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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RRM2B
Full Name:
Ribonucleoside-diphosphate reductase subunit M2 B
Alias:
EC 1.17.4.1; P53R2; RIR2B
Type:
Enzyme - Ribonucleotide reductase. DNA repair protein. Ribonucleoside diphosphate reductase small chain family.
Mass (Da):
40737
Number AA:
351
UniProt ID:
Q7LG56
International Prot ID:
Isoform1 - IPI00100213
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005506
GO:0004748
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0009186
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
G
L
D
Q
D
E
R
S
S
S
D
T
N
E
S
Site 2
S19
L
D
Q
D
E
R
S
S
S
D
T
N
E
S
E
Site 3
S20
D
Q
D
E
R
S
S
S
D
T
N
E
S
E
I
Site 4
T22
D
E
R
S
S
S
D
T
N
E
S
E
I
K
S
Site 5
S25
S
S
S
D
T
N
E
S
E
I
K
S
N
E
E
Site 6
S29
T
N
E
S
E
I
K
S
N
E
E
P
L
L
R
Site 7
S38
E
E
P
L
L
R
K
S
S
R
R
F
V
I
F
Site 8
S39
E
P
L
L
R
K
S
S
R
R
F
V
I
F
P
Site 9
S72
T
A
E
E
V
D
L
S
K
D
L
P
H
W
N
Site 10
Y87
K
L
K
A
D
E
K
Y
F
I
S
H
I
L
A
Site 11
S112
E
N
L
V
E
R
F
S
Q
E
V
Q
V
P
E
Site 12
T144
M
Y
S
L
L
I
D
T
Y
I
R
D
P
K
K
Site 13
Y145
Y
S
L
L
I
D
T
Y
I
R
D
P
K
K
R
Site 14
Y164
N
A
I
E
T
M
P
Y
V
K
K
K
A
D
W
Site 15
S181
R
W
I
A
D
R
K
S
T
F
G
E
R
V
V
Site 16
T182
W
I
A
D
R
K
S
T
F
G
E
R
V
V
A
Site 17
S220
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
Site 18
S225
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
Site 19
S247
Q
Y
L
V
N
K
P
S
E
E
R
V
R
E
I
Site 20
S329
N
F
F
E
K
R
V
S
E
Y
Q
R
F
A
V
Site 21
Y331
F
E
K
R
V
S
E
Y
Q
R
F
A
V
M
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation