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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX46
Full Name:
Probable ATP-dependent RNA helicase DDX46
Alias:
DEAD box protein 46; EC 3.6.1.-; KIAA0801; PRP5
Type:
Enzyme - Helicase
Mass (Da):
117362
Number AA:
1031
UniProt ID:
Q7L014
International Prot ID:
IPI00329791
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015030
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
G
R
E
S
R
H
Y
R
K
R
S
A
S
R
Site 2
S12
S
R
H
Y
R
K
R
S
A
S
R
G
R
S
G
Site 3
S14
H
Y
R
K
R
S
A
S
R
G
R
S
G
S
R
Site 4
S18
R
S
A
S
R
G
R
S
G
S
R
S
R
S
R
Site 5
S20
A
S
R
G
R
S
G
S
R
S
R
S
R
S
P
Site 6
S22
R
G
R
S
G
S
R
S
R
S
R
S
P
S
D
Site 7
S24
R
S
G
S
R
S
R
S
R
S
P
S
D
K
R
Site 8
S26
G
S
R
S
R
S
R
S
P
S
D
K
R
S
K
Site 9
S28
R
S
R
S
R
S
P
S
D
K
R
S
K
R
G
Site 10
S32
R
S
P
S
D
K
R
S
K
R
G
D
D
R
R
Site 11
S40
K
R
G
D
D
R
R
S
R
S
R
D
R
D
R
Site 12
S42
G
D
D
R
R
S
R
S
R
D
R
D
R
R
R
Site 13
S52
R
D
R
R
R
E
R
S
R
S
R
D
K
R
R
Site 14
S54
R
R
R
E
R
S
R
S
R
D
K
R
R
S
R
Site 15
S60
R
S
R
D
K
R
R
S
R
S
R
D
R
K
R
Site 16
S62
R
D
K
R
R
S
R
S
R
D
R
K
R
L
R
Site 17
S71
D
R
K
R
L
R
R
S
R
S
R
E
R
D
R
Site 18
S73
K
R
L
R
R
S
R
S
R
E
R
D
R
S
R
Site 19
S79
R
S
R
E
R
D
R
S
R
E
R
R
R
S
R
Site 20
S85
R
S
R
E
R
R
R
S
R
S
R
D
R
R
R
Site 21
S87
R
E
R
R
R
S
R
S
R
D
R
R
R
S
R
Site 22
S93
R
S
R
D
R
R
R
S
R
S
R
S
R
G
R
Site 23
S95
R
D
R
R
R
S
R
S
R
S
R
G
R
R
S
Site 24
S97
R
R
R
S
R
S
R
S
R
G
R
R
S
R
S
Site 25
S102
S
R
S
R
G
R
R
S
R
S
S
S
P
G
N
Site 26
S104
S
R
G
R
R
S
R
S
S
S
P
G
N
K
S
Site 27
S105
R
G
R
R
S
R
S
S
S
P
G
N
K
S
K
Site 28
S106
G
R
R
S
R
S
S
S
P
G
N
K
S
K
K
Site 29
S111
S
S
S
P
G
N
K
S
K
K
T
E
N
R
S
Site 30
T114
P
G
N
K
S
K
K
T
E
N
R
S
R
S
K
Site 31
S118
S
K
K
T
E
N
R
S
R
S
K
E
K
T
D
Site 32
S120
K
T
E
N
R
S
R
S
K
E
K
T
D
G
G
Site 33
T124
R
S
R
S
K
E
K
T
D
G
G
E
S
S
K
Site 34
S130
K
T
D
G
G
E
S
S
K
E
K
K
K
D
K
Site 35
S199
M
K
Q
G
K
K
W
S
L
E
D
D
D
D
D
Site 36
Y231
E
L
D
P
L
D
A
Y
M
E
E
V
K
E
E
Site 37
S246
V
K
K
F
N
M
R
S
V
K
G
G
G
G
N
Site 38
S257
G
G
G
N
E
K
K
S
G
P
T
V
T
K
V
Site 39
S277
T
K
K
A
V
V
D
S
D
K
K
K
G
E
L
Site 40
Y294
N
D
Q
D
A
M
E
Y
S
S
E
E
E
E
V
Site 41
S295
D
Q
D
A
M
E
Y
S
S
E
E
E
E
V
D
Site 42
S296
Q
D
A
M
E
Y
S
S
E
E
E
E
V
D
L
Site 43
T305
E
E
E
V
D
L
Q
T
A
L
T
G
Y
Q
T
Site 44
Y328
V
D
H
G
K
I
E
Y
E
P
F
R
K
N
F
Site 45
Y336
E
P
F
R
K
N
F
Y
V
E
V
P
E
L
A
Site 46
S346
V
P
E
L
A
K
M
S
Q
E
E
V
N
V
F
Site 47
T361
R
L
E
M
E
G
I
T
V
K
G
K
G
C
P
Site 48
S386
I
S
M
K
I
L
N
S
L
K
K
H
G
Y
E
Site 49
Y392
N
S
L
K
K
H
G
Y
E
K
P
T
P
I
Q
Site 50
T396
K
H
G
Y
E
K
P
T
P
I
Q
T
Q
A
I
Site 51
S439
R
H
I
M
D
Q
R
S
L
E
E
G
E
G
P
Site 52
T452
G
P
I
A
V
I
M
T
P
T
R
E
L
A
L
Site 53
T454
I
A
V
I
M
T
P
T
R
E
L
A
L
Q
I
Site 54
T462
R
E
L
A
L
Q
I
T
K
E
C
K
K
F
S
Site 55
T518
A
A
N
S
G
R
V
T
N
L
R
R
V
T
Y
Site 56
Y525
T
N
L
R
R
V
T
Y
V
V
L
D
E
A
D
Site 57
T556
N
V
R
P
D
R
Q
T
V
M
F
S
A
T
F
Site 58
S560
D
R
Q
T
V
M
F
S
A
T
F
P
R
A
M
Site 59
S621
G
H
Y
Q
E
S
G
S
V
I
I
F
V
D
K
Site 60
S643
L
K
D
L
M
R
A
S
Y
P
C
M
S
L
H
Site 61
Y644
K
D
L
M
R
A
S
Y
P
C
M
S
L
H
G
Site 62
Y656
L
H
G
G
I
D
Q
Y
D
R
D
S
I
I
N
Site 63
Y694
H
L
I
L
V
V
N
Y
S
C
P
N
H
Y
E
Site 64
Y703
C
P
N
H
Y
E
D
Y
V
H
R
A
G
R
T
Site 65
Y718
G
R
A
G
N
K
G
Y
A
Y
T
F
I
T
E
Site 66
Y720
A
G
N
K
G
Y
A
Y
T
F
I
T
E
D
Q
Site 67
T721
G
N
K
G
Y
A
Y
T
F
I
T
E
D
Q
A
Site 68
T743
K
A
L
E
L
S
G
T
A
V
P
P
D
L
E
Site 69
S754
P
D
L
E
K
L
W
S
D
F
K
D
Q
Q
K
Site 70
S770
E
G
K
I
I
K
K
S
S
G
F
S
G
K
G
Site 71
S771
G
K
I
I
K
K
S
S
G
F
S
G
K
G
F
Site 72
S774
I
K
K
S
S
G
F
S
G
K
G
F
K
F
D
Site 73
T783
K
G
F
K
F
D
E
T
E
Q
A
L
A
N
E
Site 74
S804
A
A
L
G
L
Q
D
S
D
D
E
D
A
A
V
Site 75
S819
D
I
D
E
Q
I
E
S
M
F
N
S
K
K
R
Site 76
S823
Q
I
E
S
M
F
N
S
K
K
R
V
K
D
M
Site 77
S869
Q
K
N
L
G
I
E
S
Q
D
V
M
Q
Q
A
Site 78
T885
N
A
I
L
R
G
G
T
I
L
A
P
T
V
S
Site 79
T895
A
P
T
V
S
A
K
T
I
A
E
Q
L
A
E
Site 80
Y910
K
I
N
A
K
L
N
Y
V
P
L
E
K
Q
E
Site 81
S928
Q
D
G
G
Q
N
E
S
F
K
R
Y
E
E
E
Site 82
Y932
Q
N
E
S
F
K
R
Y
E
E
E
L
E
I
N
Site 83
T944
E
I
N
D
F
P
Q
T
A
R
W
K
V
T
S
Site 84
S951
T
A
R
W
K
V
T
S
K
E
A
L
Q
R
I
Site 85
S959
K
E
A
L
Q
R
I
S
E
Y
S
E
A
A
I
Site 86
S962
L
Q
R
I
S
E
Y
S
E
A
A
I
T
I
R
Site 87
T967
E
Y
S
E
A
A
I
T
I
R
G
T
Y
F
P
Site 88
T971
A
A
I
T
I
R
G
T
Y
F
P
P
G
K
E
Site 89
Y972
A
I
T
I
R
G
T
Y
F
P
P
G
K
E
P
Site 90
Y987
K
E
G
E
R
K
I
Y
L
A
I
E
S
A
N
Site 91
T1006
Q
K
A
K
A
E
I
T
R
L
I
K
E
E
L
Site 92
S1019
E
L
I
R
L
Q
N
S
Y
Q
P
T
N
K
G
Site 93
Y1020
L
I
R
L
Q
N
S
Y
Q
P
T
N
K
G
R
Site 94
T1023
L
Q
N
S
Y
Q
P
T
N
K
G
R
Y
K
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation