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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAMTS13
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 13
Alias:
von Willebrand factor-cleaving protease
Type:
Mass (Da):
153604
Number AA:
1427
UniProt ID:
Q76LX8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S47
A
L
E
P
Q
A
V
S
S
Y
L
S
P
G
A
Site 2
S48
L
E
P
Q
A
V
S
S
Y
L
S
P
G
A
P
Site 3
Y49
E
P
Q
A
V
S
S
Y
L
S
P
G
A
P
L
Site 4
S51
Q
A
V
S
S
Y
L
S
P
G
A
P
L
K
G
Site 5
S62
P
L
K
G
R
P
P
S
P
G
F
Q
R
Q
R
Site 6
T100
F
Q
A
H
Q
E
D
T
E
R
Y
V
L
T
N
Site 7
Y103
H
Q
E
D
T
E
R
Y
V
L
T
N
L
N
I
Site 8
S119
A
E
L
L
R
D
P
S
L
G
A
Q
F
R
V
Site 9
S158
L
L
S
V
C
G
W
S
Q
T
I
N
P
E
D
Site 10
T160
S
V
C
G
W
S
Q
T
I
N
P
E
D
D
T
Site 11
T167
T
I
N
P
E
D
D
T
D
P
G
H
A
D
L
Site 12
T196
N
R
Q
V
R
G
V
T
Q
L
G
G
A
C
S
Site 13
T211
P
T
W
S
C
L
I
T
E
D
T
G
F
D
L
Site 14
S229
I
A
H
E
I
G
H
S
F
G
L
E
H
D
G
Site 15
S240
E
H
D
G
A
P
G
S
G
C
G
P
S
G
H
Site 16
S245
P
G
S
G
C
G
P
S
G
H
V
M
A
S
D
Site 17
S263
P
R
A
G
L
A
W
S
P
C
S
R
R
Q
L
Site 18
S266
G
L
A
W
S
P
C
S
R
R
Q
L
L
S
L
Site 19
S272
C
S
R
R
Q
L
L
S
L
L
S
A
G
R
A
Site 20
S292
P
P
R
P
Q
P
G
S
A
G
H
P
P
D
A
Site 21
Y304
P
D
A
Q
P
G
L
Y
Y
S
A
N
E
Q
C
Site 22
S306
A
Q
P
G
L
Y
Y
S
A
N
E
Q
C
R
V
Site 23
T323
G
P
K
A
V
A
C
T
F
A
R
E
H
L
D
Site 24
S345
H
T
D
P
L
D
Q
S
S
C
S
R
L
L
V
Site 25
S346
T
D
P
L
D
Q
S
S
C
S
R
L
L
V
P
Site 26
S373
C
S
K
G
R
C
R
S
L
V
E
L
T
P
I
Site 27
S388
A
A
V
H
G
R
W
S
S
W
G
P
R
S
P
Site 28
S389
A
V
H
G
R
W
S
S
W
G
P
R
S
P
C
Site 29
S394
W
S
S
W
G
P
R
S
P
C
S
R
S
C
G
Site 30
S397
W
G
P
R
S
P
C
S
R
S
C
G
G
G
V
Site 31
S399
P
R
S
P
C
S
R
S
C
G
G
G
V
V
T
Site 32
T406
S
C
G
G
G
V
V
T
R
R
R
Q
C
N
N
Site 33
T435
L
Q
A
E
M
C
N
T
Q
A
C
E
K
T
Q
Site 34
T441
N
T
Q
A
C
E
K
T
Q
L
E
F
M
S
Q
Site 35
S447
K
T
Q
L
E
F
M
S
Q
Q
C
A
R
T
D
Site 36
S460
T
D
G
Q
P
L
R
S
S
P
G
G
A
S
F
Site 37
S461
D
G
Q
P
L
R
S
S
P
G
G
A
S
F
Y
Site 38
S466
R
S
S
P
G
G
A
S
F
Y
H
W
G
A
A
Site 39
Y468
S
P
G
G
A
S
F
Y
H
W
G
A
A
V
P
Site 40
S477
W
G
A
A
V
P
H
S
Q
G
D
A
L
C
R
Site 41
S501
F
I
M
K
R
G
D
S
F
L
D
G
T
R
C
Site 42
T506
G
D
S
F
L
D
G
T
R
C
M
P
S
G
P
Site 43
S511
D
G
T
R
C
M
P
S
G
P
R
E
D
G
T
Site 44
T518
S
G
P
R
E
D
G
T
L
S
L
C
V
S
G
Site 45
S520
P
R
E
D
G
T
L
S
L
C
V
S
G
S
C
Site 46
S553
Q
V
C
G
G
D
N
S
T
C
S
P
R
K
G
Site 47
T554
V
C
G
G
D
N
S
T
C
S
P
R
K
G
S
Site 48
S556
G
G
D
N
S
T
C
S
P
R
K
G
S
F
T
Site 49
S561
T
C
S
P
R
K
G
S
F
T
A
G
R
A
R
Site 50
T563
S
P
R
K
G
S
F
T
A
G
R
A
R
E
Y
Site 51
T575
R
E
Y
V
T
F
L
T
V
T
P
N
L
T
S
Site 52
S612
V
A
G
K
M
S
I
S
P
N
T
T
Y
P
S
Site 53
T615
K
M
S
I
S
P
N
T
T
Y
P
S
L
L
E
Site 54
T616
M
S
I
S
P
N
T
T
Y
P
S
L
L
E
D
Site 55
Y617
S
I
S
P
N
T
T
Y
P
S
L
L
E
D
G
Site 56
Y628
L
E
D
G
R
V
E
Y
R
V
A
L
T
E
D
Site 57
T633
V
E
Y
R
V
A
L
T
E
D
R
L
P
R
L
Site 58
Y658
E
D
A
D
I
Q
V
Y
R
R
Y
G
E
E
Y
Site 59
Y661
D
I
Q
V
Y
R
R
Y
G
E
E
Y
G
N
L
Site 60
Y665
Y
R
R
Y
G
E
E
Y
G
N
L
T
R
P
D
Site 61
T674
N
L
T
R
P
D
I
T
F
T
Y
F
Q
P
K
Site 62
Y677
R
P
D
I
T
F
T
Y
F
Q
P
K
P
R
Q
Site 63
Y708
A
G
L
R
W
V
N
Y
S
C
L
D
Q
A
R
Site 64
T721
A
R
K
E
L
V
E
T
V
Q
C
Q
G
S
Q
Site 65
S727
E
T
V
Q
C
Q
G
S
Q
Q
P
P
A
W
P
Site 66
S757
D
F
G
P
C
S
A
S
C
G
G
G
L
R
E
Site 67
S775
R
C
V
E
A
Q
G
S
L
L
K
T
L
P
P
Site 68
T779
A
Q
G
S
L
L
K
T
L
P
P
A
R
C
R
Site 69
T798
Q
P
A
V
A
L
E
T
C
N
P
Q
P
C
P
Site 70
S811
C
P
A
R
W
E
V
S
E
P
S
S
C
T
S
Site 71
S814
R
W
E
V
S
E
P
S
S
C
T
S
A
G
G
Site 72
S815
W
E
V
S
E
P
S
S
C
T
S
A
G
G
A
Site 73
S818
S
E
P
S
S
C
T
S
A
G
G
A
G
L
A
Site 74
T843
D
G
L
E
A
P
V
T
E
G
P
G
S
V
D
Site 75
S848
P
V
T
E
G
P
G
S
V
D
E
K
L
P
A
Site 76
T874
G
W
G
H
L
D
A
T
S
A
G
E
K
A
P
Site 77
S875
W
G
H
L
D
A
T
S
A
G
E
K
A
P
S
Site 78
S882
S
A
G
E
K
A
P
S
P
W
G
S
I
R
T
Site 79
S886
K
A
P
S
P
W
G
S
I
R
T
G
A
Q
A
Site 80
S937
E
E
L
C
G
L
A
S
K
P
G
S
R
R
E
Site 81
S941
G
L
A
S
K
P
G
S
R
R
E
V
C
Q
A
Site 82
Y957
P
C
P
A
R
W
Q
Y
K
L
A
A
C
S
V
Site 83
Y976
G
V
V
R
R
I
L
Y
C
A
R
A
H
G
E
Site 84
T993
G
E
E
I
L
L
D
T
Q
C
Q
G
L
P
R
Site 85
S1008
P
E
P
Q
E
A
C
S
L
E
P
C
P
P
R
Site 86
S1020
P
P
R
W
K
V
M
S
L
G
P
C
S
A
S
Site 87
T1098
G
I
Q
R
R
R
D
T
C
L
G
P
Q
A
Q
Site 88
T1121
Q
H
L
P
K
P
V
T
V
R
G
C
W
A
G
Site 89
T1135
G
P
C
V
G
Q
G
T
P
S
L
V
P
H
E
Site 90
S1137
C
V
G
Q
G
T
P
S
L
V
P
H
E
E
A
Site 91
T1151
A
A
A
P
G
R
T
T
A
T
P
A
G
A
S
Site 92
T1153
A
P
G
R
T
T
A
T
P
A
G
A
S
L
E
Site 93
S1158
T
A
T
P
A
G
A
S
L
E
W
S
Q
A
R
Site 94
S1170
Q
A
R
G
L
L
F
S
P
A
P
Q
P
R
R
Site 95
S1186
L
P
G
P
Q
E
N
S
V
Q
S
S
A
C
G
Site 96
S1190
Q
E
N
S
V
Q
S
S
A
C
G
R
Q
H
L
Site 97
T1202
Q
H
L
E
P
T
G
T
I
D
M
R
G
P
G
Site 98
S1233
T
L
R
V
L
E
S
S
L
N
C
S
A
G
D
Site 99
T1261
C
R
K
L
L
D
M
T
F
S
S
K
T
N
T
Site 100
S1263
K
L
L
D
M
T
F
S
S
K
T
N
T
L
V
Site 101
T1268
T
F
S
S
K
T
N
T
L
V
V
R
Q
R
C
Site 102
Y1286
G
G
G
V
L
L
R
Y
G
S
Q
L
A
P
E
Site 103
T1294
G
S
Q
L
A
P
E
T
F
Y
R
E
C
D
M
Site 104
S1312
G
P
W
G
E
I
V
S
P
S
L
S
P
A
T
Site 105
S1314
W
G
E
I
V
S
P
S
L
S
P
A
T
S
N
Site 106
S1316
E
I
V
S
P
S
L
S
P
A
T
S
N
A
G
Site 107
T1319
S
P
S
L
S
P
A
T
S
N
A
G
G
C
R
Site 108
S1320
P
S
L
S
P
A
T
S
N
A
G
G
C
R
L
Site 109
T1363
S
Y
I
L
I
R
D
T
H
S
L
R
T
T
A
Site 110
S1365
I
L
I
R
D
T
H
S
L
R
T
T
A
F
H
Site 111
T1369
D
T
H
S
L
R
T
T
A
F
H
G
Q
Q
V
Site 112
Y1378
F
H
G
Q
Q
V
L
Y
W
E
S
E
S
S
Q
Site 113
S1384
L
Y
W
E
S
E
S
S
Q
A
E
M
E
F
S
Site 114
S1391
S
Q
A
E
M
E
F
S
E
G
F
L
K
A
Q
Site 115
S1400
G
F
L
K
A
Q
A
S
L
R
G
Q
Y
W
T
Site 116
Y1405
Q
A
S
L
R
G
Q
Y
W
T
L
Q
S
W
V
Site 117
T1407
S
L
R
G
Q
Y
W
T
L
Q
S
W
V
P
E
Site 118
S1420
P
E
M
Q
D
P
Q
S
W
K
G
K
E
G
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation