KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CYB5R4
Full Name:
Cytochrome b5 reductase 4
Alias:
B5+b5R; Cb5/cb5R; EC 1.6.2.2; Flavohemoprotein b5/b5R; NB5R4; NCB5OR; N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing
Type:
Cell development/differentiation, Endoplasmic reticulum, Oxidoreductase
Mass (Da):
59474
Number AA:
521
UniProt ID:
Q7L1T6
International Prot ID:
IPI00008236
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0016174
GO:0004128
GO:0020037
PhosphoSite+
KinaseNET
Biological Process:
GO:0048468
GO:0003032
GO:0006091
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
L
N
V
P
S
Q
S
F
P
A
P
R
Site 2
S8
M
L
N
V
P
S
Q
S
F
P
A
P
R
S
Q
Site 3
S14
Q
S
F
P
A
P
R
S
Q
Q
R
V
A
S
G
Site 4
S20
R
S
Q
Q
R
V
A
S
G
G
R
S
K
V
P
Site 5
S24
R
V
A
S
G
G
R
S
K
V
P
L
K
Q
G
Site 6
S33
V
P
L
K
Q
G
R
S
L
M
D
W
I
R
L
Site 7
T41
L
M
D
W
I
R
L
T
K
S
G
K
D
L
T
Site 8
S43
D
W
I
R
L
T
K
S
G
K
D
L
T
G
L
Site 9
T48
T
K
S
G
K
D
L
T
G
L
K
G
R
L
I
Site 10
T58
K
G
R
L
I
E
V
T
E
E
E
L
K
K
H
Site 11
Y80
I
C
I
R
G
F
V
Y
N
V
S
P
Y
M
E
Site 12
Y85
F
V
Y
N
V
S
P
Y
M
E
Y
H
P
G
G
Site 13
S102
E
L
M
R
A
A
G
S
D
G
T
E
L
F
D
Site 14
Y117
Q
V
H
R
W
V
N
Y
E
S
M
L
K
E
C
Site 15
Y139
K
P
A
V
L
K
D
Y
R
E
E
E
K
K
V
Site 16
S154
L
N
G
M
L
P
K
S
Q
V
T
D
T
L
A
Site 17
T157
M
L
P
K
S
Q
V
T
D
T
L
A
K
E
G
Site 18
T159
P
K
S
Q
V
T
D
T
L
A
K
E
G
P
S
Site 19
S166
T
L
A
K
E
G
P
S
Y
P
S
Y
D
W
F
Site 20
Y167
L
A
K
E
G
P
S
Y
P
S
Y
D
W
F
Q
Site 21
S169
K
E
G
P
S
Y
P
S
Y
D
W
F
Q
T
D
Site 22
Y170
E
G
P
S
Y
P
S
Y
D
W
F
Q
T
D
S
Site 23
T175
P
S
Y
D
W
F
Q
T
D
S
L
V
T
I
A
Site 24
S203
I
V
D
H
Q
N
D
S
F
R
A
E
T
I
I
Site 25
T208
N
D
S
F
R
A
E
T
I
I
K
D
C
L
Y
Site 26
S230
H
E
V
Q
E
D
F
S
V
R
V
V
E
S
V
Site 27
S264
H
P
L
K
N
H
N
S
L
I
P
R
K
D
T
Site 28
T271
S
L
I
P
R
K
D
T
G
L
Y
Y
R
K
C
Site 29
Y274
P
R
K
D
T
G
L
Y
Y
R
K
C
Q
L
I
Site 30
Y275
R
K
D
T
G
L
Y
Y
R
K
C
Q
L
I
S
Site 31
T287
L
I
S
K
E
D
V
T
H
D
T
R
L
F
C
Site 32
Y326
G
T
E
I
V
K
P
Y
T
P
V
S
G
S
L
Site 33
S332
P
Y
T
P
V
S
G
S
L
L
S
E
F
K
E
Site 34
T361
I
Y
P
T
G
L
F
T
P
E
L
D
R
L
Q
Site 35
S374
L
Q
I
G
D
F
V
S
V
S
S
P
E
G
N
Site 36
S376
I
G
D
F
V
S
V
S
S
P
E
G
N
F
K
Site 37
S377
G
D
F
V
S
V
S
S
P
E
G
N
F
K
I
Site 38
T414
K
I
L
N
Y
A
L
T
D
I
P
S
L
R
K
Site 39
S438
E
D
D
I
I
W
R
S
Q
L
E
K
L
A
F
Site 40
S461
F
V
L
S
A
P
I
S
E
W
N
G
K
Q
G
Site 41
S471
N
G
K
Q
G
H
I
S
P
A
L
L
S
E
F
Site 42
S476
H
I
S
P
A
L
L
S
E
F
L
K
R
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation