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Updated November 2019
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Protein Info
Short Name:
JMJD1B
Full Name:
Lysine-specific demethylase 3B
Alias:
C5orf7; JHD2B; Jumonji domain-containing protein 1B; KIAA1082; Lysine (K)-specific demethylase 3B; NET22; Nuclear protein 5qNCA
Type:
Demethylase; Oxidoreductase; EC 1.14.11.-
Mass (Da):
191611
Number AA:
1761
UniProt ID:
Q7LBC6
International Prot ID:
IPI00298935
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005506
GO:0016702
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0055114
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T51
T
R
A
W
R
A
G
T
V
R
A
M
S
G
A
Site 2
Y139
G
S
V
V
P
V
E
Y
L
L
D
R
E
L
R
Site 3
S149
D
R
E
L
R
F
L
S
D
A
N
G
L
H
L
Site 4
S163
L
F
Q
M
G
T
D
S
Q
N
Q
I
L
L
E
Site 5
T177
E
H
A
A
L
R
E
T
V
N
A
L
I
S
D
Site 6
S183
E
T
V
N
A
L
I
S
D
Q
K
L
Q
E
I
Site 7
S192
Q
K
L
Q
E
I
F
S
R
G
P
Y
S
V
Q
Site 8
Y196
E
I
F
S
R
G
P
Y
S
V
Q
G
H
R
V
Site 9
S197
I
F
S
R
G
P
Y
S
V
Q
G
H
R
V
K
Site 10
Y206
Q
G
H
R
V
K
I
Y
Q
P
E
G
E
E
G
Site 11
Y216
E
G
E
E
G
W
L
Y
G
V
V
S
H
Q
D
Site 12
S220
G
W
L
Y
G
V
V
S
H
Q
D
S
I
T
R
Site 13
S224
G
V
V
S
H
Q
D
S
I
T
R
L
M
E
V
Site 14
T226
V
S
H
Q
D
S
I
T
R
L
M
E
V
S
V
Site 15
T234
R
L
M
E
V
S
V
T
E
S
G
E
I
K
S
Site 16
S236
M
E
V
S
V
T
E
S
G
E
I
K
S
V
D
Site 17
S241
T
E
S
G
E
I
K
S
V
D
P
R
L
I
H
Site 18
S255
H
V
M
L
M
D
N
S
T
P
Q
S
E
G
G
Site 19
T256
V
M
L
M
D
N
S
T
P
Q
S
E
G
G
T
Site 20
S259
M
D
N
S
T
P
Q
S
E
G
G
T
L
K
A
Site 21
T263
T
P
Q
S
E
G
G
T
L
K
A
V
K
S
S
Site 22
S269
G
T
L
K
A
V
K
S
S
K
G
K
K
K
R
Site 23
S278
K
G
K
K
K
R
E
S
I
E
G
K
D
G
R
Site 24
S289
K
D
G
R
R
R
K
S
A
S
D
S
G
C
D
Site 25
S291
G
R
R
R
K
S
A
S
D
S
G
C
D
P
A
Site 26
S293
R
R
K
S
A
S
D
S
G
C
D
P
A
S
K
Site 27
S299
D
S
G
C
D
P
A
S
K
K
L
K
G
D
R
Site 28
S311
G
D
R
G
E
V
D
S
N
G
S
D
G
G
E
Site 29
S314
G
E
V
D
S
N
G
S
D
G
G
E
A
S
R
Site 30
S320
G
S
D
G
G
E
A
S
R
G
P
W
K
G
G
Site 31
S330
P
W
K
G
G
N
A
S
G
E
P
G
L
D
Q
Site 32
S344
Q
R
A
K
Q
P
P
S
T
F
V
P
Q
I
N
Site 33
T345
R
A
K
Q
P
P
S
T
F
V
P
Q
I
N
R
Site 34
T358
N
R
N
I
R
F
A
T
Y
T
K
E
N
G
R
Site 35
T360
N
I
R
F
A
T
Y
T
K
E
N
G
R
T
L
Site 36
T366
Y
T
K
E
N
G
R
T
L
V
V
Q
D
E
P
Site 37
T378
D
E
P
V
G
G
D
T
P
A
S
F
T
P
Y
Site 38
S381
V
G
G
D
T
P
A
S
F
T
P
Y
S
T
A
Site 39
T383
G
D
T
P
A
S
F
T
P
Y
S
T
A
T
G
Site 40
Y385
T
P
A
S
F
T
P
Y
S
T
A
T
G
Q
T
Site 41
S386
P
A
S
F
T
P
Y
S
T
A
T
G
Q
T
P
Site 42
T392
Y
S
T
A
T
G
Q
T
P
L
A
P
E
V
G
Site 43
T409
E
N
K
E
A
G
K
T
L
E
Q
V
G
Q
G
Site 44
T433
T
A
S
S
T
P
N
T
V
R
I
S
D
T
G
Site 45
S437
T
P
N
T
V
R
I
S
D
T
G
L
A
A
G
Site 46
T439
N
T
V
R
I
S
D
T
G
L
A
A
G
T
V
Site 47
S455
E
K
Q
K
G
S
R
S
Q
A
S
G
E
N
S
Site 48
S458
K
G
S
R
S
Q
A
S
G
E
N
S
R
N
S
Site 49
S462
S
Q
A
S
G
E
N
S
R
N
S
I
L
A
S
Site 50
S465
S
G
E
N
S
R
N
S
I
L
A
S
S
G
F
Site 51
S478
G
F
G
A
P
L
P
S
S
S
Q
P
L
T
F
Site 52
S479
F
G
A
P
L
P
S
S
S
Q
P
L
T
F
G
Site 53
S480
G
A
P
L
P
S
S
S
Q
P
L
T
F
G
S
Site 54
T484
P
S
S
S
Q
P
L
T
F
G
S
G
R
S
Q
Site 55
S487
S
Q
P
L
T
F
G
S
G
R
S
Q
S
N
G
Site 56
S490
L
T
F
G
S
G
R
S
Q
S
N
G
V
L
A
Site 57
S492
F
G
S
G
R
S
Q
S
N
G
V
L
A
T
E
Site 58
S506
E
N
K
P
L
G
F
S
F
G
C
S
S
A
Q
Site 59
S510
L
G
F
S
F
G
C
S
S
A
Q
E
A
Q
K
Site 60
S537
M
S
Q
T
L
P
T
S
N
Y
F
T
T
V
S
Site 61
Y539
Q
T
L
P
T
S
N
Y
F
T
T
V
S
E
S
Site 62
T541
L
P
T
S
N
Y
F
T
T
V
S
E
S
L
A
Site 63
T542
P
T
S
N
Y
F
T
T
V
S
E
S
L
A
D
Site 64
S546
Y
F
T
T
V
S
E
S
L
A
D
D
S
S
S
Site 65
S551
S
E
S
L
A
D
D
S
S
S
R
D
S
F
K
Site 66
S552
E
S
L
A
D
D
S
S
S
R
D
S
F
K
Q
Site 67
S553
S
L
A
D
D
S
S
S
R
D
S
F
K
Q
S
Site 68
S556
D
D
S
S
S
R
D
S
F
K
Q
S
L
E
S
Site 69
S560
S
R
D
S
F
K
Q
S
L
E
S
L
S
S
G
Site 70
S563
S
F
K
Q
S
L
E
S
L
S
S
G
L
C
K
Site 71
S566
Q
S
L
E
S
L
S
S
G
L
C
K
G
R
S
Site 72
S573
S
G
L
C
K
G
R
S
V
L
G
T
D
T
K
Site 73
T577
K
G
R
S
V
L
G
T
D
T
K
P
G
S
K
Site 74
T579
R
S
V
L
G
T
D
T
K
P
G
S
K
A
G
Site 75
S583
G
T
D
T
K
P
G
S
K
A
G
S
S
V
D
Site 76
S587
K
P
G
S
K
A
G
S
S
V
D
R
K
V
P
Site 77
S588
P
G
S
K
A
G
S
S
V
D
R
K
V
P
A
Site 78
T600
V
P
A
E
S
M
P
T
L
T
P
A
F
P
R
Site 79
T602
A
E
S
M
P
T
L
T
P
A
F
P
R
S
L
Site 80
S608
L
T
P
A
F
P
R
S
L
L
N
A
R
T
P
Site 81
T614
R
S
L
L
N
A
R
T
P
E
N
H
E
N
L
Site 82
S629
F
L
Q
P
P
K
L
S
R
E
E
P
S
N
P
Site 83
S647
F
V
E
K
V
E
H
S
P
F
S
S
F
A
S
Site 84
S650
K
V
E
H
S
P
F
S
S
F
A
S
Q
A
S
Site 85
S651
V
E
H
S
P
F
S
S
F
A
S
Q
A
S
G
Site 86
S654
S
P
F
S
S
F
A
S
Q
A
S
G
S
S
S
Site 87
S657
S
S
F
A
S
Q
A
S
G
S
S
S
S
A
T
Site 88
S659
F
A
S
Q
A
S
G
S
S
S
S
A
T
T
V
Site 89
S661
S
Q
A
S
G
S
S
S
S
A
T
T
V
T
S
Site 90
S662
Q
A
S
G
S
S
S
S
A
T
T
V
T
S
K
Site 91
T664
S
G
S
S
S
S
A
T
T
V
T
S
K
V
A
Site 92
T665
G
S
S
S
S
A
T
T
V
T
S
K
V
A
P
Site 93
T667
S
S
S
A
T
T
V
T
S
K
V
A
P
S
W
Site 94
S668
S
S
A
T
T
V
T
S
K
V
A
P
S
W
P
Site 95
S673
V
T
S
K
V
A
P
S
W
P
E
S
H
S
S
Site 96
S677
V
A
P
S
W
P
E
S
H
S
S
A
D
S
A
Site 97
S679
P
S
W
P
E
S
H
S
S
A
D
S
A
S
L
Site 98
S680
S
W
P
E
S
H
S
S
A
D
S
A
S
L
A
Site 99
S683
E
S
H
S
S
A
D
S
A
S
L
A
K
K
K
Site 100
S685
H
S
S
A
D
S
A
S
L
A
K
K
K
P
L
Site 101
T695
K
K
K
P
L
F
I
T
T
D
S
S
K
L
V
Site 102
T696
K
K
P
L
F
I
T
T
D
S
S
K
L
V
S
Site 103
S703
T
D
S
S
K
L
V
S
G
V
L
G
S
A
L
Site 104
S708
L
V
S
G
V
L
G
S
A
L
T
S
G
G
P
Site 105
T711
G
V
L
G
S
A
L
T
S
G
G
P
S
L
S
Site 106
S718
T
S
G
G
P
S
L
S
A
M
G
N
G
R
S
Site 107
S725
S
A
M
G
N
G
R
S
S
S
P
T
S
S
L
Site 108
S726
A
M
G
N
G
R
S
S
S
P
T
S
S
L
T
Site 109
S727
M
G
N
G
R
S
S
S
P
T
S
S
L
T
Q
Site 110
T729
N
G
R
S
S
S
P
T
S
S
L
T
Q
P
I
Site 111
S730
G
R
S
S
S
P
T
S
S
L
T
Q
P
I
E
Site 112
S731
R
S
S
S
P
T
S
S
L
T
Q
P
I
E
M
Site 113
T733
S
S
P
T
S
S
L
T
Q
P
I
E
M
P
T
Site 114
T740
T
Q
P
I
E
M
P
T
L
S
S
S
P
T
E
Site 115
S742
P
I
E
M
P
T
L
S
S
S
P
T
E
E
R
Site 116
S743
I
E
M
P
T
L
S
S
S
P
T
E
E
R
P
Site 117
S744
E
M
P
T
L
S
S
S
P
T
E
E
R
P
T
Site 118
T746
P
T
L
S
S
S
P
T
E
E
R
P
T
V
G
Site 119
T751
S
P
T
E
E
R
P
T
V
G
P
G
Q
Q
D
Site 120
T764
Q
D
N
P
L
L
K
T
F
S
N
V
F
G
R
Site 121
S766
N
P
L
L
K
T
F
S
N
V
F
G
R
H
S
Site 122
S773
S
N
V
F
G
R
H
S
G
G
F
L
S
S
P
Site 123
S778
R
H
S
G
G
F
L
S
S
P
A
D
F
S
Q
Site 124
S779
H
S
G
G
F
L
S
S
P
A
D
F
S
Q
E
Site 125
S784
L
S
S
P
A
D
F
S
Q
E
N
K
A
P
F
Site 126
S798
F
E
A
V
K
R
F
S
L
D
E
R
S
L
A
Site 127
S803
R
F
S
L
D
E
R
S
L
A
C
R
Q
D
S
Site 128
S810
S
L
A
C
R
Q
D
S
D
S
S
T
N
S
D
Site 129
S812
A
C
R
Q
D
S
D
S
S
T
N
S
D
L
S
Site 130
S813
C
R
Q
D
S
D
S
S
T
N
S
D
L
S
D
Site 131
T814
R
Q
D
S
D
S
S
T
N
S
D
L
S
D
L
Site 132
S816
D
S
D
S
S
T
N
S
D
L
S
D
L
S
D
Site 133
S819
S
S
T
N
S
D
L
S
D
L
S
D
S
E
E
Site 134
S822
N
S
D
L
S
D
L
S
D
S
E
E
Q
L
Q
Site 135
S824
D
L
S
D
L
S
D
S
E
E
Q
L
Q
A
K
Site 136
T832
E
E
Q
L
Q
A
K
T
G
L
K
G
I
P
E
Site 137
S852
L
G
P
N
G
E
R
S
A
E
L
L
L
G
K
Site 138
S860
A
E
L
L
L
G
K
S
K
G
K
Q
A
P
K
Site 139
T872
A
P
K
G
R
P
R
T
A
P
L
K
V
G
Q
Site 140
S880
A
P
L
K
V
G
Q
S
V
L
K
D
V
S
K
Site 141
S886
Q
S
V
L
K
D
V
S
K
V
K
K
L
K
Q
Site 142
S894
K
V
K
K
L
K
Q
S
G
E
P
F
L
Q
D
Site 143
S933
K
E
Q
E
Q
D
D
S
T
V
A
C
R
F
F
Site 144
T934
E
Q
E
Q
D
D
S
T
V
A
C
R
F
F
H
Site 145
T948
H
F
R
R
L
I
F
T
R
K
G
V
L
R
V
Site 146
S960
L
R
V
E
G
F
L
S
P
Q
Q
S
D
P
D
Site 147
S964
G
F
L
S
P
Q
Q
S
D
P
D
A
M
N
L
Site 148
Y1057
F
G
V
C
L
D
C
Y
R
L
R
K
S
R
P
Site 149
S1062
D
C
Y
R
L
R
K
S
R
P
R
S
E
T
E
Site 150
S1066
L
R
K
S
R
P
R
S
E
T
E
E
M
G
D
Site 151
T1068
K
S
R
P
R
S
E
T
E
E
M
G
D
E
E
Site 152
S1087
L
K
C
A
K
G
Q
S
H
E
P
E
N
L
M
Site 153
S1133
C
I
S
R
Q
N
K
S
V
L
R
P
A
V
T
Site 154
S1144
P
A
V
T
N
G
M
S
Q
L
P
S
I
N
P
Site 155
S1148
N
G
M
S
Q
L
P
S
I
N
P
S
A
S
S
Site 156
S1152
Q
L
P
S
I
N
P
S
A
S
S
G
N
E
T
Site 157
S1154
P
S
I
N
P
S
A
S
S
G
N
E
T
T
F
Site 158
S1155
S
I
N
P
S
A
S
S
G
N
E
T
T
F
S
Site 159
T1159
S
A
S
S
G
N
E
T
T
F
S
G
G
G
G
Site 160
T1160
A
S
S
G
N
E
T
T
F
S
G
G
G
G
P
Site 161
S1162
S
G
N
E
T
T
F
S
G
G
G
G
P
A
P
Site 162
T1171
G
G
G
P
A
P
V
T
T
P
E
P
D
H
V
Site 163
T1172
G
G
P
A
P
V
T
T
P
E
P
D
H
V
P
Site 164
T1184
H
V
P
K
A
D
S
T
D
I
R
S
E
E
P
Site 165
S1188
A
D
S
T
D
I
R
S
E
E
P
L
K
T
D
Site 166
T1194
R
S
E
E
P
L
K
T
D
S
S
A
S
N
S
Site 167
S1196
E
E
P
L
K
T
D
S
S
A
S
N
S
N
S
Site 168
S1197
E
P
L
K
T
D
S
S
A
S
N
S
N
S
E
Site 169
S1199
L
K
T
D
S
S
A
S
N
S
N
S
E
L
K
Site 170
S1201
T
D
S
S
A
S
N
S
N
S
E
L
K
A
I
Site 171
S1203
S
S
A
S
N
S
N
S
E
L
K
A
I
R
P
Site 172
T1215
I
R
P
P
C
P
D
T
A
P
P
S
S
A
L
Site 173
S1219
C
P
D
T
A
P
P
S
S
A
L
H
W
L
A
Site 174
S1220
P
D
T
A
P
P
S
S
A
L
H
W
L
A
D
Site 175
S1242
E
E
T
K
E
A
G
S
L
R
S
V
L
N
K
Site 176
S1245
K
E
A
G
S
L
R
S
V
L
N
K
E
S
H
Site 177
S1251
R
S
V
L
N
K
E
S
H
S
P
F
G
L
D
Site 178
S1253
V
L
N
K
E
S
H
S
P
F
G
L
D
S
F
Site 179
S1259
H
S
P
F
G
L
D
S
F
N
S
T
A
K
V
Site 180
T1263
G
L
D
S
F
N
S
T
A
K
V
S
P
L
T
Site 181
S1267
F
N
S
T
A
K
V
S
P
L
T
P
K
L
F
Site 182
T1270
T
A
K
V
S
P
L
T
P
K
L
F
N
S
L
Site 183
S1276
L
T
P
K
L
F
N
S
L
L
L
G
P
T
A
Site 184
S1284
L
L
L
G
P
T
A
S
N
N
K
T
E
G
S
Site 185
T1288
P
T
A
S
N
N
K
T
E
G
S
S
L
R
D
Site 186
S1291
S
N
N
K
T
E
G
S
S
L
R
D
L
L
H
Site 187
S1292
N
N
K
T
E
G
S
S
L
R
D
L
L
H
S
Site 188
S1299
S
L
R
D
L
L
H
S
G
P
G
K
L
P
Q
Site 189
T1307
G
P
G
K
L
P
Q
T
P
L
D
T
G
I
P
Site 190
T1311
L
P
Q
T
P
L
D
T
G
I
P
F
P
P
V
Site 191
S1322
F
P
P
V
F
S
T
S
S
A
G
V
K
S
K
Site 192
S1328
T
S
S
A
G
V
K
S
K
A
S
L
P
N
F
Site 193
S1331
A
G
V
K
S
K
A
S
L
P
N
F
L
D
H
Site 194
T1349
S
V
V
E
N
K
K
T
S
D
A
S
K
R
A
Site 195
S1353
N
K
K
T
S
D
A
S
K
R
A
C
N
L
T
Site 196
T1360
S
K
R
A
C
N
L
T
D
T
Q
K
E
V
K
Site 197
T1362
R
A
C
N
L
T
D
T
Q
K
E
V
K
E
M
Site 198
T1380
L
N
V
L
D
P
H
T
S
H
S
W
L
C
D
Site 199
S1426
G
V
H
K
K
L
K
S
E
L
W
K
P
E
A
Site 200
S1435
L
W
K
P
E
A
F
S
Q
E
F
G
D
Q
D
Site 201
S1475
I
I
C
K
R
L
R
S
E
D
G
Q
P
M
V
Site 202
Y1514
E
N
L
P
L
P
E
Y
T
K
R
D
G
R
L
Site 203
S1525
D
G
R
L
N
L
A
S
R
L
P
S
Y
F
V
Site 204
S1529
N
L
A
S
R
L
P
S
Y
F
V
R
P
D
L
Site 205
Y1530
L
A
S
R
L
P
S
Y
F
V
R
P
D
L
G
Site 206
Y1541
P
D
L
G
P
K
M
Y
N
A
Y
G
L
I
T
Site 207
T1556
A
E
D
R
R
V
G
T
T
N
L
H
L
D
V
Site 208
T1589
H
D
E
E
V
L
K
T
I
D
E
G
D
A
D
Site 209
T1599
E
G
D
A
D
E
V
T
K
Q
R
I
H
D
G
Site 210
Y1617
P
G
A
L
W
H
I
Y
A
A
K
D
A
E
K
Site 211
Y1653
P
I
H
D
Q
S
W
Y
L
D
Q
T
L
R
K
Site 212
T1657
Q
S
W
Y
L
D
Q
T
L
R
K
R
L
Y
E
Site 213
Y1663
Q
T
L
R
K
R
L
Y
E
E
Y
G
V
Q
G
Site 214
Y1666
R
K
R
L
Y
E
E
Y
G
V
Q
G
W
A
I
Site 215
Y1695
P
H
Q
V
H
N
L
Y
S
C
I
K
V
A
E
Site 216
S1706
K
V
A
E
D
F
V
S
P
E
H
V
K
H
C
Site 217
T1717
V
K
H
C
F
R
L
T
Q
E
F
R
H
L
S
Site 218
S1724
T
Q
E
F
R
H
L
S
N
T
H
T
N
H
E
Site 219
T1726
E
F
R
H
L
S
N
T
H
T
N
H
E
D
K
Site 220
T1728
R
H
L
S
N
T
H
T
N
H
E
D
K
L
Q
Site 221
S1756
G
T
L
K
A
H
E
S
K
L
A
R
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation