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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PARS2
Full Name:
Probable prolyl-tRNA synthetase, mitochondrial
Alias:
DKFZp727A071; EC=6.1.1.15; Proline tRNA ligase 2, mitochondrial; Proline-tRNA ligase; Prolyl-tRNA synthetase 2, mitochondrial; ProRS; SYPM
Type:
Ligase; EC 6.1.1.15
Mass (Da):
53263
Number AA:
475
UniProt ID:
Q7L3T8
International Prot ID:
IPI00553006
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004827
PhosphoSite+
KinaseNET
Biological Process:
GO:0006433
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
A
T
C
S
R
Q
L
S
G
Y
V
P
C
R
F
Site 2
Y24
C
S
R
Q
L
S
G
Y
V
P
C
R
F
H
H
Site 3
S43
R
G
R
R
L
L
L
S
R
V
F
Q
P
Q
N
Site 4
S58
L
R
E
D
R
V
L
S
L
Q
D
K
S
D
D
Site 5
S63
V
L
S
L
Q
D
K
S
D
D
L
T
C
K
S
Site 6
T67
Q
D
K
S
D
D
L
T
C
K
S
Q
R
L
M
Site 7
S70
S
D
D
L
T
C
K
S
Q
R
L
M
L
Q
V
Site 8
Y88
Y
P
A
S
P
G
C
Y
H
L
L
P
Y
T
V
Site 9
Y93
G
C
Y
H
L
L
P
Y
T
V
R
A
M
E
K
Site 10
S121
G
Q
K
V
N
M
P
S
L
S
P
A
E
L
W
Site 11
S123
K
V
N
M
P
S
L
S
P
A
E
L
W
Q
A
Site 12
Y152
R
D
R
H
G
K
E
Y
C
L
G
P
T
H
E
Site 13
T163
P
T
H
E
E
A
I
T
A
L
I
A
S
Q
K
Site 14
S173
I
A
S
Q
K
K
L
S
Y
K
Q
L
P
F
L
Site 15
Y182
K
Q
L
P
F
L
L
Y
Q
V
T
R
K
F
R
Site 16
Y205
L
L
R
G
R
E
F
Y
M
K
D
M
Y
T
F
Site 17
Y210
E
F
Y
M
K
D
M
Y
T
F
D
S
S
P
E
Site 18
T211
F
Y
M
K
D
M
Y
T
F
D
S
S
P
E
A
Site 19
S214
K
D
M
Y
T
F
D
S
S
P
E
A
A
Q
Q
Site 20
S215
D
M
Y
T
F
D
S
S
P
E
A
A
Q
Q
T
Site 21
T284
S
F
S
A
N
M
E
T
L
D
L
S
Q
M
N
Site 22
T300
P
A
C
Q
G
P
L
T
K
T
K
G
I
E
V
Site 23
T310
K
G
I
E
V
G
H
T
F
Y
L
G
T
K
Y
Site 24
Y312
I
E
V
G
H
T
F
Y
L
G
T
K
Y
S
S
Site 25
Y317
T
F
Y
L
G
T
K
Y
S
S
I
F
N
A
Q
Site 26
S356
A
A
A
I
E
V
L
S
T
E
D
C
V
R
W
Site 27
S365
E
D
C
V
R
W
P
S
L
L
A
P
Y
Q
A
Site 28
S387
G
S
K
E
Q
A
A
S
E
L
I
G
Q
L
Y
Site 29
T398
G
Q
L
Y
D
H
I
T
E
A
V
P
Q
L
H
Site 30
T414
E
V
L
L
D
D
R
T
H
L
T
I
G
N
R
Site 31
T417
L
D
D
R
T
H
L
T
I
G
N
R
L
K
D
Site 32
Y430
K
D
A
N
K
F
G
Y
P
F
V
I
I
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation