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Updated November 2019
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Protein Info
Short Name:
HECW1
Full Name:
E3 ubiquitin-protein ligase HECW1
Alias:
HECT, C2 and WW domain-containing protein 1;NEDD4-like E3 ubiquitin-protein ligase 1
Type:
Mass (Da):
179554
Number AA:
1606
UniProt ID:
Q76N89
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
L
G
L
A
A
M
A
S
P
S
R
N
S
Q
S
Site 2
S26
L
A
A
M
A
S
P
S
R
N
S
Q
S
R
R
Site 3
S29
M
A
S
P
S
R
N
S
Q
S
R
R
R
C
K
Site 4
S31
S
P
S
R
N
S
Q
S
R
R
R
C
K
E
P
Site 5
Y41
R
C
K
E
P
L
R
Y
S
Y
N
P
D
Q
F
Site 6
Y43
K
E
P
L
R
Y
S
Y
N
P
D
Q
F
H
N
Site 7
T62
G
G
P
H
D
G
V
T
I
P
R
S
T
S
D
Site 8
S66
D
G
V
T
I
P
R
S
T
S
D
T
D
L
V
Site 9
T67
G
V
T
I
P
R
S
T
S
D
T
D
L
V
T
Site 10
S68
V
T
I
P
R
S
T
S
D
T
D
L
V
T
S
Site 11
T70
I
P
R
S
T
S
D
T
D
L
V
T
S
D
S
Site 12
T74
T
S
D
T
D
L
V
T
S
D
S
R
S
T
L
Site 13
S75
S
D
T
D
L
V
T
S
D
S
R
S
T
L
M
Site 14
S77
T
D
L
V
T
S
D
S
R
S
T
L
M
V
S
Site 15
S79
L
V
T
S
D
S
R
S
T
L
M
V
S
S
S
Site 16
T80
V
T
S
D
S
R
S
T
L
M
V
S
S
S
Y
Site 17
S84
S
R
S
T
L
M
V
S
S
S
Y
Y
S
I
G
Site 18
S85
R
S
T
L
M
V
S
S
S
Y
Y
S
I
G
H
Site 19
S86
S
T
L
M
V
S
S
S
Y
Y
S
I
G
H
S
Site 20
Y87
T
L
M
V
S
S
S
Y
Y
S
I
G
H
S
Q
Site 21
Y88
L
M
V
S
S
S
Y
Y
S
I
G
H
S
Q
D
Site 22
S89
M
V
S
S
S
Y
Y
S
I
G
H
S
Q
D
L
Site 23
Y128
L
S
E
N
F
L
D
Y
K
N
R
G
V
N
G
Site 24
S149
I
W
K
I
D
A
S
S
Y
F
V
E
P
E
T
Site 25
Y150
W
K
I
D
A
S
S
Y
F
V
E
P
E
T
K
Site 26
Y162
E
T
K
I
C
F
K
Y
Y
H
G
V
S
G
A
Site 27
T174
S
G
A
L
R
A
T
T
P
S
V
T
V
K
N
Site 28
S176
A
L
R
A
T
T
P
S
V
T
V
K
N
S
A
Site 29
T178
R
A
T
T
P
S
V
T
V
K
N
S
A
A
P
Site 30
S182
P
S
V
T
V
K
N
S
A
A
P
I
F
K
S
Site 31
T195
K
S
I
G
A
D
E
T
V
Q
G
Q
G
S
R
Site 32
S201
E
T
V
Q
G
Q
G
S
R
R
L
I
S
F
S
Site 33
S206
Q
G
S
R
R
L
I
S
F
S
L
S
D
F
Q
Site 34
S208
S
R
R
L
I
S
F
S
L
S
D
F
Q
A
M
Site 35
Y228
M
F
F
N
P
D
P
Y
L
K
I
S
I
Q
P
Site 36
S232
P
D
P
Y
L
K
I
S
I
Q
P
G
K
H
S
Site 37
S239
S
I
Q
P
G
K
H
S
I
F
P
A
L
P
H
Site 38
S253
H
H
G
Q
E
R
R
S
K
I
I
G
N
T
V
Site 39
T259
R
S
K
I
I
G
N
T
V
N
P
I
W
Q
A
Site 40
S270
I
W
Q
A
E
Q
F
S
F
V
S
L
P
T
D
Site 41
S290
V
K
D
K
F
A
K
S
R
P
I
I
K
R
F
Site 42
S302
K
R
F
L
G
K
L
S
M
P
V
Q
R
L
L
Site 43
Y321
I
G
D
R
V
V
S
Y
T
L
G
R
R
L
P
Site 44
T322
G
D
R
V
V
S
Y
T
L
G
R
R
L
P
T
Site 45
T329
T
L
G
R
R
L
P
T
D
H
V
S
G
Q
L
Site 46
S344
Q
F
R
F
E
I
T
S
S
I
H
P
D
D
E
Site 47
S345
F
R
F
E
I
T
S
S
I
H
P
D
D
E
E
Site 48
S354
H
P
D
D
E
E
I
S
L
S
T
E
P
E
S
Site 49
S356
D
D
E
E
I
S
L
S
T
E
P
E
S
A
Q
Site 50
S361
S
L
S
T
E
P
E
S
A
Q
I
Q
D
S
P
Site 51
S367
E
S
A
Q
I
Q
D
S
P
M
N
N
L
M
E
Site 52
S375
P
M
N
N
L
M
E
S
G
S
G
E
P
R
S
Site 53
S377
N
N
L
M
E
S
G
S
G
E
P
R
S
E
A
Site 54
S382
S
G
S
G
E
P
R
S
E
A
P
E
S
S
E
Site 55
S387
P
R
S
E
A
P
E
S
S
E
S
W
K
P
E
Site 56
S388
R
S
E
A
P
E
S
S
E
S
W
K
P
E
Q
Site 57
S390
E
A
P
E
S
S
E
S
W
K
P
E
Q
L
G
Site 58
S400
P
E
Q
L
G
E
G
S
V
P
D
G
P
G
N
Site 59
S409
P
D
G
P
G
N
Q
S
I
E
L
S
R
P
A
Site 60
S413
G
N
Q
S
I
E
L
S
R
P
A
E
E
A
A
Site 61
S432
A
G
D
Q
G
M
V
S
V
G
P
E
G
A
G
Site 62
S481
E
D
G
E
A
P
A
S
T
K
E
E
P
L
E
Site 63
T492
E
P
L
E
E
E
A
T
T
Q
S
R
A
G
R
Site 64
T493
P
L
E
E
E
A
T
T
Q
S
R
A
G
R
E
Site 65
S513
Q
E
E
E
G
D
V
S
T
L
E
Q
G
E
G
Site 66
T514
E
E
E
G
D
V
S
T
L
E
Q
G
E
G
R
Site 67
S527
G
R
L
Q
L
R
A
S
V
K
R
K
S
R
P
Site 68
S532
R
A
S
V
K
R
K
S
R
P
C
S
L
P
V
Site 69
S536
K
R
K
S
R
P
C
S
L
P
V
S
E
L
E
Site 70
S548
E
L
E
T
V
I
A
S
A
C
G
D
P
E
T
Site 71
T555
S
A
C
G
D
P
E
T
P
R
T
H
Y
I
R
Site 72
T558
G
D
P
E
T
P
R
T
H
Y
I
R
I
H
T
Site 73
Y560
P
E
T
P
R
T
H
Y
I
R
I
H
T
L
L
Site 74
T565
T
H
Y
I
R
I
H
T
L
L
H
S
M
P
S
Site 75
S569
R
I
H
T
L
L
H
S
M
P
S
A
Q
G
G
Site 76
S572
T
L
L
H
S
M
P
S
A
Q
G
G
S
A
A
Site 77
T590
D
G
A
E
E
E
S
T
L
K
D
S
S
E
K
Site 78
S594
E
E
S
T
L
K
D
S
S
E
K
D
G
L
S
Site 79
S595
E
S
T
L
K
D
S
S
E
K
D
G
L
S
E
Site 80
S601
S
S
E
K
D
G
L
S
E
V
D
T
V
A
A
Site 81
T605
D
G
L
S
E
V
D
T
V
A
A
D
P
S
A
Site 82
T624
R
E
E
P
E
G
A
T
P
G
T
A
H
P
G
Site 83
T627
P
E
G
A
T
P
G
T
A
H
P
G
H
S
G
Site 84
S633
G
T
A
H
P
G
H
S
G
G
H
F
P
S
L
Site 85
S639
H
S
G
G
H
F
P
S
L
A
N
G
A
A
Q
Site 86
T650
G
A
A
Q
D
G
D
T
H
P
S
T
G
S
E
Site 87
S653
Q
D
G
D
T
H
P
S
T
G
S
E
S
D
S
Site 88
T654
D
G
D
T
H
P
S
T
G
S
E
S
D
S
S
Site 89
S656
D
T
H
P
S
T
G
S
E
S
D
S
S
P
R
Site 90
S658
H
P
S
T
G
S
E
S
D
S
S
P
R
Q
G
Site 91
S660
S
T
G
S
E
S
D
S
S
P
R
Q
G
G
D
Site 92
S661
T
G
S
E
S
D
S
S
P
R
Q
G
G
D
H
Site 93
S669
P
R
Q
G
G
D
H
S
C
E
G
C
D
A
S
Site 94
S679
G
C
D
A
S
C
C
S
P
S
C
Y
S
S
S
Site 95
Y683
S
C
C
S
P
S
C
Y
S
S
S
C
Y
S
T
Site 96
S684
C
C
S
P
S
C
Y
S
S
S
C
Y
S
T
S
Site 97
S685
C
S
P
S
C
Y
S
S
S
C
Y
S
T
S
C
Site 98
S686
S
P
S
C
Y
S
S
S
C
Y
S
T
S
C
Y
Site 99
Y688
S
C
Y
S
S
S
C
Y
S
T
S
C
Y
S
S
Site 100
S689
C
Y
S
S
S
C
Y
S
T
S
C
Y
S
S
S
Site 101
T690
Y
S
S
S
C
Y
S
T
S
C
Y
S
S
S
C
Site 102
S691
S
S
S
C
Y
S
T
S
C
Y
S
S
S
C
Y
Site 103
Y693
S
C
Y
S
T
S
C
Y
S
S
S
C
Y
S
A
Site 104
S694
C
Y
S
T
S
C
Y
S
S
S
C
Y
S
A
S
Site 105
S695
Y
S
T
S
C
Y
S
S
S
C
Y
S
A
S
C
Site 106
S696
S
T
S
C
Y
S
S
S
C
Y
S
A
S
C
Y
Site 107
Y698
S
C
Y
S
S
S
C
Y
S
A
S
C
Y
S
P
Site 108
S699
C
Y
S
S
S
C
Y
S
A
S
C
Y
S
P
S
Site 109
S701
S
S
S
C
Y
S
A
S
C
Y
S
P
S
C
Y
Site 110
Y703
S
C
Y
S
A
S
C
Y
S
P
S
C
Y
N
G
Site 111
Y708
S
C
Y
S
P
S
C
Y
N
G
N
R
F
A
S
Site 112
S715
Y
N
G
N
R
F
A
S
H
T
R
F
S
S
V
Site 113
T717
G
N
R
F
A
S
H
T
R
F
S
S
V
D
S
Site 114
S720
F
A
S
H
T
R
F
S
S
V
D
S
A
K
I
Site 115
S721
A
S
H
T
R
F
S
S
V
D
S
A
K
I
S
Site 116
S724
T
R
F
S
S
V
D
S
A
K
I
S
E
S
T
Site 117
S728
S
V
D
S
A
K
I
S
E
S
T
V
F
S
S
Site 118
S730
D
S
A
K
I
S
E
S
T
V
F
S
S
Q
D
Site 119
T731
S
A
K
I
S
E
S
T
V
F
S
S
Q
D
D
Site 120
S734
I
S
E
S
T
V
F
S
S
Q
D
D
E
E
E
Site 121
S735
S
E
S
T
V
F
S
S
Q
D
D
E
E
E
E
Site 122
S744
D
D
E
E
E
E
N
S
A
F
E
S
V
P
D
Site 123
S748
E
E
N
S
A
F
E
S
V
P
D
S
M
Q
S
Site 124
S752
A
F
E
S
V
P
D
S
M
Q
S
P
E
L
D
Site 125
S755
S
V
P
D
S
M
Q
S
P
E
L
D
P
E
S
Site 126
S762
S
P
E
L
D
P
E
S
T
N
G
A
G
P
W
Site 127
T763
P
E
L
D
P
E
S
T
N
G
A
G
P
W
Q
Site 128
S783
P
S
G
H
V
E
R
S
P
E
G
L
E
S
P
Site 129
S789
R
S
P
E
G
L
E
S
P
V
A
G
P
S
N
Site 130
S795
E
S
P
V
A
G
P
S
N
R
R
E
G
E
C
Site 131
S808
E
C
P
I
L
H
N
S
Q
P
V
S
Q
L
P
Site 132
S812
L
H
N
S
Q
P
V
S
Q
L
P
S
L
R
P
Site 133
S816
Q
P
V
S
Q
L
P
S
L
R
P
E
H
H
H
Site 134
Y824
L
R
P
E
H
H
H
Y
P
T
I
D
E
P
L
Site 135
Y847
D
S
H
G
R
V
F
Y
V
D
H
V
N
R
T
Site 136
T854
Y
V
D
H
V
N
R
T
T
T
W
Q
R
P
T
Site 137
T855
V
D
H
V
N
R
T
T
T
W
Q
R
P
T
A
Site 138
T856
D
H
V
N
R
T
T
T
W
Q
R
P
T
A
A
Site 139
T861
T
T
T
W
Q
R
P
T
A
A
A
T
P
D
G
Site 140
T865
Q
R
P
T
A
A
A
T
P
D
G
M
R
R
S
Site 141
S872
T
P
D
G
M
R
R
S
G
S
I
Q
Q
M
E
Site 142
S874
D
G
M
R
R
S
G
S
I
Q
Q
M
E
Q
L
Site 143
Y885
M
E
Q
L
N
R
R
Y
Q
N
I
Q
R
T
I
Site 144
S897
R
T
I
A
T
E
R
S
E
E
D
S
G
S
Q
Site 145
S901
T
E
R
S
E
E
D
S
G
S
Q
S
C
E
Q
Site 146
S903
R
S
E
E
D
S
G
S
Q
S
C
E
Q
A
P
Site 147
S905
E
E
D
S
G
S
Q
S
C
E
Q
A
P
A
G
Site 148
S919
G
G
G
G
G
G
G
S
D
S
E
A
E
S
S
Site 149
S921
G
G
G
G
G
S
D
S
E
A
E
S
S
Q
S
Site 150
S925
G
S
D
S
E
A
E
S
S
Q
S
S
L
D
L
Site 151
S926
S
D
S
E
A
E
S
S
Q
S
S
L
D
L
R
Site 152
S928
S
E
A
E
S
S
Q
S
S
L
D
L
R
R
E
Site 153
S929
E
A
E
S
S
Q
S
S
L
D
L
R
R
E
G
Site 154
S937
L
D
L
R
R
E
G
S
L
S
P
V
N
S
Q
Site 155
S939
L
R
R
E
G
S
L
S
P
V
N
S
Q
K
I
Site 156
S943
G
S
L
S
P
V
N
S
Q
K
I
T
L
L
L
Site 157
T947
P
V
N
S
Q
K
I
T
L
L
L
Q
S
P
A
Site 158
T965
I
T
N
P
E
F
F
T
V
L
H
A
N
Y
S
Site 159
S972
T
V
L
H
A
N
Y
S
A
Y
R
V
F
T
S
Site 160
Y974
L
H
A
N
Y
S
A
Y
R
V
F
T
S
S
T
Site 161
T978
Y
S
A
Y
R
V
F
T
S
S
T
C
L
K
H
Site 162
S979
S
A
Y
R
V
F
T
S
S
T
C
L
K
H
M
Site 163
Y1000
D
A
R
N
F
E
R
Y
Q
H
N
R
D
L
V
Site 164
T1028
P
R
G
W
E
I
K
T
D
Q
Q
G
K
S
F
Site 165
S1034
K
T
D
Q
Q
G
K
S
F
F
V
D
H
N
S
Site 166
T1044
V
D
H
N
S
R
A
T
T
F
I
D
P
R
I
Site 167
T1045
D
H
N
S
R
A
T
T
F
I
D
P
R
I
P
Site 168
T1063
G
R
L
P
N
H
L
T
H
R
Q
H
L
Q
R
Site 169
S1073
Q
H
L
Q
R
L
R
S
Y
S
A
G
E
A
S
Site 170
Y1074
H
L
Q
R
L
R
S
Y
S
A
G
E
A
S
E
Site 171
S1075
L
Q
R
L
R
S
Y
S
A
G
E
A
S
E
V
Site 172
S1080
S
Y
S
A
G
E
A
S
E
V
S
R
N
R
G
Site 173
S1089
V
S
R
N
R
G
A
S
L
L
A
R
P
G
H
Site 174
S1104
S
L
V
A
A
I
R
S
Q
H
Q
H
E
S
L
Site 175
S1110
R
S
Q
H
Q
H
E
S
L
P
L
A
Y
N
D
Site 176
S1138
M
L
Q
E
R
Q
P
S
L
A
R
N
H
T
L
Site 177
T1144
P
S
L
A
R
N
H
T
L
R
E
K
I
H
Y
Site 178
Y1151
T
L
R
E
K
I
H
Y
I
R
T
E
G
N
H
Site 179
S1195
A
A
F
H
P
G
Y
S
F
S
P
R
C
S
P
Site 180
S1197
F
H
P
G
Y
S
F
S
P
R
C
S
P
C
S
Site 181
S1201
Y
S
F
S
P
R
C
S
P
C
S
S
P
Q
N
Site 182
S1204
S
P
R
C
S
P
C
S
S
P
Q
N
S
P
G
Site 183
S1205
P
R
C
S
P
C
S
S
P
Q
N
S
P
G
L
Site 184
S1209
P
C
S
S
P
Q
N
S
P
G
L
Q
R
A
S
Site 185
S1216
S
P
G
L
Q
R
A
S
A
R
A
P
S
P
Y
Site 186
S1221
R
A
S
A
R
A
P
S
P
Y
R
R
D
F
E
Site 187
Y1223
S
A
R
A
P
S
P
Y
R
R
D
F
E
A
K
Site 188
Y1235
E
A
K
L
R
N
F
Y
R
K
L
E
A
K
G
Site 189
T1263
R
D
H
L
L
E
G
T
F
N
Q
V
M
A
Y
Site 190
Y1270
T
F
N
Q
V
M
A
Y
S
R
K
E
L
Q
R
Site 191
Y1281
E
L
Q
R
N
K
L
Y
V
T
F
V
G
E
E
Site 192
T1283
Q
R
N
K
L
Y
V
T
F
V
G
E
E
G
L
Site 193
Y1292
V
G
E
E
G
L
D
Y
S
G
P
S
R
E
F
Site 194
S1293
G
E
E
G
L
D
Y
S
G
P
S
R
E
F
F
Site 195
S1304
R
E
F
F
F
L
L
S
Q
E
L
F
N
P
Y
Site 196
Y1311
S
Q
E
L
F
N
P
Y
Y
G
L
F
E
Y
S
Site 197
Y1312
Q
E
L
F
N
P
Y
Y
G
L
F
E
Y
S
A
Site 198
Y1317
P
Y
Y
G
L
F
E
Y
S
A
N
D
T
Y
T
Site 199
T1322
F
E
Y
S
A
N
D
T
Y
T
V
Q
I
S
P
Site 200
Y1323
E
Y
S
A
N
D
T
Y
T
V
Q
I
S
P
M
Site 201
T1324
Y
S
A
N
D
T
Y
T
V
Q
I
S
P
M
S
Site 202
S1378
L
R
L
P
C
D
L
S
D
L
E
Y
L
D
E
Site 203
Y1382
C
D
L
S
D
L
E
Y
L
D
E
E
F
H
Q
Site 204
T1418
E
E
V
F
G
Q
V
T
E
R
E
L
K
S
G
Site 205
Y1501
D
W
R
N
N
T
E
Y
R
G
G
Y
H
D
G
Site 206
Y1505
N
T
E
Y
R
G
G
Y
H
D
G
H
L
V
I
Site 207
S1539
Q
F
V
T
G
T
S
S
V
P
Y
E
G
F
A
Site 208
Y1542
T
G
T
S
S
V
P
Y
E
G
F
A
A
L
R
Site 209
S1551
G
F
A
A
L
R
G
S
N
G
L
R
R
F
C
Site 210
S1567
E
K
W
G
K
I
T
S
L
P
R
A
H
T
C
Site 211
T1573
T
S
L
P
R
A
H
T
C
F
N
R
L
D
L
Site 212
Y1583
N
R
L
D
L
P
P
Y
P
S
Y
S
M
L
Y
Site 213
S1585
L
D
L
P
P
Y
P
S
Y
S
M
L
Y
E
K
Site 214
S1587
L
P
P
Y
P
S
Y
S
M
L
Y
E
K
L
L
Site 215
T1595
M
L
Y
E
K
L
L
T
A
V
E
E
T
S
T
Site 216
T1602
T
A
V
E
E
T
S
T
F
G
L
E
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation