
C
A
A
D
Site 130
T854
V
H
C
A
A
D
G
T
V
E
L
K
A
G
P
Site 131
S862
V
E
L
K
A
G
P
S
K
N
I
P
N
P
S
Site 132
S869
S
K
N
I
P
N
P
S
A
S
S
K
T
D
A
Site 133
S913
A
T
T
A
P
A
G
S
A
P
P
S
S
T
L
Site 134
S917
P
A
G
S
A
P
P
S
S
T
L
P
A
A
S
Site 135
S918
A
G
S
A
P
P
S
S
T
L
P
A
A
S
S
Site 136
T919
G
S
A
P
P
S
S
T
L
P
A
A
S
S
L
Site 137
S924
S
S
T
L
P
A
A
S
S
L
K
T
P
G
T
Site 138
S925
S
T
L
P
A
A
S
S
L
K
T
P
G
T
S
Site 139
T928
P
A
A
S
S
L
K
T
P
G
T
S
L
N
M
Site 140
T931
S
S
L
K
T
P
G
T
S
L
N
M
N
G
P
Site 141
S932
S
L
K
T
P
G
T
S
L
N
M
N
G
P
T
Site 142
T939
S
L
N
M
N
G
P
T
L
R
P
T
S
S
I
Site 143
T943
N
G
P
T
L
R
P
T
S
S
I
P
A
N
N
Site 144
S944
G
P
T
L
R
P
T
S
S
I
P
A
N
N
P
Site 145
S945
P
T
L
R
P
T
S
S
I
P
A
N
N
P
L
Site 146
T973
Q
I
L
P
K
P
L
T
K
V
E
M
K
T
V
Site 147
T979
L
T
K
V
E
M
K
T
V
P
L
T
A
K
E
Site 148
T983
E
M
K
T
V
P
L
T
A
K
E
E
R
G
M
Site 149
T996
G
M
G
A
L
I
A
T
N
T
T
E
N
S
T
Site 150
T998
G
A
L
I
A
T
N
T
T
E
N
S
T
R
E
Site 151
S1002
A
T
N
T
T
E
N
S
T
R
E
E
V
N
E
Site 152
T1003
T
N
T
T
E
N
S
T
R
E
E
V
N
E
R
Site 153
S1012
E
E
V
N
E
R
Q
S
H
P
A
T
Q
Q
Q
Site 154
T1016
E
R
Q
S
H
P
A
T
Q
Q
Q
L
G
K
T
Site 155
T1023
T
Q
Q
Q
L
G
K
T
L
Q
S
K
Q
L
P
Site 156
S1047
S
A
K
E
L
R
D
S
S
I
D
T
H
Q
Y
Site 157
S1048
A
K
E
L
R
D
S
S
I
D
T
H
Q
Y
H
Site 158
T1051
L
R
D
S
S
I
D
T
H
Q
Y
H
E
G
L
Site 159
Y1054
S
S
I
D
T
H
Q
Y
H
E
G
L
S
K
A
Site 160
S1059
H
Q
Y
H
E
G
L
S
K
A
T
Q
D
Q
I
Site 161
S1081
V
R
R
Q
N
L
L
S
V
V
P
P
S
Q
F
Site 162
S1101
G
F
Q
L
E
D
I
S
T
S
Q
R
F
M
L
Site 163
T1102
F
Q
L
E
D
I
S
T
S
Q
R
F
M
L
G
Site 164
S1103
Q
L
E
D
I
S
T
S
Q
R
F
M
L
G
F
Site 165
T1115
L
G
F
A
G
R
R
T
S
K
P
A
M
A
G
Site 166
S1116
G
F
A
G
R
R
T
S
K
P
A
M
A
G
H
Site 167
Y1124
K
P
A
M
A
G
H
Y
L
L
N
I
S
T
Y
Site 168
S1129
G
H
Y
L
L
N
I
S
T
Y
G
R
G
S
E
Site 169
T1130
H
Y
L
L
N
I
S
T
Y
G
R
G
S
E
S
Site 170
Y1131
Y
L
L
N
I
S
T
Y
G
R
G
S
E
S
F
Site 171
S1135
I
S
T
Y
G
R
G
S
E
S
F
R
R
T
H
Site 172
S1137
T
Y
G
R
G
S
E
S
F
R
R
T
H
S
V
Site 173
T1141
G
S
E
S
F
R
R
T
H
S
V
N
P
E
D
Site 174
S1143
E
S
F
R
R
T
H
S
V
N
P
E
D
R
F
Site 175
S1154
E
D
R
F
C
L
S
S
P
T
E
A
L
K
M
Site 176
T1164
E
A
L
K
M
G
Y
T
D
C
K
N
A
T
G
Site 177
T1170
Y
T
D
C
K
N
A
T
G
E
S
S
S
S
K
Site 178
S1176
A
T
G
E
S
S
S
S
K
E
D
D
T
D
E
Site 179
T1181
S
S
S
K
E
D
D
T
D
E
E
S
T
G
D
Site 180
S1185
E
D
D
T
D
E
E
S
T
G
D
E
Q
E
S
Site 181
S1192
S
T
G
D
E
Q
E
S
V
T
V
K
E
E
P
Site 182
T1194
G
D
E
Q
E
S
V
T
V
K
E
E
P
Q
V
Site 183
S1202
V
K
E
E
P
Q
V
S
Q
S
A
G
K
G
D
Site 184
S1204
E
E
P
Q
V
S
Q
S
A
G
K
G
D
T
S
Site 185
S1211
S
A
G
K
G
D
T
S
S
G
P
H
S
R
E
Site 186
S1212
A
G
K
G
D
T
S
S
G
P
H
S
R
E
T
Site 187
S1216
D
T
S
S
G
P
H
S
R
E
T
L
S
T
S
Site 188
T1219
S
G
P
H
S
R
E
T
L
S
T
S
D
C
L
Site 189
S1221
P
H
S
R
E
T
L
S
T
S
D
C
L
A
S
Site 190
T1222
H
S
R
E
T
L
S
T
S
D
C
L
A
S
K
Site 191
S1223
S
R
E
T
L
S
T
S
D
C
L
A
S
K
N
Site 192
T1242
I
P
L
N
E
Q
T
T
L
S
K
E
N
Y
L
Site 193
S1244
L
N
E
Q
T
T
L
S
K
E
N
Y
L
F
T
Site 194
Y1248
T
T
L
S
K
E
N
Y
L
F
T
R
G
Q
T
Site 195
T1255
Y
L
F
T
R
G
Q
T
F
D
E
K
T
L
A
Site 196
T1260
G
Q
T
F
D
E
K
T
L
A
R
D
L
I
Q
Site 197
S1284
V
R
G
K
A
I
R
S
S
P
E
L
F
S
S
Site 198
S1285
R
G
K
A
I
R
S
S
P
E
L
F
S
S
T
Site 199
S1290
R
S
S
P
E
L
F
S
S
T
V
L
P
L
P
Site 200
T1302
P
L
P
A
D
S
P
T
H
Q
P
L
L
L
P
Site 201
Y1317
P
L
Q
T
P
K
L
Y
G
S
P
T
Q
I
G
Site 202
S1319
Q
T
P
K
L
Y
G
S
P
T
Q
I
G
P
S
Site 203
T1321
P
K
L
Y
G
S
P
T
Q
I
G
P
S
Y
R
Site 204
S1326
S
P
T
Q
I
G
P
S
Y
R
G
M
I
N
V
Site 205
Y1327
P
T
Q
I
G
P
S
Y
R
G
M
I
N
V
S
Site 206
S1334
Y
R
G
M
I
N
V
S
T
S
S
D
M
D
H
Site 207
T1335
R
G
M
I
N
V
S
T
S
S
D
M
D
H
N
Site 208
S1343
S
S
D
M
D
H
N
S
A
V
P
G
S
Q
V
Site 209
S1348
H
N
S
A
V
P
G
S
Q
V
S
S
N
V
G
Site 210
S1352
V
P
G
S
Q
V
S
S
N
V
G
D
V
M
S
Site 211
S1370
T
V
T
T
I
P
A
S
Q
A
M
N
P
S
S
Site 212
S1377
S
Q
A
M
N
P
S
S
H
G
Q
T
I
P
V
Site 213
T1381
N
P
S
S
H
G
Q
T
I
P
V
Q
A
F
S
Site 214
S1392
Q
A
F
S
E
E
N
S
I
E
G
T
P
S
K
Site 215
T1396
E
E
N
S
I
E
G
T
P
S
K
C
Y
C
R
Site 216
S1398
N
S
I
E
G
T
P
S
K
C
Y
C
R
L
K
Site 217
Y1401
E
G
T
P
S
K
C
Y
C
R
L
K
A
M
I
Site 218
S1430
G
P
S
K
L
C
V
S
C
L
V
V
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation