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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KNDC1
Full Name:
Protein very KIND
Alias:
BB439H18.3; C10orf23; Cerebral protein 9; FLJ25027; Hucep-9; KIAA1768; Kinase non-catalytic C-lobe domain (KIND) containing 1; Kinase non-catalytic C-lobe domain-containing protein 1; KIND domain-containing protein 1; Ras-GEF domain-containing family 2; Ras-GEF domain-containing family member 2; RASGEF2; Very KIND; VKIND
Type:
Cell development/differentiation; Guanine nucleotide exchange factor, Ras
Mass (Da):
191378
Number AA:
1749
UniProt ID:
Q76NI1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0051056
GO:0007264
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
D
P
A
A
A
D
L
Y
E
E
D
G
K
D
L
Site 2
Y22
D
G
K
D
L
D
F
Y
D
F
E
P
L
P
T
Site 3
T29
Y
D
F
E
P
L
P
T
L
P
E
D
E
E
N
Site 4
S38
P
E
D
E
E
N
V
S
L
A
D
I
L
S
L
Site 5
S51
S
L
R
D
R
G
L
S
E
Q
E
A
W
A
V
Site 6
S100
V
C
F
M
E
Q
L
S
D
D
P
E
G
A
F
Site 7
T115
V
P
P
E
F
D
V
T
G
N
T
F
E
A
H
Site 8
T118
E
F
D
V
T
G
N
T
F
E
A
H
I
Y
S
Site 9
Y124
N
T
F
E
A
H
I
Y
S
L
G
A
T
L
K
Site 10
T141
L
E
Y
V
A
E
P
T
L
E
P
R
L
S
Q
Site 11
S147
P
T
L
E
P
R
L
S
Q
D
L
E
A
L
L
Site 12
S155
Q
D
L
E
A
L
L
S
R
M
Q
A
E
D
P
Site 13
S170
G
D
R
P
D
L
E
S
I
I
A
L
C
E
E
Site 14
S183
E
E
K
L
Q
L
T
S
S
C
R
V
C
R
S
Site 15
S184
E
K
L
Q
L
T
S
S
C
R
V
C
R
S
L
Site 16
S190
S
S
C
R
V
C
R
S
L
S
A
V
G
R
R
Site 17
S211
F
G
A
L
Q
D
V
S
E
S
S
W
R
E
R
Site 18
S214
L
Q
D
V
S
E
S
S
W
R
E
R
P
A
P
Site 19
S234
R
R
P
P
G
D
P
S
T
D
P
E
V
L
P
Site 20
T235
R
P
P
G
D
P
S
T
D
P
E
V
L
P
T
Site 21
T242
T
D
P
E
V
L
P
T
P
E
G
P
E
S
E
Site 22
S248
P
T
P
E
G
P
E
S
E
T
S
R
G
P
R
Site 23
S251
E
G
P
E
S
E
T
S
R
G
P
R
A
S
P
Site 24
S257
T
S
R
G
P
R
A
S
P
T
K
A
L
L
S
Site 25
T259
R
G
P
R
A
S
P
T
K
A
L
L
S
T
P
Site 26
S264
S
P
T
K
A
L
L
S
T
P
V
R
N
G
E
Site 27
T265
P
T
K
A
L
L
S
T
P
V
R
N
G
E
S
Site 28
S272
T
P
V
R
N
G
E
S
H
S
R
E
G
L
A
Site 29
S274
V
R
N
G
E
S
H
S
R
E
G
L
A
G
L
Site 30
S300
D
R
D
A
L
R
R
S
R
L
R
K
V
Q
T
Site 31
T307
S
R
L
R
K
V
Q
T
F
P
R
L
L
S
D
Site 32
S313
Q
T
F
P
R
L
L
S
D
S
P
E
A
T
L
Site 33
T319
L
S
D
S
P
E
A
T
L
C
L
P
L
T
R
Site 34
S329
L
P
L
T
R
G
K
S
Q
L
P
I
S
E
L
Site 35
S334
G
K
S
Q
L
P
I
S
E
L
F
S
P
D
P
Site 36
S338
L
P
I
S
E
L
F
S
P
D
P
R
K
A
F
Site 37
S353
L
D
R
K
N
G
L
S
S
F
Q
A
Q
P
K
Site 38
S354
D
R
K
N
G
L
S
S
F
Q
A
Q
P
K
C
Site 39
S382
R
V
P
C
A
G
R
S
T
D
R
G
P
G
V
Site 40
T383
V
P
C
A
G
R
S
T
D
R
G
P
G
V
P
Site 41
S392
R
G
P
G
V
P
G
S
P
G
Q
P
E
T
S
Site 42
T398
G
S
P
G
Q
P
E
T
S
H
P
S
Q
G
P
Site 43
S399
S
P
G
Q
P
E
T
S
H
P
S
Q
G
P
A
Site 44
S402
Q
P
E
T
S
H
P
S
Q
G
P
A
E
A
P
Site 45
S416
P
A
D
P
R
D
A
S
G
E
A
Q
T
P
R
Site 46
T421
D
A
S
G
E
A
Q
T
P
R
D
D
E
R
I
Site 47
S445
A
A
A
E
Q
W
V
S
L
Q
D
L
L
S
Q
Site 48
S451
V
S
L
Q
D
L
L
S
Q
L
G
R
P
F
R
Site 49
T475
A
C
L
R
A
L
Q
T
R
P
E
H
P
A
Y
Site 50
Y482
T
R
P
E
H
P
A
Y
L
C
L
D
S
V
L
Site 51
S506
Q
P
P
P
A
N
G
S
Y
D
S
F
F
L
A
Site 52
Y507
P
P
P
A
N
G
S
Y
D
S
F
F
L
A
P
Site 53
S509
P
A
N
G
S
Y
D
S
F
F
L
A
P
E
L
Site 54
T523
L
A
E
E
R
L
V
T
E
K
A
S
V
Y
C
Site 55
S542
L
W
T
A
A
K
F
S
V
P
R
N
H
K
L
Site 56
S566
L
L
D
M
A
R
R
S
A
P
E
R
P
S
A
Site 57
S572
R
S
A
P
E
R
P
S
A
A
E
A
I
K
V
Site 58
S591
L
L
Q
R
G
M
D
S
R
K
I
L
A
H
L
Site 59
Y606
R
A
S
I
C
Q
V
Y
Q
E
E
E
T
I
S
Site 60
S613
Y
Q
E
E
E
T
I
S
L
Q
N
A
F
S
V
Site 61
S626
S
V
V
E
L
K
P
S
V
A
P
A
P
E
P
Site 62
S700
P
A
L
A
Q
E
E
S
E
E
R
G
G
Q
R
Site 63
S716
G
E
G
E
E
K
L
S
L
E
A
H
A
G
S
Site 64
S723
S
L
E
A
H
A
G
S
P
S
L
K
T
P
D
Site 65
S725
E
A
H
A
G
S
P
S
L
K
T
P
D
G
P
Site 66
T728
A
G
S
P
S
L
K
T
P
D
G
P
V
P
G
Site 67
S749
A
P
E
P
L
G
A
S
V
Q
R
D
S
A
Q
Site 68
S754
G
A
S
V
Q
R
D
S
A
Q
G
R
P
C
P
Site 69
S775
N
Q
P
E
G
A
S
S
A
A
P
G
S
P
V
Site 70
S780
A
S
S
A
A
P
G
S
P
V
P
A
P
P
T
Site 71
T820
P
D
A
L
G
P
T
T
A
H
H
G
P
R
H
Site 72
S834
H
P
P
K
P
P
R
S
K
A
T
E
R
P
G
Site 73
T850
E
P
E
G
P
G
A
T
P
A
G
E
R
D
D
Site 74
S859
A
G
E
R
D
D
Q
S
P
D
S
V
P
E
R
Site 75
S862
R
D
D
Q
S
P
D
S
V
P
E
R
P
R
P
Site 76
T888
A
S
P
L
P
G
R
T
A
C
P
S
L
Q
E
Site 77
S892
P
G
R
T
A
C
P
S
L
Q
E
A
T
R
L
Site 78
Y909
E
E
F
A
F
D
G
Y
L
D
N
G
L
E
A
Site 79
Y946
S
E
K
F
C
D
L
Y
W
D
E
K
L
L
Q
Site 80
S964
K
V
V
N
G
Q
A
S
P
S
P
S
T
A
E
Site 81
S966
V
N
G
Q
A
S
P
S
P
S
T
A
E
E
A
Site 82
S968
G
Q
A
S
P
S
P
S
T
A
E
E
A
G
S
Site 83
S975
S
T
A
E
E
A
G
S
Q
L
E
G
S
Q
S
Site 84
S980
A
G
S
Q
L
E
G
S
Q
S
P
R
S
P
S
Site 85
S982
S
Q
L
E
G
S
Q
S
P
R
S
P
S
S
K
Site 86
S985
E
G
S
Q
S
P
R
S
P
S
S
K
R
P
S
Site 87
S987
S
Q
S
P
R
S
P
S
S
K
R
P
S
L
H
Site 88
S988
Q
S
P
R
S
P
S
S
K
R
P
S
L
H
R
Site 89
S992
S
P
S
S
K
R
P
S
L
H
R
L
G
K
E
Site 90
T1006
E
K
P
A
M
A
R
T
S
S
R
A
P
C
S
Site 91
S1007
K
P
A
M
A
R
T
S
S
R
A
P
C
S
P
Site 92
S1008
P
A
M
A
R
T
S
S
R
A
P
C
S
P
T
Site 93
S1013
T
S
S
R
A
P
C
S
P
T
S
V
S
D
V
Site 94
S1016
R
A
P
C
S
P
T
S
V
S
D
V
D
S
D
Site 95
S1018
P
C
S
P
T
S
V
S
D
V
D
S
D
A
L
Site 96
S1022
T
S
V
S
D
V
D
S
D
A
L
S
R
G
N
Site 97
S1026
D
V
D
S
D
A
L
S
R
G
N
F
E
V
G
Site 98
S1039
V
G
F
R
P
Q
R
S
V
K
A
E
R
A
Q
Site 99
S1061
R
R
P
A
G
G
A
S
D
V
E
A
V
T
R
Site 100
S1080
K
G
V
G
P
A
L
S
P
G
P
A
G
F
Q
Site 101
S1088
P
G
P
A
G
F
Q
S
C
S
P
G
W
C
S
Site 102
Y1110
F
G
A
D
V
H
N
Y
V
K
D
L
G
R
Q
Site 103
S1128
G
A
L
P
D
A
Q
S
P
E
L
E
Q
Q
L
Site 104
Y1142
L
M
M
E
K
R
N
Y
R
K
T
L
K
F
Y
Site 105
T1145
E
K
R
N
Y
R
K
T
L
K
F
Y
Q
K
L
Site 106
T1166
N
K
G
S
D
V
K
T
M
L
S
K
L
K
G
Site 107
S1180
G
Q
L
E
E
M
K
S
R
V
Q
F
L
S
L
Site 108
S1186
K
S
R
V
Q
F
L
S
L
V
K
K
Y
L
Q
Site 109
Y1196
K
K
Y
L
Q
V
M
Y
A
E
R
W
G
L
E
Site 110
S1224
P
C
D
T
L
D
F
S
P
L
D
E
S
S
S
Site 111
S1229
D
F
S
P
L
D
E
S
S
S
L
I
F
Y
N
Site 112
S1231
S
P
L
D
E
S
S
S
L
I
F
Y
N
V
N
Site 113
Y1235
E
S
S
S
L
I
F
Y
N
V
N
K
H
P
G
Site 114
Y1272
S
D
A
F
L
E
G
Y
V
Q
Q
F
L
Y
T
Site 115
S1299
F
L
L
D
R
I
N
S
T
L
T
R
A
H
Q
Site 116
T1300
L
L
D
R
I
N
S
T
L
T
R
A
H
Q
D
Site 117
T1309
T
R
A
H
Q
D
P
T
S
T
F
T
K
I
Y
Site 118
S1310
R
A
H
Q
D
P
T
S
T
F
T
K
I
Y
R
Site 119
T1311
A
H
Q
D
P
T
S
T
F
T
K
I
Y
R
R
Site 120
Y1331
Q
A
W
V
E
D
C
Y
A
V
D
F
P
R
N
Site 121
S1339
A
V
D
F
P
R
N
S
G
L
L
G
K
L
E
Site 122
S1350
G
K
L
E
D
F
I
S
S
K
I
L
P
L
D
Site 123
T1382
A
E
G
N
P
R
G
T
D
L
E
N
P
R
E
Site 124
S1405
N
A
L
C
K
R
L
S
E
D
G
I
S
R
K
Site 125
S1410
R
L
S
E
D
G
I
S
R
K
S
F
P
W
R
Site 126
S1413
E
D
G
I
S
R
K
S
F
P
W
R
L
P
R
Site 127
Y1434
P
P
H
K
E
R
P
Y
T
I
A
A
A
L
P
Site 128
T1435
P
H
K
E
R
P
Y
T
I
A
A
A
L
P
K
Site 129
Y1450
P
C
F
L
E
D
F
Y
G
P
C
A
K
T
S
Site 130
T1456
F
Y
G
P
C
A
K
T
S
E
K
G
P
Y
F
Site 131
Y1462
K
T
S
E
K
G
P
Y
F
L
T
E
Y
S
T
Site 132
T1465
E
K
G
P
Y
F
L
T
E
Y
S
T
H
Q
L
Site 133
Y1467
G
P
Y
F
L
T
E
Y
S
T
H
Q
L
F
S
Site 134
T1469
Y
F
L
T
E
Y
S
T
H
Q
L
F
S
Q
L
Site 135
S1474
Y
S
T
H
Q
L
F
S
Q
L
T
L
L
Q
Q
Site 136
T1505
L
G
V
M
D
K
S
T
A
I
P
K
A
S
S
Site 137
S1511
S
T
A
I
P
K
A
S
S
S
E
S
L
S
A
Site 138
S1512
T
A
I
P
K
A
S
S
S
E
S
L
S
A
K
Site 139
S1513
A
I
P
K
A
S
S
S
E
S
L
S
A
K
T
Site 140
S1515
P
K
A
S
S
S
E
S
L
S
A
K
T
C
S
Site 141
S1517
A
S
S
S
E
S
L
S
A
K
T
C
S
L
F
Site 142
T1520
S
E
S
L
S
A
K
T
C
S
L
F
L
P
N
Site 143
Y1533
P
N
Y
V
Q
D
K
Y
L
L
Q
L
L
R
N
Site 144
S1545
L
R
N
A
D
D
V
S
T
W
V
A
A
E
I
Site 145
S1599
E
H
L
A
V
R
Q
S
P
A
W
R
I
L
P
Site 146
S1627
E
V
F
L
K
S
D
S
L
C
L
M
E
G
R
Site 147
T1641
R
R
F
R
A
Q
P
T
L
P
S
A
H
L
L
Site 148
S1670
T
N
G
A
H
R
W
S
K
L
R
N
I
A
K
Site 149
S1680
R
N
I
A
K
V
V
S
Q
V
H
A
F
Q
E
Site 150
T1691
A
F
Q
E
N
P
Y
T
F
S
P
D
P
K
L
Site 151
S1693
Q
E
N
P
Y
T
F
S
P
D
P
K
L
Q
S
Site 152
S1700
S
P
D
P
K
L
Q
S
Y
L
K
Q
R
I
A
Site 153
Y1701
P
D
P
K
L
Q
S
Y
L
K
Q
R
I
A
R
Site 154
S1710
K
Q
R
I
A
R
F
S
G
A
D
I
S
T
L
Site 155
S1715
R
F
S
G
A
D
I
S
T
L
A
A
D
S
R
Site 156
T1716
F
S
G
A
D
I
S
T
L
A
A
D
S
R
A
Site 157
S1721
I
S
T
L
A
A
D
S
R
A
N
F
H
Q
V
Site 158
S1729
R
A
N
F
H
Q
V
S
S
E
K
H
S
R
K
Site 159
S1734
Q
V
S
S
E
K
H
S
R
K
I
Q
D
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation