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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
G2E3
Full Name:
G2/M phase-specific E3 ubiquitin-protein ligase
Alias:
Type:
Mass (Da):
80504
Number AA:
706
UniProt ID:
Q7L622
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
N
E
S
K
P
G
D
S
Q
N
L
A
C
V
F
Site 2
Y27
H
D
D
C
P
N
K
Y
G
E
K
K
T
K
E
Site 3
Y42
K
W
N
L
T
V
H
Y
Y
C
L
L
M
S
S
Site 4
Y62
G
K
E
E
E
G
V
Y
G
F
L
I
E
D
I
Site 5
Y102
A
P
R
C
K
R
S
Y
H
F
P
C
G
L
Q
Site 6
S141
T
S
N
N
Y
R
E
S
L
P
C
T
I
C
L
Site 7
S156
E
F
I
E
P
I
P
S
Y
N
I
L
R
S
P
Site 8
S215
H
I
P
E
K
D
A
S
W
E
L
E
E
N
A
Site 9
Y223
W
E
L
E
E
N
A
Y
Q
E
L
L
Q
H
Y
Site 10
Y230
Y
Q
E
L
L
Q
H
Y
E
R
C
D
V
R
R
Site 11
Y246
R
C
K
E
G
R
D
Y
N
A
P
D
S
K
W
Site 12
S271
S
G
T
H
L
A
C
S
S
L
R
S
W
E
Q
Site 13
S272
G
T
H
L
A
C
S
S
L
R
S
W
E
Q
N
Site 14
Y290
L
E
C
R
G
I
I
Y
N
S
G
E
F
Q
K
Site 15
S306
K
K
H
V
L
P
N
S
N
N
V
G
I
T
D
Site 16
S320
D
C
L
L
E
E
S
S
P
K
L
P
R
Q
S
Site 17
S327
S
P
K
L
P
R
Q
S
P
G
S
Q
S
K
D
Site 18
S330
L
P
R
Q
S
P
G
S
Q
S
K
D
L
L
R
Site 19
S340
K
D
L
L
R
Q
G
S
K
F
R
R
N
V
S
Site 20
S347
S
K
F
R
R
N
V
S
T
L
L
I
E
L
G
Site 21
T348
K
F
R
R
N
V
S
T
L
L
I
E
L
G
F
Site 22
T361
G
F
Q
I
K
K
K
T
K
R
L
Y
I
N
K
Site 23
Y365
K
K
K
T
K
R
L
Y
I
N
K
A
N
I
W
Site 24
S387
R
N
R
N
F
N
P
S
Y
A
I
E
V
A
Y
Site 25
Y388
N
R
N
F
N
P
S
Y
A
I
E
V
A
Y
V
Site 26
S408
F
G
S
E
H
P
G
S
K
Q
E
F
L
S
L
Site 27
S414
G
S
K
Q
E
F
L
S
L
L
M
Q
H
L
E
Site 28
S424
M
Q
H
L
E
N
S
S
L
F
E
G
S
L
S
Site 29
S429
N
S
S
L
F
E
G
S
L
S
K
N
L
S
L
Site 30
S431
S
L
F
E
G
S
L
S
K
N
L
S
L
N
S
Site 31
S435
G
S
L
S
K
N
L
S
L
N
S
Q
A
L
K
Site 32
S438
S
K
N
L
S
L
N
S
Q
A
L
K
E
N
L
Site 33
Y446
Q
A
L
K
E
N
L
Y
Y
E
A
G
K
M
L
Site 34
Y447
A
L
K
E
N
L
Y
Y
E
A
G
K
M
L
A
Site 35
S463
S
L
V
H
G
G
P
S
P
G
F
F
S
K
T
Site 36
T554
H
V
I
Q
R
V
H
T
P
F
E
S
F
K
Q
Site 37
S558
R
V
H
T
P
F
E
S
F
K
Q
G
L
K
T
Site 38
S591
C
H
K
P
E
S
L
S
A
K
I
L
S
E
L
Site 39
S615
K
A
L
G
F
W
N
S
Y
L
Q
A
V
E
D
Site 40
Y616
A
L
G
F
W
N
S
Y
L
Q
A
V
E
D
G
Site 41
S625
Q
A
V
E
D
G
K
S
T
T
T
M
E
D
I
Site 42
T650
P
P
A
G
F
K
P
T
P
S
I
E
C
L
H
Site 43
S652
A
G
F
K
P
T
P
S
I
E
C
L
H
V
D
Site 44
T688
F
Q
E
N
M
D
F
T
I
R
N
T
L
R
L
Site 45
T692
M
D
F
T
I
R
N
T
L
R
L
E
K
E
E
Site 46
S700
L
R
L
E
K
E
E
S
S
H
Y
I
G
H
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation