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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRC8D
Full Name:
Leucine-rich repeat-containing protein 8D
Alias:
Leucine-rich repeat-containing 8D; LRC8D; LRRC5
Type:
Mass (Da):
98201
Number AA:
858
UniProt ID:
Q7L1W4
International Prot ID:
IPI00018213
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
L
N
D
I
Q
P
T
Y
R
I
L
K
P
W
W
Site 2
S64
V
L
P
S
P
V
N
S
K
A
H
T
P
P
G
Site 3
T68
P
V
N
S
K
A
H
T
P
P
G
N
A
E
V
Site 4
T77
P
G
N
A
E
V
T
T
N
I
P
K
M
E
A
Site 5
T94
N
Q
D
Q
D
G
R
T
T
N
D
I
S
F
G
Site 6
T95
Q
D
Q
D
G
R
T
T
N
D
I
S
F
G
T
Site 7
S99
G
R
T
T
N
D
I
S
F
G
T
S
A
V
T
Site 8
S103
N
D
I
S
F
G
T
S
A
V
T
P
D
I
P
Site 9
T114
P
D
I
P
L
R
A
T
Y
P
R
T
D
F
A
Site 10
Y115
D
I
P
L
R
A
T
Y
P
R
T
D
F
A
L
Site 11
T118
L
R
A
T
Y
P
R
T
D
F
A
L
P
N
Q
Site 12
T135
K
K
E
K
K
D
P
T
G
R
K
T
N
L
D
Site 13
T139
K
D
P
T
G
R
K
T
N
L
D
F
Q
Q
Y
Site 14
Y161
Y
H
L
A
L
P
W
Y
S
K
Y
F
P
Y
L
Site 15
Y186
S
S
N
F
W
F
K
Y
P
K
T
C
S
K
V
Site 16
T209
K
C
F
E
S
P
W
T
T
K
A
L
S
E
T
Site 17
T210
C
F
E
S
P
W
T
T
K
A
L
S
E
T
A
Site 18
S214
P
W
T
T
K
A
L
S
E
T
A
C
E
D
S
Site 19
S221
S
E
T
A
C
E
D
S
E
E
N
K
Q
R
I
Site 20
T229
E
E
N
K
Q
R
I
T
G
A
Q
T
L
P
K
Site 21
S239
Q
T
L
P
K
H
V
S
T
S
S
D
E
G
S
Site 22
S241
L
P
K
H
V
S
T
S
S
D
E
G
S
P
S
Site 23
S242
P
K
H
V
S
T
S
S
D
E
G
S
P
S
A
Site 24
S246
S
T
S
S
D
E
G
S
P
S
A
S
T
P
M
Site 25
S248
S
S
D
E
G
S
P
S
A
S
T
P
M
I
N
Site 26
S250
D
E
G
S
P
S
A
S
T
P
M
I
N
K
T
Site 27
T251
E
G
S
P
S
A
S
T
P
M
I
N
K
T
G
Site 28
T257
S
T
P
M
I
N
K
T
G
F
K
F
S
A
E
Site 29
S301
F
R
A
H
V
E
D
S
D
L
I
Y
K
L
Y
Site 30
Y349
K
V
E
H
L
I
G
Y
E
V
F
E
C
T
H
Site 31
S396
R
I
P
L
K
E
Y
S
F
E
K
V
R
E
E
Site 32
S404
F
E
K
V
R
E
E
S
S
F
S
D
I
P
D
Site 33
S405
E
K
V
R
E
E
S
S
F
S
D
I
P
D
V
Site 34
S407
V
R
E
E
S
S
F
S
D
I
P
D
V
K
N
Site 35
Y426
L
L
H
M
V
D
Q
Y
D
Q
L
Y
S
K
R
Site 36
Y430
V
D
Q
Y
D
Q
L
Y
S
K
R
F
G
V
F
Site 37
S439
K
R
F
G
V
F
L
S
E
V
S
E
N
K
L
Site 38
S450
E
N
K
L
R
E
I
S
L
N
H
E
W
T
F
Site 39
T456
I
S
L
N
H
E
W
T
F
E
K
L
R
Q
H
Site 40
S465
E
K
L
R
Q
H
I
S
R
N
A
Q
D
K
Q
Site 41
S510
A
K
I
P
A
K
I
S
Q
M
T
N
L
Q
E
Site 42
S533
K
V
E
Q
T
A
F
S
F
L
R
D
H
L
R
Site 43
Y566
L
K
N
L
R
E
L
Y
L
I
G
N
L
N
S
Site 44
S583
N
K
M
I
G
L
E
S
L
R
E
L
R
H
L
Site 45
S597
L
K
I
L
H
V
K
S
N
L
T
K
V
P
S
Site 46
T600
L
H
V
K
S
N
L
T
K
V
P
S
N
I
T
Site 47
S604
S
N
L
T
K
V
P
S
N
I
T
D
V
A
P
Site 48
S667
L
Q
E
L
D
L
K
S
N
N
I
R
T
I
E
Site 49
S678
R
T
I
E
E
I
I
S
F
Q
H
L
K
R
L
Site 50
S710
T
H
V
K
N
L
E
S
L
Y
F
S
N
N
K
Site 51
Y712
V
K
N
L
E
S
L
Y
F
S
N
N
K
L
E
Site 52
S714
N
L
E
S
L
Y
F
S
N
N
K
L
E
S
L
Site 53
S789
L
G
Q
N
C
I
T
S
L
P
E
K
V
G
Q
Site 54
S798
P
E
K
V
G
Q
L
S
Q
L
T
Q
L
E
L
Site 55
S826
Q
C
R
M
L
K
K
S
G
L
V
V
E
D
H
Site 56
T837
V
E
D
H
L
F
D
T
L
P
L
E
V
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation