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Updated November 2019
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Protein Info
Short Name:
SUPT6H
Full Name:
Transcription elongation factor SPT6
Alias:
Chromatin structural protein; Emb-5; KIAA0162; KIAA0162, SPT6H; SPT6H; SPTH6; Suppressor of Ty 6; Suppressor of Ty 6 homolog protein; SUPTH6; Tat-cotransactivator 2 protein; Tat-CT2
Type:
Nuclear receptor co-regulator; Transcription factor
Mass (Da):
199073
Number AA:
1726
UniProt ID:
Q7KZ85
International Prot ID:
IPI00430770
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0016788
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006338
GO:0006357
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
D
F
V
E
S
E
A
E
E
S
E
E
Site 2
S12
V
E
S
E
A
E
E
S
E
E
E
Y
N
D
E
Site 3
Y16
A
E
E
S
E
E
E
Y
N
D
E
G
E
V
V
Site 4
T27
G
E
V
V
P
R
V
T
K
K
F
V
E
E
E
Site 5
S73
E
G
E
E
D
E
G
S
D
S
G
D
S
E
D
Site 6
S75
E
E
D
E
G
S
D
S
G
D
S
E
D
D
V
Site 7
S78
E
G
S
D
S
G
D
S
E
D
D
V
G
H
K
Site 8
T90
G
H
K
K
R
K
R
T
S
F
D
D
R
L
E
Site 9
S91
H
K
K
R
K
R
T
S
F
D
D
R
L
E
D
Site 10
Y118
K
V
K
R
G
Q
K
Y
R
R
V
K
K
M
S
Site 11
S125
Y
R
R
V
K
K
M
S
D
D
E
D
D
D
E
Site 12
S179
E
E
E
D
D
E
E
S
D
I
D
D
F
I
V
Site 13
Y223
I
F
G
V
D
F
D
Y
D
E
F
E
K
Y
N
Site 14
Y229
D
Y
D
E
F
E
K
Y
N
E
Y
D
E
E
L
Site 15
Y232
E
F
E
K
Y
N
E
Y
D
E
E
L
E
E
E
Site 16
Y242
E
L
E
E
E
Y
E
Y
E
D
D
E
A
E
G
Site 17
T259
R
V
R
P
K
K
T
T
K
K
R
V
S
R
R
Site 18
S264
K
T
T
K
K
R
V
S
R
R
S
I
F
E
M
Site 19
S267
K
K
R
V
S
R
R
S
I
F
E
M
Y
E
P
Site 20
Y272
R
R
S
I
F
E
M
Y
E
P
S
E
L
E
S
Site 21
S275
I
F
E
M
Y
E
P
S
E
L
E
S
S
H
L
Site 22
S279
Y
E
P
S
E
L
E
S
S
H
L
T
D
Q
D
Site 23
S280
E
P
S
E
L
E
S
S
H
L
T
D
Q
D
N
Site 24
T283
E
L
E
S
S
H
L
T
D
Q
D
N
E
I
R
Site 25
T292
Q
D
N
E
I
R
A
T
D
L
P
E
R
F
Q
Site 26
S302
P
E
R
F
Q
L
R
S
I
P
V
K
G
A
E
Site 27
Y321
E
E
E
A
D
W
I
Y
R
N
A
F
A
T
P
Site 28
T327
I
Y
R
N
A
F
A
T
P
T
I
S
L
Q
E
Site 29
S331
A
F
A
T
P
T
I
S
L
Q
E
S
C
D
Y
Site 30
S335
P
T
I
S
L
Q
E
S
C
D
Y
L
D
R
G
Site 31
Y338
S
L
Q
E
S
C
D
Y
L
D
R
G
Q
P
A
Site 32
S346
L
D
R
G
Q
P
A
S
S
F
S
R
K
G
P
Site 33
S347
D
R
G
Q
P
A
S
S
F
S
R
K
G
P
S
Site 34
S349
G
Q
P
A
S
S
F
S
R
K
G
P
S
T
I
Site 35
S354
S
F
S
R
K
G
P
S
T
I
Q
K
I
K
E
Site 36
T355
F
S
R
K
G
P
S
T
I
Q
K
I
K
E
A
Site 37
Y383
I
A
F
Y
R
K
E
Y
V
E
P
E
L
H
I
Site 38
T414
R
I
R
K
E
N
L
T
R
L
F
E
K
M
Q
Site 39
Y425
E
K
M
Q
A
Y
Q
Y
E
Q
I
S
A
D
P
Site 40
S429
A
Y
Q
Y
E
Q
I
S
A
D
P
D
K
P
L
Site 41
T445
D
G
I
R
A
L
D
T
T
D
M
E
R
L
K
Site 42
T446
G
I
R
A
L
D
T
T
D
M
E
R
L
K
D
Site 43
S456
E
R
L
K
D
V
Q
S
M
D
E
L
K
D
V
Site 44
Y464
M
D
E
L
K
D
V
Y
N
H
F
L
L
Y
Y
Site 45
Y470
V
Y
N
H
F
L
L
Y
Y
G
R
D
I
P
K
Site 46
Y471
Y
N
H
F
L
L
Y
Y
G
R
D
I
P
K
M
Site 47
S519
G
P
E
L
K
Q
A
S
R
R
D
M
Y
T
I
Site 48
Y524
Q
A
S
R
R
D
M
Y
T
I
C
Q
S
A
G
Site 49
T525
A
S
R
R
D
M
Y
T
I
C
Q
S
A
G
L
Site 50
T542
L
A
K
K
F
G
L
T
P
E
Q
F
G
E
N
Site 51
S553
F
G
E
N
L
R
D
S
Y
Q
R
H
E
T
E
Site 52
Y554
G
E
N
L
R
D
S
Y
Q
R
H
E
T
E
Q
Site 53
T559
D
S
Y
Q
R
H
E
T
E
Q
F
P
A
E
P
Site 54
Y573
P
L
E
L
A
K
D
Y
V
C
S
Q
F
P
T
Site 55
S576
L
A
K
D
Y
V
C
S
Q
F
P
T
P
E
A
Site 56
T609
V
R
Q
V
L
R
Q
T
F
Q
E
R
A
K
L
Site 57
T619
E
R
A
K
L
N
I
T
P
T
K
K
G
R
K
Site 58
T621
A
K
L
N
I
T
P
T
K
K
G
R
K
D
V
Site 59
Y633
K
D
V
D
E
A
H
Y
A
Y
S
F
K
Y
L
Site 60
Y639
H
Y
A
Y
S
F
K
Y
L
K
N
K
P
V
K
Site 61
T684
E
G
Y
G
N
D
Q
T
Y
F
E
E
I
K
Q
Site 62
Y685
G
Y
G
N
D
Q
T
Y
F
E
E
I
K
Q
F
Site 63
Y693
F
E
E
I
K
Q
F
Y
Y
R
D
E
F
S
H
Site 64
Y694
E
E
I
K
Q
F
Y
Y
R
D
E
F
S
H
Q
Site 65
T710
Q
E
W
N
R
Q
R
T
M
A
I
E
R
A
L
Site 66
Y722
R
A
L
Q
Q
F
L
Y
V
Q
M
A
K
E
L
Site 67
Y750
K
A
C
S
R
K
L
Y
N
W
L
R
V
A
P
Site 68
T806
V
N
G
E
G
E
V
T
D
F
L
R
L
P
H
Site 69
T815
F
L
R
L
P
H
F
T
K
R
R
T
A
W
R
Site 70
T819
P
H
F
T
K
R
R
T
A
W
R
E
E
E
R
Site 71
T835
K
K
A
Q
D
I
E
T
L
K
K
F
L
L
N
Site 72
T849
N
K
K
P
H
V
V
T
V
A
G
E
N
R
D
Site 73
Y893
D
N
E
L
A
I
L
Y
M
N
S
K
K
S
E
Site 74
S899
L
Y
M
N
S
K
K
S
E
A
E
F
R
D
Y
Site 75
Y906
S
E
A
E
F
R
D
Y
P
P
V
L
R
Q
A
Site 76
S915
P
V
L
R
Q
A
V
S
L
A
R
R
I
Q
D
Site 77
T998
G
L
G
P
R
K
G
T
H
L
L
K
I
L
K
Site 78
T1009
K
I
L
K
Q
N
N
T
R
L
E
S
R
T
Q
Site 79
S1013
Q
N
N
T
R
L
E
S
R
T
Q
L
V
T
M
Site 80
T1015
N
T
R
L
E
S
R
T
Q
L
V
T
M
C
H
Site 81
T1019
E
S
R
T
Q
L
V
T
M
C
H
M
G
P
K
Site 82
S1041
F
L
K
I
D
T
A
S
L
G
D
S
T
D
S
Site 83
S1045
D
T
A
S
L
G
D
S
T
D
S
Y
I
E
V
Site 84
T1046
T
A
S
L
G
D
S
T
D
S
Y
I
E
V
L
Site 85
S1048
S
L
G
D
S
T
D
S
Y
I
E
V
L
D
G
Site 86
Y1049
L
G
D
S
T
D
S
Y
I
E
V
L
D
G
S
Site 87
T1062
G
S
R
V
H
P
E
T
Y
E
W
A
R
K
M
Site 88
S1079
D
A
L
E
Y
D
E
S
A
E
D
A
N
P
A
Site 89
Y1116
E
E
L
E
R
Q
G
Y
G
D
K
H
I
T
L
Site 90
Y1124
G
D
K
H
I
T
L
Y
D
I
R
A
E
L
S
Site 91
S1131
Y
D
I
R
A
E
L
S
C
R
Y
K
D
L
R
Site 92
T1139
C
R
Y
K
D
L
R
T
A
Y
R
S
P
N
T
Site 93
Y1141
Y
K
D
L
R
T
A
Y
R
S
P
N
T
E
E
Site 94
S1143
D
L
R
T
A
Y
R
S
P
N
T
E
E
I
F
Site 95
T1157
F
N
M
L
T
K
E
T
P
E
T
F
Y
I
G
Site 96
T1160
L
T
K
E
T
P
E
T
F
Y
I
G
K
L
I
Site 97
T1172
K
L
I
I
C
N
V
T
G
I
A
H
R
R
P
Site 98
S1183
H
R
R
P
Q
G
E
S
Y
D
Q
A
I
R
N
Site 99
Y1184
R
R
P
Q
G
E
S
Y
D
Q
A
I
R
N
D
Site 100
S1246
F
I
P
T
K
F
L
S
D
K
V
V
K
R
P
Site 101
T1280
E
K
F
S
A
D
L
T
C
R
T
S
D
L
M
Site 102
S1284
A
D
L
T
C
R
T
S
D
L
M
D
R
N
N
Site 103
Y1300
W
K
L
P
K
D
T
Y
Y
D
F
D
A
E
A
Site 104
Y1301
K
L
P
K
D
T
Y
Y
D
F
D
A
E
A
A
Site 105
T1323
M
K
R
K
Q
Q
R
T
T
Y
I
K
R
V
I
Site 106
T1324
K
R
K
Q
Q
R
T
T
Y
I
K
R
V
I
A
Site 107
Y1325
R
K
Q
Q
R
T
T
Y
I
K
R
V
I
A
H
Site 108
S1360
G
D
V
I
I
R
P
S
S
K
G
E
N
H
L
Site 109
S1361
D
V
I
I
R
P
S
S
K
G
E
N
H
L
T
Site 110
T1368
S
K
G
E
N
H
L
T
V
T
W
K
V
S
D
Site 111
T1370
G
E
N
H
L
T
V
T
W
K
V
S
D
G
I
Site 112
Y1378
W
K
V
S
D
G
I
Y
Q
H
V
D
V
R
E
Site 113
S1393
E
G
K
E
N
A
F
S
L
G
A
T
L
W
I
Site 114
T1397
N
A
F
S
L
G
A
T
L
W
I
N
S
E
E
Site 115
S1402
G
A
T
L
W
I
N
S
E
E
F
E
D
L
D
Site 116
S1421
R
Y
V
Q
P
M
A
S
F
A
R
D
L
L
N
Site 117
Y1431
R
D
L
L
N
H
K
Y
Y
Q
D
C
S
G
G
Site 118
Y1432
D
L
L
N
H
K
Y
Y
Q
D
C
S
G
G
D
Site 119
T1450
L
E
E
L
L
I
K
T
K
K
E
K
P
T
F
Site 120
T1456
K
T
K
K
E
K
P
T
F
I
P
Y
F
I
C
Site 121
Y1476
P
G
K
F
L
L
G
Y
Q
P
R
G
K
P
R
Site 122
Y1486
R
G
K
P
R
I
E
Y
V
T
V
T
P
E
G
Site 123
T1488
K
P
R
I
E
Y
V
T
V
T
P
E
G
F
R
Site 124
T1490
R
I
E
Y
V
T
V
T
P
E
G
F
R
Y
R
Site 125
Y1496
V
T
P
E
G
F
R
Y
R
G
Q
I
F
P
T
Site 126
Y1515
F
R
W
F
K
D
H
Y
Q
D
P
V
P
G
I
Site 127
T1523
Q
D
P
V
P
G
I
T
P
S
S
S
N
R
T
Site 128
S1525
P
V
P
G
I
T
P
S
S
S
S
R
T
R
T
Site 129
S1526
V
P
G
I
T
P
S
S
S
S
R
T
R
T
P
Site 130
S1527
P
G
I
T
P
S
S
S
S
R
T
R
T
P
A
Site 131
S1528
G
I
T
P
S
S
S
S
R
T
R
T
P
A
S
Site 132
T1530
T
P
S
S
S
S
R
T
R
T
P
A
S
I
N
Site 133
T1532
S
S
S
S
R
T
R
T
P
A
S
I
N
A
T
Site 134
S1535
S
R
T
R
T
P
A
S
I
N
A
T
P
A
N
Site 135
T1539
T
P
A
S
I
N
A
T
P
A
N
I
N
L
A
Site 136
T1580
Q
G
Q
N
P
N
A
T
P
A
Q
W
A
S
S
Site 137
S1586
A
T
P
A
Q
W
A
S
S
Q
Y
G
Y
G
G
Site 138
S1587
T
P
A
Q
W
A
S
S
Q
Y
G
Y
G
G
S
Site 139
Y1589
A
Q
W
A
S
S
Q
Y
G
Y
G
G
S
G
G
Site 140
Y1591
W
A
S
S
Q
Y
G
Y
G
G
S
G
G
G
S
Site 141
S1594
S
Q
Y
G
Y
G
G
S
G
G
G
S
S
A
Y
Site 142
S1598
Y
G
G
S
G
G
G
S
S
A
Y
H
V
F
P
Site 143
S1599
G
G
S
G
G
G
S
S
A
Y
H
V
F
P
T
Site 144
Y1601
S
G
G
G
S
S
A
Y
H
V
F
P
T
P
A
Site 145
T1606
S
A
Y
H
V
F
P
T
P
A
Q
Q
P
V
A
Site 146
T1614
P
A
Q
Q
P
V
A
T
P
L
M
T
P
S
Y
Site 147
T1618
P
V
A
T
P
L
M
T
P
S
Y
S
Y
T
T
Site 148
S1620
A
T
P
L
M
T
P
S
Y
S
Y
T
T
P
S
Site 149
Y1621
T
P
L
M
T
P
S
Y
S
Y
T
T
P
S
Q
Site 150
Y1623
L
M
T
P
S
Y
S
Y
T
T
P
S
Q
P
I
Site 151
T1624
M
T
P
S
Y
S
Y
T
T
P
S
Q
P
I
T
Site 152
T1625
T
P
S
Y
S
Y
T
T
P
S
Q
P
I
T
T
Site 153
S1627
S
Y
S
Y
T
T
P
S
Q
P
I
T
T
P
Q
Site 154
T1631
T
T
P
S
Q
P
I
T
T
P
Q
Y
H
Q
L
Site 155
T1632
T
P
S
Q
P
I
T
T
P
Q
Y
H
Q
L
Q
Site 156
Y1635
Q
P
I
T
T
P
Q
Y
H
Q
L
Q
A
S
T
Site 157
S1641
Q
Y
H
Q
L
Q
A
S
T
T
P
Q
S
A
Q
Site 158
T1643
H
Q
L
Q
A
S
T
T
P
Q
S
A
Q
A
Q
Site 159
S1646
Q
A
S
T
T
P
Q
S
A
Q
A
Q
P
Q
P
Site 160
S1654
A
Q
A
Q
P
Q
P
S
S
S
S
R
Q
R
Q
Site 161
S1655
Q
A
Q
P
Q
P
S
S
S
S
R
Q
R
Q
Q
Site 162
S1656
A
Q
P
Q
P
S
S
S
S
R
Q
R
Q
Q
Q
Site 163
S1666
Q
R
Q
Q
Q
P
K
S
N
S
H
A
A
I
D
Site 164
S1668
Q
Q
Q
P
K
S
N
S
H
A
A
I
D
W
G
Site 165
T1697
R
K
Q
K
Q
R
L
T
P
R
P
S
P
S
P
Site 166
S1701
Q
R
L
T
P
R
P
S
P
S
P
M
I
E
S
Site 167
S1703
L
T
P
R
P
S
P
S
P
M
I
E
S
T
P
Site 168
S1708
S
P
S
P
M
I
E
S
T
P
M
S
I
A
G
Site 169
T1709
P
S
P
M
I
E
S
T
P
M
S
I
A
G
D
Site 170
T1718
M
S
I
A
G
D
A
T
P
L
L
D
E
M
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation