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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MEPCE
Full Name:
7SK snRNA methylphosphate capping enzyme
Alias:
BCDIN3; Bicoid-interacting protein 3 homolog; Bicoid-interacting protein 3 homologue; Bin3 homolog; FLJ20257; Methylphosphate capping enzyme
Type:
EC 2.1.1.; EC 2.1.1.-; Methyltransferase; RNA processing; Transcription regulation
Mass (Da):
74355
Number AA:
689
UniProt ID:
Q7L2J0
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008168
GO:0008168
GO:0016740
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
P
P
P
L
K
D
E
S
G
G
G
G
G
P
T
Site 2
T31
S
G
G
G
G
G
P
T
V
P
P
H
Q
E
A
Site 3
S40
P
P
H
Q
E
A
A
S
G
E
L
R
G
G
T
Site 4
T47
S
G
E
L
R
G
G
T
E
R
G
P
G
R
C
Site 5
S57
G
P
G
R
C
A
P
S
A
G
S
P
A
A
A
Site 6
S60
R
C
A
P
S
A
G
S
P
A
A
A
V
G
R
Site 7
S69
A
A
A
V
G
R
E
S
P
G
A
A
A
T
S
Site 8
T75
E
S
P
G
A
A
A
T
S
S
S
G
P
Q
A
Site 9
S76
S
P
G
A
A
A
T
S
S
S
G
P
Q
A
Q
Site 10
S77
P
G
A
A
A
T
S
S
S
G
P
Q
A
Q
Q
Site 11
S78
G
A
A
A
T
S
S
S
G
P
Q
A
Q
Q
H
Site 12
S94
G
G
G
P
Q
A
Q
S
H
G
E
A
R
L
S
Site 13
S101
S
H
G
E
A
R
L
S
D
P
P
G
R
A
A
Site 14
T122
E
R
R
G
G
G
G
T
E
L
G
P
P
A
P
Site 15
Y136
P
P
R
P
R
N
G
Y
Q
P
H
R
P
P
G
Site 16
S152
G
G
G
K
R
R
N
S
C
N
V
G
G
G
G
Site 17
S175
K
R
R
R
R
V
N
S
D
C
D
S
V
L
P
Site 18
S179
R
V
N
S
D
C
D
S
V
L
P
S
N
F
L
Site 19
S199
F
D
P
L
N
L
N
S
L
L
D
E
E
V
S
Site 20
T208
L
D
E
E
V
S
R
T
L
N
A
E
T
P
K
Site 21
T213
S
R
T
L
N
A
E
T
P
K
S
S
P
L
P
Site 22
S216
L
N
A
E
T
P
K
S
S
P
L
P
A
K
G
Site 23
S217
N
A
E
T
P
K
S
S
P
L
P
A
K
G
R
Site 24
S240
K
D
I
T
D
P
L
S
L
N
T
C
T
D
E
Site 25
T243
T
D
P
L
S
L
N
T
C
T
D
E
G
H
V
Site 26
T245
P
L
S
L
N
T
C
T
D
E
G
H
V
V
L
Site 27
S254
E
G
H
V
V
L
A
S
P
L
K
T
G
R
K
Site 28
T258
V
L
A
S
P
L
K
T
G
R
K
R
H
R
H
Site 29
S279
Q
Q
Q
A
A
G
G
S
E
S
H
P
V
P
P
Site 30
S281
Q
A
A
G
G
S
E
S
H
P
V
P
P
T
A
Site 31
T287
E
S
H
P
V
P
P
T
A
P
L
T
P
L
L
Site 32
T291
V
P
P
T
A
P
L
T
P
L
L
H
G
E
G
Site 33
S300
L
L
H
G
E
G
A
S
Q
Q
P
R
H
R
G
Site 34
S330
N
C
R
D
E
V
V
S
P
L
P
S
A
L
Q
Site 35
S334
E
V
V
S
P
L
P
S
A
L
Q
G
P
S
G
Site 36
S340
P
S
A
L
Q
G
P
S
G
S
L
S
A
P
P
Site 37
S344
Q
G
P
S
G
S
L
S
A
P
P
A
A
S
V
Site 38
S353
P
P
A
A
S
V
I
S
A
P
P
S
S
S
S
Site 39
S357
S
V
I
S
A
P
P
S
S
S
S
R
H
R
K
Site 40
S358
V
I
S
A
P
P
S
S
S
S
R
H
R
K
R
Site 41
S359
I
S
A
P
P
S
S
S
S
R
H
R
K
R
R
Site 42
S360
S
A
P
P
S
S
S
S
R
H
R
K
R
R
R
Site 43
T368
R
H
R
K
R
R
R
T
S
S
K
S
E
A
G
Site 44
S369
H
R
K
R
R
R
T
S
S
K
S
E
A
G
A
Site 45
S370
R
K
R
R
R
T
S
S
K
S
E
A
G
A
R
Site 46
S372
R
R
R
T
S
S
K
S
E
A
G
A
R
G
G
Site 47
S383
A
R
G
G
G
Q
G
S
K
E
K
G
R
G
S
Site 48
S390
S
K
E
K
G
R
G
S
W
G
G
R
H
H
H
Site 49
Y415
K
Q
Q
R
K
F
Q
Y
G
N
Y
C
K
Y
Y
Site 50
Y418
R
K
F
Q
Y
G
N
Y
C
K
Y
Y
G
Y
R
Site 51
Y421
Q
Y
G
N
Y
C
K
Y
Y
G
Y
R
N
P
S
Site 52
Y422
Y
G
N
Y
C
K
Y
Y
G
Y
R
N
P
S
C
Site 53
Y424
N
Y
C
K
Y
Y
G
Y
R
N
P
S
C
E
D
Site 54
S428
Y
Y
G
Y
R
N
P
S
C
E
D
G
R
L
R
Site 55
S482
I
D
S
R
L
I
H
S
A
R
Q
N
I
R
H
Site 56
Y490
A
R
Q
N
I
R
H
Y
L
S
E
E
L
R
L
Site 57
T501
E
L
R
L
P
P
Q
T
L
E
G
D
P
G
A
Site 58
T515
A
E
G
E
E
G
T
T
T
V
R
K
R
S
C
Site 59
T516
E
G
E
E
G
T
T
T
V
R
K
R
S
C
F
Site 60
S521
T
T
T
V
R
K
R
S
C
F
P
A
S
L
T
Site 61
S526
K
R
S
C
F
P
A
S
L
T
A
S
R
G
P
Site 62
T572
D
D
L
V
E
A
Q
T
P
E
Y
D
V
V
L
Site 63
Y604
K
R
M
F
R
R
I
Y
R
H
L
R
P
G
G
Site 64
S621
V
L
E
P
Q
P
W
S
S
Y
G
K
R
K
T
Site 65
S622
L
E
P
Q
P
W
S
S
Y
G
K
R
K
T
L
Site 66
T628
S
S
Y
G
K
R
K
T
L
T
E
T
I
Y
K
Site 67
T630
Y
G
K
R
K
T
L
T
E
T
I
Y
K
N
Y
Site 68
Y634
K
T
L
T
E
T
I
Y
K
N
Y
Y
R
I
Q
Site 69
Y637
T
E
T
I
Y
K
N
Y
Y
R
I
Q
L
K
P
Site 70
S649
L
K
P
E
Q
F
S
S
Y
L
T
S
P
D
V
Site 71
T652
E
Q
F
S
S
Y
L
T
S
P
D
V
G
F
S
Site 72
S653
Q
F
S
S
Y
L
T
S
P
D
V
G
F
S
S
Site 73
S660
S
P
D
V
G
F
S
S
Y
E
L
V
A
T
P
Site 74
Y661
P
D
V
G
F
S
S
Y
E
L
V
A
T
P
H
Site 75
T666
S
S
Y
E
L
V
A
T
P
H
N
T
S
K
G
Site 76
Y679
K
G
F
Q
R
P
V
Y
L
F
H
K
A
R
S
Site 77
S686
Y
L
F
H
K
A
R
S
P
S
H
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation