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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DOK3
Full Name:
Docking protein 3
Alias:
Docking protein 3; FLJ22570
Type:
Adapter/scaffold protein
Mass (Da):
53288
Number AA:
496
UniProt ID:
Q7L591
International Prot ID:
IPI00156649
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005158
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Docking protein 3 Y398 phosphosite-specific antibody AB-PN508#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN508#Docking protein 3 (E395-L401, human) pY398 phosphopeptide - Powder PE-04AHH99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHH99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
T
R
G
A
R
L
R
S
D
A
R
A
Q
L
N
Site 2
S19
R
A
Q
L
N
Q
L
S
L
D
G
G
T
G
S
Site 3
S26
S
L
D
G
G
T
G
S
G
Q
K
G
K
C
E
Site 4
S37
G
K
C
E
E
F
P
S
S
L
S
S
V
S
P
Site 5
S38
K
C
E
E
F
P
S
S
L
S
S
V
S
P
G
Site 6
S40
E
E
F
P
S
S
L
S
S
V
S
P
G
L
E
Site 7
S41
E
F
P
S
S
L
S
S
V
S
P
G
L
E
A
Site 8
Y70
P
I
K
D
G
I
L
Y
Q
Q
H
V
K
F
G
Site 9
S101
S
G
V
A
R
L
E
S
W
E
V
R
D
G
G
Site 10
S116
L
G
A
A
G
D
R
S
A
G
P
G
R
R
G
Site 11
T148
G
E
S
C
P
R
D
T
G
A
F
L
L
T
T
Site 12
T154
D
T
G
A
F
L
L
T
T
T
E
R
S
H
L
Site 13
T182
C
Q
L
A
F
P
G
T
G
E
A
S
S
G
S
Site 14
S187
P
G
T
G
E
A
S
S
G
S
T
D
A
Q
S
Site 15
S189
T
G
E
A
S
S
G
S
T
D
A
Q
S
P
K
Site 16
T190
G
E
A
S
S
G
S
T
D
A
Q
S
P
K
R
Site 17
S194
S
G
S
T
D
A
Q
S
P
K
R
G
L
V
P
Site 18
S206
L
V
P
M
E
E
N
S
I
Y
S
S
W
Q
E
Site 19
Y208
P
M
E
E
N
S
I
Y
S
S
W
Q
E
V
G
Site 20
S210
E
E
N
S
I
Y
S
S
W
Q
E
V
G
E
F
Site 21
T253
Q
L
R
E
A
K
G
T
Q
A
L
Y
S
W
P
Site 22
Y257
A
K
G
T
Q
A
L
Y
S
W
P
Y
H
F
L
Site 23
S269
H
F
L
R
K
F
G
S
D
K
G
V
F
S
F
Site 24
S275
G
S
D
K
G
V
F
S
F
E
A
G
R
R
C
Site 25
S284
E
A
G
R
R
C
H
S
G
E
G
L
F
A
F
Site 26
T318
R
E
R
L
P
E
L
T
R
P
Q
P
C
P
L
Site 27
T329
P
C
P
L
P
R
A
T
S
L
P
S
L
D
T
Site 28
S330
C
P
L
P
R
A
T
S
L
P
S
L
D
T
P
Site 29
S333
P
R
A
T
S
L
P
S
L
D
T
P
G
E
L
Site 30
T336
T
S
L
P
S
L
D
T
P
G
E
L
R
E
M
Site 31
T351
P
P
G
P
E
P
P
T
S
R
K
M
H
L
A
Site 32
S352
P
G
P
E
P
P
T
S
R
K
M
H
L
A
E
Site 33
S364
L
A
E
P
G
P
Q
S
L
P
L
L
L
G
P
Site 34
S378
P
E
P
N
D
L
A
S
G
L
Y
A
S
V
C
Site 35
Y381
N
D
L
A
S
G
L
Y
A
S
V
C
K
R
A
Site 36
S389
A
S
V
C
K
R
A
S
G
P
P
G
N
E
H
Site 37
Y398
P
P
G
N
E
H
L
Y
E
N
L
C
V
L
E
Docking protein 3 Y398 phosphosite-specific antibody AB-PN508#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN508#Docking protein 3 (E395-L401, human) pY398 phosphopeptide - Powder PE-04AHH99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHH99
Site 38
S407
N
L
C
V
L
E
A
S
P
T
L
H
G
G
E
Site 39
T409
C
V
L
E
A
S
P
T
L
H
G
G
E
P
E
Site 40
S423
E
P
H
E
G
P
G
S
R
S
P
T
T
S
P
Site 41
S425
H
E
G
P
G
S
R
S
P
T
T
S
P
I
Y
Site 42
T427
G
P
G
S
R
S
P
T
T
S
P
I
Y
H
N
Site 43
T428
P
G
S
R
S
P
T
T
S
P
I
Y
H
N
G
Site 44
S429
G
S
R
S
P
T
T
S
P
I
Y
H
N
G
Q
Site 45
Y432
S
P
T
T
S
P
I
Y
H
N
G
Q
D
L
S
Site 46
S447
W
P
G
P
A
N
D
S
T
L
E
A
Q
Y
R
Site 47
T448
P
G
P
A
N
D
S
T
L
E
A
Q
Y
R
R
Site 48
Y453
D
S
T
L
E
A
Q
Y
R
R
L
L
E
L
D
Site 49
T465
E
L
D
Q
V
E
G
T
G
R
P
D
P
Q
A
Site 50
T480
G
F
K
A
K
L
V
T
L
L
S
R
E
R
R
Site 51
S483
A
K
L
V
T
L
L
S
R
E
R
R
K
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation